NO962955L - Makroinnkapslede sekretceller og fremgangsmåte til fremstilling av samme - Google Patents

Makroinnkapslede sekretceller og fremgangsmåte til fremstilling av samme

Info

Publication number
NO962955L
NO962955L NO962955A NO962955A NO962955L NO 962955 L NO962955 L NO 962955L NO 962955 A NO962955 A NO 962955A NO 962955 A NO962955 A NO 962955A NO 962955 L NO962955 L NO 962955L
Authority
NO
Norway
Prior art keywords
macro
encapsulated
producing
same
secretory cells
Prior art date
Application number
NO962955A
Other languages
English (en)
Other versions
NO962955D0 (no
NO323228B1 (no
Inventor
Kanti Jain
Albert Rubin
Original Assignee
Rogosin Inst The
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rogosin Inst The filed Critical Rogosin Inst The
Publication of NO962955D0 publication Critical patent/NO962955D0/no
Publication of NO962955L publication Critical patent/NO962955L/no
Publication of NO323228B1 publication Critical patent/NO323228B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012—Cell encapsulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/76—Agarose, agar-agar

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Dispersion Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Endocrinology (AREA)
  • Physiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NO19962955A 1994-01-13 1996-07-15 En agaroseovertrukket, agarosesekretorisk celleperle, en fremgangsmate for fremstilling derav, samt en fremgangsmate for konservering av agarosesekretoriske celler. NO323228B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18126994A 1994-01-13 1994-01-13
PCT/US1995/000400 WO1995019430A1 (en) 1994-01-13 1995-01-12 Macroencapsulated secretory cells

Publications (3)

Publication Number Publication Date
NO962955D0 NO962955D0 (no) 1996-07-15
NO962955L true NO962955L (no) 1996-09-11
NO323228B1 NO323228B1 (no) 2007-02-05

Family

ID=22663563

Family Applications (2)

Application Number Title Priority Date Filing Date
NO19962955A NO323228B1 (no) 1994-01-13 1996-07-15 En agaroseovertrukket, agarosesekretorisk celleperle, en fremgangsmate for fremstilling derav, samt en fremgangsmate for konservering av agarosesekretoriske celler.
NO20051359A NO324570B1 (no) 1994-01-13 2005-03-16 Agaroseovertrukket, agarosekollagensektretorisk celleperle og fremgangsmate til fremstilling derav samt fremgangsmate for konservering av sekretoriske celler.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20051359A NO324570B1 (no) 1994-01-13 2005-03-16 Agaroseovertrukket, agarosekollagensektretorisk celleperle og fremgangsmate til fremstilling derav samt fremgangsmate for konservering av sekretoriske celler.

Country Status (18)

Country Link
US (3) US5643569A (no)
EP (3) EP1418228B1 (no)
JP (4) JP3948742B2 (no)
KR (1) KR100474803B1 (no)
CN (1) CN1087779C (no)
AT (3) ATE275194T1 (no)
AU (1) AU681240C (no)
CA (1) CA2181156C (no)
DE (3) DE69534865T2 (no)
DK (2) DK1418228T3 (no)
ES (3) ES2309849T3 (no)
FI (1) FI118853B (no)
IL (1) IL112330A (no)
NO (2) NO323228B1 (no)
NZ (3) NZ329619A (no)
PT (3) PT742818E (no)
RU (2) RU2208636C2 (no)
WO (1) WO1995019430A1 (no)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5834005A (en) * 1992-02-24 1998-11-10 Encelle, Inc. Bioartificial devices and cellular matrices therefor
US5824331A (en) * 1992-02-24 1998-10-20 Encelle, Inc. Bioartificial devices and cellular matrices therefor
US6231881B1 (en) 1992-02-24 2001-05-15 Anton-Lewis Usala Medium and matrix for long-term proliferation of cells
US5830492A (en) * 1992-02-24 1998-11-03 Encelle, Inc. Bioartificial devices and cellular matrices therefor
USRE39542E1 (en) * 1994-01-13 2007-04-03 The Rogosin Institute Preparation of agarose coated, solid agarose-collagen beads containing secretory cells
ATE275194T1 (de) * 1994-01-13 2004-09-15 Rogosin Inst Makroeingekapselte sekretorische zellen
WO1996027662A1 (en) * 1995-03-03 1996-09-12 Metabolex, Inc. Novel encapsulation process by a gelling polymer
US5916790A (en) * 1995-03-03 1999-06-29 Metabolex, Inc. Encapsulation compositions, and methods
US5965125A (en) 1995-10-25 1999-10-12 Transkaryotic Therapies, Inc. Hybrid matrix implants and explants
US6419920B1 (en) 1995-10-25 2002-07-16 Trans Karyotic Therapies, Inc. Hybrid matrix implants and explants
AU6496996A (en) * 1996-02-23 1997-09-10 Circle Biomedical, Inc. Novel artificial pancreas
US6303151B1 (en) * 1996-04-03 2001-10-16 The Rogosin Institute Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
US7297331B2 (en) 1996-04-03 2007-11-20 The Rogosin Institute Beads containing restricted cancer cells producing material suppressing cancer cell proliferation
US6224912B1 (en) * 1996-04-03 2001-05-01 The Rogo Institute Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
US5888497A (en) * 1996-04-03 1999-03-30 The Rogosin Institute Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation
KR100477296B1 (ko) * 1996-04-03 2005-05-16 더 로고신 인스티튜트 확산성의생물학적산물생산세포를함유하는이식가능한아가로오스-콜라겐비드,및그의용도
DK0914043T3 (da) * 1996-04-03 2004-02-09 Rogosin Inst Implanterbare agarose-kollagen-korn, som indeholder celler, der dannet et diffunderbart produkt, og anvendelser heraf
DK1538202T3 (en) 1996-09-13 2014-03-24 Shire Human Genetic Therapies PREPARATION OF HUMANT ALPHA-GALACTOSIDASE A
AU8577498A (en) * 1997-07-22 1999-02-16 General Hospital Corporation, The Modulation of multicellular aggregates by solid stress
US5922339A (en) * 1998-01-27 1999-07-13 Usala; Anton-Lewis Compositions and methods for biocompatible implants
US6303355B1 (en) 1999-03-22 2001-10-16 Duke University Method of culturing, cryopreserving and encapsulating pancreatic islet cells
US6365385B1 (en) * 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
US6391576B1 (en) * 1999-10-13 2002-05-21 Japan Bioindustry Association Method for isolating a microbe
US6279656B1 (en) 1999-11-03 2001-08-28 Santrol, Inc. Downhole chemical delivery system for oil and gas wells
NZ523461A (en) 2000-05-31 2004-11-26 Encelle Inc Method of treating chronic ulcers
AU2003294541A1 (en) * 2002-12-24 2004-07-22 An-Go-Gen Inc. Encapsulated cell for therapy
WO2004075855A2 (en) 2003-02-26 2004-09-10 Biomed Solutions, Llc Process for in vivo treatment of specific biological targets in bodily fluid
US20050053586A1 (en) 2003-09-04 2005-03-10 Bryan Conn Entrapped stem cells and uses thereof
US20060121077A1 (en) * 2004-11-11 2006-06-08 Lawrence Gazda Method for treating patients with implants of islets which have been kept in long term, in vitro culture
ES2379008T3 (es) * 2005-09-26 2012-04-19 The Rogosin Institute, Inc. Macroperlas que contienen células secretoras que comprenden agarosa Seakem Gold, y sus usos
US20070116680A1 (en) * 2005-11-18 2007-05-24 Rensselaer Polytechnic Institute Stem cells within gel microenvironments
ES2386123T3 (es) * 2006-06-16 2012-08-09 Fmc Biopolymer As Dispositivo celular con una matriz de colágeno revestida de alginato, proceso para su formación y utilizaciones
WO2008090501A1 (en) * 2007-01-24 2008-07-31 Koninklijke Philips Electronics N. V. Process for treating cultured cells
CN101835908A (zh) 2007-08-23 2010-09-15 英特瑞克斯顿股份有限公司 诊断疾病的方法和组合物
NZ584848A (en) * 2007-09-28 2012-09-28 Intrexon Corp Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof
RU2405561C2 (ru) * 2008-12-31 2010-12-10 Общество с ограниченной ответственностью "Медицинский научно-консультативный центр "Академическая больница" Способ лечения заболеваний щитовидной железы, сопровождаемых гипотиреозом
DE102010040687A1 (de) 2010-09-14 2012-03-15 Hamilton Bonaduz Ag Verfahren zum Herstellen von Wirkstoff-Beads
US10655120B2 (en) 2011-03-21 2020-05-19 The University Of Newcastle Upon Tyne Transport of cells in hydrogels
DE102011050024A1 (de) 2011-04-29 2012-10-31 Hamilton Bonaduz Ag Analysevorrichtung für eine berührungslose Analyse der Ausformung eines transparenten Körpers und Verfahren zur Durchführung der berührungslosen Analyse
JP5986226B2 (ja) 2012-01-31 2016-09-06 ザ ロゴシン インスティチュート, インク.The Rogosin Institute, Inc マクロビーズ製造のための改良方法
KR101327630B1 (ko) * 2012-03-05 2013-11-13 울산대학교 산학협력단 아텔로콜라겐을 이용한 췌도세포 이식용 담체의 제조방법 그리고 이를 이용하여 제조된 인공췌장
UY38389A (es) 2018-09-27 2020-04-30 Sigilon Therapeutics Inc Dispositivos implantables para terapia celular y métodos relacionados
WO2024081310A1 (en) 2022-10-11 2024-04-18 Sigilon Therapeutics, Inc. Engineered cells and implantable elements for treatment of disease
WO2024081309A1 (en) 2022-10-11 2024-04-18 Sigilon Therapeutics, Inc. Engineered cells and implantable elements for treatment of disease

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4409331A (en) * 1979-03-28 1983-10-11 Damon Corporation Preparation of substances with encapsulated cells
US4391909A (en) * 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
US4352883A (en) * 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
SE441009B (sv) * 1982-03-08 1985-09-02 Kjell Nilsson Sett att immobilisera levande biomaterial i perlformiga polymerer
US4798786A (en) * 1982-05-06 1989-01-17 Stolle Research And Development Corporation Living cells encapsulated in crosslinked protein
CA1196862A (en) * 1983-06-01 1985-11-19 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4663286A (en) * 1984-02-13 1987-05-05 Damon Biotech, Inc. Encapsulation of materials
US4902295A (en) * 1985-08-26 1990-02-20 Hana Biologics, Inc. Transplantable artificial tissue
US4997443A (en) * 1985-08-26 1991-03-05 Hana Biologics, Inc. Transplantable artificial tissue and process
SE8604684L (sv) * 1986-11-03 1988-05-04 Excorim Kommanditbolag Sett att belegga fasta partiklar med en hydrofil gel samt genom settet belagda partiklar
US5053332A (en) * 1989-07-24 1991-10-01 Cook Richard B Agarose beads, preferably incorporating biological materials
SU1742330A1 (ru) * 1990-06-18 1992-06-23 Саратовский филиал Всесоюзного научно-исследовательского института генетики и селекции промышленных микроорганизмов Способ получени биокатализатора в полисахаридном носителе
US5227298A (en) * 1990-08-17 1993-07-13 The Trustees Of Columbia University In The City Of New York Method for microencapuslation of cells or tissue
FR2686250A1 (fr) * 1992-01-16 1993-07-23 Coletica Compositions injectables contenant en suspension des microcapsules a base de collagene, leur utilisation biomedicale et des compositions pharmaceutiques.
DE69331058D1 (de) * 1992-05-29 2001-12-06 Univ California Beschichtetes transplantat sowie herstellungsverfahren dafür
WO1994012161A1 (en) * 1992-11-24 1994-06-09 Clover Consolidated, Limited Cytoprotective, biocompatible, retrievable macrocapsules
ATE275194T1 (de) * 1994-01-13 2004-09-15 Rogosin Inst Makroeingekapselte sekretorische zellen
US5888497A (en) * 1996-04-03 1999-03-30 The Rogosin Institute Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation
US6224912B1 (en) * 1996-04-03 2001-05-01 The Rogo Institute Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment

Also Published As

Publication number Publication date
MX9602765A (es) 1998-06-30
PT1666585E (pt) 2008-12-10
JP2007020585A (ja) 2007-02-01
EP0742818A1 (en) 1996-11-20
JPH09510868A (ja) 1997-11-04
ES2227544T3 (es) 2005-04-01
DE69535842D1 (de) 2008-10-23
EP0742818A4 (en) 2002-01-09
RU2208636C2 (ru) 2003-07-20
NZ509363A (en) 2006-02-24
JP2006345875A (ja) 2006-12-28
EP1666585B1 (en) 2008-09-10
PT742818E (pt) 2004-12-31
IL112330A (en) 1999-01-26
FI118853B (fi) 2008-04-15
DK1418228T3 (da) 2006-07-17
WO1995019430A1 (en) 1995-07-20
JP3989492B2 (ja) 2007-10-10
FI962841A0 (fi) 1996-07-12
CA2181156C (en) 2001-10-16
CN1087779C (zh) 2002-07-17
ES2260568T3 (es) 2006-11-01
ATE408005T1 (de) 2008-09-15
US5643569A (en) 1997-07-01
KR100474803B1 (ko) 2005-03-10
CN1141650A (zh) 1997-01-29
NZ278809A (en) 1998-03-25
ATE320482T1 (de) 2006-04-15
DE69533437T2 (de) 2005-09-15
ES2309849T3 (es) 2008-12-16
DK1666585T3 (da) 2009-01-12
RU2177503C2 (ru) 2001-12-27
PT1418228E (pt) 2006-09-29
IL112330A0 (en) 1995-03-30
USRE38027E1 (en) 2003-03-11
FI962841L (fi) 1996-09-12
AU681240C (en) 2006-12-07
JP3948742B2 (ja) 2007-07-25
DE69534865D1 (de) 2006-05-11
CA2181156A1 (en) 1995-07-20
ATE275194T1 (de) 2004-09-15
USRE40555E1 (en) 2008-10-28
EP1418228B1 (en) 2006-03-15
EP0742818B1 (en) 2004-09-01
NZ329619A (en) 1999-09-29
AU1526795A (en) 1995-08-01
DE69533437D1 (de) 2004-10-07
KR20050005235A (ko) 2005-01-13
NO20051359L (no) 1996-09-11
JP4435134B2 (ja) 2010-03-17
HK1084693A1 (en) 2006-08-04
NO962955D0 (no) 1996-07-15
NO324570B1 (no) 2007-11-26
EP1666585A1 (en) 2006-06-07
NO323228B1 (no) 2007-02-05
DE69534865T2 (de) 2006-08-17
AU681240B2 (en) 1997-08-21
JP2005137376A (ja) 2005-06-02
EP1418228A1 (en) 2004-05-12

Similar Documents

Publication Publication Date Title
NO962955D0 (no) Makroinnkapslede sekretceller og fremgangsmåte til fremstilling av samme
HUP9903761A3 (en) Method for the fabrication of electrochemical cells
DK160795C (da) System til hjemmefremstilling af cigaretter, samt fremgangsmaade og indretning til fremstilling af cigaretter ved anvendelse af systemet
DK46594A (da) Isolerede elektriske lederpar og fremgangsmåde samt apparat til fremstilling af samme
NO975557L (no) Immortalisering og dissimortalisering av celler
NO861174L (no) Fralandsplattform og fremgangsmaate ved installering av samme.
EP0153719A3 (en) Method and apparatus for controlling the gain of an amplifier system
DE69608686D1 (de) Gewickelte elektrochemische zelle, herstellungsverfahren und verwendung der zelle
DK0954903T3 (da) Fremgangsmåde til regulering af effektforstærkningen
NO972275D0 (no) Varmekabel og fremgangsmåte for fremstilling
DE3465393D1 (en) Porous gas diffusion electrode and method of producing the same
NO944994D0 (no) Fremgangsmåte til inaktivering av katalaseenzym
DK0800426T3 (da) Fremgangsmåde til fremstilling af plane dele og plane dele fremstillet ifølge fremgangsmåden
DE59611238D1 (de) Verfahren zur Leistungsregelung von Funkgeräten
DE3484085D1 (de) Gepfropfte polyalphaolefinen und deren herstellungsverfahren.
DK27282A (da) Heparinnetvaerk og fremgangsmaade til fremstilling deraf
DE3373599D1 (en) Method for the automatic output power control of an amplifier
IT1280263B1 (it) Apparecchiatura e metodo per il controllo di accumulatori elettrici.
FI955452A0 (fi) Anolysointimenetelmä, laitteisto sitä varten ja jauhatuksen säätömenetelmä
DK153281C (da) Tobakspibe og fremgangsmaade til fremstilling af samme
DE59604231D1 (de) Gasdurchlässige hochspannungsisolation
NO954062D0 (no) Tannbörste og fremgangsmåte til fremstilling av samme
DK143493D0 (da) Gaskanal og fremgangsmaade til fremstilling af samme
DK206084D0 (da) Fremgangsmaade og apparat til indvendig isolering af aftraekskanaler,isaer skorsten
GB9519057D0 (en) Method for the fabrication of electrodes

Legal Events

Date Code Title Description
MK1K Patent expired