DK143107B - Fremgangsmaade til fremstilling af 2-isopropylaminopyrimidin - Google Patents
Fremgangsmaade til fremstilling af 2-isopropylaminopyrimidin Download PDFInfo
- Publication number
- DK143107B DK143107B DK250679AA DK250679A DK143107B DK 143107 B DK143107 B DK 143107B DK 250679A A DK250679A A DK 250679AA DK 250679 A DK250679 A DK 250679A DK 143107 B DK143107 B DK 143107B
- Authority
- DK
- Denmark
- Prior art keywords
- isopropylaminopyrimidine
- preparing
- aminopyrimidine
- acetone
- soc
- Prior art date
Links
- FTCYIGBVOHNHCD-UHFFFAOYSA-N isaxonine Chemical compound CC(C)NC1=NC=CC=N1 FTCYIGBVOHNHCD-UHFFFAOYSA-N 0.000 title description 7
- 238000000034 method Methods 0.000 title description 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- LJXQPZWIHJMPQQ-UHFFFAOYSA-N pyrimidin-2-amine Chemical compound NC1=NC=CC=N1 LJXQPZWIHJMPQQ-UHFFFAOYSA-N 0.000 description 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- UNCQVRBWJWWJBF-UHFFFAOYSA-N 2-chloropyrimidine Chemical compound ClC1=NC=CC=N1 UNCQVRBWJWWJBF-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- 238000006088 Dimroth rearrangement reaction Methods 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 150000001350 alkyl halides Chemical class 0.000 description 1
- 230000029936 alkylation Effects 0.000 description 1
- 238000005804 alkylation reaction Methods 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 description 1
- 238000005580 one pot reaction Methods 0.000 description 1
- 238000005932 reductive alkylation reaction Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Description
143107
Opfindelsen angår en fremgangsmåde til fremstilling af 2-isopropylaminopyrimidin, der frembyder den fordel, at fremgangsmåden er en ettrinsreaktion, der giver et forøget udbytte sammenlignet med hidtil kendte fremgangsmåder til 5 fremstilling af 2-isopropylaminopyrimidin ud fra 2-amino-pyrimidin.
Det er også kendt at fremstille 2-isopropylaminopyrimidin ud fra 2-chlorpyrimidin og isopropylamin; dette er beskrevet af Brown D. J. et Harper J. S. J. Chem. Soc.
10 5542 (1965).
Kun en reduktiv alkylering syntes indtil videre at være udført for at fremstille 2-alkylaminopyrimidin udfra 2-aminopyrimidin under anvendelse af myresyre; se I.A.
Kaye et I.C. Kogon Réc. Trav. Chim. 71» 309 (1952).
15 2-isopropylaminopyrimidin kan også fremstilles ved alky lering af 2-aminopyrimidin ved hjælp af alkylhalogenid, der giver 2-alkyl-l,2-dihydro-2-iminopyrlmidiner, der under basiske betingelser omdannes til de tilsvarende 2-alkylaminopyrimidiner ved Dimroth-omlejring (Brown 20 D.J. et Paddon-Row M.N.J. Chem. Soc (C) 903 (1967).
Imidlertid giver alle disse hidtil kendte fremgangsmåder 2-isopropylaminopyrimidin sædvanligvis i ringe udbytte, under 50%.
Ved fremgangsmåden ifølge opfindelsen, der er ejendommelig 25 ved det i kravets kendetegnende del angivne, har man opnået, at 2-isopropylaminopyrimidin kan opnås i særdeles gode udbytter ved at omsætte 2-aminopyrimidin i acetone i nærværelse af den organiske carboxylsyre med et overskud af et alkalimetalborhydrid. Ved denne reaktion er acetone både 30 et af reagenserne og opløsningsmiddel; af denne grund er et stort overskud af acetone nødvendig.
Opfindelsen beskrives nærmere i følgende eksempel: I en 2-liter reaktor udstyret med omrøring, opvarmnings-
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ18759578 | 1978-06-16 | ||
| NZ18759578 | 1978-06-16 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK250679A DK250679A (da) | 1979-12-17 |
| DK143107B true DK143107B (da) | 1981-03-30 |
| DK143107C DK143107C (da) | 1981-11-09 |
Family
ID=19918473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK250679A DK143107C (da) | 1978-06-16 | 1979-06-15 | Fremgangsmaade til fremstilling af 2-isopropylaminopyrimidin |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4266057A (da) |
| EP (1) | EP0006387B1 (da) |
| JP (1) | JPS6054311B2 (da) |
| AR (1) | AR219608A1 (da) |
| AT (1) | ATE2618T1 (da) |
| AU (1) | AU522443B2 (da) |
| CA (1) | CA1108142A (da) |
| DE (1) | DE2964895D1 (da) |
| DK (1) | DK143107C (da) |
| ES (1) | ES481586A1 (da) |
| FI (1) | FI68620C (da) |
| IE (1) | IE48348B1 (da) |
| IL (1) | IL57352A0 (da) |
| IN (1) | IN151973B (da) |
| MX (1) | MX5605E (da) |
| NO (1) | NO153688C (da) |
| PT (1) | PT69764A (da) |
| ZA (1) | ZA792487B (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3738295A1 (de) * | 1987-09-03 | 1989-03-16 | Tecon Gmbh | Reaktor und verfahren zum biologischen reinigen von schadstoffhaltigem wasser |
| US5264435A (en) * | 1988-12-29 | 1993-11-23 | Mitsui Petrochemical Industries, Ltd. | Pyrimidines and their pharmaceutical acceptable salts, and their use as medicines |
| HU206337B (en) * | 1988-12-29 | 1992-10-28 | Mitsui Petrochemical Ind | Process for producing pyrimidine derivatives and pharmaceutical compositions |
| US20100233101A1 (en) | 2009-02-13 | 2010-09-16 | Micropure, Inc. | Composition and method for the oxidative consumption of salivary biomolecules |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3984414A (en) * | 1971-10-09 | 1976-10-05 | Societe D'etudes De Produits Chimiques | Dichloroacetate salt of 2-isopropylamino pyrimidine |
| GB1525995A (en) * | 1976-02-18 | 1978-09-27 | Soc D Etudes Prod Chimique | Aminopyrimidine salt |
-
1979
- 1979-05-21 IL IL57352A patent/IL57352A0/xx not_active IP Right Cessation
- 1979-05-21 IN IN352/DEL/79A patent/IN151973B/en unknown
- 1979-05-22 ZA ZA792487A patent/ZA792487B/xx unknown
- 1979-05-23 FI FI791635A patent/FI68620C/fi not_active IP Right Cessation
- 1979-06-06 JP JP54070001A patent/JPS6054311B2/ja not_active Expired
- 1979-06-07 CA CA329,411A patent/CA1108142A/en not_active Expired
- 1979-06-11 US US06/047,477 patent/US4266057A/en not_active Expired - Lifetime
- 1979-06-12 PT PT69764A patent/PT69764A/pt unknown
- 1979-06-12 AU AU47980/79A patent/AU522443B2/en not_active Expired
- 1979-06-14 AR AR276919A patent/AR219608A1/es active
- 1979-06-15 NO NO791994A patent/NO153688C/no unknown
- 1979-06-15 ES ES481586A patent/ES481586A1/es not_active Expired
- 1979-06-15 MX MX798088U patent/MX5605E/es unknown
- 1979-06-15 DK DK250679A patent/DK143107C/da not_active IP Right Cessation
- 1979-06-15 DE DE7979400393T patent/DE2964895D1/de not_active Expired
- 1979-06-15 EP EP79400393A patent/EP0006387B1/fr not_active Expired
- 1979-06-15 AT AT79400393T patent/ATE2618T1/de not_active IP Right Cessation
- 1979-08-08 IE IE1149/79A patent/IE48348B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IE48348B1 (en) | 1984-12-26 |
| AR219608A1 (es) | 1980-08-29 |
| AU522443B2 (en) | 1982-06-03 |
| EP0006387A1 (fr) | 1980-01-09 |
| JPS55393A (en) | 1980-01-05 |
| IE791149L (en) | 1979-12-16 |
| IN151973B (da) | 1983-09-17 |
| AU4798079A (en) | 1979-12-20 |
| IL57352A0 (en) | 1979-09-30 |
| FI68620C (fi) | 1985-10-10 |
| CA1108142A (en) | 1981-09-01 |
| JPS6054311B2 (ja) | 1985-11-29 |
| MX5605E (es) | 1983-11-07 |
| ZA792487B (en) | 1980-06-25 |
| PT69764A (en) | 1979-07-01 |
| NO153688C (no) | 1986-06-11 |
| US4266057A (en) | 1981-05-05 |
| FI68620B (fi) | 1985-06-28 |
| DK143107C (da) | 1981-11-09 |
| ES481586A1 (es) | 1980-06-16 |
| NO791994L (no) | 1979-12-18 |
| FI791635A7 (fi) | 1979-12-17 |
| EP0006387B1 (fr) | 1983-02-23 |
| NO153688B (no) | 1986-01-27 |
| DE2964895D1 (en) | 1983-03-31 |
| DK250679A (da) | 1979-12-17 |
| ATE2618T1 (de) | 1983-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |