DK148681A - Forbedrede vektorer og fremgangsmaader til fremstilling af saadanne vektorer og til ekspression af klonede gener - Google Patents

Forbedrede vektorer og fremgangsmaader til fremstilling af saadanne vektorer og til ekspression af klonede gener

Info

Publication number
DK148681A
DK148681A DK148681A DK148681A DK148681A DK 148681 A DK148681 A DK 148681A DK 148681 A DK148681 A DK 148681A DK 148681 A DK148681 A DK 148681A DK 148681 A DK148681 A DK 148681A
Authority
DK
Denmark
Prior art keywords
vectors
procedures
expression
manufacturing
cloned genes
Prior art date
Application number
DK148681A
Other languages
English (en)
Other versions
DK171301B1 (da
Inventor
W C Fiers
E R Remaut
Original Assignee
Biogen Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27260930&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK148681(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biogen Nv filed Critical Biogen Nv
Publication of DK148681A publication Critical patent/DK148681A/da
Application granted granted Critical
Publication of DK171301B1 publication Critical patent/DK171301B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/73—Expression systems using phage (lambda) regulatory sequences
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/22011—Polyomaviridae, e.g. polyoma, SV40, JC
    • C12N2710/22022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
DK148681A 1980-06-06 1981-04-01 Plasmid-vektorer, fremgangsmåde til fremstilling deraf samt fremgangsmåde til fremstilling af polypeptid DK171301B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB8018701 1980-06-06
GB8018701 1980-06-06
GB8026661 1980-08-15
GB8026661 1980-08-15
GB8028983 1980-09-08
GB8028983 1980-09-08

Publications (2)

Publication Number Publication Date
DK148681A true DK148681A (da) 1981-12-07
DK171301B1 DK171301B1 (da) 1996-08-26

Family

ID=27260930

Family Applications (1)

Application Number Title Priority Date Filing Date
DK148681A DK171301B1 (da) 1980-06-06 1981-04-01 Plasmid-vektorer, fremgangsmåde til fremstilling deraf samt fremgangsmåde til fremstilling af polypeptid

Country Status (17)

Country Link
EP (1) EP0041767B1 (da)
JP (6) JPH0787785B2 (da)
KR (1) KR860001557B1 (da)
BG (1) BG60443B2 (da)
BR (1) BR8101972A (da)
CA (1) CA1207251A (da)
DD (1) DD158918A5 (da)
DE (1) DE3177298T2 (da)
DK (1) DK171301B1 (da)
ES (1) ES500967A0 (da)
FI (1) FI811009L (da)
GR (1) GR74282B (da)
IE (1) IE63126B1 (da)
IL (1) IL62553A (da)
NO (1) NO811119L (da)
PH (1) PH22618A (da)
YU (1) YU87581A (da)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58765A (en) * 1979-11-21 1986-09-30 Yeda Res & Dev Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta
US5510472A (en) * 1979-11-21 1996-04-23 Yeda Research And Development Co. Ltd. Production of recombinant human interferon-beta2
US5554513A (en) * 1979-11-21 1996-09-10 Yeda Research & Development Co. Ltd. Production of recombinant human interferon-beta2
JP2687995B2 (ja) 1980-04-03 1997-12-08 バイオゲン インコーポレイテッド Ｄｎａ配列、組替えｄｎａ分子およびヒト繊維芽細胞インターフェロン様ポリペプチドの製造方法
IL65475A0 (en) * 1981-04-17 1982-07-30 Meloy Lab Production of immune interferon and its mrna
EP0068693A3 (en) * 1981-06-16 1983-07-20 Genentech, Inc. Production of foot and mouth disease vaccine from microbially expressed antigens
JPS5835198A (ja) * 1981-08-28 1983-03-01 Mitsubishi Petrochem Co Ltd 新規ベクター
ZA831854B (en) * 1982-03-26 1984-01-25 Biogen Nv Small peptides with the specificity of foot and mouth disease viral antigens
JPS58183659A (ja) * 1982-03-31 1983-10-26 ジェネテイックス、インスチチュ−ト、インコ−ポレ−テッド 修飾プロインシュリン前駆体、これを暗号化するｄｎａ配列およびそれらの産生方法
FR2526661B1 (fr) * 1982-05-13 1986-02-21 Transgene Sa Nouveaux vecteurs d'expression de la proteine antigenique de la rage et leur application a la preparation de vaccins
US4582800A (en) * 1982-07-12 1986-04-15 Hoffmann-La Roche Inc. Novel vectors and method for controlling interferon expression
CA1209501A (en) * 1982-09-16 1986-08-12 Nikos Panayotatos Expression vector
CA1341012C (en) * 1982-09-27 2000-06-06 Biogen, Inc. Dna sequences, recombinant dna molecules and processes for producing swine growth hormone-like polypeptides
EP0121569B1 (en) * 1982-10-08 1990-08-22 Kyowa Hakko Kogyo Co., Ltd. Novel vector
CA1303530C (en) * 1983-01-21 1992-06-16 Michael Courtney EXPRESSION VECTORS AND THEIR USE FOR THE PREPARATION OF A PROTEIN HAVING HUMAN .alpha. -ANTITRYPSIN ACTIVITY
FR2539758B1 (fr) * 1983-01-21 1985-11-15 Transgene Sa Nouveaux vecteurs d'expression et leur application a la preparation d'une proteine ayant l'activite de l'antitrypsine-a1 humaine
GB8308235D0 (en) * 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
DE3319242A1 (de) * 1983-05-27 1984-11-29 Battelle-Institut E.V., 6000 Frankfurt Verfahren und plasmid zur steuerung der expression von klonierten genen
BG49718A3 (bg) * 1983-07-15 1992-01-15 Bio- Technology General Corp Метод за получаване на полипептид със супероксиддисмутазна активност
US5670371A (en) * 1983-07-15 1997-09-23 Bio-Technology General Corp. Bacterial expression of superoxide dismutase
US5162216A (en) * 1983-09-23 1992-11-10 Enzon Labs Inc. Hybrid gene regulatory region operable in E. coli
FR2556365B1 (fr) * 1983-12-09 1987-07-31 Transgene Sa Vecteurs de clonage et d'expression de l'interferon-g, bacteries transformees et procede de preparation de l'interferon-g
WO1985003522A1 (en) * 1984-02-08 1985-08-15 Cetus Corporation Monitoring and control systems for recombinant manipulations
US4711845A (en) * 1984-08-31 1987-12-08 Cetus Corporation Portable temperature-sensitive control cassette
US5059529A (en) * 1984-08-27 1991-10-22 Bio-Technology General Corp. Stabilized expression vectors containing λPL promoter and the gene for the cI434 repressor, plasmids containing the vectors, hosts containing the plasmids and related methods
US5081020A (en) * 1984-08-27 1992-01-14 Bio-Technology General Corp. Expression vectors containing λPL promoter, T1 T2 rRNA termination sequence and origin of replication derived from a constitutive high copy number plasmid hosts and related methods
US5143836A (en) * 1984-08-27 1992-09-01 Bio-Technology General Corp. Plasmids for expression of human superoxide dismutase (SOD) analogs containing lambda pl promoter with engineered restriction site for substituting ribosomal binding sites and methods of use thereof
US5759816A (en) * 1984-08-27 1998-06-02 Bio-Technology General Corp. Expression vectors containing λPL promoter and T1 T2 rRNA termination sequence plasmids containing the vectors hosts containing the plasmids and related methods
US5126252A (en) * 1984-08-27 1992-06-30 Bio-Technology General Corp. Expressions vectors containing Lambda PL promoter and T1 T2 RNA termination sequence, plasmids containing the vectors, hosts containing the plasmids and relatedmethods
US5112744A (en) * 1984-08-27 1992-05-12 Bio-Technology General Corp. Plasmids for the production of human Cu-Zn superoxide dismutase, bacterial hosts containing the plasmids and methods for production and recovery of such superoxide dismutase
US5162217A (en) * 1984-08-27 1992-11-10 Bio-Technology General Corp. Plasmids for expression of human superoxide dismutase (SOD) analogs containing lambda PL promoter with engineered restriction site for substituting ribosomal binding sites and methods of use thereof
CA1340597C (en) * 1984-08-27 1999-06-22 Haim Aviv Expression vectors containing pl promoter, and engineered restriction site for convenient replacement of ribosomal binding site, plasmids containing the vectors, hosts containing the plasmids and related methods
US4766066A (en) * 1984-09-27 1988-08-23 Eli Lilly And Company Method of using bacteriophage lambda p1 promoter to produce a functional polypeptide in streptomyces
US5510238A (en) * 1984-10-26 1996-04-23 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Production of human T-cell leukemia (lymphotropic) retrovirus (HTLV-I) envelope protein fragments in bacteria and use in seroepidemiological studies
ATE73856T1 (de) 1984-12-21 1992-04-15 Biogen Inc Reinigung, herstellung und verwendung von tumor- nekrosisfaktoren.
US5182196A (en) * 1985-10-09 1993-01-26 Biogen, Inc. Expression systems for overproduction of desired proteins
EP0303925B1 (de) * 1987-08-17 1995-06-07 F. Hoffmann-La Roche Ag Hochreprimierbare Expressionskontrollsequenzen
JP2003204783A (ja) * 1999-07-19 2003-07-22 Ajinomoto Co Inc 発酵法による目的物質の製造法
US7579005B2 (en) 2005-11-28 2009-08-25 E. I. Du Pont De Nemours And Company Process for recombinant expression and purification of antimicrobial peptides using periplasmic targeting signals as precipitable hydrophobic tags

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2687995B2 (ja) * 1980-04-03 1997-12-08 バイオゲン インコーポレイテッド Ｄｎａ配列、組替えｄｎａ分子およびヒト繊維芽細胞インターフェロン様ポリペプチドの製造方法
DD160279A5 (de) * 1980-05-12 1983-05-25 Biogen Nv Verfahren zur herstellung eines die spezifitaet von mks-virus-antigenen aufweisenden polypeptits

Also Published As

Publication number Publication date
NO811119L (no) 1981-12-07
GR74282B (da) 1984-06-21
IL62553A0 (en) 1981-06-29
JPH10304876A (ja) 1998-11-17
CA1207251A (en) 1986-07-08
BR8101972A (pt) 1982-08-17
JP3158951B2 (ja) 2001-04-23
JPH0838177A (ja) 1996-02-13
ES8302774A1 (es) 1983-01-16
ES500967A0 (es) 1983-01-16
JP3158953B2 (ja) 2001-04-23
IE810757L (en) 1981-12-06
JPH0838179A (ja) 1996-02-13
EP0041767B1 (en) 1993-03-03
EP0041767A2 (en) 1981-12-16
IE63126B1 (en) 1995-03-22
JP2001136966A (ja) 2001-05-22
DE3177298D1 (de) 1993-04-08
DE3177298T2 (de) 1993-07-01
KR860001557B1 (ko) 1986-10-04
JPS5714599A (en) 1982-01-25
JPH0838176A (ja) 1996-02-13
PH22618A (en) 1988-10-28
EP0041767A3 (en) 1982-09-29
DD158918A5 (de) 1983-02-09
FI811009A7 (fi) 1981-12-07
JPH0787785B2 (ja) 1995-09-27
IL62553A (en) 1984-12-31
KR830005353A (ko) 1983-08-13
YU87581A (en) 1984-04-30
JP3158952B2 (ja) 2001-04-23
BG60443B2 (bg) 1995-03-31
FI811009L (fi) 1981-12-07
DK171301B1 (da) 1996-08-26

Similar Documents

Publication Publication Date Title
DK148681A (da) Forbedrede vektorer og fremgangsmaader til fremstilling af saadanne vektorer og til ekspression af klonede gener
DK9879A (da) Taetningsring og fremgangsmaade til fremstilling af en saadan
DK109581A (da) Fremgangsmaade og vektororganisme til kontrolleret akkumulering af klonede heterologe genprodukter i bacillus subtilis
DK313479A (da) Pose af formstof og fremgangsmaade til dens fremstilling
DK217782A (da) Tastatur og fremgangsmaade til fremstilling af dette
DK157263C (da) Reaktionskuvette og reaktionsbakke bestaaende af et antal af saadanne reaktionskuvetter
DK187879A (da) Kontraventil og fremgangsmaade til fremstilling af en saadan
DK149842C (da) Fremgangsmaade til fremstilling af d-camphorat af l-carnitinamid og d-camphorat af d-carnitinamid
DK319281A (da) Femgangsmaade til fremstilling af benzisoselenazoloner
DK123579A (da) Servostyreventil og fremgangsmaade til fremstilling af en saadan
DK219585D0 (da) Fremgangsmaade, vektorer og transformanter til ekspression af heterologe polypeptider i gaer
DK132779A (da) Fremgangsmaade til fremstilling af cishexahydrodibenzoepyranoner og tetrahydrobenzoxoiner
DK308382A (da) Raketfartoej
DK90079A (da) Gennemskrivningsmateriale og fremgangsmaade til fremstilling deraf
DK479981A (da) Fremgangsmaade til fremstilling af 3-aryl-3-hydroxyphthalimidiner
DK532481A (da) Fremgangsmaade til fremstilling af jern og molybdaenoxidbaserede katalysatorer
DK179781A (da) Deazapurinnucleosid kompositioner ineholdende dette og fremgangsmaade til fremstilling af saadanne kompositioner
DK238180A (da) Forbedrede celler til blyakkumulatorer og fremgangsmaade til fremstilling af saadanne celler
DK151570C (da) Afsvovlningsmiddel og fremgangsmaade til fremstilling deraf
DK106680A (da) Fremgangsmaade og indretninger til beskyttelse af stationaere undervandskonstruktioner
BE875293A (fr) Nouveaux agents anti-salissures et application desdits agents
DK331381A (da) Fremgangsmaade til fremstilling af 1-klor-1-pmetoxybenzoylformaldoxim-n-metylkarbamat
DK54779A (da) Testosteronestere og fremgangsmaade til fremstilling deraf
DK117177A (da) Fremgangsmade og reaktor til fremstilling af kobberphthalocyanin
DK157365C (da) Fremgangsmaade til fremstilling af 1,2,4-triazol

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed
PUP Patent expired