DK159987D0 - Fremgangsmaade til fremstilling af forskolin ud fra9-deoxy-forskolin samt ved fremgangsmaaden anvendelige mellemprodukter - Google Patents

Fremgangsmaade til fremstilling af forskolin ud fra9-deoxy-forskolin samt ved fremgangsmaaden anvendelige mellemprodukter

Info

Publication number: DK159987D0
Authority: DK; Denmark
Prior art keywords: beta; alpha; epoxy; school; tetrahydroxylabd
Prior art date: 1986-03-31

Application number

DK159987A

Other languages

English (en)

Other versions

DK159987A (da

Inventor

Nicholas J Hrib

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-03-31

Filing date

1987-03-30

Publication date

1987-03-30

1987-03-30 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1987-03-30 Publication of DK159987D0 publication Critical patent/DK159987D0/da

1987-10-01 Publication of DK159987A publication Critical patent/DK159987A/da

Links

239000000543 intermediate Substances 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
SPEUIVXLLWOEMJ-UHFFFAOYSA-N 1,1-dimethoxyethane Chemical compound COC(C)OC SPEUIVXLLWOEMJ-UHFFFAOYSA-N 0.000 abstract 3
SUZLHDUTVMZSEV-WESICCPUSA-N (3R,4aR,5S,6S,6aS,10S,10aS,10bS)-3-ethenyl-6,10-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1H-benzo[f]chromen-5-yl acetate Chemical compound O=C([C@@H]12)C[C@](C)(C=C)O[C@]1(C)[C@@H](OC(=O)C)[C@@H](O)[C@@H]1[C@]2(C)[C@@H](O)CCC1(C)C SUZLHDUTVMZSEV-WESICCPUSA-N 0.000 abstract 2
SUZLHDUTVMZSEV-UHFFFAOYSA-N Deoxycoleonol Natural products C12C(=O)CC(C)(C=C)OC2(C)C(OC(=O)C)C(O)C2C1(C)C(O)CCC2(C)C SUZLHDUTVMZSEV-UHFFFAOYSA-N 0.000 abstract 2
OHCQJHSOBUTRHG-KGGHGJDLSA-N FORSKOLIN Chemical compound O=C([C@@]12O)C[C@](C)(C=C)O[C@]1(C)[C@@H](OC(=O)C)[C@@H](O)[C@@H]1[C@]2(C)[C@@H](O)CCC1(C)C OHCQJHSOBUTRHG-KGGHGJDLSA-N 0.000 abstract 2
150000002084 enol ethers Chemical class 0.000 abstract 2
230000002378 acidificating effect Effects 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
OHCQJHSOBUTRHG-UHFFFAOYSA-N colforsin Natural products OC12C(=O)CC(C)(C=C)OC1(C)C(OC(=O)C)C(O)C1C2(C)C(O)CCC1(C)C OHCQJHSOBUTRHG-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
WPDITXOBNLYZHH-UHFFFAOYSA-N desacetylforskolin Natural products O1C(C)(C=C)CC(=O)C2(O)C3(C)C(O)CCC(C)(C)C3C(O)C(O)C21C WPDITXOBNLYZHH-UHFFFAOYSA-N 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
150000004965 peroxy acids Chemical class 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/06—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical being a hydroxyalkyl group esterified by a fatty acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Crystallography & Structural Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Auxiliary Devices For And Details Of Packaging Control (AREA)
Shaping Of Tube Ends By Bending Or Straightening (AREA)
Excavating Of Shafts Or Tunnels (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Toys (AREA)
Steroid Compounds (AREA)

DK159987A 1986-03-31 1987-03-30 Fremgangsmaade til fremstilling af forskolin ud fra9-deoxy-forskolin samt ved fremgangsmaaden anvendelige mellemprodukter DK159987A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/846,550 US4734513A (en)	1986-03-31	1986-03-31	Method of synthesizing forskolin from 9-deoxyforskolin

Publications (2)

Publication Number	Publication Date
DK159987D0 true DK159987D0 (da)	1987-03-30
DK159987A DK159987A (da)	1987-10-01

Family

ID=25298260

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK159987A DK159987A (da)	1986-03-31	1987-03-30	Fremgangsmaade til fremstilling af forskolin ud fra9-deoxy-forskolin samt ved fremgangsmaaden anvendelige mellemprodukter

Country Status (13)

Country	Link
US (1)	US4734513A (da)
EP (1)	EP0243646B1 (da)
JP (1)	JPS62249981A (da)
KR (1)	KR900007626B1 (da)
AT (1)	ATE45353T1 (da)
AU (1)	AU585143B2 (da)
DE (1)	DE3760422D1 (da)
DK (1)	DK159987A (da)
ES (1)	ES2010511B3 (da)
GR (1)	GR3000203T3 (da)
IL (1)	IL82047A (da)
PT (1)	PT84584B (da)
ZA (1)	ZA872266B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5008407A (en) *	1986-03-31	1991-04-16	Hoechst-Roussel Pharmaceuticals Inc.	Method of synthesizing forskolin from 9-deoxyforskolin
US5023344A (en) *	1986-11-20	1991-06-11	Hoechst-Roussel Pharmaceuticals Incorporated	12-halogenated forskolin derivatives
US5070209A (en) *	1986-11-20	1991-12-03	Hoechst Roussel Pharmaceuticals Inc.	12-halogenated forskolin derivatives
US4978678A (en) *	1986-11-20	1990-12-18	Hoechst-Roussel Pharmaceuticals Inc.	12-halogenated forskolin derivatives
US4999351A (en) *	1989-01-11	1991-03-12	Hoechst-Roussel Pharmaceuticals, Inc.	7-aryl and heteroaryl ethers of desacetylforskolin
JP3557095B2 (ja) *	1998-04-20	2004-08-25	高砂香料工業株式会社	メラニン産生抑制剤

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2654796A1 (de) *	1976-12-03	1978-06-08	Hoechst Ag	Polyoxygenierte labdan-derivate
US4517200A (en) *	1982-12-27	1985-05-14	Schering-Plough Corporation	Method for treating allergic reactions with forskolin
US4564626A (en) *	1983-04-01	1986-01-14	Schering Corporation	Methods of inducing bronchodilation
DE3407514A1 (de) *	1984-03-01	1985-09-26	Hoechst Ag, 6230 Frankfurt	Verwendung von polyoxygenierten labdanderivaten zur behandlung von konstriktionen der atemwege
EP0191166B1 (en) *	1984-12-14	1991-02-06	Hoechst-Roussel Pharmaceuticals Incorporated	Aminoacyllabdanes, a process and intermediates for their preparation and their use as medicaments
US4639443A (en) *	1985-03-01	1987-01-27	Hoechst-Roussel Pharmaceuticals Inc.	Labdane compounds, pharmaceutical compositions and use

1986
- 1986-03-31 US US06/846,550 patent/US4734513A/en not_active Expired - Lifetime
1987
- 1987-03-18 ES ES87103939T patent/ES2010511B3/es not_active Expired
- 1987-03-18 AT AT87103939T patent/ATE45353T1/de not_active IP Right Cessation
- 1987-03-18 EP EP87103939A patent/EP0243646B1/en not_active Expired
- 1987-03-18 DE DE8787103939T patent/DE3760422D1/de not_active Expired
- 1987-03-27 ZA ZA872266A patent/ZA872266B/xx unknown
- 1987-03-30 KR KR1019870002930A patent/KR900007626B1/ko not_active Expired
- 1987-03-30 IL IL82047A patent/IL82047A/xx unknown
- 1987-03-30 AU AU70765/87A patent/AU585143B2/en not_active Ceased
- 1987-03-30 DK DK159987A patent/DK159987A/da not_active IP Right Cessation
- 1987-03-30 PT PT84584A patent/PT84584B/pt not_active IP Right Cessation
- 1987-03-30 JP JP62074581A patent/JPS62249981A/ja active Pending
1989
- 1989-11-01 GR GR89400227T patent/GR3000203T3/el unknown

Also Published As

Publication number	Publication date
US4734513A (en)	1988-03-29
DK159987A (da)	1987-10-01
EP0243646A1 (en)	1987-11-04
IL82047A0 (en)	1987-10-20
PT84584B (pt)	1989-11-30
EP0243646B1 (en)	1989-08-09
ATE45353T1 (de)	1989-08-15
ES2010511B3 (es)	1989-11-16
AU7076587A (en)	1987-10-08
IL82047A (en)	1992-02-16
GR3000203T3 (en)	1990-12-31
ZA872266B (en)	1987-11-25
DE3760422D1 (en)	1989-09-14
AU585143B2 (en)	1989-06-08
JPS62249981A (ja)	1987-10-30
KR870008908A (ko)	1987-10-21
PT84584A (en)	1987-04-01
KR900007626B1 (ko)	1990-10-17

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Legal Events

Date	Code	Title	Description
1993-02-22	ATS	Application withdrawn
1999-09-13	PBP	Patent lapsed