DK1572105T3 - Detektion af mikrometastase af melamoner og brystcancer i paraffinindlejret tumor drænende lymfeknuder ved hjælp af kvantitativ multimaker RT-PCR - Google Patents

Detektion af mikrometastase af melamoner og brystcancer i paraffinindlejret tumor drænende lymfeknuder ved hjælp af kvantitativ multimaker RT-PCR

Info

Publication number: DK1572105T3
Authority: DK; Denmark
Prior art keywords: paraffin; detection; quantitative; pcr; multimaker
Prior art date: 2002-11-14

Application number

DK03783510.5T

Other languages

English (en)

Inventor

Dave S B Hoon

Hiroya Takeuchi

Original Assignee

Wayne John Cancer Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-11-14

Filing date

2003-11-14

Publication date

2011-10-17

2003-11-14 Application filed by Wayne John Cancer Inst filed Critical Wayne John Cancer Inst

2011-10-17 Application granted granted Critical

2011-10-17 Publication of DK1572105T3 publication Critical patent/DK1572105T3/da

Links

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206010006187 Breast cancer Diseases 0.000 title 1
208000026310 Breast neoplasm Diseases 0.000 title 1
206010028980 Neoplasm Diseases 0.000 title 1
208000003788 Neoplasm Micrometastasis Diseases 0.000 title 1
210000001165 lymph node Anatomy 0.000 title 1
238000003757 reverse transcription PCR Methods 0.000 title 1
SSOORFWOBGFTHL-OTEJMHTDSA-N (4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-5-carbamimidamido-1-[[(2S)-5-carbamimidamido-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-5-oxopentanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O SSOORFWOBGFTHL-OTEJMHTDSA-N 0.000 abstract 2
206010055113 Breast cancer metastatic Diseases 0.000 abstract 2
206010009944 Colon cancer Diseases 0.000 abstract 2
206010027480 Metastatic malignant melanoma Diseases 0.000 abstract 2
206010061902 Pancreatic neoplasm Diseases 0.000 abstract 2
208000005718 Stomach Neoplasms Diseases 0.000 abstract 2
238000003556 assay Methods 0.000 abstract 2
208000029742 colonic neoplasm Diseases 0.000 abstract 2
206010017758 gastric cancer Diseases 0.000 abstract 2
230000002496 gastric effect Effects 0.000 abstract 2
208000015486 malignant pancreatic neoplasm Diseases 0.000 abstract 2
208000021039 metastatic melanoma Diseases 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
210000000496 pancreas Anatomy 0.000 abstract 2
208000008443 pancreatic carcinoma Diseases 0.000 abstract 2
201000011549 stomach cancer Diseases 0.000 abstract 2
LKKMLIBUAXYLOY-UHFFFAOYSA-N 3-Amino-1-methyl-5H-pyrido[4,3-b]indole Chemical compound N1C2=CC=CC=C2C2=C1C=C(N)N=C2C LKKMLIBUAXYLOY-UHFFFAOYSA-N 0.000 abstract 1
206010061819 Disease recurrence Diseases 0.000 abstract 1
-1 GalNAcT Proteins 0.000 abstract 1
108010045100 HSP27 Heat-Shock Proteins Proteins 0.000 abstract 1
102100039165 Heat shock protein beta-1 Human genes 0.000 abstract 1
101000994460 Homo sapiens Keratin, type I cytoskeletal 20 Proteins 0.000 abstract 1
101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 abstract 1
101000613490 Homo sapiens Paired box protein Pax-3 Proteins 0.000 abstract 1
102100032700 Keratin, type I cytoskeletal 20 Human genes 0.000 abstract 1
102100031413 L-dopachrome tautomerase Human genes 0.000 abstract 1
101710093778 L-dopachrome tautomerase Proteins 0.000 abstract 1
102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 abstract 1
102100040891 Paired box protein Pax-3 Human genes 0.000 abstract 1
238000011529 RT qPCR Methods 0.000 abstract 1
101710173694 Short transient receptor potential channel 2 Proteins 0.000 abstract 1
102100030511 Stanniocalcin-1 Human genes 0.000 abstract 1
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102000003425 Tyrosinase Human genes 0.000 abstract 1
108060008724 Tyrosinase Proteins 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
101150087532 mitF gene Proteins 0.000 abstract 1
230000004083 survival effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Immunology (AREA)
Wood Science & Technology (AREA)
Pathology (AREA)
Genetics & Genomics (AREA)
Analytical Chemistry (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Physics & Mathematics (AREA)
Oncology (AREA)
Hospice & Palliative Care (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

DK03783510.5T 2002-11-14 2003-11-14 Detektion af mikrometastase af melamoner og brystcancer i paraffinindlejret tumor drænende lymfeknuder ved hjælp af kvantitativ multimaker RT-PCR DK1572105T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US42621602P	2002-11-14	2002-11-14
PCT/US2003/036493 WO2004045521A2 (en)	2002-11-14	2003-11-14	Detection of micro metastasis of melanoma and breast cancer in paraffin-embedded tumor draining lymph nodes by multimaker quantitative rt-pcr

Publications (1)

Publication Number	Publication Date
DK1572105T3 true DK1572105T3 (da)	2011-10-17

Family

ID=32326322

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK03783510.5T DK1572105T3 (da)	2002-11-14	2003-11-14	Detektion af mikrometastase af melamoner og brystcancer i paraffinindlejret tumor drænende lymfeknuder ved hjælp af kvantitativ multimaker RT-PCR

Country Status (6)

Country	Link
US (3)	US7910295B2 (da)
EP (2)	EP1572105B1 (da)
AT (1)	ATE522620T1 (da)
AU (1)	AU2003290925A1 (da)
DK (1)	DK1572105T3 (da)
WO (1)	WO2004045521A2 (da)

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US8039218B2 (en)	2002-11-14	2011-10-18	John Wayne Cancer Institute	Detection of cancer cells in body fluids
EP1572105B1 (en)	2002-11-14	2011-08-31	John Wayne Cancer Institute	Detection of micro metastasis of melanoma and breast cancer in paraffin-embedded tumor draining lymph nodes by multimaker quantitative rt-pcr
CA2571642A1 (en) *	2004-07-09	2006-02-16	University Of Pittsburgh - Of The Commonwealth System Of Higher Educatio N	Identification of markers in lung and breast cancer
WO2006031843A2 (en) *	2004-09-14	2006-03-23	John Wayne Cancer Institute	Detection of cancer cells in body fluids
US8289381B2 (en) *	2005-01-05	2012-10-16	Avantis Medical Systems, Inc.	Endoscope with an imaging catheter assembly and method of configuring an endoscope
US8797392B2 (en) *	2005-01-05	2014-08-05	Avantis Medical Sytems, Inc.	Endoscope assembly with a polarizing filter
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US20060149129A1 (en) *	2005-01-05	2006-07-06	Watts H D	Catheter with multiple visual elements
US8235887B2 (en)	2006-01-23	2012-08-07	Avantis Medical Systems, Inc.	Endoscope assembly with retroscope
GB2424886A (en) *	2005-04-04	2006-10-11	Dxs Ltd	Polynucleotide primers against epidermal growth factor receptor and method of detecting gene mutations
US20070207467A1 (en) *	2006-03-01	2007-09-06	Ming Xu	Detection of lymph node metastasis from gastric carcinoma
JP2009537283A (ja) *	2006-05-19	2009-10-29	アヴァンティスメディカルシステムズインコーポレイテッド	ビデオアーチファクトの影響を低減するための装置および方法
US20070281305A1 (en) *	2006-06-05	2007-12-06	Sean Wuxiong Cao	Detection of lymph node metastasis from gastric carcinoma
GB0612342D0 (en) *	2006-06-21	2006-08-02	Glaxosmithkline Biolog Sa	Method
JP4943074B2 (ja) *	2006-07-03	2012-05-30	シスメックス株式会社	がん転移の判定方法及び装置
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US8064666B2 (en)	2007-04-10	2011-11-22	Avantis Medical Systems, Inc.	Method and device for examining or imaging an interior surface of a cavity
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US20110054236A1 (en) *	2009-08-25	2011-03-03	The Regents Of The University Of Michigan	Compositions and methods for targeting tumors
RU2016144405A (ru) *	2014-05-23	2018-06-26	Дженентек, Инк.	MiT БИОМАРКЕРЫ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
RU2566732C1 (ru) *	2014-07-08	2015-10-27	Федеральное государственное бюджетное учреждение "Научно-исследовательский институт онкологии" Сибирского отделения Российской академии медицинских наук (ФГБУ "НИИ онкологии" СО РАМН)	Способ прогнозирования лимфогенного метастазирования при инвазивной карциноме неспецифического типа молочной железы
WO2019152788A1 (en) *	2018-02-02	2019-08-08	Morgan And Mendel Genomics, Inc.	Robust genomic predictor of breast and lung cancer metastasis
US20210164056A1 (en) *	2018-07-25	2021-06-03	The University Of Chicago	Use of metastases-specific signatures for treatment of cancer
KR102448589B1 (ko) *	2020-10-08	2022-09-27	가톨릭대학교 산학협력단	췌장암의 전이를 예측하기 위한 바이오마커 및 이의 용도

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AU662906B2 (en) *	1991-06-26	1995-09-21	F. Hoffmann-La Roche Ag	Methods for detection of carcinoma metastases by nucleic acid amplification
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EP1572105B1 (en)	2002-11-14	2011-08-31	John Wayne Cancer Institute	Detection of micro metastasis of melanoma and breast cancer in paraffin-embedded tumor draining lymph nodes by multimaker quantitative rt-pcr

2003
- 2003-11-14 EP EP03783510A patent/EP1572105B1/en not_active Expired - Lifetime
- 2003-11-14 US US10/713,808 patent/US7910295B2/en not_active Expired - Fee Related
- 2003-11-14 WO PCT/US2003/036493 patent/WO2004045521A2/en not_active Ceased
- 2003-11-14 AU AU2003290925A patent/AU2003290925A1/en not_active Abandoned
- 2003-11-14 EP EP10012718A patent/EP2363500A1/en not_active Withdrawn
- 2003-11-14 DK DK03783510.5T patent/DK1572105T3/da active
- 2003-11-14 AT AT03783510T patent/ATE522620T1/de not_active IP Right Cessation
2011
- 2011-01-12 US US13/005,127 patent/US20110207136A1/en not_active Abandoned
2012
- 2012-12-11 US US13/710,970 patent/US20130231259A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1572105B1 (en)	2011-08-31
EP1572105A4 (en)	2008-03-12
EP1572105A2 (en)	2005-09-14
EP2363500A1 (en)	2011-09-07
US7910295B2 (en)	2011-03-22
ATE522620T1 (de)	2011-09-15
US20110207136A1 (en)	2011-08-25
AU2003290925A8 (en)	2004-06-15
AU2003290925A1 (en)	2004-06-15
US20040265845A1 (en)	2004-12-30
WO2004045521A3 (en)	2007-05-10
US20130231259A1 (en)	2013-09-05
WO2004045521A2 (en)	2004-06-03

Publication	Publication Date	Title
DK1572105T3 (da)	2011-10-17	Detektion af mikrometastase af melamoner og brystcancer i paraffinindlejret tumor drænende lymfeknuder ved hjælp af kvantitativ multimaker RT-PCR
DK1761651T3 (da)	2010-05-17	MNRA-forhold i urinsedimenter og/eller urin som en prognostisk og/eller teranostisk markør for prostatakræft
Dai et al.	2017	Does tumor size have its prognostic role in colorectal cancer? Re-evaluating its value in colorectal adenocarcinoma with different macroscopic growth pattern
Patel et al.	2010	Expression of the tumor suppressor Krüppel-like factor 4 as a prognostic predictor for colon cancer
Chiang et al.	2008	Overexpression of galectin-1 at the tumor invasion front is associated with poor prognosis in early-stage oral squamous cell carcinoma
EP1599603A4 (en)	2007-08-22	DIAGNOSIS AND PROGNOSIS OF PANCREATIC CANCER
WO2007095644A3 (en)	2007-12-27	Reagents and methods for cancer prognosis and pathological staging
Jo et al.	2012	CpG island methylator phenotype infers a poor disease-free survival in locally advanced rectal cancer
DK1587957T3 (da)	2010-09-27	Genekspressionsmarkør til prognose af brystkræft
DE69833572D1 (de)	2006-05-04	Verfahren zur bestimmung des metastasierungspotentials unter verwendung des asp1 gens
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CR9100A (es)	2007-08-28	Metodos y sistemas para el pronostico y tratamiento de tumores solidos
WO2009019370A3 (fr)	2009-04-09	Procede de dosage de l'apolipoproteine aii pour le diagnostic in vitro du cancer colorectal
Safi et al.	2017	The importance of lymph node ratio for locoregional recurrence of squamous cell carcinoma of the tongue
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Marijon et al.	2011	Epithelial-to-mesenchymal transition and acquired resistance to sunitinib in a patient with hepatocellular carcinoma
Zheng et al.	2010	The role of Reg IV gene and its encoding product in gastric carcinogenesis
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ATE545867T1 (de)	2012-03-15	I-plastin-testverfahren zur in-vitro-diagnose von kolorektalkarzinom
Christoph et al.	2007	Urinary cytokeratin 20 mRNA expression has the potential to predict recurrence in superficial transitional cell carcinoma of the bladder
Rawson et al.	2020	From Breslow to BRAF and immunotherapy: evolving concepts in melanoma pathogenesis and disease progression and their implications for changing management over the last 50 years