DK141749B - Analogifremgangsmåde til fremstilling af pyridincarboxamidoethylbenzensulfonylurinstof-forbindelser. - Google Patents

Analogifremgangsmåde til fremstilling af pyridincarboxamidoethylbenzensulfonylurinstof-forbindelser. Download PDF

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Publication number
DK141749B
DK141749B DK210074AA DK210074A DK141749B DK 141749 B DK141749 B DK 141749B DK 210074A A DK210074A A DK 210074AA DK 210074 A DK210074 A DK 210074A DK 141749 B DK141749 B DK 141749B
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DK
Denmark
Prior art keywords
compounds
prod
mol
urea
methoxynicotinamido
Prior art date
Application number
DK210074AA
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Danish (da)
English (en)
Other versions
DK141749C (fr
Inventor
Donald Ernest Kuhla
Reinhard Sarges
Original Assignee
Pfizer
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Application filed by Pfizer filed Critical Pfizer
Publication of DK141749B publication Critical patent/DK141749B/da
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Publication of DK141749C publication Critical patent/DK141749C/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK210074AA 1973-05-04 1974-04-17 Analogifremgangsmåde til fremstilling af pyridincarboxamidoethylbenzensulfonylurinstof-forbindelser. DK141749B (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US357466A US3879403A (en) 1973-05-04 1973-05-04 Benzenesulfonylurea derivatives
US35746673 1973-05-04

Publications (2)

Publication Number Publication Date
DK141749B true DK141749B (da) 1980-06-09
DK141749C DK141749C (fr) 1980-10-27

Family

ID=23405725

Family Applications (1)

Application Number Title Priority Date Filing Date
DK210074AA DK141749B (da) 1973-05-04 1974-04-17 Analogifremgangsmåde til fremstilling af pyridincarboxamidoethylbenzensulfonylurinstof-forbindelser.

Country Status (27)

Country Link
US (1) US3879403A (fr)
JP (1) JPS5839829B2 (fr)
AR (1) AR202815A1 (fr)
AT (1) AT342615B (fr)
AU (1) AU460423B2 (fr)
BE (1) BE813807A (fr)
BG (1) BG25080A3 (fr)
CA (1) CA1010042A (fr)
CH (1) CH582675A5 (fr)
CS (1) CS191232B2 (fr)
DD (1) DD111679A5 (fr)
DE (1) DE2419198C3 (fr)
DK (1) DK141749B (fr)
ES (1) ES425343A1 (fr)
FI (1) FI55498C (fr)
FR (1) FR2227865B1 (fr)
GB (1) GB1450801A (fr)
HU (1) HU166760B (fr)
IE (1) IE39116B1 (fr)
IL (1) IL44570A (fr)
LU (1) LU69889A1 (fr)
NL (1) NL171053C (fr)
PL (1) PL96708B1 (fr)
RO (2) RO69254A (fr)
SE (1) SE389866B (fr)
SU (1) SU632300A3 (fr)
YU (1) YU106174A (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2706977A1 (de) * 1977-02-18 1978-08-24 Hoechst Ag Benzoesaeuren und deren derivate sowie verfahren zu ihrer herstellung
DE2720926C2 (de) * 1977-05-10 1983-02-17 Hoechst Ag, 6000 Frankfurt Benzolsulfonylharnstoffe und Verfahren zu ihrer Herstellung
DK455480A (da) * 1979-11-30 1981-05-31 Du Pont Fremgangsmaade til fremstilling af herbicide n- (substituerede heterocycliske aminocarbonyl)-aromatiske sulfonamider
US4716231A (en) * 1987-04-27 1987-12-29 Pfizer Inc. Chlorination of 2-methoxynicotinic acid
JPH042618U (fr) * 1990-04-25 1992-01-10
KR101308227B1 (ko) * 2005-04-21 2013-09-13 이시하라 산교 가부시끼가이샤 니코틴산 유도체 또는 그의 염의 제조 방법
JP5148836B2 (ja) * 2005-04-21 2013-02-20 石原産業株式会社 ニコチン酸誘導体又はその塩の製造方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1031088A (en) * 1964-04-16 1966-05-25 Hoechst Ag Benzenesulphonyl-ureas and process for their manufacture

Also Published As

Publication number Publication date
SE389866B (sv) 1976-11-22
RO69254A (fr) 1982-09-09
BG25080A3 (en) 1978-07-12
HU166760B (fr) 1975-05-28
CS191232B2 (en) 1979-06-29
DK141749C (fr) 1980-10-27
IL44570A (en) 1977-01-31
NL171053B (nl) 1982-09-01
FI55498C (fi) 1979-08-10
IE39116L (en) 1974-11-04
AR202815A1 (es) 1975-07-24
YU106174A (en) 1982-02-28
ES425343A1 (es) 1976-06-01
CH582675A5 (fr) 1976-12-15
DE2419198B2 (de) 1980-04-10
CA1010042A (en) 1977-05-10
AT342615B (de) 1978-04-10
ATA316874A (de) 1977-08-15
RO64480A (fr) 1979-05-15
NL171053C (nl) 1983-02-01
FI55498B (fi) 1979-04-30
DE2419198C3 (de) 1980-12-11
IE39116B1 (en) 1978-08-02
FR2227865B1 (fr) 1977-08-19
AU460423B2 (en) 1975-04-07
IL44570A0 (en) 1974-06-30
SU632300A3 (ru) 1978-11-05
AU6759874A (en)
GB1450801A (en) 1976-09-29
US3879403A (en) 1975-04-22
DE2419198A1 (de) 1974-11-14
JPS5839829B2 (ja) 1983-09-01
FR2227865A1 (fr) 1974-11-29
NL7405187A (fr) 1974-11-06
BE813807A (fr) 1974-10-17
DD111679A5 (fr) 1975-03-05
PL96708B1 (pl) 1978-01-31
LU69889A1 (fr) 1974-11-21
JPS5013379A (fr) 1975-02-12

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