DK139974B - Fremgangsmåde til fremstilling af 8,14-dihydrothebain eller dihydrocodeinon ud fra thebain ved reduktion under anvendelse af diimin dannet som ustabilt mellemprodukt som reduktionsmiddel. - Google Patents

Fremgangsmåde til fremstilling af 8,14-dihydrothebain eller dihydrocodeinon ud fra thebain ved reduktion under anvendelse af diimin dannet som ustabilt mellemprodukt som reduktionsmiddel.

Info

Publication number: DK139974B
Authority: DK; Denmark
Prior art keywords: dihydrothebain; thebain; dihydrocodeinone; reduction; preparation
Prior art date: 1970-12-11

Application number

DK603371AA

Other languages

Danish (da)

English (en)

Other versions

DK139974C (cs

Inventor

Edward Leon Grew

Alastair Agnew Robertson

Original Assignee

Macfarlan Smith Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1970-12-11

Filing date

1971-12-09

Publication date

1979-05-28

1971-12-09 Application filed by Macfarlan Smith Ltd filed Critical Macfarlan Smith Ltd

1979-05-28 Publication of DK139974B publication Critical patent/DK139974B/da

1979-12-10 Application granted granted Critical

1979-12-10 Publication of DK139974C publication Critical patent/DK139974C/da

Links

239000003638 chemical reducing agent Substances 0.000 title 1
RAABOESOVLLHRU-UHFFFAOYSA-N diazene Chemical compound N=N RAABOESOVLLHRU-UHFFFAOYSA-N 0.000 title 1
229910000071 diazene Inorganic materials 0.000 title 1
LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 title 1
229960000240 hydrocodone Drugs 0.000 title 1
FQXXSQDCDRQNQE-UHFFFAOYSA-N markiertes Thebain Natural products COC1=CC=C2C(N(CC3)C)CC4=CC=C(OC)C5=C4C23C1O5 FQXXSQDCDRQNQE-UHFFFAOYSA-N 0.000 title 1
QKQQEIVDLRUZRP-UHFFFAOYSA-N northebaine Natural products COC1=CC=C2C(NCC3)CC4=CC=C(OC)C5=C4C23C1O5 QKQQEIVDLRUZRP-UHFFFAOYSA-N 0.000 title 1
FQXXSQDCDRQNQE-VMDGZTHMSA-N thebaine Chemical compound C([C@@H](N(CC1)C)C2=CC=C3OC)C4=CC=C(OC)C5=C4[C@@]21[C@H]3O5 FQXXSQDCDRQNQE-VMDGZTHMSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK603371AA 1970-12-11 1971-12-09 Fremgangsmåde til fremstilling af 8,14-dihydrothebain eller dihydrocodeinon ud fra thebain ved reduktion under anvendelse af diimin dannet som ustabilt mellemprodukt som reduktionsmiddel. DK139974B (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB5892670		1970-12-11

Publications (2)

Publication Number	Publication Date
DK139974B true DK139974B (da)	1979-05-28
DK139974C DK139974C (cs)	1979-12-10

Family

ID=10482707

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK603371AA DK139974B (da)	1970-12-11	1971-12-09	Fremgangsmåde til fremstilling af 8,14-dihydrothebain eller dihydrocodeinon ud fra thebain ved reduktion under anvendelse af diimin dannet som ustabilt mellemprodukt som reduktionsmiddel.

Country Status (17)

Country	Link
US (1)	US3812132A (cs)
JP (1)	JPS5511678B1 (cs)
AU (1)	AU459401B2 (cs)
BE (1)	BE776304A (cs)
CA (1)	CA958412A (cs)
CH (1)	CH556340A (cs)
CS (1)	CS176251B2 (cs)
DE (1)	DE2159348A1 (cs)
DK (1)	DK139974B (cs)
FR (1)	FR2117924B1 (cs)
GB (1)	GB1317210A (cs)
HU (1)	HU164465B (cs)
IL (1)	IL38268A (cs)
NL (1)	NL175622C (cs)
PL (1)	PL81441B1 (cs)
SE (1)	SE388422B (cs)
YU (1)	YU39064B (cs)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS59142770A (ja) *	1983-02-02	1984-08-16	Trio Kenwood Corp	カセツトテ−プレコ−ダの駆動機構
GB2429206A (en) *	2004-07-09	2007-02-21	Tasmanian Alkaloids Pty Ltd	Process for the synthesis of hydromorphone
CA2674915C (en)	2006-10-17	2015-06-30	Penick Corporation	Process for preparing oxymorphone
US20080125592A1 (en) *	2006-10-17	2008-05-29	Penick Corporation	Process for preparing oxymorphone, naltrexone, and buprenorphine
AU2007313103C1 (en)	2006-10-17	2014-01-30	Penick Corporation	Process for preparing oxymorphone
GB0624880D0 (en) *	2006-12-14	2007-01-24	Johnson Matthey Plc	Improved method for making analgesics
US9131649B2 (en)	2008-03-07	2015-09-15	Tasmanian Alkaloids Pty. Ltd	Papaver somniferum strain with high concentration of thebaine
US8541647B2 (en)	2008-05-29	2013-09-24	Tasmania Alkaloids Pty, Ltd.	Papaver somniferum with high concentration of codeine
PL2480555T3 (pl) *	2009-09-22	2016-05-31	SpecGx LLC	Sposoby wytwarzania hydrokodonu, hydromorfonu albo ich pochodnych
JP2013529595A (ja)	2010-06-11	2013-07-22	ローズテクノロジーズ	第３級アミンのｎ−脱アルキル化方法
ES2645725T3 (es)	2010-06-11	2017-12-07	Rhodes Technologies	Procesos catalizados por metales de transición para la preparación de compuestos de N-alilo y uso de los mismos
CA2919602C (en)	2013-08-02	2018-03-13	Johnson Matthey Public Limited Company	Process for the preparation of oxymorphone
WO2015134003A1 (en)	2014-03-05	2015-09-11	Johnson Matthey Public Limited Company	Processes for making hydrocodone, hydromorphone and their derivatives
US9273060B2 (en)	2014-03-05	2016-03-01	Johnson Matthey Public Limited Company	Processes for making hydrocodone, hydromorphone and their derivatives
US10155771B2 (en)	2015-11-04	2018-12-18	Noramco, Inc.	Selective reduction of morphinan alkaloids

1970
- 1970-12-11 GB GB5892670A patent/GB1317210A/en not_active Expired
1971
- 1971-11-24 PL PL1971151754A patent/PL81441B1/pl unknown
- 1971-11-30 DE DE19712159348 patent/DE2159348A1/de not_active Withdrawn
- 1971-11-30 IL IL38268A patent/IL38268A/en unknown
- 1971-11-30 CA CA128,915A patent/CA958412A/en not_active Expired
- 1971-12-02 US US00204298A patent/US3812132A/en not_active Expired - Lifetime
- 1971-12-03 AU AU36469/71A patent/AU459401B2/en not_active Expired
- 1971-12-06 BE BE776304A patent/BE776304A/xx not_active IP Right Cessation
- 1971-12-07 JP JP9899371A patent/JPS5511678B1/ja active Pending
- 1971-12-07 FR FR7143867A patent/FR2117924B1/fr not_active Expired
- 1971-12-09 DK DK603371AA patent/DK139974B/da unknown
- 1971-12-09 YU YU03086/71A patent/YU39064B/xx unknown
- 1971-12-09 CS CS8571A patent/CS176251B2/cs unknown
- 1971-12-10 CH CH1811571A patent/CH556340A/xx not_active IP Right Cessation
- 1971-12-10 SE SE7115886A patent/SE388422B/xx unknown
- 1971-12-10 HU HUMA2294A patent/HU164465B/hu unknown
- 1971-12-13 NL NLAANVRAGE7117082,A patent/NL175622C/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
US3812132A (en)	1974-05-21
SE388422B (sv)	1976-10-04
JPS5511678B1 (cs)	1980-03-26
HU164465B (cs)	1974-02-28
GB1317210A (en)	1973-05-16
YU39064B (en)	1984-04-30
IL38268A0 (en)	1972-01-27
CH556340A (de)	1974-11-29
FR2117924B1 (cs)	1975-02-07
DE2159348A1 (de)	1972-06-15
NL175622B (nl)	1984-07-02
CA958412A (en)	1974-11-26
PL81441B1 (cs)	1975-08-30
NL7117082A (cs)	1972-06-13
BE776304A (fr)	1972-06-06
AU459401B2 (en)	1975-03-27
IL38268A (en)	1974-11-29
FR2117924A1 (cs)	1972-07-28
AU3646971A (en)	1973-06-07
NL175622C (nl)	1984-12-03
YU308671A (en)	1982-06-30
DK139974C (cs)	1979-12-10
CS176251B2 (cs)	1977-06-30

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