DK1419178T3 - Somatostatin-analoger, der binder sig til alle somatostatin-receptor-undertyper, og deres anvendelse - Google Patents

Somatostatin-analoger, der binder sig til alle somatostatin-receptor-undertyper, og deres anvendelse

Info

Publication number: DK1419178T3
Authority: DK; Denmark
Prior art keywords: present; chelators; amino acid; somatostatin; naphthylalanine
Prior art date: 2001-08-10

Application number

DK02794598T

Other languages

English (en)

Inventor

Helmut Robert Maecke

Jean Claude Reubi

Hans Rink

Klaus-Peter Eisenwiener

Original Assignee

Univ Bern

Univ Hospital Basel

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-10

Filing date

2002-08-07

Publication date

2006-10-02

2002-08-07 Application filed by Univ Bern, Univ Hospital Basel filed Critical Univ Bern

2006-10-02 Application granted granted Critical

2006-10-02 Publication of DK1419178T3 publication Critical patent/DK1419178T3/da

Links

NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title abstract 2
108050001286 Somatostatin Receptor Proteins 0.000 title 1
102000011096 Somatostatin receptor Human genes 0.000 title 1
239000002738 chelating agent Substances 0.000 abstract 5
235000001014 amino acid Nutrition 0.000 abstract 3
YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 abstract 2
BKQQPCDQZZTLSE-UHFFFAOYSA-N 2-amino-3-naphthalen-1-ylpropanoic acid;hydrochloride Chemical compound Cl.C1=CC=C2C(CC(N)C(O)=O)=CC=CC2=C1 BKQQPCDQZZTLSE-UHFFFAOYSA-N 0.000 abstract 2
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 2
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 2
150000001413 amino acids Chemical class 0.000 abstract 2
125000005647 linker group Chemical group 0.000 abstract 2
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 2
COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 2
JHALWMSZGCVVEM-UHFFFAOYSA-N 2-[4,7-bis(carboxymethyl)-1,4,7-triazonan-1-yl]acetic acid Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CC1 JHALWMSZGCVVEM-UHFFFAOYSA-N 0.000 abstract 1
KOUZWQLNUJWNIA-UHFFFAOYSA-N 2-hydrazinylpyridine-3-carboxamide Chemical compound NNC1=NC=CC=C1C(N)=O KOUZWQLNUJWNIA-UHFFFAOYSA-N 0.000 abstract 1
125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
239000004475 Arginine Substances 0.000 abstract 1
WHUUTDBJXJRKMK-GSVOUGTGSA-N D-glutamic acid Chemical compound OC(=O)[C@H](N)CCC(O)=O WHUUTDBJXJRKMK-GSVOUGTGSA-N 0.000 abstract 1
OGNSCSPNOLGXSM-VKHMYHEASA-N L-2,4-diaminobutyric acid Chemical compound NCC[C@H](N)C(O)=O OGNSCSPNOLGXSM-VKHMYHEASA-N 0.000 abstract 1
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 abstract 1
QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 abstract 1
UBQYURCVBFRUQT-UHFFFAOYSA-N N-benzoyl-Ferrioxamine B Chemical compound CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN UBQYURCVBFRUQT-UHFFFAOYSA-N 0.000 abstract 1
RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 abstract 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
239000004473 Threonine Substances 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
-1 aromatic amino acid Chemical group 0.000 abstract 1
239000011616 biotin Substances 0.000 abstract 1
229960002685 biotin Drugs 0.000 abstract 1
235000020958 biotin Nutrition 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001728 carbonyl compounds Chemical class 0.000 abstract 1
235000013477 citrulline Nutrition 0.000 abstract 1
229960002173 citrulline Drugs 0.000 abstract 1
230000008878 coupling Effects 0.000 abstract 1
238000010168 coupling process Methods 0.000 abstract 1
238000005859 coupling reaction Methods 0.000 abstract 1
239000007850 fluorescent dye Substances 0.000 abstract 1
230000026030 halogenation Effects 0.000 abstract 1
238000005658 halogenation reaction Methods 0.000 abstract 1
230000003278 mimic effect Effects 0.000 abstract 1
230000007935 neutral effect Effects 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 abstract 1
229940075620 somatostatin analogue Drugs 0.000 abstract 1
125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Immunology (AREA)
Toxicology (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

DK02794598T 2001-08-10 2002-08-07 Somatostatin-analoger, der binder sig til alle somatostatin-receptor-undertyper, og deres anvendelse DK1419178T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP01203033A EP1283216A1 (en)	2001-08-10	2001-08-10	Somatostatin analogues binding to all somatostatin receptor subtypes and their use

Publications (1)

Publication Number	Publication Date
DK1419178T3 true DK1419178T3 (da)	2006-10-02

Family

ID=8180776

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02794598T DK1419178T3 (da)	2001-08-10	2002-08-07	Somatostatin-analoger, der binder sig til alle somatostatin-receptor-undertyper, og deres anvendelse

Country Status (12)

Country	Link
US (2)	US7192570B2 (da)
EP (2)	EP1283216A1 (da)
JP (1)	JP2005508886A (da)
AT (1)	ATE328005T1 (da)
AU (1)	AU2002333396B2 (da)
CA (1)	CA2456881A1 (da)
CY (1)	CY1105177T1 (da)
DE (1)	DE60211917T2 (da)
DK (1)	DK1419178T3 (da)
ES (1)	ES2266616T3 (da)
PT (1)	PT1419178E (da)
WO (1)	WO2003014158A1 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1283216A1 (en)	2001-08-10	2003-02-12	Mallinckrodt Inc.	Somatostatin analogues binding to all somatostatin receptor subtypes and their use
DK1603598T3 (da) *	2003-03-19	2009-01-26	Univ Bern	Radiomærkede konjugater baseret på substans P og anvendelser heraf
BRPI0617195A2 (pt) *	2005-10-14	2011-07-19	Stichting Katholieke Univ	interleucina-8 marcada através de um ou mais sìtios porções de hidrazinonicotinamida (hynic) especificamente conjugado e seu uso em diagnóstico de infecção e inflamação
PL2383289T3 (pl)	2006-10-16	2015-03-31	Salk Inst Biological Studies	Antagoniści somatostatyny selektywni względem receptora (SSTR2)
US8691761B2 (en)	2006-10-16	2014-04-08	Jean E. F. Rivier	Somatostatin receptor 2 antagonists
US8535639B2 (en)	2007-07-17	2013-09-17	The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services	Trifunctional imaging agent for monoclonal antibody tumor-targeted imaging
US9186128B2 (en)	2008-10-01	2015-11-17	Covidien Lp	Needle biopsy device
US11298113B2 (en)	2008-10-01	2022-04-12	Covidien Lp	Device for needle biopsy with integrated needle protection
US8968210B2 (en)	2008-10-01	2015-03-03	Covidien LLP	Device for needle biopsy with integrated needle protection
US9332973B2 (en)	2008-10-01	2016-05-10	Covidien Lp	Needle biopsy device with exchangeable needle and integrated needle protection
US9782565B2 (en)	2008-10-01	2017-10-10	Covidien Lp	Endoscopic ultrasound-guided biliary access system
GB0903496D0 (en) *	2009-02-27	2009-04-08	Cambridge Entpr Ltd	Methods for identification
ES2351569B8 (es) *	2009-05-07	2012-06-20	Bcn Peptides S.A.	Ligandos peptídicos de receptores de somatostatina.
GB0922369D0 (en)	2009-12-22	2010-02-03	Hammersmith Imanet Ltd	Labelled biotin conjugates
TWI523863B (zh)	2012-11-01	2016-03-01	艾普森藥品公司	體抑素－多巴胺嵌合體類似物
HK1213486A1 (zh)	2012-11-01	2016-07-08	Ipsen Pharma S.A.S.	促生长素抑制素类似物及其二聚体
JP6410339B2 (ja) *	2013-03-25	2018-10-24	国立大学法人千葉大学	放射性核種標識オクトレオチド誘導体
US11279732B2 (en)	2016-02-09	2022-03-22	Cdrd Ventures Inc.	Somatostatin receptor antagonist compounds and methods of using the same
SI3568205T1 (sl)	2017-01-12	2023-12-29	Radiomedix Inc.	Zdravljenje rakastih celic, ki prekomerno izražajo receptorje za somatostatin, z uporabo derivatov okreotida, kelatiranih v radioizotope
CN108440664A (zh) *	2018-03-27	2018-08-24	上海欣科医药有限公司	一种用于癌症检测的生长抑素类似物及其制备方法和应用
CN112538103B (zh) *	2020-12-28	2022-10-25	合肥科生景肽生物科技有限公司	制备生长激素释放抑制素的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5819669B2 (ja) *	1978-10-28	1983-04-19	白井松新薬株式会社	新規生理活性ペプチド化合物及びその製造法
US5620675A (en) *	1992-06-23	1997-04-15	Diatech, Inc.	Radioactive peptides
US6051206A (en) *	1994-06-03	2000-04-18	Diatide, Inc	Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
US6355613B1 (en) *	1996-07-31	2002-03-12	Peptor Limited	Conformationally constrained backbone cyclized somatostatin analogs
US6180082B1 (en) *	1997-11-24	2001-01-30	Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College	Method to enhance tissue accumulation of radiolabeled compounds
US6358491B1 (en) *	1999-08-27	2002-03-19	Berlex Laboratories, Inc.	Somatostatin analogs
EP1086947A1 (en) *	1999-09-01	2001-03-28	Pfizer Products Inc.	Somatostatin antagonists and agonists that act at the SST subtype 2 receptor
EP1283216A1 (en)	2001-08-10	2003-02-12	Mallinckrodt Inc.	Somatostatin analogues binding to all somatostatin receptor subtypes and their use

2001
- 2001-08-10 EP EP01203033A patent/EP1283216A1/en not_active Withdrawn
2002
- 2002-08-07 DE DE60211917T patent/DE60211917T2/de not_active Expired - Lifetime
- 2002-08-07 AT AT02794598T patent/ATE328005T1/de not_active IP Right Cessation
- 2002-08-07 DK DK02794598T patent/DK1419178T3/da active
- 2002-08-07 EP EP02794598A patent/EP1419178B1/en not_active Expired - Lifetime
- 2002-08-07 PT PT02794598T patent/PT1419178E/pt unknown
- 2002-08-07 WO PCT/EP2002/009004 patent/WO2003014158A1/en not_active Ceased
- 2002-08-07 ES ES02794598T patent/ES2266616T3/es not_active Expired - Lifetime
- 2002-08-07 AU AU2002333396A patent/AU2002333396B2/en not_active Ceased
- 2002-08-07 JP JP2003519107A patent/JP2005508886A/ja not_active Ceased
- 2002-08-07 US US10/486,310 patent/US7192570B2/en not_active Expired - Fee Related
- 2002-08-07 CA CA002456881A patent/CA2456881A1/en not_active Abandoned
2006
- 2006-08-29 CY CY20061101213T patent/CY1105177T1/el unknown
2007
- 2007-03-08 US US11/683,734 patent/US7541018B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU2002333396B2 (en)	2008-05-22
ATE328005T1 (de)	2006-06-15
US7541018B2 (en)	2009-06-02
EP1283216A1 (en)	2003-02-12
US20040242842A1 (en)	2004-12-02
WO2003014158A1 (en)	2003-02-20
DE60211917D1 (de)	2006-07-06
US20070154392A1 (en)	2007-07-05
DE60211917T2 (de)	2007-01-18
EP1419178B1 (en)	2006-05-31
US7192570B2 (en)	2007-03-20
JP2005508886A (ja)	2005-04-07
PT1419178E (pt)	2006-09-29
CY1105177T1 (el)	2010-03-03
CA2456881A1 (en)	2003-02-20
ES2266616T3 (es)	2007-03-01
EP1419178A1 (en)	2004-05-19

Publication	Publication Date	Title
ATE328005T1 (de)	2006-06-15	Alle somatostatinrezeptorsubtypen-bindende somatostatinanaloge und deren verwendung
NO324217B1 (no)	2007-09-10	Kondenserte azepinderivater og deres anvendelse som antidiuretiske midler
WO2003002489A3 (en)	2003-04-24	Solid-phase electrophilic fluorination
YU57603A (sh)	2006-08-17	Inhibitori fosfodiesteraze 4
BR9903586A (pt)	2000-09-26	Composições de toner
MY122262A (en)	2006-04-29	Lh-rh peptide analogues their uses and pharmaceutical compositions containing them
HUP0401738A2 (hu)	2004-12-28	Prolin után hasító proteázok inhibitorai és ezeket tartalmazó gyógyszerkészítmények
BR9912033A (pt)	2001-05-22	Composições para lavar roupa e limpeza
MXPA04006581A (es)	2004-10-04	Derivados de sulfonato y su empleo como acidos latentes.
DK1189692T3 (da)	2004-07-26	Hidtil ukendte triazinbaserede detoksificeringsmidler og deres anvendelse
JP2005508886A5 (da)	2009-06-04
WO2002081499A3 (en)	2003-05-08	Somatostatin agonists
YU57999A (sh)	2002-06-19	N-triazolil-2-indolkarboksamidi i njihova primena kao agonista za cck-a
AU6854598A (en)	1998-11-13	4,1-benzoxazepines, their analogues, and their use as somatostatin agonists
ATE356140T1 (de)	2007-03-15	Gd3 mimetische peptide
DK0805685T3 (da)	2001-11-19	Hidtil ukendte antifungale cyclohexapeptider
TW429253B (en)	2001-04-11	Novel pyrazole compounds
WO2002072602A3 (en)	2003-03-20	Somatostatin antagonists
PT1282617E (pt)	2009-12-09	Derivados de hidantoína com afinidade para os receptores da somatostatina
DK1127064T3 (da)	2006-05-22	Hidtil ukendte aminosyresekvenser, DNA, der koder for aminosyresekvenserme, antistoffer, der er rettet mod sådanne sekvenser, og forskellige anvendelser deraf
ATE239034T1 (de)	2003-05-15	Mechanismus-orientierte inhibitoren der dipeptidylpeptidase i
DE60139893D1 (de)	2009-10-22	Neue fructosyl-aminosäureoxidase
DE69827614D1 (de)	2004-12-23	Chinoxalindionen
BR0010488A (pt)	2002-02-13	Tienocicloalqu(en)ilamino-1,3,5-triazinas substituìdas
TW200516345A (en)	2005-05-16	Dissolution inhibitors in photoresist compositions for microlithography