DK1589807T3 - Transgene ananasplanter med modificerede carotenoidniveauer og fremgangsmåder til deres fremstilling - Google Patents

Transgene ananasplanter med modificerede carotenoidniveauer og fremgangsmåder til deres fremstilling

Info

Publication number
DK1589807T3
DK1589807T3 DK03790354.9T DK03790354T DK1589807T3 DK 1589807 T3 DK1589807 T3 DK 1589807T3 DK 03790354 T DK03790354 T DK 03790354T DK 1589807 T3 DK1589807 T3 DK 1589807T3
Authority
DK
Denmark
Prior art keywords
methods
preparation
carotenoid levels
pineapple plants
modified carotenoid
Prior art date
Application number
DK03790354.9T
Other languages
English (en)
Inventor
Thomas R Young
Ebrahim Firoozabady
Original Assignee
Del Monte Fresh Produce Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Del Monte Fresh Produce Company filed Critical Del Monte Fresh Produce Company
Application granted granted Critical
Publication of DK1589807T3 publication Critical patent/DK1589807T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/825—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving pigment biosynthesis
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H4/00—Plant reproduction by tissue culture techniques ; Tissue culture techniques therefor
    • A01H4/008—Methods for regeneration to complete plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8202—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by biological means, e.g. cell mediated or natural vector
    • C12N15/8205—Agrobacterium mediated transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Botany (AREA)
  • Environmental Sciences (AREA)
  • Nutrition Science (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Fruits And Vegetables (AREA)
DK03790354.9T 2002-12-06 2003-12-05 Transgene ananasplanter med modificerede carotenoidniveauer og fremgangsmåder til deres fremstilling DK1589807T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43132302P 2002-12-06 2002-12-06
PCT/US2003/038664 WO2004052085A1 (en) 2002-12-06 2003-12-05 Transgenic pineapple plants with modified carotenoid levels and methods of their production

Publications (1)

Publication Number Publication Date
DK1589807T3 true DK1589807T3 (da) 2012-02-13

Family

ID=32507709

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03790354.9T DK1589807T3 (da) 2002-12-06 2003-12-05 Transgene ananasplanter med modificerede carotenoidniveauer og fremgangsmåder til deres fremstilling

Country Status (11)

Country Link
US (1) US8049067B2 (da)
EP (2) EP1589807B1 (da)
JP (1) JP2006508681A (da)
KR (2) KR20110066979A (da)
AT (1) ATE531805T1 (da)
AU (2) AU2003293407B2 (da)
DK (1) DK1589807T3 (da)
ES (1) ES2376868T3 (da)
IL (2) IL168840A (da)
PT (1) PT1589807E (da)
WO (2) WO2004052085A1 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7663021B2 (en) 2002-12-06 2010-02-16 Del Monte Fresh Produce Company Transgenic pineapple plants with modified carotenoid levels and methods of their production
KR20110066979A (ko) * 2002-12-06 2011-06-17 델몬트 후레쉬 프로듀스 컴퍼니 변형된 카로테노이드 수준을 갖는 형질전환 파인애플 식물 및 그 생산 방법
AU2005321630A1 (en) 2004-07-02 2006-07-06 Metanomics Gmbh Process for the production of fine chemicals
EP1974049A2 (en) * 2004-12-17 2008-10-01 Metanomics GmbH Process for the control of production of fine chemicals
EP2444496A1 (en) 2005-04-15 2012-04-25 Del Monte Fresh Produce Company Plant promoters, terminators, genes, vectors and related transformed plants
EP2390337B1 (en) 2006-08-31 2017-10-11 Monsanto Technology LLC Plant transformation without selection
CN101407807B (zh) * 2008-11-19 2013-11-06 暨南大学 对染色体进行处理而改变细胞遗传特性的方法及其应用
CN101979584B (zh) * 2010-07-15 2012-05-30 华中农业大学 β-胡萝卜素羟化酶基因DSM2在控制水稻抗旱性中的应用
ITRM20110491A1 (it) * 2011-09-19 2013-03-20 Aep Advanced Ecopower Patents Sa Pianta oleaginosa transgenica.
WO2013112997A1 (en) * 2012-01-27 2013-08-01 The Texas A&M University System Pathogen resistant citrus compositions, organisms, systems, and methods
USPP25763P3 (en) 2012-06-04 2015-08-04 Del Monte Fresh Produce Pineapple plant named ‘Rosé’
KR101979878B1 (ko) * 2015-11-18 2019-05-17 씨제이브리딩 주식회사 신품종 배추 식물
CN109006488A (zh) * 2018-10-15 2018-12-18 四川农业大学 一种基于以芽繁芽的红苞凤梨培育方法
CN110129291B (zh) * 2019-04-16 2021-06-08 扬州大学 大麦耐湿调控基因HvACO1、蛋白及其在育种中的应用
CN110463607A (zh) * 2019-09-09 2019-11-19 新疆农业大学 野生欧洲李叶片组织培养的方法

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4945050A (en) * 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
EP0229174A1 (en) 1985-07-16 1987-07-22 The Salk Institute For Biological Studies Genetic alteration of plants with retroviruses
JPS62291904A (ja) 1986-06-12 1987-12-18 Namiki Precision Jewel Co Ltd 永久磁石の製造方法
JPH02503263A (ja) 1986-10-01 1990-10-11 ザ　プラント　セル　リサーチ　インスティチュート，インコーポレイテッド ククミス種植物のインビトロでの遺伝的形質転換および制御再生
NZ230375A (en) 1988-09-09 1991-07-26 Lubrizol Genetics Inc Synthetic gene encoding b. thuringiensis insecticidal protein
DK0413019T3 (da) 1989-02-24 2001-11-12 Monsanto Technology Llc Syntetiske plantegener og fremgangsmåde til fremstilling af disse
US5034323A (en) 1989-03-30 1991-07-23 Dna Plant Technology Corporation Genetic engineering of novel plant phenotypes
JP2950888B2 (ja) * 1989-04-21 1999-09-20 麒麟麦酒株式会社 カロチノイドの合成に有用なｄｎａ鎖
US5429939A (en) * 1989-04-21 1995-07-04 Kirin Beer Kabushiki Kaisha DNA sequences useful for the synthesis of carotenoids
GB8928179D0 (en) * 1989-12-13 1990-02-14 Ici Plc Dna,constructs,cells and plants derived therefrom
US5530188A (en) * 1990-03-02 1996-06-25 Amoco Corporation Beta-carotene biosynthesis in genetically engineered hosts
US5684238A (en) * 1990-03-02 1997-11-04 Amoco Corporation Biosynthesis of zeaxanthin and glycosylated zeaxanthin in genetically engineered hosts
US5618988A (en) * 1990-03-02 1997-04-08 Amoco Corporation Enhanced carotenoid accumulation in storage organs of genetically engineered plants
CA2055447C (en) * 1990-03-02 2006-12-19 Rodney Lee Ausich Biosynthesis of carotenoids in genetically engineered hosts
US5530189A (en) * 1990-03-02 1996-06-25 Amoco Corporation Lycopene biosynthesis in genetically engineered hosts
EP0528819A1 (en) 1990-04-18 1993-03-03 Plant Genetic Systems, N.V. Modified bacillus thuringiensis insecticidal-crystal protein genes and their expression in plant cells
US5262316A (en) * 1991-11-22 1993-11-16 Dna Plant Technology Corporation Genetically transformed pepper plants and methods for their production
DE69334225D1 (de) * 1992-07-07 2008-07-31 Japan Tobacco Inc Verfahren zur transformation einer monokotyledon pflanze
FR2709496B1 (fr) * 1993-08-30 1995-11-03 Limagrain Holding Groupe Procédé de production de plantes transgéniques, entièrement transformées en génération T0, à partir de méristèmes.
DK0672752T3 (da) 1993-09-03 2004-10-04 Japan Tobacco Inc Fremgangsmåde til transformering af monocotyledoner ved anvendelse af scutella af uudviklede embryoner
US5426039A (en) 1993-09-08 1995-06-20 Bio-Rad Laboratories, Inc. Direct molecular cloning of primer extended DNA containing an alkane diol
US5792903A (en) * 1993-10-25 1998-08-11 Yissum Research Development Company Of Hebrew University Of Jerusalem Lycopene cyclase gene
US5545817A (en) 1994-03-11 1996-08-13 Calgene, Inc. Enhanced expression in a plant plastid
WO1996036717A2 (en) * 1995-05-17 1996-11-21 Centre National De La Recherche Scientifique Dna sequences encoding a lycopene cyclase, antisense sequences derived therefrom and their use for the modification of carotenoids levels in plants
US6087563A (en) * 1996-01-29 2000-07-11 Arizona Board Of Regents On Behalf Of The University Of Arizona Cloned arabidopsis p-hydroxyphenyl pyruvic acid dioxygenase DNA
US6642021B2 (en) * 1996-03-29 2003-11-04 University Of Maryland Methods of producing carotenoids by the expression of plant ε-cyclase genes
US5744341A (en) * 1996-03-29 1998-04-28 University Of Maryland College Park Genes of carotenoid biosynthesis and metabolism and a system for screening for such genes
AUPN958296A0 (en) * 1996-05-01 1996-05-23 Golden Circle Limited Novel acc synthase genes from pineapple
GB9611981D0 (en) * 1996-06-07 1996-08-07 Zeneca Ltd Enhancement of gene expression
US5955269A (en) * 1996-06-20 1999-09-21 Rutgers, The State University Of New Jersey Methods of screening foods for nutraceuticals
US6429356B1 (en) * 1996-08-09 2002-08-06 Calgene Llc Methods for producing carotenoid compounds, and specialty oils in plant seeds
AU4058497A (en) * 1996-08-09 1998-03-06 Calgene Llc Methods for producing carotenoid compounds and speciality oils in plant seeds
US6242257B1 (en) * 1996-10-29 2001-06-05 Council Of Scientific & Industrial Research Tissue culture process for producing a large number of viable cotton plants in vitro
US5908771A (en) * 1997-01-31 1999-06-01 R. J. Reynolds Tobacco Company Method for regeneration of salvia species
BR9805900B1 (pt) * 1997-02-20 2009-05-05 processo para integrar um fragmento de dna no genoma de uma célula de uma planta manocotiledÈnea.
US5952543A (en) * 1997-02-25 1999-09-14 Dna Plant Technology Corporation Genetically transformed pineapple plants and methods for their production
US6140555A (en) * 1997-06-06 2000-10-31 Mississippi State University Methods for maize transformation coupled with adventitious regeneration utilizing nodal section explants and mature zygotic embryos
US6133035A (en) * 1997-07-16 2000-10-17 Dna Plant Technology Corporation Method of genetically transforming banana plants
EP1017268A1 (en) * 1997-09-24 2000-07-12 The Regents Of The University Of California Methods and compositions for transformation of cereals using cultured shoot meristematic tissue
US5948956A (en) * 1997-10-16 1999-09-07 Oms Investments, Inc. Transgenic plants and method for node segment transformation
JP3032841B2 (ja) * 1997-12-02 2000-04-17 農林水産省果樹試験場長 β−カロテンハイドロキシラーゼ遺伝子
US6653530B1 (en) * 1998-02-13 2003-11-25 Calgene Llc Methods for producing carotenoid compounds, tocopherol compounds, and specialty oils in plant seeds
AU3902799A (en) * 1998-05-14 1999-11-29 University Of Hawaii Compositions and methods for genetic transformation of pineapple
US6037522A (en) * 1998-06-23 2000-03-14 Rhone-Poulenc Agro Agrobacterium-mediated transformation of monocots
US6252141B1 (en) * 1998-08-14 2001-06-26 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Tomato gene B polynucleotides coding for lycopene cyclase
ID29949A (id) * 1998-09-15 2001-10-25 Genesis Res & Dev Corp Ltd Metoda untuk memproduksi tanaman-tanaman yang dimodifikasi secara genetik, bahan-bahan tanaman dan produk-produk yang diproduksi dengan cara itu
US6043072A (en) * 1998-11-05 2000-03-28 Washington State University Research Foundation Nucleic acids encoding Taxus geranylgeranyl diphosphate synthase, and methods of use
US6835540B2 (en) * 2001-03-16 2004-12-28 Mendel Biotechnology, Inc. Biosynthetic pathway transcription factors
JP2003525589A (ja) * 1999-04-07 2003-09-02 メンデル・バイオテクノロジー・インコーポレーテッド 遺伝的形質育種法
USPP12861P2 (en) * 1999-07-15 2002-08-20 Cirad Pineapple plant named ‘RL 41’
AU6780700A (en) 1999-08-18 2001-03-13 Paradigm Genetics, Inc. Methods and apparatus for transformation of monocotyledenous plants using agrobacterium in combination with vacuum filtration
AUPQ388399A0 (en) * 1999-11-05 1999-12-02 State Of Queensland Through Its Department Of Primary Industries, The A method of transformation
CA2390597A1 (en) * 1999-11-17 2001-05-25 Mendel Biotechnology, Inc. Pathogen tolerance genes
DE10015458A1 (de) 2000-03-29 2001-10-11 Inst Pflanzengenetik & Kultur Verfahren zur raschen Herstellung von transgenen, markergen-freien Pflanzen
IT1317038B1 (it) * 2000-06-05 2003-05-26 Vitroplant Vivai Di Zuccherell Metodo per la rigenerazione di piante e suoi usi per lamoltiplicazione e/o la trasformazione di piante.
EP2281890A1 (en) * 2000-07-31 2011-02-09 Danisco US Inc. Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
WO2002014523A2 (en) * 2000-08-11 2002-02-21 Syngenta Participations Ag Methods for stable transformation of plants
AUPR143100A0 (en) 2000-11-10 2000-12-07 Bureau Of Sugar Experiment Stations Plant transformation
BR0116797A (pt) 2000-12-22 2005-01-18 Monsanto Technology Llc Processo de transformação de plantas com seleção e identificação inicial de eventos na linhagem germinativa
DE10102338A1 (de) 2001-01-19 2002-07-25 Basf Plant Science Gmbh Verfahren zur Expression von Biosynthesegenen in pflanzlichen Samen unter Verwendung von neuen multiplen Expressionskonstrukten
KR20110066979A (ko) * 2002-12-06 2011-06-17 델몬트 후레쉬 프로듀스 컴퍼니 변형된 카로테노이드 수준을 갖는 형질전환 파인애플 식물 및 그 생산 방법

Also Published As

Publication number Publication date
WO2004052085A1 (en) 2004-06-24
IL168840A (en) 2010-12-30
EP1571899A4 (en) 2006-08-30
WO2004053082A3 (en) 2004-10-14
IL168921A (en) 2013-07-31
AU2003293407A1 (en) 2004-06-30
AU2003302775B2 (en) 2010-05-27
EP1571899A2 (en) 2005-09-14
US8049067B2 (en) 2011-11-01
JP2006508681A (ja) 2006-03-16
EP1589807B1 (en) 2011-11-02
KR101209345B1 (ko) 2012-12-07
AU2003302775A1 (en) 2004-06-30
AU2003293407B2 (en) 2010-03-04
PT1589807E (pt) 2012-02-02
ES2376868T3 (es) 2012-03-20
KR20050084157A (ko) 2005-08-26
EP1589807A1 (en) 2005-11-02
ATE531805T1 (de) 2011-11-15
WO2004053082A2 (en) 2004-06-24
US20060130171A1 (en) 2006-06-15
EP1589807A4 (en) 2007-09-12
KR20110066979A (ko) 2011-06-17

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