DK151489A - 2,3,4,-substituerede imidazoler og 3,4,5-substituerede 1,2,4-triazoler, deres fremstilling og laegemidler indeholdende forbindelserne - Google Patents

2,3,4,-substituerede imidazoler og 3,4,5-substituerede 1,2,4-triazoler, deres fremstilling og laegemidler indeholdende forbindelserne

Info

Publication number
DK151489A
DK151489A DK151489A DK151489A DK151489A DK 151489 A DK151489 A DK 151489A DK 151489 A DK151489 A DK 151489A DK 151489 A DK151489 A DK 151489A DK 151489 A DK151489 A DK 151489A
Authority
DK
Denmark
Prior art keywords
substituted
imidazols
triazoles
compounds
preparation
Prior art date
Application number
DK151489A
Other languages
English (en)
Other versions
DK151489D0 (da
Inventor
Kurt Schromm
Anton Mentrup
Ernst-Otto Renth
Hubert Heuer
Gojko Muacevic
Franz Birke
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of DK151489D0 publication Critical patent/DK151489D0/da
Publication of DK151489A publication Critical patent/DK151489A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK151489A 1988-03-30 1989-03-29 2,3,4,-substituerede imidazoler og 3,4,5-substituerede 1,2,4-triazoler, deres fremstilling og laegemidler indeholdende forbindelserne DK151489A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3810848A DE3810848A1 (de) 1988-03-30 1988-03-30 Neue 2,3,4-substituierte imidazole und 3,4,5-substituierte 1,2,4-triazole, ihre herstellung und verwendung

Publications (2)

Publication Number Publication Date
DK151489D0 DK151489D0 (da) 1989-03-29
DK151489A true DK151489A (da) 1989-10-01

Family

ID=6351100

Family Applications (1)

Application Number Title Priority Date Filing Date
DK151489A DK151489A (da) 1988-03-30 1989-03-29 2,3,4,-substituerede imidazoler og 3,4,5-substituerede 1,2,4-triazoler, deres fremstilling og laegemidler indeholdende forbindelserne

Country Status (18)

Country Link
EP (1) EP0335381A1 (da)
JP (1) JPH02503679A (da)
KR (1) KR900700459A (da)
AU (1) AU3228689A (da)
DD (1) DD283620A5 (da)
DE (2) DE3810848A1 (da)
DK (1) DK151489A (da)
FI (1) FI891449L (da)
FR (1) FR2629457A1 (da)
GB (1) GB2216890A (da)
HU (1) HUT52091A (da)
IL (1) IL89788A0 (da)
NO (1) NO891293L (da)
PL (1) PL278547A1 (da)
PT (1) PT90142A (da)
WO (1) WO1989009212A1 (da)
YU (1) YU65489A (da)
ZA (1) ZA892259B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3927483A1 (de) * 1989-08-19 1991-02-21 Boehringer Ingelheim Kg Neue substituierte heterocyclische fuenfringe, ihre herstellung und verwendung
US5120749A (en) * 1991-02-20 1992-06-09 Abbott Laboratories Platelet activating antagonists
US5155117A (en) * 1991-04-12 1992-10-13 G. D. Searle & Co. 1-arylheteroarylalkyl substituted-1h-1,2,4-triazole compounds for treatment of circulatory disorders
ES2162792T3 (es) * 1991-09-18 2002-01-16 Glaxo Group Ltd Derivados de benzanilida como antagonistas de 5-ht1d.
TW226993B (da) * 1992-05-29 1994-07-21 Kumiai Chemical Industry Co
EP1601666A2 (en) 2002-07-02 2005-12-07 Schering Corporation New neuropeptide y y5 receptor antagonists
WO2004007477A1 (fr) * 2002-07-04 2004-01-22 Aventis Pharma S.A. Nouveaux derives acyl hydrazino du thiophene, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
TW200505450A (en) 2003-02-03 2005-02-16 Janssen Pharmaceutica Nv Quinoline-derived amide modulators of vanilloid VR1 receptor
ES2465469T3 (es) 2005-01-14 2014-06-05 Gilead Connecticut, Inc. Diaril ureas 1,3-sustituidas como moduladores de la actividad quinasa
US7777040B2 (en) 2005-05-03 2010-08-17 Cgi Pharmaceuticals, Inc. Certain substituted ureas, as modulators of kinase activity
UY30892A1 (es) 2007-02-07 2008-09-02 Smithkline Beckman Corp Inhibidores de la actividad akt
NZ594064A (en) 2009-01-30 2012-08-31 Glaxosmithkline Llc Crystalline n-{ (1s)-2-amino-1-[(3-fluorophenyl)methyl]ethyl} -5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride
EP2509961B1 (en) 2009-12-11 2016-03-09 Autifony Therapeutics Limited Imidazolidinedione derivatives
KR101862375B1 (ko) 2010-12-06 2018-05-29 오티포니 세라피틱스 리미티드 Kv3 억제제로서 유용한 하이단토인 유도체
US9193704B2 (en) 2011-06-07 2015-11-24 Autifony Therapeutics Limited Hydantoin derivatives as KV3 inhibitors
JP2015517563A (ja) 2012-05-22 2015-06-22 アウトイフオンイ トヘラペウトイクス リミテッド Ｋｖ３阻害剤としてのヒダントイン誘導体
CN104334547B (zh) 2012-05-22 2017-06-06 奥蒂福尼疗法有限公司 作为kv3抑制剂的三唑类
WO2021138540A1 (en) 2020-01-03 2021-07-08 Berg Llc Polycyclic amides as ube2k modulators for treating cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3842089A (en) * 1971-08-18 1974-10-15 Upjohn Co 4-(alpha-(phenyl)-o-toly)-4h-1,2,4-triazoles
GB1378617A (en) * 1972-05-05 1974-12-27 Upjohn Co Triazolylbenzophenones
FR2269938A2 (en) * 1974-05-08 1975-12-05 Delalande Sa 5-Hydroxymethyl-3,4-diphenyl-1,2,4-triazoles - with anticholinergic, bronchodilator, antidepressant, analgesic, vasodilator activity, etc.
FR2539127B1 (fr) * 1983-01-10 1985-08-23 Roussel Uclaf Nouveaux derives du 4h-1,2,4-triazole, leur procede de preparation et leur application comme medicaments
PH30676A (en) * 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
YU136287A (en) * 1986-07-25 1990-06-30 Boehringer Kg Process for preparing new 1,4 benzodiazepines
FR2813807B1 (fr) * 2000-09-14 2002-11-15 Filtrauto Filtre a gazole incluant un circuit electrique et dispositif de filtration comportant un tel filtre

Also Published As

Publication number Publication date
EP0335381A1 (de) 1989-10-04
HUT52091A (en) 1990-06-28
IL89788A0 (en) 1989-09-28
PT90142A (pt) 1989-11-10
DE3810848A1 (de) 1989-10-19
GB2216890A (en) 1989-10-18
FI891449A7 (fi) 1989-10-01
DE3990284D2 (en) 1990-04-05
FR2629457A1 (fr) 1989-10-06
YU65489A (en) 1991-04-30
JPH02503679A (ja) 1990-11-01
FI891449A0 (fi) 1989-03-28
DD283620A5 (de) 1990-10-17
WO1989009212A1 (fr) 1989-10-05
PL278547A1 (en) 1990-01-08
KR900700459A (ko) 1990-08-13
DK151489D0 (da) 1989-03-29
GB8907042D0 (en) 1989-05-10
NO891293D0 (no) 1989-03-28
AU3228689A (en) 1989-10-05
ZA892259B (en) 1990-12-28
NO891293L (no) 1989-10-02
FI891449L (fi) 1989-10-01

Similar Documents

Publication Publication Date Title
DK151489D0 (da) 2,3,4,-substituerede imidazoler og 3,4,5-substituerede 1,2,4-triazoler, deres fremstilling og laegemidler indeholdende forbindelserne
DK133288D0 (da) Imidazolforbindelser, deres fremstilling og biocide midler indeholdende forbindelserne
TR22573A (tr) Bazi 2-(2-'nitrobenzoil)-1-3 sikloheksan dion "lar"
DK430485D0 (da) Trans-6-(2-(substitueretpyrrol-1-yl)alkyl)-pyran-2-oner, deres fremstilling og farmaceutiske anvendelse
DK313188A (da) 9-alfa-hydroxy-steroider, deres og de tilsvarende 9(11)-dehydro-derivaters fremstilling og laegemidler indeholdende steroiderne
DK157488D0 (da) Substituerede triazolinoner, deres fremstilling og anvendelse
DK162491D0 (da) Heterocycliske forbindelser, deres fremstilling og farmaceutiske praeparater indeholdende forbindelserne
DK451588A (da) Heterocycliske forbindelser, deres fremstilling og laegemidler indeholdende forbindelserne
FI913983A7 (fi) Sienenvastaiset triatsolin johdannaiset, niiden valmistus ja käytöt
DK175686A (da) Fluorerede 1-(alfa-phenylalkyl)-1h-1,2,3-triazolforbindelser samt deres fremstilling og anvendelse
FI952682A0 (fi) Insektisidisiä 5-substituoituja 2,4-diamiinipyrimidiinijohdannaisia
DK179888A (da) 1,5-substituerede 1h-imidazoler
DK101689D0 (da) 4-substituerede pyrazolooe3,4-daapyrimidinderivater
DK117089D0 (da) 3,4,5-substituerede 4h-1,2,4-triazoler, deres fremstilling og anvendelse
DK57685A (da) 1,2,4-triazolderivater
NO934633D0 (no) Kondenserte, heterocykliske forbindelser, deres fremstilling og anvendelse
DK496785D0 (da) 5-fluoruracilderivater, deres fremstilling og laegemidler indeholdende saadanne forbindelser
IL94057A0 (en) 5-substituted 3-arylisoxazole derivatives and insecticidal compositions containing the same
DK686688A (da) 8,9-annelerede beta-carboliner, deres fremstilling og laegemidler indeholdende forbindelserne
DK33389D0 (da) Kondenserede diazepinoner, deres fremstilling og laegemidler indeholdende forbindelserne
DK185389A (da) 3,5-substituerede 1,2,4-oxadiazoler, deres fremstiling og anvendelse
DK199389D0 (da) Heterocykliske forbindelser, deres fremstilling og anvendelse
DK162391D0 (da) Heterocycliske forbindelser, deres fremstilling og farmaceutiske praeparater indeholdende forbindelserne
ATE74595T1 (de) N-substituierte triazol-derivate, ihre herstellung und ihre verwendung.
DK142188D0 (da) Heterocykliske forbindelser, deres fremstilling og anvendelse

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment
PBP Patent lapsed