DK1480953T3 - Fremgangsmåde til fremstilling af aripiprazol - Google Patents
Fremgangsmåde til fremstilling af aripiprazolInfo
- Publication number
- DK1480953T3 DK1480953T3 DK03780889T DK03780889T DK1480953T3 DK 1480953 T3 DK1480953 T3 DK 1480953T3 DK 03780889 T DK03780889 T DK 03780889T DK 03780889 T DK03780889 T DK 03780889T DK 1480953 T3 DK1480953 T3 DK 1480953T3
- Authority
- DK
- Denmark
- Prior art keywords
- aripiprazole
- preparation
- Prior art date
Links
- CEUORZQYGODEFX-UHFFFAOYSA-N Aripirazole Chemical compound ClC1=CC=CC(N2CCN(CCCCOC=3C=C4NC(=O)CCC4=CC=3)CC2)=C1Cl CEUORZQYGODEFX-UHFFFAOYSA-N 0.000 title 1
- 229960004372 aripiprazole Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003002996 | 2003-01-09 | ||
| PCT/JP2003/016256 WO2004063162A1 (en) | 2003-01-09 | 2003-12-18 | Process for preparing aripiprazole |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK1480953T3 true DK1480953T3 (da) | 2005-12-19 |
| DK1480953T4 DK1480953T4 (da) | 2010-11-15 |
Family
ID=32652780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03780889.6T DK1480953T4 (da) | 2003-01-09 | 2003-12-18 | Fremgangsmåde til fremstilling af aripiprazol |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6995264B2 (da) |
| EP (1) | EP1480953B2 (da) |
| JP (2) | JP5797090B2 (da) |
| KR (1) | KR100583667B1 (da) |
| CN (1) | CN1263742C (da) |
| AR (1) | AR042702A1 (da) |
| AT (1) | ATE308524T1 (da) |
| AU (1) | AU2003288755C1 (da) |
| BR (2) | BRPI0305500B1 (da) |
| CA (1) | CA2676216A1 (da) |
| DE (1) | DE60302139T3 (da) |
| DK (1) | DK1480953T4 (da) |
| EG (1) | EG23557A (da) |
| ES (1) | ES2250919T5 (da) |
| MX (1) | MXPA04002519A (da) |
| MY (1) | MY129831A (da) |
| SI (1) | SI1480953T2 (da) |
| TW (1) | TWI258470B (da) |
| WO (1) | WO2004063162A1 (da) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2550726A1 (en) * | 2003-12-16 | 2005-06-30 | Teva Pharmaceutical Industries Ltd. | Methods of preparing aripiprazole crystalline forms |
| US7714129B2 (en) * | 2003-12-16 | 2010-05-11 | Teva Pharmaceutical Industries Ltd. | Methods of preparing anhydrous aripiprazole form II |
| MXPA06008828A (es) * | 2004-02-05 | 2007-04-25 | Teva Pharma | Proceso para preparar aripiprazol. |
| US7507823B2 (en) | 2004-05-06 | 2009-03-24 | Bristol-Myers Squibb Company | Process of making aripiprazole particles |
| KR101041551B1 (ko) * | 2004-10-08 | 2011-06-15 | 수벤 라이프 사이언시스 리미티드 | 아리피프라졸 제조를 위해 유용한 신규 중간체와 신규중간체 및 아리피프라졸 제조 방법 |
| DE102005048695A1 (de) * | 2004-10-12 | 2006-05-18 | Chemagis Ltd. | Verfahren zur Herstellung und Reinigung von Carbostyrilverbindungen wie beispielsweise Aripiprazol und 7-(4-Halobutoxy)-3,4-dihydro-2(1H)-quinolinonen |
| EP1812397A1 (en) * | 2004-11-18 | 2007-08-01 | Synthon B.V. | Process of making crystalline aripiprazole |
| CN1303068C (zh) * | 2005-01-11 | 2007-03-07 | 中国人民解放军第二军医大学 | 一种阿立哌唑的制备方法 |
| TWI320783B (en) | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
| CA2622758A1 (en) * | 2005-09-15 | 2007-03-29 | Elan Pharma International, Limited | Nanoparticulate aripiprazole formulations |
| EP1919453A2 (en) * | 2005-12-22 | 2008-05-14 | Teva Pharmaceutical Industries Ltd | Processes for reducing particle size of aripiprazole |
| US20070149782A1 (en) * | 2005-12-23 | 2007-06-28 | Michael Brand | Methods of preparing a crystalline form of 7-(4-chlorobutoxy)-3,4-dihydro-2(1h)-quinolinone and the use thereof in the synthesis of Aripiprazole |
| EP1845088B1 (en) * | 2006-04-10 | 2009-07-22 | Ranbaxy Laboratories Limited | An improved process for the preparation of aripipirazole |
| EP2162135A4 (en) | 2007-05-21 | 2012-02-22 | Reviva Pharmaceuticals Inc | COMPOSITIONS, SYNTHESIS AND METHOD FOR THE APPLICATION OF ATTAINED CHINOLINONE-BASED ANTIPSYCHOTICS |
| EP2299814A4 (en) | 2008-05-27 | 2011-06-15 | Reviva Pharmaceuticals Inc | COMPOSITIONS, SYNTHESIS AND METHOD FOR USE OF ANTIPSYCHOTICS ON PIPERAZINE BASIS |
| CN101781246B (zh) * | 2009-01-15 | 2012-02-29 | 成都康弘药业集团股份有限公司 | 一种合成阿立哌唑的改进方法 |
| PT2400968T (pt) | 2009-02-26 | 2016-12-09 | Reviva Pharmaceuticals Inc | Composições, sintese e métodos de utilização dos derivados de arilpiperazína |
| JOP20200109A1 (ar) | 2012-04-23 | 2017-06-16 | Otsuka Pharma Co Ltd | مستحضر قابل للحقن |
| WO2016181406A1 (en) * | 2015-05-08 | 2016-11-17 | Davuluri Ramamohan Rao | Improved process for the preparation of aripiprazole with reduced particle size |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54130587A (en) * | 1978-03-30 | 1979-10-09 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
| DE3034237A1 (de) † | 1979-09-18 | 1981-04-16 | Otsuka Pharmaceutical Co. Ltd., Tokyo | Carbostyrilderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende, antihistaminisch wirkende mittel |
| JP2608788B2 (ja) * | 1988-10-31 | 1997-05-14 | 大塚製薬 株式会社 | 精神分裂病治療剤 |
| US5006528A (en) * | 1988-10-31 | 1991-04-09 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
| JP4060523B2 (ja) † | 1999-11-24 | 2008-03-12 | 大塚製薬株式会社 | カルボスチリル誘導体の製造法 |
| AR033485A1 (es) † | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
-
2003
- 2003-12-18 SI SI200330153T patent/SI1480953T2/sl unknown
- 2003-12-18 EP EP03780889A patent/EP1480953B2/en not_active Expired - Lifetime
- 2003-12-18 BR BRPI0305500-0A patent/BRPI0305500B1/pt unknown
- 2003-12-18 DK DK03780889.6T patent/DK1480953T4/da active
- 2003-12-18 AU AU2003288755A patent/AU2003288755C1/en not_active Ceased
- 2003-12-18 AT AT03780889T patent/ATE308524T1/de active
- 2003-12-18 ES ES03780889T patent/ES2250919T5/es not_active Expired - Lifetime
- 2003-12-18 TW TW092135997A patent/TWI258470B/zh not_active IP Right Cessation
- 2003-12-18 WO PCT/JP2003/016256 patent/WO2004063162A1/en not_active Ceased
- 2003-12-18 KR KR1020047003990A patent/KR100583667B1/ko not_active Expired - Lifetime
- 2003-12-18 CA CA002676216A patent/CA2676216A1/en not_active Abandoned
- 2003-12-18 BR BR0305500-0A patent/BR0305500A/pt not_active IP Right Cessation
- 2003-12-18 DE DE60302139T patent/DE60302139T3/de not_active Expired - Lifetime
- 2003-12-18 MX MXPA04002519A patent/MXPA04002519A/es active IP Right Grant
-
2004
- 2004-01-05 EG EG2004010004A patent/EG23557A/xx active
- 2004-01-05 AR ARP040100006A patent/AR042702A1/es not_active Application Discontinuation
- 2004-01-08 MY MYPI20040043A patent/MY129831A/en unknown
- 2004-01-08 US US10/752,490 patent/US6995264B2/en not_active Expired - Lifetime
- 2004-01-09 CN CNB2004100020641A patent/CN1263742C/zh not_active Expired - Lifetime
-
2011
- 2011-11-04 JP JP2011241871A patent/JP5797090B2/ja not_active Expired - Lifetime
-
2014
- 2014-03-06 JP JP2014043786A patent/JP2014148511A/ja active Pending
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