DK1556029T3 - Thiomolybdatsalte og anvendelser deraf - Google Patents

Thiomolybdatsalte og anvendelser deraf Download PDF

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DK1556029T3
DK1556029T3 DK03765973.7T DK03765973T DK1556029T3 DK 1556029 T3 DK1556029 T3 DK 1556029T3 DK 03765973 T DK03765973 T DK 03765973T DK 1556029 T3 DK1556029 T3 DK 1556029T3
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Prior art keywords
tetrathiomolybdate
bis
compound
compounds
cancer
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DK03765973.7T
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Inventor
Robert J Ternansky
Andrew Mazar
Patricia L Gladstone
Dimitri Coucouvanis
Amy L Allan
Sean M O'hare
Mellissa L P Price
Steven Robert Pirie-Shepherd
Fernando Donate
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Wilson Therapeutics Ab
Univ Michigan
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Priority claimed from US10/202,346 external-priority patent/US20040019043A1/en
Application filed by Wilson Therapeutics Ab, Univ Michigan filed Critical Wilson Therapeutics Ab
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Publication of DK1556029T3 publication Critical patent/DK1556029T3/da

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
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    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
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    • C07C219/06—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having the hydroxy groups esterified by carboxylic acids having the esterifying carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms of an acyclic saturated carbon skeleton
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Claims (12)

1. Thiomolybdatforbindelse, eller et solvat eller hydrat deraf valgt fra gruppen bestående af propan-l,3-bis (trimethylamnnoniunn)tetrathionnolybdat; bis(l-ethyl-3-methyl-l/7-imidazolium)tetrathionnolybdat; bis(trinnethylphenylannnnoniunn)tetrathiomolybdat; bis(tetrapropylammoniunn)tetrathionnolybdat; bis(cholin)tetrathiomolybdat; bis(triethylphenylannnnonium)tetrathiomolybdat; bis(methyltriethylammonium)tetrathiomolybdat; bis(l,l-dimethylpyrrolidinium)-tetrathiomolybdat; bis(trimethylbenzylammonium)tetrathiomolybdat; pentan-l,5-bis (trimethylammonium)tetrathiomolybdat; bis(vinyltrimethylammonium)tetrathiomolybdat; bis(cyclopropylmethyltrimethylammonium)tetrathiomolybdat; hexan-l,6-bis(trimethyl-ammonium)tetrathiomolybdat; bis(acetylcholin)tetrathiomolybdat; bis(l,4-dimethylpyridinium)tetrathiomolybdat; ethylenbis(trimethylammonium)tetra-thiomolybdat; butan-l,4-bis(trimethylammonium)tetrathiomolybdat.
2. Thiomolybdatforbindelse, eller et solvat eller hydrat deraf, ifølge krav 1, der har øget stabilitet under atmosfæriske betingelser som sammenlignet med bis(ammonium)tetrathiomolybdat, valgt fra gruppen bestående af propan-1, 3-bis (trimethylammonium)tetrathiomolybdat; bis(l-ethyl-3-methyl-lH-imidazolium)tetrathio-molybdat; bis(trimethylphenylammonium)tetrathiomolybdat; bis(tetrapropylammonium)tetrathiomolybdat; bis(cholin)tetrathiomolybdat; bis(triethylphenylammonium)tetrathiomolybdat; bis(methyltriethylammonium)tetrathiomolybdat; bis(l,l-dimethylpyrrolidinium)tetra-thiomolybdat; bis(trimethylbenzylammonium)tetrathiomolybdat; pentan-l,5-bis (trimethylammonium)tetrathiomolybdat; bis(vinyltrimethylammonium)tetrathiomolybdat; bis(cyclopropylmethyltrimethylammonium)tetrathiomolybdat; hexan-l,6-bis (trimethylammonium)tetrathiomolybdat.
3. Tetrathiomolybdatforbindelsen ifølge krav 1 eller 2, til anvendelse som et medikament.
4. Tetrathiomolybdatforbindelsen ifølge krav 1 eller 2, til anvendelse i en fremgangsmåde til behandling af en sygdom eller tilstand valgt fra gruppen bestående af cancer, våd macula degeneration, rheumatoid arthritis, afvigende vaskularisering, forhøjede kobberniveauer, kobbermetabolismeforstyrrelser, og fedme.
5. Tetrathiomolybdatforbindelsen ifølge krav 4, til anvendelse i en fremgangsmåde til behandling af en cancer valgt fra gruppen bestående af brystcancer, nyrecancer, hjernecancer, tarmcancer, prostatacancer, chondrosarcom, angiosarcom, og lungecarcinom.
6. Tetrathiomolybdatforbindelsen ifølge krav 4, til anvendelse i en fremgangsmåde til behandling af en neurodegerativ sygdom valgt fra gruppen bestående af Alzheimer's sygdom, amyotrof lateral sklerose, og prionsygdom.
7. Tetrathiomolybdatforbindelsen ifølge krav 1 eller 2, til anvendelse i en fremgangsmåde til behandling af Wilson's sygdom.
8. Tetrathiomolybdatforbindelsen ifølge krav 1 eller 2, til anvendelse som et medikament i kombination med mindst et andet terapeutisk middel.
9. Tetrathiomolybdatforbindelsen ifølge krav 8, hvor det andet terapeutiske middel er valgt fra kemoterapeutiske midler, antimetabolitter, purinanaloger, naturprodukter, platinkoordineringskomplekser, mitoxantron, hydroxyu ri nstof, procarbazin, hormoner, antagonister, anti-angiogenesemidler, anti-angiogeneseinhibitorer, apoptose-inducerende midler og anti-fedmemidler.
10. Tetrathiomolybdatforbindelsen ifølge et hvilket som helst af kravene 1-9, hvor tetrathiomolybdatforbindelsen er bis(cholin)tetrathiomolybdat.
11. Bis(cholin)tetrathiomolybdat til anvendelse i en fremgangsmåde til behandling af Wilson's sygdom.
12. Thiomolybdatforbindelse valgt fra gruppen bestående af tetrathiomolybdatforbindelser ifølge krav 1 eller 2 til anvendelse i en fremgangsmåde til behandling af det humane eller dyriske legeme, hvor forbindelsen administreres én eller to gange pr. dag ved oral forsinket frigivelses-administration.
DK03765973.7T 2002-07-23 2003-07-22 Thiomolybdatsalte og anvendelser deraf DK1556029T3 (da)

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Application Number Priority Date Filing Date Title
US10/202,346 US20040019043A1 (en) 2002-07-23 2002-07-23 Thiomolybdate analogues and uses thereof
US43474202P 2002-12-18 2002-12-18
US43695803A 2003-05-12 2003-05-12
US10/447,585 US7189865B2 (en) 2002-07-23 2003-05-28 Thiomolybdate analogues and uses thereof
PCT/US2003/023031 WO2004009034A2 (en) 2002-07-23 2003-07-22 Thiomolybdate analogues and uses thereof

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WO2004009034A2 (en) 2004-01-29
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EP1556029A4 (en) 2008-06-25
KR20050053596A (ko) 2005-06-08
US20040019087A1 (en) 2004-01-29
ES2448800T3 (es) 2014-03-17
PT1556029E (pt) 2014-03-04
CN1684678A (zh) 2005-10-19
EP1556029A2 (en) 2005-07-27
JP2006506466A (ja) 2006-02-23
SI1556029T1 (sl) 2014-06-30
MXPA05000870A (es) 2005-08-29
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