DK140834B - Analogifremgangsmåde til fremstilling af biguanidsalte. - Google Patents

Analogifremgangsmåde til fremstilling af biguanidsalte.

Info

Publication number: DK140834B
Authority: DK; Denmark
Prior art keywords: preparation; analogous process; biguanide salts; biguanide; salts
Prior art date: 1974-10-11

Application number

DK457475AA

Other languages

Danish (da)

English (en)

Other versions

DK140834C (fr

DK457475A (fr

Inventor

Ulf Fischer

Eckehard Lorch

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-10-11

Filing date

1975-10-10

Publication date

1979-11-26

1975-10-10 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1976-04-12 Publication of DK457475A publication Critical patent/DK457475A/da

1979-11-26 Publication of DK140834B publication Critical patent/DK140834B/da

1980-04-28 Application granted granted Critical

1980-04-28 Publication of DK140834C publication Critical patent/DK140834C/da

Links

150000004283 biguanides Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C07C279/26—X and Y being nitrogen atoms, i.e. biguanides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK457475AA 1974-10-11 1975-10-10 Analogifremgangsmåde til fremstilling af biguanidsalte. DK140834B (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH1369774A CH602612A5 (fr)	1974-10-11	1974-10-11

Publications (3)

Publication Number	Publication Date
DK457475A DK457475A (fr)	1976-04-12
DK140834B true DK140834B (da)	1979-11-26
DK140834C DK140834C (fr)	1980-04-28

Family

ID=4394567

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK457475AA DK140834B (da)	1974-10-11	1975-10-10	Analogifremgangsmåde til fremstilling af biguanidsalte.

Country Status (26)

Country	Link
US (1)	US4028402A (fr)
JP (1)	JPS51125718A (fr)
AR (1)	AR209457A1 (fr)
AT (1)	AT343676B (fr)
BE (1)	BE834369A (fr)
BR (1)	BR7506595A (fr)
CA (1)	CA1053258A (fr)
CH (1)	CH602612A5 (fr)
CU (1)	CU34371A (fr)
DD (1)	DD123322A5 (fr)
DE (1)	DE2542598A1 (fr)
DK (1)	DK140834B (fr)
ES (1)	ES441673A1 (fr)
FI (1)	FI752626A7 (fr)
FR (1)	FR2287221A1 (fr)
GB (1)	GB1473256A (fr)
IE (1)	IE41807B1 (fr)
IL (1)	IL48116A (fr)
LU (1)	LU73557A1 (fr)
NL (1)	NL7511890A (fr)
NO (1)	NO753447L (fr)
PH (1)	PH12279A (fr)
PL (1)	PL95259B1 (fr)
SE (1)	SE7511357L (fr)
SU (1)	SU572200A3 (fr)
ZA (1)	ZA755861B (fr)

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FR2401898A1 (fr) *	1977-09-05	1979-03-30	Aec Chim Organ Biolog	Nouveau sel de l'acide patoique
US20020006899A1 (en) *	1998-10-06	2002-01-17	Pospisilik Andrew J.	Use of dipeptidyl peptidase IV effectors for lowering blood pressure in mammals
DE122010000020I1 (de)	1996-04-25	2010-07-08	Prosidion Ltd	Verfahren zur Senkung des Blutglukosespiegels in Säugern
US6399658B1 (en)	1996-12-24	2002-06-04	Sumitomo Pharmaceuticals Co., Ltd.	Composition containing ascorbic acid
DE19823831A1 (de)	1998-05-28	1999-12-02	Probiodrug Ges Fuer Arzneim	Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen
DE19828114A1 (de)	1998-06-24	2000-01-27	Probiodrug Ges Fuer Arzneim	Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV
DE19828113A1 (de)	1998-06-24	2000-01-05	Probiodrug Ges Fuer Arzneim	Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV
DE19834591A1 (de)	1998-07-31	2000-02-03	Probiodrug Ges Fuer Arzneim	Verfahren zur Steigerung des Blutglukosespiegels in Säugern
US20030176357A1 (en) *	1998-10-06	2003-09-18	Pospisilik Andrew J.	Dipeptidyl peptidase IV inhibitors and their uses for lowering blood pressure levels
DE19926233C1 (de)	1999-06-10	2000-10-19	Probiodrug Ges Fuer Arzneim	Verfahren zur Herstellung von Thiazolidin
DE19940130A1 (de) *	1999-08-24	2001-03-01	Probiodrug Ges Fuer Arzneim	Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung
JP4719393B2 (ja)	1999-10-06	2011-07-06	敏男宮田	カルボニルストレス改善剤
US20080076811A1 (en) *	2000-01-21	2008-03-27	Bork Balkan	Combinations comprising depeptidypeptidase-iv inhibitors and antidiabetic agents
AU2001254763A1 (en) *	2000-03-31	2001-10-08	Prosidion Limited	Method for the improvement of islet signaling in diabetes mellitus and for its prevention
FR2809310B1 (fr)	2000-05-26	2004-02-13	Centre Nat Rech Scient	Utilisation de derives de biguanide pour fabriquer un medicament ayant un effet cicatrisant
JP2005097117A (ja) *	2000-06-30	2005-04-14	Chugai Pharmaceut Co Ltd	糖尿病治療剤
US7132104B1 (en)	2000-10-27	2006-11-07	Probiodrug Ag	Modulation of central nervous system (CNS) dipeptidyl peptidase IV (DPIV) -like activity for the treatment of neurological and neuropsychological disorders
ZA200302394B (en) *	2000-10-27	2004-03-29	Probiodrug Ag	Method for the treatment of neurological and neuropsychological disorders.
US6890905B2 (en)	2001-04-02	2005-05-10	Prosidion Limited	Methods for improving islet signaling in diabetes mellitus and for its prevention
US7368421B2 (en)	2001-06-27	2008-05-06	Probiodrug Ag	Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis
DE10150203A1 (de)	2001-10-12	2003-04-17	Probiodrug Ag	Peptidylketone als Inhibitoren der DPIV
US20030130199A1 (en) *	2001-06-27	2003-07-10	Von Hoersten Stephan	Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents
EP1492525A2 (fr) *	2001-08-16	2005-01-05	Probiodrug AG	Utilisation d'inhibiteurs de la proline endopeptidase pour moduler la concentration d'inositol (1,4,5) triphosphate dependante des cascades de signaux intracellulaires
US6844316B2 (en)	2001-09-06	2005-01-18	Probiodrug Ag	Inhibitors of dipeptidyl peptidase I
SK3622004A3 (sk)	2002-02-28	2005-02-04	Prosidion Limited	Inhibítory DPIV na báze glutaminylu
US20030232761A1 (en) *	2002-03-28	2003-12-18	Hinke Simon A.	Novel analogues of glucose-dependent insulinotropic polypeptide
US20040033051A1 (en) *	2002-08-16	2004-02-19	Ip Kiril Kun Wan	Method and system for producing and displaying visual presentations which inhibit off-screen duplication
US20040058876A1 (en) *	2002-09-18	2004-03-25	Torsten Hoffmann	Secondary binding site of dipeptidyl peptidase IV (DP IV)
EP1543023B1 (fr) *	2002-09-18	2010-03-17	Prosidion Limited	Site secondaire de liaison de dipeptidyl peptidase (dp iv)
NZ568459A (en)	2003-05-05	2009-06-26	Probiodrug Ag	Use of effectors of glutaminyl and glutamate cyclases
JP4806628B2 (ja)	2003-05-05	2011-11-02	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤
CA2542419C (fr) *	2003-10-15	2013-06-04	Probiodrug Ag	Utilisation d'inhibiteurs de la glutamyl cyclase dans le traitement de la demence britannique familiale et de la demence danoise familiale
US20100099721A1 (en) *	2003-11-03	2010-04-22	Probiodrug Ag	Novel compounds for the treatment of neurological disorders
US20050171112A1 (en) *	2003-11-03	2005-08-04	Probiodrug Ag	Combinations useful for the treatment of neuronal disorders
KR101099206B1 (ko)	2004-02-05	2011-12-27	프로비오드룩 아게	신규한 글루타미닐 시클라제 저해제
CN101652131A (zh)	2007-01-29	2010-02-17	韩兀制药株式会社	N,n-二甲基亚氨基二碳亚氨酸二酰胺乙酸盐、其制备方法和包含其的药物组合物
US20080188457A1 (en) *	2007-02-02	2008-08-07	Braincells, Inc.	Modulation of Neurogenesis with Biguanides and GSK3-beta Agents
EP2203418B1 (fr) *	2007-09-21	2017-10-25	HanAll Biopharma Co., Ltd.	Diamide dicarboxylate n, n- diméthyl imidodicarbonimidique, son procédé de production et compositions pharmaceutiques le comprenant
WO2009088220A2 (fr) *	2008-01-08	2009-07-16	Hanall Pharmaceutical Company. Ltd	Diamide nicotinate n,n-diméthyl imidodicarbonimidique, son procédé de production et composition pharmaceutique le comprenant
CN102159539B (zh) *	2008-06-26	2014-04-16	矽烷实验室股份公司	用于血糖控制的新型二甲双胍甘氨酸盐
US20110021634A1 (en)	2009-06-18	2011-01-27	Patel Pranav Dushyant	Processes for preparing metformin hydrochloride
WO2011049400A2 (fr) *	2009-10-23	2011-04-28	한올바이오파마주식회사	Composition pharmaceutique contenant un sel d'addition d'acide de n,n-diméthyl diamide imidocarbonimidique pour une action anticancéreuse
KR101324283B1 (ko)	2010-04-27	2013-11-01	한올바이오파마주식회사	바이구아나이드 화합물의 신규 염, 그의 제조방법, 그를 포함하는 약제학적 조성물
MX2019003725A (es)	2016-09-30	2019-08-12	Laboratorios Silanes S A De C V	Glicinato de metformina, composiciones farmaceuticas que comprenden la misma, y metodos de uso de la misma.
US11510886B2 (en)	2016-09-30	2022-11-29	Laboratorios Silanes, S.A. De C.V.	Metformin amino acid compounds and methods of using the same
CN106986791A (zh) *	2017-05-11	2017-07-28	杜剑平	一种治疗肿瘤的药物化合物及其制备方法和应用
CN107118130A (zh) *	2017-05-11	2017-09-01	杜剑平	一类治疗肿瘤的药物化合物及其应用

Family Cites Families (1)

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Publication number	Priority date	Publication date	Assignee	Title
US3179562A (en) *	1961-08-23	1965-04-20	Du Pont	Treatment of diabetes with alpha, alpha substituted acetic acid derivatives

1974
- 1974-10-11 CH CH1369774A patent/CH602612A5/xx not_active IP Right Cessation
1975
- 1975-09-15 ZA ZA00755861A patent/ZA755861B/xx unknown
- 1975-09-17 IL IL48116A patent/IL48116A/xx unknown
- 1975-09-19 FI FI752626A patent/FI752626A7/fi not_active Application Discontinuation
- 1975-09-24 DE DE19752542598 patent/DE2542598A1/de not_active Withdrawn
- 1975-10-06 IE IE2184/75A patent/IE41807B1/en unknown
- 1975-10-08 US US05/620,525 patent/US4028402A/en not_active Expired - Lifetime
- 1975-10-08 CU CU7534371A patent/CU34371A/es unknown
- 1975-10-08 PH PH17640A patent/PH12279A/en unknown
- 1975-10-09 SE SE7511357A patent/SE7511357L/xx unknown
- 1975-10-09 LU LU73557A patent/LU73557A1/xx unknown
- 1975-10-09 JP JP50121432A patent/JPS51125718A/ja active Pending
- 1975-10-09 SU SU7502178502A patent/SU572200A3/ru active
- 1975-10-09 CA CA237,343A patent/CA1053258A/fr not_active Expired
- 1975-10-09 FR FR7530907A patent/FR2287221A1/fr not_active Withdrawn
- 1975-10-09 BR BR7506595*A patent/BR7506595A/pt unknown
- 1975-10-09 NL NL7511890A patent/NL7511890A/xx not_active Application Discontinuation
- 1975-10-10 NO NO753447A patent/NO753447L/no unknown
- 1975-10-10 AT AT776375A patent/AT343676B/de active
- 1975-10-10 ES ES441673A patent/ES441673A1/es not_active Expired
- 1975-10-10 DD DD188797A patent/DD123322A5/xx unknown
- 1975-10-10 GB GB4161175A patent/GB1473256A/en not_active Expired
- 1975-10-10 DK DK457475AA patent/DK140834B/da unknown
- 1975-10-10 BE BE160823A patent/BE834369A/fr unknown
- 1975-10-10 PL PL1975183923A patent/PL95259B1/pl unknown
- 1975-10-11 AR AR260639A patent/AR209457A1/es active

Also Published As

Publication number	Publication date
DK140834C (fr)	1980-04-28
FI752626A7 (fr)	1976-04-12
NO753447L (fr)	1976-04-13
GB1473256A (en)	1977-05-11
IL48116A0 (en)	1975-11-25
ATA776375A (de)	1977-10-15
DD123322A5 (fr)	1976-12-12
IE41807L (en)	1976-04-11
DE2542598A1 (de)	1976-04-22
CA1053258A (fr)	1979-04-24
DK457475A (fr)	1976-04-12
FR2287221A1 (fr)	1976-05-07
PH12279A (en)	1978-12-12
ES441673A1 (es)	1977-04-01
SE7511357L (sv)	1976-04-12
IE41807B1 (en)	1980-03-26
CU34371A (es)	1979-06-01
NL7511890A (nl)	1976-04-13
BE834369A (fr)	1976-04-12
LU73557A1 (fr)	1977-05-24
JPS51125718A (en)	1976-11-02
PL95259B1 (pl)	1977-10-31
AR209457A1 (es)	1977-04-29
BR7506595A (pt)	1976-08-17
ZA755861B (en)	1976-08-25
AT343676B (de)	1978-06-12
US4028402A (en)	1977-06-07
IL48116A (en)	1979-07-25
CH602612A5 (fr)	1978-07-31
SU572200A3 (ru)	1977-09-05
AU8497775A (en)	1977-03-24

Publication	Publication Date	Title
DK138655B (da)	1978-10-09	Fremgangsmåde til fremstilling af N-phosphonomethyl-glycin.
DK572975A (da)	1976-06-21	Fremgangsmade til fremstilling af hidtil ukendte pyridylguanidiner
DK134559B (da)	1976-11-29	Fremgangsmåde til fremstilling af N-phosphonomethylglycinforbindelser.
DK135716B (da)	1977-06-13	Analogifremgangsmåde til fremstilling af methyl-5-propylthio-2-benzimidazolcarbamat.
DK136075B (da)	1977-08-08	Analogifremgangsmåde til fremstilling af 11beta-hydroxy-16-methyl-3-oxo-17alfa-acyloxyandrosta-1,4,15-trien-17beta-carboxylater.
DK135711B (da)	1977-06-13	Analogifremgangsmåde til fremstilling af hidtil ukendte, hjerteaktive substituerede fenoxyisopropanolaminer.
DK179675A (da)	1975-10-27	Fremgangsmade til fremstilling af 6-amino-5-r3-2,4-diaminopyrimidin-3-oxider
DK137835B (da)	1978-05-16	Analogifremgangsmåde til fremstilling af thienothiazinderivater.
DK139580B (da)	1979-03-12	Analogifremgangsmåde til fremstilling af additionssalte af piperidylindolderivater.
DK135796B (da)	1977-06-27	Fremgangsmåde til fremstilling af alkyl-tert-alkylethere.
DK139846B (da)	1979-04-30	Analogifremgangsmåde til fremstilling af 3-alkoxypyrazin-2-carboxamider.
DK138321B (da)	1978-08-14	Analogifremgangsmåde til fremstilling af 5-halogen-2,3-kresotinsyrederivater.
DK138230B (da)	1978-07-31	Analogifremgangsmåde til fremstilling af vincanolsalte.
DK138898B (da)	1978-11-13	Fremgangsmåde til fremstilling af N-phosphonomethylglycin.
DK390975A (da)	1976-03-26	Fremgangsmade til fremstilling af omega-nor-cycloalkyl-13,14-dehydroprostaglandiner
DK135538B (da)	1977-05-16	Fremgangsmåde til fremstilling af 17alfa-ethynyl-(5alfa)-2-androsten-17-beta-ol.
DK138227B (da)	1978-07-31	Analogifremgangsmåde til fremstilling af substituerede xanthon-2-carboxylsyreforbindelser.
DK139574B (da)	1979-03-12	Analogifremgangsmåde til fremstilling af terpeno-phenoxy-alkylaminer eller syreadditionssalte deraf.
DK139682B (da)	1979-03-26	Analogifremgangsmåde til fremstilling af eburnameninderivater.
DK136313B (da)	1977-09-26	Analogifremgangsmåde til fremstilling af N-substituerede m-trifluormethylbenzylaminer.
DK139140B (da)	1978-12-27	Fremgangsmåde til fremstilling af dilactonforbindelser.
DK140557B (da)	1979-10-01	Analogifremgangsmåde til fremstilling af sultiner af 17-hydroxy-3-oxo-17alfa-pregn-4-en-21-sulfinsyrer.
DK137646B (da)	1978-04-10	Fremgangsmåde til fremstilling af 6-chlor-2-chlormethyl-4-phenylquinazolin-3-oxid.
DK138694B (da)	1978-10-16	Fremgangsmåde til fremstilling af phenylphosphonothiodichlorid.
DK140670B (da)	1979-10-22	Analogifremgangsmåde til fremstilling af ergopeptinderivater.