DK1408968T3 - Receptoradapteret nikotinafvænning gennem en kombination af atropin, scopolamin, clonidin - Google Patents

Receptoradapteret nikotinafvænning gennem en kombination af atropin, scopolamin, clonidin

Info

Publication number: DK1408968T3
Authority: DK; Denmark
Prior art keywords: atropine; scopolamine; clonidine; combination; patch
Prior art date: 2001-07-25

Application number

DK02753025T

Other languages

English (en)

Inventor

Wolfgang J Kox

Mario Hensel

Original Assignee

Wolfgang J Kox

Mario Hensel

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-25

Filing date

2002-07-18

Publication date

2006-03-27

2002-07-18 Application filed by Wolfgang J Kox, Mario Hensel filed Critical Wolfgang J Kox

2006-03-27 Application granted granted Critical

2006-03-27 Publication of DK1408968T3 publication Critical patent/DK1408968T3/da

Links

229930000680 A04AD01 - Scopolamine Natural products 0.000 title abstract 5
229930003347 Atropine Natural products 0.000 title abstract 5
RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 title abstract 5
STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 title abstract 5
STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 title abstract 5
RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 title abstract 5
229960000396 atropine Drugs 0.000 title abstract 5
STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 title abstract 5
229960002646 scopolamine Drugs 0.000 title abstract 5
GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 title abstract 4
229960002896 clonidine Drugs 0.000 title abstract 4
SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title 1
238000001784 detoxification Methods 0.000 title 1
229960002715 nicotine Drugs 0.000 title 1
SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 title 1
238000010255 intramuscular injection Methods 0.000 abstract 2
239000007927 intramuscular injection Substances 0.000 abstract 2
SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 abstract 1
229940124133 Acetylcholine release inhibitor Drugs 0.000 abstract 1
206010057852 Nicotine dependence Diseases 0.000 abstract 1
208000025569 Tobacco Use disease Diseases 0.000 abstract 1
230000002738 anti-smoking effect Effects 0.000 abstract 1
238000009246 art therapy Methods 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
229960002748 norepinephrine Drugs 0.000 abstract 1
SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK02753025T 2001-07-25 2002-07-18 Receptoradapteret nikotinafvænning gennem en kombination af atropin, scopolamin, clonidin DK1408968T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE10136228A DE10136228A1 (de)	2001-07-25	2001-07-25	Rezeptoradaptierter Nikotinetzug durch anticholinerge und noradrenerge Blockade

Publications (1)

Publication Number	Publication Date
DK1408968T3 true DK1408968T3 (da)	2006-03-27

Family

ID=7693048

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02753025T DK1408968T3 (da)	2001-07-25	2002-07-18	Receptoradapteret nikotinafvænning gennem en kombination af atropin, scopolamin, clonidin

Country Status (7)

Country	Link
EP (1)	EP1408968B1 (da)
AT (1)	ATE310520T1 (da)
CY (1)	CY1107651T1 (da)
DE (4)	DE10136228A1 (da)
DK (1)	DK1408968T3 (da)
ES (1)	ES2254709T3 (da)
WO (1)	WO2003015782A2 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007145874A1 (en) *	2006-06-08	2007-12-21	Hythiam, Inc.	Anti-nicotine treatment comprising use of three anticholinergic agents
EP2095814A1 (de)	2008-02-26	2009-09-02	Wolfgang J. Kox	Medikamentengestützter Nikotinentzug
CN103494810A (zh) *	2013-09-25	2014-01-08	青岛市市立医院	治疗网络成瘾的药物组合物
KR102729111B1 (ko) *	2021-09-28	2024-11-13	한국과학기술연구원	니코틴 중독 또는 금단 증상 예방 또는 치료용 약학 조성물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4555397A (en) *	1983-08-12	1985-11-26	Nicholas Bachynsky	Method for anti-cholinergic blockage of withdrawal symptoms in smoking cessation
US4788189A (en) *	1988-02-29	1988-11-29	Glazer Howard I	Method to treat smoking withdrawal symptoms by potentiated central noradrenergic blocking
JPH11505547A (ja) *	1996-03-13	1999-05-21	エールユニバーシティ	ナルトレキソン及び関連化合物を用いる禁煙処置
US6132754A (en) *	1999-02-23	2000-10-17	Hudson; Paul J.	Method for helping a patient eliminate tobacco dependency
WO2000074651A1 (de) *	1999-06-02	2000-12-14	Hexal Ag	Pharmazeutische zusammensetzung zur nasalen anwendung von wasserunlöslichen und/oder schwer wasserlöslichen wirkstoffen
DE19934523A1 (de) *	1999-07-22	2001-01-25	Novosis Pharma Ag	Transdermalsysteme zur Abgabe von Muscarin-Rezeptor-Antagonisten und ihre Verwendung zur Behandlung von Spasmen der glatten Muskulatur im urologischen Bereich

2001
- 2001-07-25 DE DE10136228A patent/DE10136228A1/de not_active Withdrawn
2002
- 2002-04-16 DE DE20205918U patent/DE20205918U1/de not_active Expired - Lifetime
- 2002-07-18 AT AT02753025T patent/ATE310520T1/de active
- 2002-07-18 ES ES02753025T patent/ES2254709T3/es not_active Expired - Lifetime
- 2002-07-18 EP EP02753025A patent/EP1408968B1/de not_active Expired - Lifetime
- 2002-07-18 WO PCT/DE2002/002626 patent/WO2003015782A2/de not_active Ceased
- 2002-07-18 DE DE10293600T patent/DE10293600B4/de not_active Expired - Fee Related
- 2002-07-18 DK DK02753025T patent/DK1408968T3/da active
- 2002-07-18 DE DE50205046T patent/DE50205046D1/de not_active Expired - Lifetime
2006
- 2006-02-01 CY CY20061100132T patent/CY1107651T1/el unknown

Also Published As

Publication number	Publication date
WO2003015782A3 (de)	2003-08-07
EP1408968A2 (de)	2004-04-21
DE10136228A1 (de)	2003-03-06
ATE310520T1 (de)	2005-12-15
EP1408968B1 (de)	2005-11-23
DE50205046D1 (de)	2005-12-29
ES2254709T3 (es)	2006-06-16
DE20205918U1 (de)	2002-12-05
WO2003015782A2 (de)	2003-02-27
DE10293600D2 (de)	2004-08-05
CY1107651T1 (el)	2012-05-23
DE10293600B4 (de)	2005-08-25

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