DK1448223T3 - Thymosin-forögelse af genetisk immunisering - Google Patents

Thymosin-forögelse af genetisk immunisering

Info

Publication number: DK1448223T3
Authority: DK; Denmark
Prior art keywords: hepatitis; virus; thymosin; augmentation; genetic immunization
Prior art date: 2001-10-26

Application number

DK02795564T

Other languages

Danish (da)

English (en)

Inventor

Jack R Wands

Original Assignee

Rhode Island Hospital

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-26

Filing date

2002-10-28

Publication date

2008-02-18

2002-10-28 Application filed by Rhode Island Hospital filed Critical Rhode Island Hospital

2008-02-18 Application granted granted Critical

2008-02-18 Publication of DK1448223T3 publication Critical patent/DK1448223T3/da

Links

102000007501 Thymosin Human genes 0.000 title abstract 4
108010046075 Thymosin Proteins 0.000 title abstract 4
230000003053 immunization Effects 0.000 title abstract 3
LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 title abstract 2
230000003416 augmentation Effects 0.000 title 1
230000002068 genetic effect Effects 0.000 title 1
238000002649 immunization Methods 0.000 title 1
241000711549 Hepacivirus C Species 0.000 abstract 4
102000040430 polynucleotide Human genes 0.000 abstract 2
108091033319 polynucleotide Proteins 0.000 abstract 2
239000002157 polynucleotide Substances 0.000 abstract 2
102000004196 processed proteins & peptides Human genes 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
230000024932 T cell mediated immunity Effects 0.000 abstract 1
208000010710 hepatitis C virus infection Diseases 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2292—Thymosin; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Immunology (AREA)
Microbiology (AREA)
Mycology (AREA)
Organic Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Endocrinology (AREA)
Zoology (AREA)
Oncology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)

DK02795564T 2001-10-26 2002-10-28 Thymosin-forögelse af genetisk immunisering DK1448223T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US33063801P	2001-10-26	2001-10-26
PCT/US2002/034535 WO2003035010A2 (en)	2001-10-26	2002-10-28	Thymosin augmentation of genetic immunization

Publications (1)

Publication Number	Publication Date
DK1448223T3 true DK1448223T3 (da)	2008-02-18

Family

ID=23290629

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02795564T DK1448223T3 (da)	2001-10-26	2002-10-28	Thymosin-forögelse af genetisk immunisering

Country Status (21)

Country	Link
US (1)	US20050054845A1 (pl)
EP (1)	EP1448223B1 (pl)
JP (1)	JP2005506997A (pl)
KR (1)	KR100902197B1 (pl)
CN (1)	CN1269524C (pl)
AT (1)	ATE382365T1 (pl)
BR (1)	BR0213554A (pl)
CA (1)	CA2464795A1 (pl)
CY (1)	CY1107371T1 (pl)
DE (1)	DE60224435T2 (pl)
DK (1)	DK1448223T3 (pl)
EA (1)	EA006743B1 (pl)
ES (1)	ES2299626T3 (pl)
IL (1)	IL161603A0 (pl)
MX (1)	MXPA04003867A (pl)
NO (1)	NO20042124L (pl)
NZ (1)	NZ532863A (pl)
PL (1)	PL370453A1 (pl)
PT (1)	PT1448223E (pl)
UA (1)	UA81613C2 (pl)
WO (1)	WO2003035010A2 (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1835931A4 (en) *	2004-12-06	2008-12-17	Sciclone Pharmaceuticals Inc	ALPHA THYMOSINE PEPTIDES AS CANCER VACCINE ADJUVANTIES
EP2427213B1 (en)	2009-05-08	2015-04-01	Sciclone Pharmaceuticals, Inc.	Alpha thymosin peptides as vaccine enhancers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4079127A (en) *	1976-10-28	1978-03-14	Board Of Regents Of The University Of Texas	Thymosin alpha 1
US4116951A (en) *	1977-04-22	1978-09-26	Hoffmann-La Roche Inc.	[Asn2 ]-thymosin α1 and analogs thereof
US4148788A (en) *	1978-01-23	1979-04-10	Hoffmann-La Roche Inc.	Synthesis of thymosin α1
DE2919592A1 (de) *	1979-05-15	1981-01-15	Max Planck Gesellschaft	Verfahren zur herstellung von thymosin- alpha 1 und derivaten davon
TW224053B (pl)	1991-09-13	1994-05-21	Paul B Chretien
US5620896A (en) *	1992-03-23	1997-04-15	University Of Massachusetts Medical Center	DNA vaccines against rotavirus infections
US5593972A (en) *	1993-01-26	1997-01-14	The Wistar Institute	Genetic immunization
US6288033B1 (en) *	1998-09-25	2001-09-11	Sciclone Pharmaceuticals, Inc.	Treatment of hepatitis B infection with thymosin alpha 1 in combination with lamivudine or in combination with lamivudine and famciclovir

2002
- 2002-10-28 ES ES02795564T patent/ES2299626T3/es not_active Expired - Lifetime
- 2002-10-28 PT PT02795564T patent/PT1448223E/pt unknown
- 2002-10-28 EP EP02795564A patent/EP1448223B1/en not_active Expired - Lifetime
- 2002-10-28 DE DE60224435T patent/DE60224435T2/de not_active Expired - Lifetime
- 2002-10-28 UA UA20040503963A patent/UA81613C2/ru unknown
- 2002-10-28 US US10/493,411 patent/US20050054845A1/en not_active Abandoned
- 2002-10-28 EA EA200400534A patent/EA006743B1/ru not_active IP Right Cessation
- 2002-10-28 MX MXPA04003867A patent/MXPA04003867A/es active IP Right Grant
- 2002-10-28 CA CA002464795A patent/CA2464795A1/en not_active Abandoned
- 2002-10-28 DK DK02795564T patent/DK1448223T3/da active
- 2002-10-28 JP JP2003537579A patent/JP2005506997A/ja active Pending
- 2002-10-28 PL PL02370453A patent/PL370453A1/pl unknown
- 2002-10-28 BR BR0213554-0A patent/BR0213554A/pt not_active IP Right Cessation
- 2002-10-28 IL IL16160302A patent/IL161603A0/xx unknown
- 2002-10-28 CN CNB028212770A patent/CN1269524C/zh not_active Expired - Fee Related
- 2002-10-28 NZ NZ532863A patent/NZ532863A/en unknown
- 2002-10-28 WO PCT/US2002/034535 patent/WO2003035010A2/en not_active Ceased
- 2002-10-28 AT AT02795564T patent/ATE382365T1/de not_active IP Right Cessation
- 2002-10-28 KR KR1020047006231A patent/KR100902197B1/ko not_active Expired - Fee Related
2004
- 2004-05-24 NO NO20042124A patent/NO20042124L/no not_active Application Discontinuation
2008
- 2008-03-28 CY CY20081100354T patent/CY1107371T1/el unknown

Also Published As

Publication number	Publication date
PL370453A1 (pl)	2005-05-30
WO2003035010A3 (en)	2003-12-04
KR20040089075A (ko)	2004-10-20
NZ532863A (en)	2006-07-28
UA81613C2 (ru)	2008-01-25
EP1448223B1 (en)	2008-01-02
MXPA04003867A (es)	2005-06-17
DE60224435D1 (de)	2008-02-14
PT1448223E (pt)	2008-01-23
KR100902197B1 (ko)	2009-06-11
ATE382365T1 (de)	2008-01-15
CN1604789A (zh)	2005-04-06
EP1448223A4 (en)	2005-11-16
ES2299626T3 (es)	2008-06-01
EP1448223A2 (en)	2004-08-25
IL161603A0 (en)	2004-09-27
CN1269524C (zh)	2006-08-16
WO2003035010A2 (en)	2003-05-01
US20050054845A1 (en)	2005-03-10
BR0213554A (pt)	2004-10-26
EA006743B1 (ru)	2006-04-28
JP2005506997A (ja)	2005-03-10
NO20042124L (no)	2004-05-24
CY1107371T1 (el)	2012-12-19
DE60224435T2 (de)	2009-01-02
EA200400534A1 (ru)	2004-12-30
CA2464795A1 (en)	2003-05-01

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TW200503752A (en)	2005-02-01	HCV vaccines
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ATE458496T1 (de)	2010-03-15	Hiv-vakzine und anwendungsverfahren
EP1530579A4 (en)	2006-02-08	RECOMBINANT ANTIBODIES AND COMPOSITIONS AND METHOD FOR THE PRODUCTION AND USE THEREOF
EP1581638A4 (en)	2005-12-28	ANTIGENS P153 AND P156 FOR THE IMMUNODIAGNOSIS OF CANINE AND HUMAN EHRLICHIOSES AND USES THEREOF
MXPA06013388A (es)	2007-06-19	Vector lentiviral recombinante para la expresion de una proteina flaviviridae y sus aplicaciones como vacuna.
TW200641126A (en)	2006-12-01	N protein mutants of porcine reproductive and respiratory syndrome virus
DK1448223T3 (da)	2008-02-18	Thymosin-forögelse af genetisk immunisering
SE9604581D0 (sv)	1996-12-12	An agent against cancer and virus infections
DK1949913T3 (da)	2010-10-04	Immunstimulatorisk kombination til profylakserne og behandlingen af hepatitis C
WO2004058807A3 (en)	2004-09-30	Mhc class i restricted t-cell stimulating peptides from hepatitis b virus
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ATE476197T1 (de)	2010-08-15	Rekombinante vakzine gegen infektion mit dem japanischen enzephalitis-virus äjevü und verfahren davon
DE10393824D2 (de)	2005-08-11	Impfstoff gegen Infektionen mit Onkoviren, wie dem felinen Leukosevirus der Katze
DE69433057D1 (de)	2003-09-25	Peptide zur verwendung bei der impfung und induktion neutralisierender antikörper gegen das menschliche immunschwäche-virus
DK1159426T3 (da)	2006-05-15	Kloning og udtryk af Haemophilus somnus transferrin-bindende proteiner
WO2005010035A3 (en)	2006-09-08	Alternate reading frame polypeptides derived from hepatitis c and methods of their use
RU2004104357A (ru)	2005-07-10	Вакцинный состав, потенцированный комбинацией днк и антигена
SE9600436D0 (sv)	1996-02-06	Vaccine against hantavirus