DK161338C - Fremgangsmaade til fremstilling af 2-hydroxyaclacinomycin a, b og n eller syreadditionssalte deraf samt en rekombinant mikroorganisme til anvendelse derved - Google Patents

Fremgangsmaade til fremstilling af 2-hydroxyaclacinomycin a, b og n eller syreadditionssalte deraf samt en rekombinant mikroorganisme til anvendelse derved

Info

Publication number
DK161338C
DK161338C DK358882A DK358882A DK161338C DK 161338 C DK161338 C DK 161338C DK 358882 A DK358882 A DK 358882A DK 358882 A DK358882 A DK 358882A DK 161338 C DK161338 C DK 161338C
Authority
DK
Denmark
Prior art keywords
hydroxyaclacinomycine
procedure
preparation
acid addition
addition salts
Prior art date
Application number
DK358882A
Other languages
English (en)
Other versions
DK358882A (da
DK161338B (da
Inventor
Akihiro Yoshimoto
Hiroyasu Tobe
Tomoyuki Ishikura
Tomio Takeuchi
Hamao Umezawa
Original Assignee
Mercian Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP12582681A external-priority patent/JPS5826895A/ja
Priority claimed from JP10725682A external-priority patent/JPS58224698A/ja
Application filed by Mercian Corp filed Critical Mercian Corp
Publication of DK358882A publication Critical patent/DK358882A/da
Publication of DK161338B publication Critical patent/DK161338B/da
Application granted granted Critical
Publication of DK161338C publication Critical patent/DK161338C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK358882A 1981-08-11 1982-08-10 Fremgangsmaade til fremstilling af 2-hydroxyaclacinomycin a, b og n eller syreadditionssalte deraf samt en rekombinant mikroorganisme til anvendelse derved DK161338C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP12582681A JPS5826895A (ja) 1981-08-11 1981-08-11 ２‐ヒドロキシアクラシノマイシンｂ
JP12582681 1981-08-11
JP10725682 1982-06-21
JP10725682A JPS58224698A (ja) 1982-06-21 1982-06-21 ２−ヒドロキシアクラシノマイシンａ及びｎの製造法

Publications (3)

Publication Number Publication Date
DK358882A DK358882A (da) 1983-02-12
DK161338B DK161338B (da) 1991-06-24
DK161338C true DK161338C (da) 1992-01-06

Family

ID=26447294

Family Applications (1)

Application Number Title Priority Date Filing Date
DK358882A DK161338C (da) 1981-08-11 1982-08-10 Fremgangsmaade til fremstilling af 2-hydroxyaclacinomycin a, b og n eller syreadditionssalte deraf samt en rekombinant mikroorganisme til anvendelse derved

Country Status (6)

Country Link
US (1) US4474945A (da)
EP (1) EP0072974B1 (da)
CA (1) CA1187434A (da)
DE (1) DE3266843D1 (da)
DK (1) DK161338C (da)
ES (1) ES514892A0 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5982395A (ja) * 1982-11-02 1984-05-12 Microbial Chem Res Found アントラサイクリン化合物、その製造法およびその用途
JPS59148795A (ja) * 1983-02-08 1984-08-25 Microbial Chem Res Found アントラサイクリン化合物、その製造法およびその用途
IE58981B1 (en) * 1985-10-15 1993-12-15 Vestar Inc Anthracycline antineoplastic agents encapsulated in phospholipid micellular particles
US4977084A (en) * 1989-02-16 1990-12-11 Board Of Trustees Operating Michigan State University Production, isolation, and identification of novel antifungal compounds
CN108864221B (zh) * 2018-06-08 2022-04-01 中国科学院上海有机化学研究所 阿克拉霉素类似物及其制法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4204038A (en) * 1976-04-07 1980-05-20 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Process for preparing antibiotics MA 144-M1 and MA 144-M2
JPS52136159A (en) * 1976-04-07 1977-11-14 Microbial Chem Res Found Anti/malignanttumor containing the same as active ingredients
US4309503A (en) * 1978-02-09 1982-01-05 Farmitalia Carlo Erba S.P.A. Preparation of 11-deoxy anthracycline antibiotics
ZA802929B (en) * 1979-05-22 1981-05-27 Hoffmann La Roche Novel tetracyclic compounds and process for the preparation thereof
DE3071391D1 (en) * 1979-09-07 1986-03-13 Sanraku Ocean Co 2-hydroxyaclacinomycin a, pharmaceutical composition containing it; 2-hydroxyaclavinone and fermentative process for preparing same
JPS5731696A (en) * 1980-08-01 1982-02-20 Sanraku Inc Anthracycline derivative
JPS5756494A (en) * 1980-09-22 1982-04-05 Microbial Chem Res Found New anthracyclin derivative
DE3168154D1 (en) * 1980-10-27 1985-02-21 Hoffmann La Roche Process for anthracycline glycosides
ATE8264T1 (de) * 1980-10-27 1984-07-15 F. Hoffmann-La Roche & Co. Aktiengesellschaft Verfahren zur herstellung von aclacinomycinen und verwendete mikroorganismen.

Also Published As

Publication number Publication date
ES8400489A1 (es) 1983-10-16
DK358882A (da) 1983-02-12
CA1187434A (en) 1985-05-21
DE3266843D1 (en) 1985-11-14
ES514892A0 (es) 1983-10-16
EP0072974B1 (en) 1985-10-09
DK161338B (da) 1991-06-24
US4474945A (en) 1984-10-02
EP0072974A1 (en) 1983-03-02

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