DK163583C - Fremgangsmaade til fremstilling af 2-brom-8-ergolinylforbindelser - Google Patents

Fremgangsmaade til fremstilling af 2-brom-8-ergolinylforbindelser

Info

Publication number: DK163583C
Authority: DK; Denmark
Prior art keywords: bromo; preparing; procedure; see diagramm; ergolinyl
Prior art date: 1983-11-03

Application number

DK515184A

Other languages

Danish (da)

English (en)

Other versions

DK163583B (da

DK515184A (da

DK515184D0 (da

Inventor

Helmut Boerner

Gregor Haffer

Gerhard Sauer

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-11-03

Filing date

1984-10-29

Publication date

1992-08-24

1984-10-29 Application filed by Schering Ag filed Critical Schering Ag

1984-10-29 Publication of DK515184D0 publication Critical patent/DK515184D0/da

1985-05-04 Publication of DK515184A publication Critical patent/DK515184A/da

1992-03-16 Publication of DK163583B publication Critical patent/DK163583B/da

1992-08-24 Application granted granted Critical

1992-08-24 Publication of DK163583C publication Critical patent/DK163583C/da

Links

238000000034 method Methods 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 title 1
CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 3
239000002253 acid Substances 0.000 abstract 3
238000007792 addition Methods 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
-1 2-bromo-8-ergolinyl compounds Chemical class 0.000 abstract 2
230000031709 bromination Effects 0.000 abstract 2
238000005893 bromination reaction Methods 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
150000008282 halocarbons Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910000042 hydrogen bromide Inorganic materials 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
- C07D457/12—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/02—Ergot alkaloids of the cyclic peptide type

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK515184A 1983-11-03 1984-10-29 Fremgangsmaade til fremstilling af 2-brom-8-ergolinylforbindelser DK163583C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3340025A DE3340025C2 (de)	1983-11-03	1983-11-03	Verfahren zur Herstellung von 2-Brom-8-ergolinyl-Verbindungen
DE3340025		1983-11-03

Publications (4)

Publication Number	Publication Date
DK515184D0 DK515184D0 (da)	1984-10-29
DK515184A DK515184A (da)	1985-05-04
DK163583B DK163583B (da)	1992-03-16
DK163583C true DK163583C (da)	1992-08-24

Family

ID=6213531

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK515184A DK163583C (da)	1983-11-03	1984-10-29	Fremgangsmaade til fremstilling af 2-brom-8-ergolinylforbindelser

Country Status (10)

Country	Link
US (1)	US4970314A (cs)
EP (1)	EP0141387B1 (cs)
JP (1)	JPS60115580A (cs)
AT (1)	ATE42103T1 (cs)
CA (1)	CA1253489A (cs)
CS (1)	CS247089B2 (cs)
DE (2)	DE3340025C2 (cs)
DK (1)	DK163583C (cs)
HU (1)	HU198714B (cs)
IE (1)	IE57909B1 (cs)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3101535A1 (de) *	1981-01-14	1982-08-12	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Neue (2-halogen-ergolinyl)-n'.n'-diethyl-harnstoffderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
DE3303616A1 (de) *	1982-02-12	1983-08-25	Sandoz-Patent-GmbH, 7850 Lörrach	Mutterkornalkaloide, verfahren zu deren herstellung sowie diese verbindungen enthaltende pharmazeutische zubereitungen
DD238051A1 (de) *	1985-06-10	1986-08-06	Dresden Arzneimittel	Verfahren zur herstellung neuer lysergsaeureamide
HU193317B (en) *	1985-06-12	1987-09-28	Richter Gedeon Vegyeszet	Process for producing 2-bromo-alpha-ergochristin
US5441961A (en) *	1992-08-27	1995-08-15	Eli Lilly And Company	Substituted cyclo or bicycloalkylamides of (8β)-6-(substituted) ergolines
CA2895829A1 (en) *	2012-12-21	2014-06-26	Map Pharmaceuticals, Inc.	Novel methysergide derivatives
BR112017015510A2 (pt)	2015-01-20	2018-01-30	Xoc Pharmaceuticals Inc	composto de fórmula estrutural (i), método de tratamento e/ou prevenção, método de agonização do receptor d2 em um indivíduo, método de antagonização do receptor d3 em um indivíduo, método de agonização do receptor 5-ht1d em um indivíduo, método de agonização do receptor 5-ht1a em um indivíduo, método de agonização seletiva do receptor 5-ht1d em vez do receptor 5-ht1b em um indivíduo, método de agonização seletiva do re-ceptor 5-ht2c em vez do receptor 5-ht2a ou 5-ht2b em um indivíduo, método de agonização do receptor 5-ht2c em um indivíduo, método de fornecimento de atividade antagonista funcional no receptor 5-ht2b ou receptor 5-ht7, e, método de fornecimento de atividade antagonista funcional nos receptores adrenérgicos em um indivíduo
CN113149982A (zh)	2015-01-20	2021-07-23	Xoc制药股份有限公司	麦角灵化合物及其用途
JP2020522504A (ja)	2017-06-01	2020-07-30	エックスオーシーファーマシューティカルズインコーポレイテッドＸｏｃＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ	多環式化合物およびそれらの用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH507249A (de) *	1968-05-31	1971-05-15	Sandoz Ag	Verfahren zur Herstellung von 2-Brom-a-ergokryptin
GB1413068A (en) *	1972-06-22	1975-11-05	Farmaceutici Italia	Bromoergolines
YU216177A (en) *	1977-09-09	1984-02-29	Rudolf Rucman	Process for preparing 2-bromo ergosine
US4166182A (en) *	1978-02-08	1979-08-28	Eli Lilly And Company	6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
YU40046B (en) *	1978-09-04	1985-06-30	Lek Tovarna Farmacevtskih	Process for preparing 2-bromo-9,10-dihydroergosine
HU180929B (en) *	1979-08-13	1983-05-30	Richter Gedeon Vegyeszet	Process for producing new bromo-vincamone derivatives
US4609731A (en) *	1979-10-10	1986-09-02	Sandoz Ltd.	Process for brominating ergot alkaloids
US4352909A (en) *	1980-08-20	1982-10-05	Ferro Corporation	Process for the bromination of polystyrenes

1983
- 1983-11-03 DE DE3340025A patent/DE3340025C2/de not_active Expired
1984
- 1984-10-25 IE IE2743/84A patent/IE57909B1/en not_active IP Right Cessation
- 1984-10-26 AT AT84112913T patent/ATE42103T1/de not_active IP Right Cessation
- 1984-10-26 EP EP84112913A patent/EP0141387B1/de not_active Expired
- 1984-10-26 DE DE8484112913T patent/DE3477666D1/de not_active Expired
- 1984-10-29 DK DK515184A patent/DK163583C/da active
- 1984-11-01 CA CA000466871A patent/CA1253489A/en not_active Expired
- 1984-11-01 CS CS848310A patent/CS247089B2/cs unknown
- 1984-11-01 JP JP59229050A patent/JPS60115580A/ja active Granted
- 1984-11-02 HU HU844078A patent/HU198714B/hu not_active IP Right Cessation
- 1984-11-05 US US06/668,344 patent/US4970314A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA1253489A (en)	1989-05-02
US4970314A (en)	1990-11-13
IE57909B1 (en)	1993-05-05
DE3340025C2 (de)	1986-01-09
JPS60115580A (ja)	1985-06-22
DK163583B (da)	1992-03-16
JPH0556349B2 (cs)	1993-08-19
CS247089B2 (en)	1986-11-13
IE842743L (en)	1985-05-03
DE3477666D1 (en)	1989-05-18
EP0141387B1 (de)	1989-04-12
ATE42103T1 (de)	1989-04-15
EP0141387A1 (de)	1985-05-15
HUT35672A (en)	1985-07-29
DE3340025A1 (de)	1985-05-23
DK515184A (da)	1985-05-04
HU198714B (en)	1989-11-28
DK515184D0 (da)	1984-10-29

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