DK148292D0 - Forbindelser - Google Patents

Forbindelser

Info

Publication number
DK148292D0
DK148292D0 DK921482A DK148292A DK148292D0 DK 148292 D0 DK148292 D0 DK 148292D0 DK 921482 A DK921482 A DK 921482A DK 148292 A DK148292 A DK 148292A DK 148292 D0 DK148292 D0 DK 148292D0
Authority
DK
Denmark
Prior art keywords
alkyl
alk
cyclo
aralkyl
relations
Prior art date
Application number
DK921482A
Other languages
English (en)
Inventor
Jens Kristian Perregaard
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Priority to DK921482A priority Critical patent/DK148292D0/da
Publication of DK148292D0 publication Critical patent/DK148292D0/da
Priority to IL10780593A priority patent/IL107805A0/xx
Priority to AT94900792T priority patent/ATE170168T1/de
Priority to JP51369094A priority patent/JP3731827B2/ja
Priority to ES94900792T priority patent/ES2119991T3/es
Priority to RU95116287A priority patent/RU2141474C1/ru
Priority to SG1996008150A priority patent/SG48233A1/en
Priority to KR1019950702357A priority patent/KR100357976B1/ko
Priority to PCT/DK1993/000413 priority patent/WO1994013620A1/en
Priority to DK94900792T priority patent/DK0673360T3/da
Priority to NZ258116A priority patent/NZ258116A/en
Priority to HU9501669A priority patent/HU225111B1/hu
Priority to SK762-95A priority patent/SK281014B6/sk
Priority to ZA939204A priority patent/ZA939204B/xx
Priority to AU55617/94A priority patent/AU675262B2/en
Priority to DE69320652T priority patent/DE69320652T2/de
Priority to CZ19951518A priority patent/CZ289820B6/cs
Priority to EP94900792A priority patent/EP0673360B1/en
Priority to CA002151377A priority patent/CA2151377C/en
Priority to US08/504,847 priority patent/US5807889A/en
Priority to FI952823A priority patent/FI114464B/fi
Priority to NO952274A priority patent/NO304686B1/no
Priority to US08/955,376 priority patent/US5972964A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/57—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems of the carbon skeleton
    • C07C211/60—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems of the carbon skeleton containing a ring other than a six-membered aromatic ring forming part of at least one of the condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/80—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Detergent Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
DK921482A 1992-12-09 1992-12-09 Forbindelser DK148292D0 (da)

Priority Applications (23)

Application Number Priority Date Filing Date Title
DK921482A DK148292D0 (da) 1992-12-09 1992-12-09 Forbindelser
IL10780593A IL107805A0 (en) 1992-12-09 1993-11-30 Aminomethylindans -benzofuranes and -benzothiophenes
CA002151377A CA2151377C (en) 1992-12-09 1993-12-08 Aminomethylindans, -benzofurans and -benzothiophenes
NZ258116A NZ258116A (en) 1992-12-09 1993-12-08 5-amino-3-aminomethyl-indan, -benzofuran, and -benzothiophene derivatives; pharmaceutical compositions
ZA939204A ZA939204B (en) 1992-12-09 1993-12-08 Aminomethylindans,-benzofuranes and -benzothiophenes
ES94900792T ES2119991T3 (es) 1992-12-09 1993-12-08 Aminometil-indanos, -benzofuranos y -benzotiofenos.
RU95116287A RU2141474C1 (ru) 1992-12-09 1993-12-08 Аминометилинданы - бензофураны и бензотиофены
SG1996008150A SG48233A1 (en) 1992-12-09 1993-12-08 Aminomethylindans - benzofuranes and - benzothiophenes
KR1019950702357A KR100357976B1 (ko) 1992-12-09 1993-12-08 아미노메틸인단, -벤조푸란 및 -벤조티오펜
PCT/DK1993/000413 WO1994013620A1 (en) 1992-12-09 1993-12-08 Aminomethylindans, -benzofuranes and -benzothiophenes
DK94900792T DK0673360T3 (da) 1992-12-09 1993-12-08 Aminomethylindaner, -benzofuraner og -benzothiophener
AT94900792T ATE170168T1 (de) 1992-12-09 1993-12-08 Aminomethylindane,-benzofurane und benzothiopene
HU9501669A HU225111B1 (en) 1992-12-09 1993-12-08 Aminomethylindans, -benzofuranes and-benzothiophenes and pharmaceutical compositions containing them
SK762-95A SK281014B6 (sk) 1992-12-09 1993-12-08 Aminometylindány, -benzofurány a -benzotiofény, ich použitie a farmaceutická zmes s ich obsahom
JP51369094A JP3731827B2 (ja) 1992-12-09 1993-12-08 アミノメチルインダン、‐ベンゾフラン及び‐ベンゾチオフエン
AU55617/94A AU675262B2 (en) 1992-12-09 1993-12-08 Aminomethylindans, -benzofuranes and -benzothiophenes
DE69320652T DE69320652T2 (de) 1992-12-09 1993-12-08 Aminomethylindane,-benzofurane und benzothiopene
CZ19951518A CZ289820B6 (cs) 1992-12-09 1993-12-08 Aminomethyl-indany, -benzofurany a -benzothiofeny, jejich pouľití a farmaceutický prostředek
EP94900792A EP0673360B1 (en) 1992-12-09 1993-12-08 Aminomethylindans, -benzofuranes and -benzothiophenes
US08/504,847 US5807889A (en) 1992-12-09 1995-06-06 Aminomethylindans, -benzofuranes and -benzothiophenes
FI952823A FI114464B (fi) 1992-12-09 1995-06-08 Menetelmä uusien terapeuttisesti käyttökelpoisten aminometyyli-indaani-, -bentsofuraani ja -bentsotiofeenijohdannaisten valmistamiseksi
NO952274A NO304686B1 (no) 1992-12-09 1995-06-08 Aminometylindaner, -benzofuraner og -benzotiofener
US08/955,376 US5972964A (en) 1992-12-09 1997-10-22 Aminomethylindans, -benzofurans and -benzothiophenes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK921482A DK148292D0 (da) 1992-12-09 1992-12-09 Forbindelser

Publications (1)

Publication Number Publication Date
DK148292D0 true DK148292D0 (da) 1992-12-09

Family

ID=8105305

Family Applications (2)

Application Number Title Priority Date Filing Date
DK921482A DK148292D0 (da) 1992-12-09 1992-12-09 Forbindelser
DK94900792T DK0673360T3 (da) 1992-12-09 1993-12-08 Aminomethylindaner, -benzofuraner og -benzothiophener

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK94900792T DK0673360T3 (da) 1992-12-09 1993-12-08 Aminomethylindaner, -benzofuraner og -benzothiophener

Country Status (21)

Country Link
US (2) US5807889A (da)
EP (1) EP0673360B1 (da)
JP (1) JP3731827B2 (da)
KR (1) KR100357976B1 (da)
AT (1) ATE170168T1 (da)
AU (1) AU675262B2 (da)
CA (1) CA2151377C (da)
CZ (1) CZ289820B6 (da)
DE (1) DE69320652T2 (da)
DK (2) DK148292D0 (da)
ES (1) ES2119991T3 (da)
FI (1) FI114464B (da)
HU (1) HU225111B1 (da)
IL (1) IL107805A0 (da)
NO (1) NO304686B1 (da)
NZ (1) NZ258116A (da)
RU (1) RU2141474C1 (da)
SG (1) SG48233A1 (da)
SK (1) SK281014B6 (da)
WO (1) WO1994013620A1 (da)
ZA (1) ZA939204B (da)

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GB9614347D0 (en) * 1996-07-09 1996-09-04 Smithkline Beecham Spa Novel compounds
FR2752839B1 (fr) * 1996-08-29 1998-10-09 Synthelabo Derives de benzofurane, leur preparation et leur application en therapeutique
DE19642451A1 (de) * 1996-10-15 1998-04-16 Merck Patent Gmbh Aminothiophencarbonsäureamide
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
SE9904674D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
US7053092B2 (en) 2001-01-29 2006-05-30 Otsuka Pharmaceutical Co., Ltd. 5-HT1a receptor subtype agonist
AR032641A1 (es) * 2001-01-29 2003-11-19 Otsuka Pharma Co Ltd Agonista de subtipo de receptor 5-ht 1a.
CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
AR033485A1 (es) 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
US8703772B2 (en) 2001-09-25 2014-04-22 Otsuka Pharmaceutical Co., Ltd. Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
TW200524915A (en) * 2003-09-26 2005-08-01 Tanabe Seiyaku Co Carbamoyl-type benzofuran derivatives
RU2402549C3 (ru) * 2005-04-14 2022-03-10 Оцука Фармасьютикал Ко., Лтд. Пиперазин-замещенные бензотиофены для лечения психических расстройств
EP2671508B1 (en) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-informatics system
US7378552B2 (en) 2005-06-07 2008-05-27 Neurocrine Biosciences, Inc. Monoamine re-uptake inhibitors and methods relating thereto
TWI329641B (en) * 2005-08-31 2010-09-01 Otsuka Pharma Co Ltd (benzo[b]thiophen-4-yl)piperazine compounds, pharmaceutical compositions comprising the same, uses of the same and processes for preparing the same
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
CN101434552B (zh) * 2007-11-16 2012-05-23 江苏恒瑞医药股份有限公司 4,5-二甲氧基-1-(甲基氨基甲基)-苯并环丁烷的拆分
RU2393855C1 (ru) * 2008-12-29 2010-07-10 Общество С Ограниченной Ответственностью "Валента-Интеллект" Средство, обладающее анксиолитической и церебропротекторной активностью, уменьшающее влечение к алкоголю
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
KR20180114970A (ko) 2009-05-06 2018-10-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN112399860B (zh) 2018-06-06 2024-08-16 麻省理工学院 用于在真核细胞中翻译的环状rna
JP7686574B2 (ja) 2019-05-22 2025-06-02 マサチューセッツ インスティテュート オブ テクノロジー 環状ｒｎａ組成物及び方法
MX2022006854A (es) 2019-12-04 2022-11-30 Orna Therapeutics Inc Composiciones y metodos de arn circular.
US12297285B2 (en) 2022-06-24 2025-05-13 Orna Therapeutics, Inc. Circular RNA encoding chimeric antigen receptors targeting BCMA

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CA2151377A1 (en) 1994-06-23
EP0673360B1 (en) 1998-08-26
CZ289820B6 (cs) 2002-04-17
DK0673360T3 (da) 1999-05-25
ES2119991T3 (es) 1998-10-16
WO1994013620A1 (en) 1994-06-23
DE69320652T2 (de) 1999-04-01
FI952823A7 (fi) 1995-06-08
JP3731827B2 (ja) 2006-01-05
SG48233A1 (en) 1998-04-17
NO952274L (no) 1995-08-02
SK76295A3 (en) 1996-02-07
FI114464B (fi) 2004-10-29
HUT73633A (en) 1996-08-28
EP0673360A1 (en) 1995-09-27
NO304686B1 (no) 1999-02-01
SK281014B6 (sk) 2000-10-09
HU9501669D0 (en) 1996-05-28
AU5561794A (en) 1994-07-04
FI952823A0 (fi) 1995-06-08
KR950704234A (ko) 1995-11-17
KR100357976B1 (ko) 2003-01-24
AU675262B2 (en) 1997-01-30
CA2151377C (en) 2005-07-05
RU95116287A (ru) 1997-06-10
RU2141474C1 (ru) 1999-11-20
US5807889A (en) 1998-09-15
ATE170168T1 (de) 1998-09-15
ZA939204B (en) 1994-08-08
NO952274D0 (no) 1995-06-08
DE69320652D1 (de) 1998-10-01
NZ258116A (en) 1996-06-25
CZ151895A3 (en) 1996-03-13
IL107805A0 (en) 1994-02-27
HU225111B1 (en) 2006-06-28
US5972964A (en) 1999-10-26

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