DK1509501T3 - 1-(Aminoalkyl)-3-sulfonylindol- og indazolderivater som 5-hydroxytryptamin-6-ligander - Google Patents
1-(Aminoalkyl)-3-sulfonylindol- og indazolderivater som 5-hydroxytryptamin-6-liganderInfo
- Publication number
- DK1509501T3 DK1509501T3 DK03736818T DK03736818T DK1509501T3 DK 1509501 T3 DK1509501 T3 DK 1509501T3 DK 03736818 T DK03736818 T DK 03736818T DK 03736818 T DK03736818 T DK 03736818T DK 1509501 T3 DK1509501 T3 DK 1509501T3
- Authority
- DK
- Denmark
- Prior art keywords
- sulfonylindole
- hydroxytryptamine
- aminoalkyl
- ligands
- indazole derivatives
- Prior art date
Links
- 125000004103 aminoalkyl group Chemical group 0.000 title 1
- 125000003453 indazolyl group Chemical class N1N=C(C2=C1C=CC=C2)* 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38569502P | 2002-06-04 | 2002-06-04 | |
| PCT/US2003/017472 WO2003101962A1 (en) | 2002-06-04 | 2003-06-03 | 1-(aminoalkyl)-3-sulfonylindole and -indazole derivatives as 5-hydroxytryptamine-6 ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1509501T3 true DK1509501T3 (da) | 2007-03-12 |
Family
ID=29712202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03736818T DK1509501T3 (da) | 2002-06-04 | 2003-06-03 | 1-(Aminoalkyl)-3-sulfonylindol- og indazolderivater som 5-hydroxytryptamin-6-ligander |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6727246B2 (da) |
| EP (1) | EP1509501B1 (da) |
| JP (1) | JP2005536473A (da) |
| CN (1) | CN1656069A (da) |
| AR (1) | AR040048A1 (da) |
| AT (1) | ATE348806T1 (da) |
| AU (1) | AU2003237355A1 (da) |
| BR (1) | BR0311436A (da) |
| CA (1) | CA2485871A1 (da) |
| CR (1) | CR7566A (da) |
| DE (1) | DE60310552T2 (da) |
| DK (1) | DK1509501T3 (da) |
| EC (1) | ECSP045473A (da) |
| ES (1) | ES2279125T3 (da) |
| MX (1) | MXPA04011315A (da) |
| NO (1) | NO20044764L (da) |
| NZ (1) | NZ536921A (da) |
| RU (1) | RU2004139099A (da) |
| TW (1) | TW200400177A (da) |
| WO (1) | WO2003101962A1 (da) |
| ZA (1) | ZA200500021B (da) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL370342A1 (en) * | 2001-09-27 | 2005-05-16 | F.Hoffmann-La Roche Ag | Indole derivatives as cox ii inhibitors |
| US20050163438A1 (en) * | 2002-02-13 | 2005-07-28 | Sander Aloysius F.M. | Integrated semiconductor optical device, method and apparatus for manufacturing such a device |
| TW200401641A (en) * | 2002-07-18 | 2004-02-01 | Wyeth Corp | 1-Heterocyclylalkyl-3-sulfonylindole or-indazole derivatives as 5-hydroxytryptamine-6 ligands |
| KR20050101551A (ko) * | 2003-02-14 | 2005-10-24 | 와이어쓰 | 5-하이드록시트립타민-6 리간드로서의헤테로사이클릴-3-설포닐인다졸 |
| EP1647549A1 (en) * | 2004-10-14 | 2006-04-19 | Laboratoire Theramex | Indazoles, benzisoxazoles and benzisothiazoles as estrogenic agents |
| AR054394A1 (es) * | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | Derivados de 2- (1h-indolilsulfanil)-aril amina |
| CA2612554A1 (en) * | 2005-06-28 | 2007-01-04 | Merck & Co., Inc. | Non-nucleoside reverse transcriptase inhibitors |
| EP1898928A2 (en) * | 2005-06-28 | 2008-03-19 | Merck & Co., Inc. | Non-nucleoside reverse transcriptase inhibitors |
| JP2008546840A (ja) * | 2005-06-28 | 2008-12-25 | メルク エンド カムパニー インコーポレーテッド | 非ヌクレオシド逆転写酵素阻害剤 |
| BRPI0614343A2 (pt) * | 2005-08-15 | 2011-03-22 | Wyeth Corp | derivados de 3-sulfonilindazol substituìdo como ligantes de 5-hidroxitriptamina-6 |
| BRPI0614341A2 (pt) * | 2005-08-15 | 2011-03-29 | Wyeth Corp | composto; método para o tratamento de um distúrbio do sistema nervoso central relacionado com o receptor de 5-ht6 ou afetado por ele em um paciente que deste necessite; composição farmacêutica; e processo |
| WO2007053353A2 (en) * | 2005-10-28 | 2007-05-10 | Wyeth | Pyrrolo[2,3-f] and [3,2-f]isoquinolinone derivatives as 5-hydroxytryptamine-6 ligands |
| AU2007235499A1 (en) * | 2006-04-05 | 2007-10-18 | Wyeth | Sulfonyl-3-heterocyclylindazole derivatives as 5-hydroxytryptamine-6 ligands |
| WO2007120596A1 (en) * | 2006-04-12 | 2007-10-25 | Wyeth | DIHYDRO[1,4]DIOXINO[2,3-e]INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS |
| CN101730680A (zh) * | 2007-05-24 | 2010-06-09 | 记忆医药公司 | 具有5-ht6受体亲和力的4’取代的化合物 |
| US20090012308A1 (en) * | 2007-06-13 | 2009-01-08 | Wyeth | Process for the manufacture of benzylsulfonylarenes |
| US20100016297A1 (en) * | 2008-06-24 | 2010-01-21 | Memory Pharmaceuticals Corporation | Alkyl-substituted 3' compounds having 5-ht6 receptor affinity |
| US20100022581A1 (en) * | 2008-07-02 | 2010-01-28 | Memory Pharmaceuticals Corporation | Pyrrolidine-substituted azaindole compounds having 5-ht6 receptor affinity |
| US20100029629A1 (en) * | 2008-07-25 | 2010-02-04 | Memory Pharmaceuticals Corporation | Acyclic compounds having 5-ht6 receptor affinity |
| US20100056531A1 (en) * | 2008-08-22 | 2010-03-04 | Memory Pharmaceuticals Corporation | Alkyl-substituted 3' compounds having 5-ht6 receptor affinity |
| RU2015102792A (ru) * | 2012-07-10 | 2016-08-27 | Ф. Хоффманн-Ля Рош Аг | Новые индазолы для лечения и профилактики респираторно-синцитиальной вирусной инфекции |
| WO2018064094A1 (en) * | 2016-09-28 | 2018-04-05 | Bristol-Myers Squibb Company | Enantioselective synthesis of pyrroloindole compounds |
| WO2018064465A1 (en) | 2016-09-29 | 2018-04-05 | The Regents Of The University Of California | Compounds for increasing neural plasticity |
| WO2018165501A1 (en) * | 2017-03-10 | 2018-09-13 | Lycera Corporation | INDOLINYL SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORγ AND THE TREATMENT OF DISEASE |
| CN111269165A (zh) * | 2018-12-05 | 2020-06-12 | 中国科学院大连化学物理研究所 | 一种3-芳基磺酰基吲哚衍生物的合成方法 |
| CN113784962B (zh) | 2019-02-27 | 2025-04-25 | 加利福尼亚大学董事会 | 用于治疗脑部疾病的氮杂环庚三烯并-吲哚类和其他杂环 |
| TW202333668A (zh) | 2021-12-15 | 2023-09-01 | 美商德利克斯醫療公司 | 經苯氧基及苄氧基取代之精神成形素(psychoplastogen)及其用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4654360A (en) | 1984-06-01 | 1987-03-31 | Syntex (U.S.A.) Inc. | 1,2,3-trisubstituted indoles for treatment of inflammation |
| FR2642755B1 (da) | 1989-02-07 | 1993-11-05 | Sanofi | |
| US5132319A (en) | 1991-03-28 | 1992-07-21 | Merck Frosst Canada, Inc. | 1-(hydroxylaminoalkyl) indole derivatives as inhibitors of leukotriene biosynthesis |
| US6100291A (en) * | 1998-03-16 | 2000-08-08 | Allelix Biopharmaceuticals Inc. | Pyrrolidine-indole compounds having 5-HT6 affinity |
| TR200003130T2 (tr) | 1998-04-28 | 2001-01-22 | Arzneimittelwerk Dresden Gmbh | Yeni hidroksiindoller, bunların fosfodiesteraz 4 inhibitörleri olarak kullanımları ve hazırlanmaları için işlemler |
| GB9819032D0 (en) * | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds IV |
| GB9820113D0 (en) | 1998-09-15 | 1998-11-11 | Merck Sharp & Dohme | Therapeutic agents |
| CZ20023544A3 (cs) | 2000-04-28 | 2004-07-14 | Baxter Healthcare Sa | Deriváty 2-acylindolu a jejich použití jako protinádorové činidlo |
| EP1401813B1 (en) * | 2001-06-07 | 2007-02-07 | F. Hoffman-la Roche AG | New indole derivatives with 5-ht6 receptor affinity |
-
2003
- 2003-05-19 TW TW092113450A patent/TW200400177A/zh unknown
- 2003-05-23 AR ARP030101812A patent/AR040048A1/es unknown
- 2003-06-03 DK DK03736818T patent/DK1509501T3/da active
- 2003-06-03 RU RU2004139099/04A patent/RU2004139099A/ru not_active Application Discontinuation
- 2003-06-03 EP EP03736818A patent/EP1509501B1/en not_active Expired - Lifetime
- 2003-06-03 US US10/453,009 patent/US6727246B2/en not_active Expired - Fee Related
- 2003-06-03 AT AT03736818T patent/ATE348806T1/de not_active IP Right Cessation
- 2003-06-03 WO PCT/US2003/017472 patent/WO2003101962A1/en not_active Ceased
- 2003-06-03 CA CA002485871A patent/CA2485871A1/en not_active Withdrawn
- 2003-06-03 JP JP2004509655A patent/JP2005536473A/ja active Pending
- 2003-06-03 MX MXPA04011315A patent/MXPA04011315A/es active IP Right Grant
- 2003-06-03 AU AU2003237355A patent/AU2003237355A1/en not_active Withdrawn
- 2003-06-03 NZ NZ536921A patent/NZ536921A/en unknown
- 2003-06-03 ES ES03736818T patent/ES2279125T3/es not_active Expired - Lifetime
- 2003-06-03 BR BR0311436-8A patent/BR0311436A/pt not_active IP Right Cessation
- 2003-06-03 DE DE60310552T patent/DE60310552T2/de not_active Expired - Lifetime
- 2003-06-03 CN CNA038124998A patent/CN1656069A/zh active Pending
-
2004
- 2004-11-03 NO NO20044764A patent/NO20044764L/no not_active Application Discontinuation
- 2004-11-04 CR CR7566A patent/CR7566A/es unknown
- 2004-12-02 EC EC2004005473A patent/ECSP045473A/es unknown
-
2005
- 2005-01-03 ZA ZA200500021A patent/ZA200500021B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60310552D1 (de) | 2007-02-01 |
| WO2003101962A1 (en) | 2003-12-11 |
| CA2485871A1 (en) | 2003-12-11 |
| BR0311436A (pt) | 2005-03-22 |
| ES2279125T3 (es) | 2007-08-16 |
| AR040048A1 (es) | 2005-03-09 |
| US6727246B2 (en) | 2004-04-27 |
| ECSP045473A (es) | 2005-01-28 |
| CR7566A (es) | 2005-01-05 |
| ZA200500021B (en) | 2006-06-28 |
| DE60310552T2 (de) | 2007-09-27 |
| TW200400177A (en) | 2004-01-01 |
| EP1509501B1 (en) | 2006-12-20 |
| RU2004139099A (ru) | 2005-06-10 |
| NO20044764L (no) | 2005-01-03 |
| NZ536921A (en) | 2006-06-30 |
| CN1656069A (zh) | 2005-08-17 |
| EP1509501A1 (en) | 2005-03-02 |
| US20030232828A1 (en) | 2003-12-18 |
| JP2005536473A (ja) | 2005-12-02 |
| ATE348806T1 (de) | 2007-01-15 |
| MXPA04011315A (es) | 2005-02-14 |
| AU2003237355A1 (en) | 2003-12-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1509501T3 (da) | 1-(Aminoalkyl)-3-sulfonylindol- og indazolderivater som 5-hydroxytryptamin-6-ligander | |
| DK1509522T3 (da) | 1-(Aminoalkyl)-3-sulfonylazaindoler som 5-hydroxytryptamin-6-ligander | |
| DK1353904T3 (da) | 1-Aryl- eller 1-alkylsulfonylbenzazolderivater som 5-hydroxytryptamin-6-ligander | |
| IL166138A0 (en) | 1-heterocyclylalkyl-3-sulfonylindole or indazole derivatives as 5-hydroxytryptamine-6 ligands | |
| DK1456206T3 (da) | Azaindolylalkylaminderivater som 5-hydroxytryptamin-6-ligander | |
| NO20031977L (no) | 1-aryl- eller 1-alkylsulfonyl-heterocyklylbenzazoler som 5- hydroksytryptamin-6-ligander | |
| DK1956004T3 (da) | Quinolinderivater og deres anvendelse som 5-HT6-ligander | |
| DK1355904T3 (da) | Heterocyclindazol- og -azaindazolforbindelser som 5-hydroxytryptamin-6-ligander | |
| IS7667A (is) | Nýjar bensimídazólafleiður | |
| IL166139A0 (en) | 1-heterocycylalkyl-3-sulfonylazaindole or- azaindazole derivatives as 5-hydroxytryptamine-6 ligands | |
| DK1233943T3 (da) | Ioniserbare indolinon derivater og anvendelse deraf som PTK ligander | |
| NO20050426L (no) | Arylkarbonylderivater som terapeutiske midler | |
| DK1455779T3 (da) | Indolylalkylaminderivater som 5-hydroxytryptamin-6-ligander | |
| IL199668A0 (en) | New benzimidazole derivatives | |
| DK1272468T3 (da) | Indolin-2-on-derivater og deres anvendelse som ligander for oxytocinreceptorerne | |
| NO20034648L (no) | Hydroksycyklyloksy-, tioksy- og -aminobenzazol-derivater som 5-hydroksytryptamin-6-ligander | |
| NO20050665L (no) | Pyrrolidonderivater som MAOE inhibitoere | |
| NO20051236L (no) | Heterobiarylderivater som matriksmetalloproteinaseinhibitorer | |
| NO20034647D0 (no) | Hydroksyclylalkoksy-, alkyloksy- og -alkylaminobenzazol- derivater som 5-hydroksytryptamin-6-ligander | |
| PL374893A1 (en) | 1-(4-benzyl-piperazin-1-yl)-3-phenyl-propenone derivatives | |
| AU2003273885A1 (en) | Morpholine-bridged indazole derivatives | |
| DK1228041T3 (da) | Indolderivater og anvendelse deraf som SHT2A-ligander | |
| AU2003209114A1 (en) | Pyrrolylalkylidene-hydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands | |
| DE602004031726D1 (de) | Indazole mit analgetischer aktivität | |
| IS7022A (is) | Nýjar indólafleiður |