DK141289D0 - Fremgangsmaade til fremstilling af en n-beskyttet alfa-l-asparagyl-l-phenylalaninmethylester - Google Patents
Fremgangsmaade til fremstilling af en n-beskyttet alfa-l-asparagyl-l-phenylalaninmethylesterInfo
- Publication number
- DK141289D0 DK141289D0 DK141289A DK141289A DK141289D0 DK 141289 D0 DK141289 D0 DK 141289D0 DK 141289 A DK141289 A DK 141289A DK 141289 A DK141289 A DK 141289A DK 141289 D0 DK141289 D0 DK 141289D0
- Authority
- DK
- Denmark
- Prior art keywords
- protected
- preparing
- methyl ester
- phenylalanine methyl
- asparagyl
- Prior art date
Links
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 3
- GWKOSRIHVSBBIA-REOHCLBHSA-N (3s)-3-aminooxolane-2,5-dione Chemical compound N[C@H]1CC(=O)OC1=O GWKOSRIHVSBBIA-REOHCLBHSA-N 0.000 abstract 2
- XYXYXSKSTZAEJW-VIFPVBQESA-N (2s)-2-(phenylmethoxycarbonylamino)butanedioic acid Chemical compound OC(=O)C[C@@H](C(O)=O)NC(=O)OCC1=CC=CC=C1 XYXYXSKSTZAEJW-VIFPVBQESA-N 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 abstract 1
- 229960005261 aspartic acid Drugs 0.000 abstract 1
- 235000003704 aspartic acid Nutrition 0.000 abstract 1
- OZPYEGOBGWQOSZ-VIFPVBQESA-N benzyl n-[(3s)-2,5-dioxooxolan-3-yl]carbamate Chemical compound C=1C=CC=CC=1COC(=O)N[C@H]1CC(=O)OC1=O OZPYEGOBGWQOSZ-VIFPVBQESA-N 0.000 abstract 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- VSDUZFOSJDMAFZ-VIFPVBQESA-N methyl L-phenylalaninate Chemical compound COC(=O)[C@@H](N)CC1=CC=CC=C1 VSDUZFOSJDMAFZ-VIFPVBQESA-N 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Seasonings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63065920A JP2647420B2 (ja) | 1988-03-22 | 1988-03-22 | N−保護−α−L−アスパルチル−L−フェニルアラニンメチルエステルの製造方法 |
| JP11040388A JP2688210B2 (ja) | 1988-05-09 | 1988-05-09 | N−保護アスパラギン酸無水物の製造法 |
| JP63110417A JP2698372B2 (ja) | 1988-05-09 | 1988-05-09 | N−保護アスパラギン酸無水物の製造方法 |
| JP63143674A JP2647439B2 (ja) | 1988-06-13 | 1988-06-13 | N−保護−α−L−アスパルチル−L−フェニルアラニンメチルエステルの製造方法 |
| JP16259388A JP2598467B2 (ja) | 1988-07-01 | 1988-07-01 | N−保護−α−L−アスパルチル−L−フェニルアラニンメチルエステルの製造方法 |
| JP16978288A JP2688213B2 (ja) | 1988-07-07 | 1988-07-07 | N−カルボベンゾキシ−l−アスパラギン酸無水物の製造法 |
| JP16978388A JP2688214B2 (ja) | 1988-07-07 | 1988-07-07 | N−カルボベンゾキシ−l−アスパラギン酸無水物の製造方法 |
| JP63180358A JP2598470B2 (ja) | 1988-07-21 | 1988-07-21 | N−ベンジルオキシカルボニル―αーL―アスパルチル―L―フェニルアラニンメチルエステルの製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK141289D0 true DK141289D0 (da) | 1989-03-22 |
| DK141289A DK141289A (da) | 1989-09-23 |
Family
ID=27572581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK141289A DK141289A (da) | 1988-03-22 | 1989-03-22 | Fremgangsmaade til fremstilling af en n-beskyttet alfa-l-asparagyl-l-phenylalaninmethylester |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0334236B1 (da) |
| KR (1) | KR910006287B1 (da) |
| AT (1) | ATE110740T1 (da) |
| AU (1) | AU605968B2 (da) |
| BR (1) | BR8901324A (da) |
| CA (1) | CA1339658C (da) |
| DE (1) | DE68917762T2 (da) |
| DK (1) | DK141289A (da) |
| NO (1) | NO891243L (da) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2697844B1 (fr) * | 1992-11-12 | 1995-01-27 | Claude Nofre | Nouveaux composés dérivés de dipeptides ou d'analogues dipeptidiques utiles comme agents édulcorants, leur procédé de préparation. |
| KR100255843B1 (ko) * | 1997-08-07 | 2000-05-01 | 허진호 | 회전형 씨디피 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4173562A (en) * | 1976-12-27 | 1979-11-06 | Monsanto Company | Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester |
-
1989
- 1989-03-16 EP EP89104832A patent/EP0334236B1/en not_active Expired - Lifetime
- 1989-03-16 CA CA000593914A patent/CA1339658C/en not_active Expired - Fee Related
- 1989-03-16 AT AT89104832T patent/ATE110740T1/de not_active IP Right Cessation
- 1989-03-16 DE DE68917762T patent/DE68917762T2/de not_active Expired - Fee Related
- 1989-03-21 BR BR898901324A patent/BR8901324A/pt not_active Application Discontinuation
- 1989-03-21 NO NO89891243A patent/NO891243L/no unknown
- 1989-03-22 AU AU31620/89A patent/AU605968B2/en not_active Ceased
- 1989-03-22 KR KR1019890003589A patent/KR910006287B1/ko not_active Expired
- 1989-03-22 DK DK141289A patent/DK141289A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE68917762D1 (de) | 1994-10-06 |
| ATE110740T1 (de) | 1994-09-15 |
| DK141289A (da) | 1989-09-23 |
| NO891243L (no) | 1989-09-25 |
| CA1339658C (en) | 1998-02-03 |
| NO891243D0 (no) | 1989-03-21 |
| EP0334236A2 (en) | 1989-09-27 |
| EP0334236A3 (en) | 1991-03-20 |
| EP0334236B1 (en) | 1994-08-31 |
| KR910006287B1 (ko) | 1991-08-19 |
| AU605968B2 (en) | 1991-01-24 |
| DE68917762T2 (de) | 1995-04-13 |
| KR890014576A (ko) | 1989-10-24 |
| AU3162089A (en) | 1989-09-28 |
| BR8901324A (pt) | 1989-11-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |