DK1418228T3 - Makroindkapslede sekretoriske celler - Google Patents

Makroindkapslede sekretoriske celler

Info

Publication number
DK1418228T3
DK1418228T3 DK03028476T DK03028476T DK1418228T3 DK 1418228 T3 DK1418228 T3 DK 1418228T3 DK 03028476 T DK03028476 T DK 03028476T DK 03028476 T DK03028476 T DK 03028476T DK 1418228 T3 DK1418228 T3 DK 1418228T3
Authority
DK
Denmark
Prior art keywords
macro
encapsulated
secretory cells
agarose
coated
Prior art date
Application number
DK03028476T
Other languages
Danish (da)
English (en)
Inventor
Kanti Jain
Albert L Rubin
Original Assignee
Rogosin Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rogosin Inst filed Critical Rogosin Inst
Application granted granted Critical
Publication of DK1418228T3 publication Critical patent/DK1418228T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012—Cell encapsulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/76—Agarose, agar-agar

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Dispersion Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK03028476T 1994-01-13 1995-01-12 Makroindkapslede sekretoriske celler DK1418228T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18126994A 1994-01-13 1994-01-13
EP95906814A EP0742818B1 (fr) 1994-01-13 1995-01-12 Cellules secretoires macro-encapsulees

Publications (1)

Publication Number Publication Date
DK1418228T3 true DK1418228T3 (da) 2006-07-17

Family

ID=22663563

Family Applications (2)

Application Number Title Priority Date Filing Date
DK06004970T DK1666585T3 (da) 1994-01-13 1995-01-12 Makroindkapslede sekretoriske celler
DK03028476T DK1418228T3 (da) 1994-01-13 1995-01-12 Makroindkapslede sekretoriske celler

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK06004970T DK1666585T3 (da) 1994-01-13 1995-01-12 Makroindkapslede sekretoriske celler

Country Status (18)

Country Link
US (3) US5643569A (fr)
EP (3) EP0742818B1 (fr)
JP (4) JP3948742B2 (fr)
KR (1) KR100474803B1 (fr)
CN (1) CN1087779C (fr)
AT (3) ATE275194T1 (fr)
AU (1) AU681240C (fr)
CA (1) CA2181156C (fr)
DE (3) DE69533437T2 (fr)
DK (2) DK1666585T3 (fr)
ES (3) ES2227544T3 (fr)
FI (1) FI118853B (fr)
IL (1) IL112330A (fr)
NO (2) NO323228B1 (fr)
NZ (3) NZ278809A (fr)
PT (3) PT1418228E (fr)
RU (2) RU2208636C2 (fr)
WO (1) WO1995019430A1 (fr)

Families Citing this family (44)

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US6231881B1 (en) 1992-02-24 2001-05-15 Anton-Lewis Usala Medium and matrix for long-term proliferation of cells
US5834005A (en) * 1992-02-24 1998-11-10 Encelle, Inc. Bioartificial devices and cellular matrices therefor
US5830492A (en) * 1992-02-24 1998-11-03 Encelle, Inc. Bioartificial devices and cellular matrices therefor
US5824331A (en) * 1992-02-24 1998-10-20 Encelle, Inc. Bioartificial devices and cellular matrices therefor
USRE39542E1 (en) * 1994-01-13 2007-04-03 The Rogosin Institute Preparation of agarose coated, solid agarose-collagen beads containing secretory cells
AU681240C (en) * 1994-01-13 2006-12-07 Rogosin Institute, The Macroencapsulated secretory cells
US5916790A (en) * 1995-03-03 1999-06-29 Metabolex, Inc. Encapsulation compositions, and methods
CA2214088A1 (fr) * 1995-03-03 1996-09-12 Metabolex Inc. Nouveau processus d'encapsulation par un polymere gelifiant
US6419920B1 (en) 1995-10-25 2002-07-16 Trans Karyotic Therapies, Inc. Hybrid matrix implants and explants
US5965125A (en) 1995-10-25 1999-10-12 Transkaryotic Therapies, Inc. Hybrid matrix implants and explants
JPH11508477A (ja) * 1996-02-23 1999-07-27 サーシ・バイオメディカル・インコーポレーテッド 新規の人工膵臓
US5888497A (en) * 1996-04-03 1999-03-30 The Rogosin Institute Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation
US7297331B2 (en) 1996-04-03 2007-11-20 The Rogosin Institute Beads containing restricted cancer cells producing material suppressing cancer cell proliferation
US6303151B1 (en) * 1996-04-03 2001-10-16 The Rogosin Institute Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
US6224912B1 (en) * 1996-04-03 2001-05-01 The Rogo Institute Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
EP1382346B1 (fr) * 1996-04-03 2007-09-26 The Rogosin Institute Milieu conditionné et produit biologique diffusible obtenu par incubation de cellules piégées
KR100477296B1 (ko) * 1996-04-03 2005-05-16 더 로고신 인스티튜트 확산성의생물학적산물생산세포를함유하는이식가능한아가로오스-콜라겐비드,및그의용도
JP4001925B2 (ja) 1996-09-13 2007-10-31 トランスカーヨティック セラピーズ インク． α―ガラクトシダーゼＡ欠損症の治療
AU8577498A (en) 1997-07-22 1999-02-16 General Hospital Corporation, The Modulation of multicellular aggregates by solid stress
US5922339A (en) * 1998-01-27 1999-07-13 Usala; Anton-Lewis Compositions and methods for biocompatible implants
US6303355B1 (en) 1999-03-22 2001-10-16 Duke University Method of culturing, cryopreserving and encapsulating pancreatic islet cells
US6365385B1 (en) 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
US6391576B1 (en) * 1999-10-13 2002-05-21 Japan Bioindustry Association Method for isolating a microbe
US6279656B1 (en) 1999-11-03 2001-08-28 Santrol, Inc. Downhole chemical delivery system for oil and gas wells
AU2001265151A1 (en) 2000-05-31 2001-12-11 Encelle, Inc. Method of stimulating hair growth
AU2003294541A1 (en) * 2002-12-24 2004-07-22 An-Go-Gen Inc. Encapsulated cell for therapy
WO2004075855A2 (fr) 2003-02-26 2004-09-10 Biomed Solutions, Llc Procede de traitement in vivo de cibles biologiques specifiques dans un fluide corporel
US20050053586A1 (en) 2003-09-04 2005-03-10 Bryan Conn Entrapped stem cells and uses thereof
WO2006053052A2 (fr) * 2004-11-11 2006-05-18 The Rogosin Institute Procede permettant de traiter des patients avec des implants d'ilots qui ont ete conserves en culture in vitro a long terme
PL1928249T3 (pl) * 2005-09-26 2012-11-30 The Rogosin Inst Inc Makroperełki zawierające komórki wydzielnicze obejmujące agarozę Seakem Gold i ich zastosowanie
US20070116680A1 (en) * 2005-11-18 2007-05-24 Rensselaer Polytechnic Institute Stem cells within gel microenvironments
EP2029727B1 (fr) * 2006-06-16 2012-04-11 FMC Biopolymer AS Dispositif cellulaire à matrice de collagène, revêtu d'alginate, procédés de préparation, et utilisations
CN101600792B (zh) * 2007-01-24 2012-03-21 皇家飞利浦电子股份有限公司 处理培养的细胞的方法
WO2009025866A1 (fr) 2007-08-23 2009-02-26 Intrexon Corporation Procédés et compositions de diagnostic d'une maladie
KR101666228B1 (ko) * 2007-09-28 2016-10-13 인트렉손 코포레이션 생물치료학적 분자를 발현시키기 위한 치료학적 유전자-스위치 작제물 및 생물반응기, 및 이의 용도
RU2405561C2 (ru) * 2008-12-31 2010-12-10 Общество с ограниченной ответственностью "Медицинский научно-консультативный центр "Академическая больница" Способ лечения заболеваний щитовидной железы, сопровождаемых гипотиреозом
DE102010040687A1 (de) 2010-09-14 2012-03-15 Hamilton Bonaduz Ag Verfahren zum Herstellen von Wirkstoff-Beads
WO2012127224A1 (fr) 2011-03-21 2012-09-27 University Of Reading Transport de cellules dans des hydrogels
DE102011050024A1 (de) * 2011-04-29 2012-10-31 Hamilton Bonaduz Ag Analysevorrichtung für eine berührungslose Analyse der Ausformung eines transparenten Körpers und Verfahren zur Durchführung der berührungslosen Analyse
RU2591518C2 (ru) 2012-01-31 2016-07-20 Де Рогозин Инститьют Инк. Усовершенствованный способ получения макрогранул
KR101327630B1 (ko) * 2012-03-05 2013-11-13 울산대학교 산학협력단 아텔로콜라겐을 이용한 췌도세포 이식용 담체의 제조방법 그리고 이를 이용하여 제조된 인공췌장
UY38389A (es) 2018-09-27 2020-04-30 Sigilon Therapeutics Inc Dispositivos implantables para terapia celular y métodos relacionados
JP2025534667A (ja) 2022-10-11 2025-10-17 シギロン セラピューティクス， インコーポレイテッド 疾患治療のための改変細胞及び移植可能エレメント
EP4602155A1 (fr) 2022-10-11 2025-08-20 Sigilon Therapeutics, Inc. Cellules modifiées et éléments implantables pour le traitement d'une maladie

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SU1742330A1 (ru) * 1990-06-18 1992-06-23 Саратовский филиал Всесоюзного научно-исследовательского института генетики и селекции промышленных микроорганизмов Способ получени биокатализатора в полисахаридном носителе
US5227298A (en) * 1990-08-17 1993-07-13 The Trustees Of Columbia University In The City Of New York Method for microencapuslation of cells or tissue
FR2686250A1 (fr) * 1992-01-16 1993-07-23 Coletica Compositions injectables contenant en suspension des microcapsules a base de collagene, leur utilisation biomedicale et des compositions pharmaceutiques.
WO1993024076A1 (fr) * 1992-05-29 1993-12-09 The Regents Of The University Of California Transplant revetu et procede de fabrication correspondant
WO1994012161A1 (fr) * 1992-11-24 1994-06-09 Clover Consolidated, Limited Macrocapsules cytoprotectrices, biocompatibles et recuperables
AU681240C (en) * 1994-01-13 2006-12-07 Rogosin Institute, The Macroencapsulated secretory cells
US6224912B1 (en) * 1996-04-03 2001-05-01 The Rogo Institute Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
US5888497A (en) * 1996-04-03 1999-03-30 The Rogosin Institute Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation

Also Published As

Publication number Publication date
EP1666585A1 (fr) 2006-06-07
AU681240C (en) 2006-12-07
DK1666585T3 (da) 2009-01-12
EP0742818B1 (fr) 2004-09-01
USRE38027E1 (en) 2003-03-11
JP2006345875A (ja) 2006-12-28
NO20051359L (no) 1996-09-11
KR100474803B1 (ko) 2005-03-10
AU1526795A (en) 1995-08-01
FI118853B (fi) 2008-04-15
EP0742818A4 (fr) 2002-01-09
NO962955D0 (no) 1996-07-15
JP3948742B2 (ja) 2007-07-25
ATE320482T1 (de) 2006-04-15
IL112330A (en) 1999-01-26
MX9602765A (es) 1998-06-30
PT1418228E (pt) 2006-09-29
PT742818E (pt) 2004-12-31
NO323228B1 (no) 2007-02-05
NZ278809A (en) 1998-03-25
CN1141650A (zh) 1997-01-29
CN1087779C (zh) 2002-07-17
AU681240B2 (en) 1997-08-21
JP2005137376A (ja) 2005-06-02
NZ509363A (en) 2006-02-24
IL112330A0 (en) 1995-03-30
DE69533437D1 (de) 2004-10-07
EP1666585B1 (fr) 2008-09-10
EP0742818A1 (fr) 1996-11-20
NO962955L (no) 1996-09-11
DE69534865T2 (de) 2006-08-17
NO324570B1 (no) 2007-11-26
JP4435134B2 (ja) 2010-03-17
CA2181156A1 (fr) 1995-07-20
JPH09510868A (ja) 1997-11-04
ES2260568T3 (es) 2006-11-01
ATE408005T1 (de) 2008-09-15
FI962841L (fi) 1996-09-12
RU2177503C2 (ru) 2001-12-27
JP3989492B2 (ja) 2007-10-10
US5643569A (en) 1997-07-01
CA2181156C (fr) 2001-10-16
ATE275194T1 (de) 2004-09-15
EP1418228A1 (fr) 2004-05-12
ES2309849T3 (es) 2008-12-16
JP2007020585A (ja) 2007-02-01
FI962841A0 (fi) 1996-07-12
WO1995019430A1 (fr) 1995-07-20
RU2208636C2 (ru) 2003-07-20
USRE40555E1 (en) 2008-10-28
PT1666585E (pt) 2008-12-10
KR20050005235A (ko) 2005-01-13
NZ329619A (en) 1999-09-29
DE69533437T2 (de) 2005-09-15
HK1084693A1 (en) 2006-08-04
DE69535842D1 (de) 2008-10-23
EP1418228B1 (fr) 2006-03-15
ES2227544T3 (es) 2005-04-01
DE69534865D1 (de) 2006-05-11

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