DK1536783T3 - Faste formuleringer, der omfatter en indolinonforbindelse - Google Patents

Faste formuleringer, der omfatter en indolinonforbindelse

Info

Publication number
DK1536783T3
DK1536783T3 DK03772489T DK03772489T DK1536783T3 DK 1536783 T3 DK1536783 T3 DK 1536783T3 DK 03772489 T DK03772489 T DK 03772489T DK 03772489 T DK03772489 T DK 03772489T DK 1536783 T3 DK1536783 T3 DK 1536783T3
Authority
DK
Denmark
Prior art keywords
solid formulations
indolinone compound
indolinone
compound
formulations
Prior art date
Application number
DK03772489T
Other languages
English (en)
Inventor
Paolo Gatti
Original Assignee
Pfizer Italia Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31994326&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1536783(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Italia Srl filed Critical Pfizer Italia Srl
Application granted granted Critical
Publication of DK1536783T3 publication Critical patent/DK1536783T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK03772489T 2002-09-10 2003-09-10 Faste formuleringer, der omfatter en indolinonforbindelse DK1536783T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42113302P 2002-09-10 2002-09-10
PCT/IB2003/005293 WO2004024127A2 (en) 2002-09-10 2003-09-10 Solid formulations comprising an indolinone compound

Publications (1)

Publication Number Publication Date
DK1536783T3 true DK1536783T3 (da) 2008-10-13

Family

ID=31994326

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03772489T DK1536783T3 (da) 2002-09-10 2003-09-10 Faste formuleringer, der omfatter en indolinonforbindelse

Country Status (32)

Country Link
US (1) US20040229930A1 (da)
EP (1) EP1536783B2 (da)
JP (1) JP2006503032A (da)
KR (1) KR20050059170A (da)
CN (1) CN1688304A (da)
AR (1) AR041193A1 (da)
AT (1) ATE403425T1 (da)
AU (1) AU2003280108B2 (da)
BR (1) BR0314182A (da)
CA (1) CA2498415C (da)
DE (1) DE60322720D1 (da)
DK (1) DK1536783T3 (da)
DO (1) DOP2003000708A (da)
ES (1) ES2309363T5 (da)
GT (1) GT200300193A (da)
HN (1) HN2003000272A (da)
MX (1) MXPA05002690A (da)
MY (1) MY136767A (da)
NL (1) NL1024261C (da)
NO (1) NO20051670L (da)
NZ (1) NZ538636A (da)
PA (1) PA8581801A1 (da)
PE (1) PE20040989A1 (da)
PL (1) PL375978A1 (da)
PT (1) PT1536783E (da)
PY (1) PY0323128A (da)
RU (1) RU2005110663A (da)
SI (1) SI1536783T1 (da)
TW (1) TW200418836A (da)
UY (1) UY27969A1 (da)
WO (1) WO2004024127A2 (da)
ZA (1) ZA200501897B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA06003661A (es) 2003-10-02 2006-06-05 Pharmacia & Upjohn Co Llc Sales y polimorfos de un compuesto de indolinona sustituido con pirrol.
CA2622870A1 (en) * 2005-09-20 2007-03-29 Pfizer Products Inc. Dosage forms and methods of treatment using a tyrosine kinase inhibitor
CN101007801A (zh) * 2006-01-27 2007-08-01 上海恒瑞医药有限公司 吡咯取代的2-二氢吲哚酮衍生物、其制法与医药上的用途
TWI482772B (zh) * 2006-08-21 2015-05-01 Astrazeneca Ab 適合口服且包含三唑并[4,5-d]嘧啶衍生物之組合物
WO2008024044A1 (en) * 2006-08-21 2008-02-28 Astrazeneca Ab Compositions, suitable for oral administration, comprising a triazolo [4, 5] pyrimidin derivate
US20090004213A1 (en) 2007-03-26 2009-01-01 Immatics Biotechnologies Gmbh Combination therapy using active immunotherapy
EP2220072A2 (en) * 2007-11-21 2010-08-25 Teva Pharmaceutical Industries Ltd. Polymorphs of sunitinib base and processes for preparation thereof
EP2113248A1 (en) 2008-04-29 2009-11-04 Ratiopharm GmbH Pharmaceutical composition comprising N-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2-,4-dimethyl-1H-pyrrole-3-carboxamide
WO2009100929A1 (en) * 2008-02-13 2009-08-20 Ratiopharm Gmbh Pharmaceutical compositions comprising n-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2- dihydro-2-oxo-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide
EP2090306A1 (en) 2008-02-13 2009-08-19 Ratiopharm GmbH Pharmaceutical compositions comprising N-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
EP2138167A1 (en) * 2008-06-24 2009-12-30 ratiopharm GmbH Pharmaceutical composition comprising N-[2-(Diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene) methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
CA2731605A1 (en) 2008-07-24 2010-01-28 Teva Pharmaceutical Industries Ltd. Sunitinib and salts thereof and their polymorphs
CA2704448A1 (en) * 2008-09-30 2010-04-08 Teva Pharmaceutical Industries Ltd. Amorphous compositions of sunitinib base and l-malic acid
WO2012042421A1 (en) 2010-09-29 2012-04-05 Pfizer Inc. Method of treating abnormal cell growth
CN103301116A (zh) * 2012-03-16 2013-09-18 大鹏药品工业株式会社 口服医药组合物
RU2737765C2 (ru) 2012-05-04 2020-12-02 Пфайзер Инк. Простатоассоциированные антигены и иммунотерапевтические схемы на основе вакцин
CN104069076A (zh) * 2013-03-29 2014-10-01 浙江九洲药业股份有限公司 一种无定型的舒尼替尼与pvp的组合物
HUE043042T2 (hu) 2013-11-01 2019-07-29 Pfizer Vektorok prosztatához kapcsolódó antigének expressziójára
WO2015110952A1 (en) 2014-01-21 2015-07-30 Wockhardt Limited Solid oral pharmaceutical compositions comprising ticagrelor or salt thereof
CN104829596B (zh) * 2014-02-10 2017-02-01 石家庄以岭药业股份有限公司 吡咯取代吲哚酮类衍生物、其制备方法、包含该衍生物的组合物、及其用途
EP3539536A1 (en) 2018-03-15 2019-09-18 MH10 Spolka z ograniczona odpowiedzialnoscia A pharmaceutical composition of sunitinib or its salt thereof in its polymorphic form i
SG11202107438WA (en) * 2019-01-09 2021-08-30 Celgene Corp Pharmaceutical compositions comprising (s)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl) benzyl)piperazin-1-yl)-3-fluorobenzonitrile and methods of using the same
WO2022006512A1 (en) * 2020-07-02 2022-01-06 The Board Of Regents Of The University Of Texas System Methods of treatment for melanoma
SI4178548T1 (sl) 2020-07-07 2024-10-30 Celgene Corporation Farmacevtski sestavki, ki obsegajo (S)-4-(4-(4-(((2-(2,6-dioksopiperidin-3-il)-1-oksoizoindolin-4-il)oksi) metil)benzil)piperazin-1-il)-3-fluorobenzonitril, in postopki uporabe le-teh
JP7633786B2 (ja) * 2020-09-18 2025-02-20 日本化薬株式会社 スニチニブリンゴ酸塩を有効成分とする医薬錠剤

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4609675A (en) * 1984-08-17 1986-09-02 The Upjohn Company Stable, high dose, high bulk density ibuprofen granulations for tablet and capsule manufacturing
US6077533A (en) * 1994-05-25 2000-06-20 Purdue Pharma L.P. Powder-layered oral dosage forms
DK1233943T3 (da) * 1999-11-24 2011-08-15 Sugen Inc Ioniserbare indolinon derivater og anvendelse deraf som PTK ligander
DE19956598A1 (de) * 1999-11-25 2001-06-13 Bosch Gmbh Robert Ventil zum Steuern von Flüssigkeiten
AR034118A1 (es) * 2000-02-15 2004-02-04 Sugen Inc Compuestos de 2-indolinonas sustituidas con pirroles inhibidoras de proteinquinasas; sus composiciones farmaceuticas e intermediarios de sintesis
DK3168218T3 (da) * 2001-08-15 2019-01-14 Pharmacia & Upjohn Co Llc Krystal omfattende et l-æblesyresalt af n-[2-(diethylamino)ethyl]-5-[(5-fluor-1,2-dihydro-2-oxo-3h-indol-3-yliden)methyl]-2,4-dimethyl-1h-pyrrol-3-carboxamid til anvendelse som et medikament
TWI259081B (en) † 2001-10-26 2006-08-01 Sugen Inc Treatment of acute myeloid leukemia with indolinone compounds

Also Published As

Publication number Publication date
NZ538636A (en) 2006-04-28
NL1024261A1 (nl) 2004-03-11
NO20051670L (no) 2005-04-04
ES2309363T3 (es) 2008-12-16
CN1688304A (zh) 2005-10-26
DOP2003000708A (es) 2004-03-31
JP2006503032A (ja) 2006-01-26
PL375978A1 (pl) 2005-12-12
GT200300193A (es) 2004-04-29
DE60322720D1 (de) 2008-09-18
MXPA05002690A (es) 2005-05-05
UY27969A1 (es) 2004-04-30
ES2309363T5 (es) 2011-12-07
RU2005110663A (ru) 2005-09-10
PY0323128A (es) 2012-12-03
BR0314182A (pt) 2005-08-09
AU2003280108A1 (en) 2004-04-30
MY136767A (en) 2008-11-28
PE20040989A1 (es) 2004-12-28
NL1024261C (nl) 2010-04-06
EP1536783B1 (en) 2008-08-06
AR041193A1 (es) 2005-05-04
EP1536783A2 (en) 2005-06-08
US20040229930A1 (en) 2004-11-18
CA2498415C (en) 2007-05-29
ATE403425T1 (de) 2008-08-15
CA2498415A1 (en) 2004-03-25
WO2004024127A3 (en) 2004-06-03
KR20050059170A (ko) 2005-06-17
PT1536783E (pt) 2008-10-10
AU2003280108B2 (en) 2007-04-05
SI1536783T1 (sl) 2008-12-31
EP1536783B2 (en) 2011-08-24
WO2004024127A2 (en) 2004-03-25
PA8581801A1 (es) 2005-02-04
TW200418836A (en) 2004-10-01
HN2003000272A (es) 2008-07-29
ZA200501897B (en) 2005-09-07

Similar Documents

Publication Publication Date Title
DE60336314D1 (de) Substituierte indole
DE60225563D1 (de) 4-amino-6-phenyl-pyrroloä2,3-düpyrimidin derivate
DK1545467T3 (da) Faste farmaceutiske formuleringer omfattende telmisartan
DE60318890D1 (de) Mandelsäure derivate
SI1536783T1 (sl) Trdne formulacije, ki vsebujejo indolinonsko spojino
DE602004024770D1 (de) Substituierte 8-perfluoro-6,7,8,9-tetrahydropyrimido-(1,2a) pyrimidin-4-on derivate
DE602004006169D1 (de) Substituierte 8'-pyri(mi)dinyl-dihydrospiro-äcycloalkylaminü-pyrimidoä1,2aüpyrimidin-6-onderivate
DE60305332D1 (de) IMIDAZOi1,2-AöPYRIDINE
IS7793A (is) Nýtt efnasamband
IS7794A (is) Nýtt efnasamband
DE60324703D1 (de) Barbitursäure derivaten.
NO20051500D0 (no) Substituerte heterocyklylpyrimidiner.
ITMI20022602A1 (it) Scatola di derivazione perfezionata, particolarmente
ES1051856Y (es) Burlete perfeccionado.
NO20044405L (no) Neurotensinaktive 2,3-diaryl-pyrazolidin derivater
ES1049838Y (es) Calzado perfeccionado.
ES1050965Y (es) Decantador perfeccionado.
ES1051803Y (es) Andamio perfeccionado.
ES1049590Y (es) Cenicero ambientador perfeccionado.
ES1048757Y (es) Calzado perfeccionado.
ES1051038Y (es) Sofa perfeccionado.
ES1051419Y (es) Zapatilla perfeccionada.
ES1051713Y (es) Sobre-nota perfeccionado.
ES1051515Y (es) Estuche perfeccionado.
ES1051947Y (es) Carpeta-archivador perfeccionada.