DK1619185T3 - 4,4-difluor-1,2,3,4-tetrahydro-5H-1-benzazepinderivat eller salt deraf - Google Patents
4,4-difluor-1,2,3,4-tetrahydro-5H-1-benzazepinderivat eller salt derafInfo
- Publication number
- DK1619185T3 DK1619185T3 DK04729502.7T DK04729502T DK1619185T3 DK 1619185 T3 DK1619185 T3 DK 1619185T3 DK 04729502 T DK04729502 T DK 04729502T DK 1619185 T3 DK1619185 T3 DK 1619185T3
- Authority
- DK
- Denmark
- Prior art keywords
- difluoro
- tetrahydro
- salt
- benzazepine derivative
- benzazepine
- Prior art date
Links
- DTSDJGNXLLPHFA-UHFFFAOYSA-N 4,4-difluoro-1,2,3,5-tetrahydro-1-benzazepine Chemical class C1C(F)(F)CCNC2=CC=CC=C21 DTSDJGNXLLPHFA-UHFFFAOYSA-N 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 102100026383 Vasopressin-neurophysin 2-copeptin Human genes 0.000 abstract 1
- 201000010064 diabetes insipidus Diseases 0.000 abstract 1
- 206010029446 nocturia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003123032 | 2003-04-28 | ||
| JP2003401126 | 2003-12-01 | ||
| PCT/JP2004/005998 WO2004096775A1 (ja) | 2003-04-28 | 2004-04-26 | ４，４－ジフルオロ－１，２，３，４－テトラヒドロ－５ｈ－１－ベンゾアゼピン誘導体又はその塩 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1619185T3 true DK1619185T3 (da) | 2011-07-18 |
Family
ID=33422056
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04729502.7T DK1619185T3 (da) | 2003-04-28 | 2004-04-26 | 4,4-difluor-1,2,3,4-tetrahydro-5H-1-benzazepinderivat eller salt deraf |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7183271B2 (da) |
| EP (1) | EP1619185B1 (da) |
| KR (1) | KR100882154B1 (da) |
| AT (1) | ATE512951T1 (da) |
| AU (1) | AU2004234258B2 (da) |
| BR (1) | BRPI0409718A (da) |
| CA (1) | CA2521492C (da) |
| DK (1) | DK1619185T3 (da) |
| IL (1) | IL171332A (da) |
| MX (1) | MXPA05011521A (da) |
| NO (1) | NO333505B1 (da) |
| NZ (1) | NZ542815A (da) |
| PL (1) | PL1619185T3 (da) |
| PT (1) | PT1619185E (da) |
| RU (1) | RU2326868C2 (da) |
| SI (1) | SI1619185T1 (da) |
| WO (1) | WO2004096775A1 (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0210397D0 (en) * | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
| SI1619185T1 (sl) | 2003-04-28 | 2011-09-30 | Astellas Pharma Inc | 4,4-difluoro-1,2,3,4-tetrahidro-5H-1-benzazepinski derivat ali njegova sol |
| JP4754566B2 (ja) | 2005-07-22 | 2011-08-24 | 持田製薬株式会社 | 新規なヘテロシクリデンアセトアミド誘導体 |
| WO2009021007A1 (en) | 2007-08-06 | 2009-02-12 | Serenity Pharmaceuticals Corporation | Methods and devices for desmopressin drug delivery |
| NO3085381T3 (da) * | 2008-05-21 | 2018-09-15 | ||
| US11963995B2 (en) | 2008-05-21 | 2024-04-23 | Ferring B.V. | Methods comprising desmopressin |
| US20100286045A1 (en) | 2008-05-21 | 2010-11-11 | Bjarke Mirner Klein | Methods comprising desmopressin |
| WO2013187406A1 (ja) * | 2012-06-11 | 2013-12-19 | アステラス製薬株式会社 | 4,4,7-トリフルオロ-1,2,3,4-テトラヒドロ-5h-1-ベンゾアゼピン化合物の製造方法及びその合成中間体 |
| US10906888B2 (en) | 2016-07-14 | 2021-02-02 | Pfizer Inc. | Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL182011B1 (en) | 1993-08-26 | 2001-10-31 | Yamanouchi Pharma Co Ltd | Benzazepine derivative, pharmaceutic composition and intermediate compounds |
| JPH11349570A (ja) | 1994-06-15 | 1999-12-21 | Otsuka Pharmaceut Co Ltd | ベンゾヘテロ環誘導体 |
| JP3215910B2 (ja) | 1994-06-15 | 2001-10-09 | 大塚製薬株式会社 | ベンゾヘテロ環誘導体 |
| ATE360617T1 (de) | 1994-06-15 | 2007-05-15 | Otsuka Pharma Co Ltd | Benzoheterocyclische verbindungen verwendbar als vasopressin- oder oxytocin-modulatoren |
| TW359669B (en) | 1995-12-15 | 1999-06-01 | Otsuka Pharma Co Ltd | Benzazepine derivatives |
| JPH09221476A (ja) | 1995-12-15 | 1997-08-26 | Otsuka Pharmaceut Co Ltd | 医薬組成物 |
| JPH09221475A (ja) | 1996-02-13 | 1997-08-26 | Yamanouchi Pharmaceut Co Ltd | 新規なオキシム誘導体 |
| AR011913A1 (es) | 1997-03-06 | 2000-09-13 | Yamano Masaki | Derivados de 4,4-difluoro-2,3,4,5-tetrahidro-1h-1-benzoazepina y composiciones farmaceuticas de los mismos. |
| JP2926335B2 (ja) | 1997-06-13 | 1999-07-28 | 大塚製薬株式会社 | 医薬組成物 |
| IL133788A0 (en) | 1997-07-30 | 2001-04-30 | American Home Prod | Tricyclic vasopressin agonists |
| ES2229523T3 (es) | 1997-07-30 | 2005-04-16 | Wyeth | Agonistas triciclicos de la vasopresina. |
| US6547395B1 (en) | 1998-02-06 | 2003-04-15 | Wavefront Sciences, Inc. | Methods of measuring moving objects and reducing exposure during wavefront measurements |
| PT1149096E (pt) | 1999-02-04 | 2003-03-31 | Wyeth Corp | N-oxidos de piridina triciclicos agonistas de vasopressina |
| GB0000079D0 (en) | 2000-01-05 | 2000-02-23 | Ferring Bv | Novel antidiuretic agents |
| KR100632882B1 (ko) | 2001-11-16 | 2006-10-13 | 아스텔라스세이야쿠 가부시키가이샤 | 4, 4-디플루오로-1, 2, 3,4-테트라하이드로-5ｈ-1-벤즈아제핀 유도체 또는 그 염 |
| SI1619185T1 (sl) | 2003-04-28 | 2011-09-30 | Astellas Pharma Inc | 4,4-difluoro-1,2,3,4-tetrahidro-5H-1-benzazepinski derivat ali njegova sol |
-
2004
- 2004-04-26 SI SI200431724T patent/SI1619185T1/sl unknown
- 2004-04-26 EP EP04729502A patent/EP1619185B1/en not_active Expired - Lifetime
- 2004-04-26 AU AU2004234258A patent/AU2004234258B2/en not_active Ceased
- 2004-04-26 WO PCT/JP2004/005998 patent/WO2004096775A1/ja not_active Ceased
- 2004-04-26 PT PT04729502T patent/PT1619185E/pt unknown
- 2004-04-26 CA CA2521492A patent/CA2521492C/en not_active Expired - Fee Related
- 2004-04-26 BR BRPI0409718-1A patent/BRPI0409718A/pt not_active IP Right Cessation
- 2004-04-26 KR KR1020057020359A patent/KR100882154B1/ko not_active Expired - Fee Related
- 2004-04-26 MX MXPA05011521A patent/MXPA05011521A/es active IP Right Grant
- 2004-04-26 AT AT04729502T patent/ATE512951T1/de active
- 2004-04-26 DK DK04729502.7T patent/DK1619185T3/da active
- 2004-04-26 PL PL04729502T patent/PL1619185T3/pl unknown
- 2004-04-26 NZ NZ542815A patent/NZ542815A/en not_active IP Right Cessation
- 2004-04-26 US US10/554,150 patent/US7183271B2/en not_active Expired - Lifetime
- 2004-04-26 RU RU2005136863/04A patent/RU2326868C2/ru not_active IP Right Cessation
-
2005
- 2005-10-10 IL IL171332A patent/IL171332A/en active IP Right Grant
- 2005-11-25 NO NO20055602A patent/NO333505B1/no not_active IP Right Cessation
-
2006
- 2006-11-14 US US11/598,732 patent/US7807664B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2521492C (en) | 2010-09-21 |
| MXPA05011521A (es) | 2006-01-23 |
| RU2326868C2 (ru) | 2008-06-20 |
| NO20055602D0 (no) | 2005-11-25 |
| NZ542815A (en) | 2009-01-31 |
| AU2004234258A1 (en) | 2004-11-11 |
| PT1619185E (pt) | 2011-08-25 |
| WO2004096775A1 (ja) | 2004-11-11 |
| BRPI0409718A (pt) | 2006-05-02 |
| ATE512951T1 (de) | 2011-07-15 |
| US20070167429A1 (en) | 2007-07-19 |
| SI1619185T1 (sl) | 2011-09-30 |
| NO333505B1 (no) | 2013-06-24 |
| IL171332A (en) | 2011-03-31 |
| US7807664B2 (en) | 2010-10-05 |
| RU2005136863A (ru) | 2006-04-20 |
| NO20055602L (no) | 2006-01-24 |
| PL1619185T3 (pl) | 2011-12-30 |
| EP1619185B1 (en) | 2011-06-15 |
| KR20060007402A (ko) | 2006-01-24 |
| CA2521492A1 (en) | 2004-11-11 |
| KR100882154B1 (ko) | 2009-02-06 |
| US7183271B2 (en) | 2007-02-27 |
| AU2004234258B2 (en) | 2009-04-09 |
| EP1619185A4 (en) | 2008-07-23 |
| EP1619185A1 (en) | 2006-01-25 |
| US20060122170A1 (en) | 2006-06-08 |
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