DK163996C - 1h-indol-3-yl-holdige 1,3-dimethyl-1h-purin-2,6-dioner, fremgangsmaade til fremstilling af forbindelserne samt farmaceutiske praeparater med indhold deraf - Google Patents

1h-indol-3-yl-holdige 1,3-dimethyl-1h-purin-2,6-dioner, fremgangsmaade til fremstilling af forbindelserne samt farmaceutiske praeparater med indhold deraf

Info

Publication number: DK163996C
Authority: DK; Denmark
Prior art keywords: compounds; indol; dimethyl; preparing; purin
Prior art date: 1984-10-01

Application number

DK444085A

Other languages

Danish (da)

English (en)

Other versions

DK163996B (da

DK444085D0 (da

DK444085A (da

Inventor

Ludo Edmond Josephine Kennis

Jan Vandenberk

Jozef Martin Boey

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-10-01

Filing date

1985-09-30

Publication date

1992-09-21

1985-09-30 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1985-09-30 Publication of DK444085D0 publication Critical patent/DK444085D0/da

1986-04-02 Publication of DK444085A publication Critical patent/DK444085A/da

1992-04-27 Publication of DK163996B publication Critical patent/DK163996B/da

1992-09-21 Application granted granted Critical

1992-09-21 Publication of DK163996C publication Critical patent/DK163996C/da

Links

150000001875 compounds Chemical class 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 2
ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 title abstract 2
239000000825 pharmaceutical preparation Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
230000002539 anti-aggressive effect Effects 0.000 abstract 1
230000002180 anti-stress Effects 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
230000000949 anxiolytic effect Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000000814 indol-3-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C([*])C2=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000001624 sedative effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)

DK444085A 1984-10-01 1985-09-30 1h-indol-3-yl-holdige 1,3-dimethyl-1h-purin-2,6-dioner, fremgangsmaade til fremstilling af forbindelserne samt farmaceutiske praeparater med indhold deraf DK163996C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US65656184		1984-10-01
US06/656,561 US4548939A (en)	1984-10-01	1984-10-01	1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones

Publications (4)

Publication Number	Publication Date
DK444085D0 DK444085D0 (da)	1985-09-30
DK444085A DK444085A (da)	1986-04-02
DK163996B DK163996B (da)	1992-04-27
DK163996C true DK163996C (da)	1992-09-21

Family

ID=24633577

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK444085A DK163996C (da)	1984-10-01	1985-09-30	1h-indol-3-yl-holdige 1,3-dimethyl-1h-purin-2,6-dioner, fremgangsmaade til fremstilling af forbindelserne samt farmaceutiske praeparater med indhold deraf

Country Status (17)

Country	Link
US (1)	US4548939A (de)
EP (1)	EP0177087B1 (de)
JP (1)	JPH0653742B2 (de)
CN (1)	CN1011311B (de)
AT (1)	ATE60604T1 (de)
AU (1)	AU576386B2 (de)
CA (1)	CA1262348A (de)
DE (1)	DE3581577D1 (de)
DK (1)	DK163996C (de)
ES (1)	ES8609324A1 (de)
FI (1)	FI83220C (de)
GR (1)	GR852375B (de)
IE (1)	IE58747B1 (de)
NO (1)	NO162069C (de)
NZ (1)	NZ213498A (de)
PT (1)	PT81229B (de)
ZA (1)	ZA857553B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH648559A5 (de) *	1981-07-20	1985-03-29	Siegfried Ag	Theophyllinderivate und verfahren zu deren herstellung.
US4742057A (en) *	1985-12-05	1988-05-03	Fujisawa Pharmaceutical Co., Ltd.	Antiallergic thiazole compounds
GB8719167D0 (en) *	1987-08-13	1987-09-23	Glaxo Group Ltd	Chemical compounds
DK172696B1 (da) *	1987-08-13	1999-05-31	Glaxo Group Ltd	Indolderivater, fremgangsmåde til fremstilling deraf og farmaceutiske præparater indeholdende forbindelserne
DK733788A (da) *	1988-01-14	1989-07-15	Fujisawa Pharmaceutical Co	Indolylpiperidinderivater og fremgangsmaade til fremstilling deraf
GB8819024D0 (en) *	1988-08-10	1988-09-14	Glaxo Group Ltd	Chemical compounds
DE8817122U1 (de) *	1988-12-22	1993-02-04	Boehringer Ingelheim Kg, 55218 Ingelheim	Neue Xanthinderivate mit Adenosinantogenistischer Wirkung
DK292A (da) *	1991-11-29	1992-01-02	Tanisake Kk	Middel
DE4414113A1 (de) *	1994-04-22	1995-10-26	Merck Patent Gmbh	3-Indolylpiperidine
CN101801362B (zh) *	2007-06-22	2014-01-22	海德拉生物科学公司	用于治疗病症的方法和组合物
US8318728B2 (en)	2008-05-14	2012-11-27	Hydra Biosciences, Inc.	Compounds and compositions for treating chemical warfare agent-induced injuries
WO2009140517A1 (en)	2008-05-14	2009-11-19	Hydra Biosciences, Inc.	Compounds and compositions for treating chemical warfare agent-induced injuries

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2322470A1 (de) *	1973-05-04	1974-11-21	Boehringer Sohn Ingelheim	Neue indolyl-piperidino-(bzw. 1,2,5,6tetrahydro-pyridyl-)butyrophenone und verfahren zu ihrer herstellung
FR2334358A1 (fr) *	1975-12-12	1977-07-08	Sogeras	Nouveaux medicaments derives de l'indole
FR2362628A1 (fr) *	1976-08-26	1978-03-24	Roussel Uclaf	Nouveaux derives du piperidyl-indole et leurs sels, procede de preparation et application a titre de medicaments
EP0011399A1 (de) *	1978-11-11	1980-05-28	FISONS plc	N-Substituierte Theophylline, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
DE2922159A1 (de) *	1979-05-31	1980-12-04	Boehringer Mannheim Gmbh	Neue xanthin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4342870A (en) *	1980-03-28	1982-08-03	Janssen Pharmaceutica N.V.	Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives
US4426383A (en) *	1980-09-04	1984-01-17	Eisai Co., Ltd.	Theophylline and theobromine derivatives
US4359468A (en) *	1981-02-25	1982-11-16	Boehringer Ingelheim Ltd.	Antiallergic N-[4-(indolyl)-piperidino-alkyl]-benzimidazolones
US4443451A (en) *	1981-07-15	1984-04-17	Janssen Pharmaceutica N.V.	Bicyclic pyrimidin-5-one derivatives
CH648559A5 (de) *	1981-07-20	1985-03-29	Siegfried Ag	Theophyllinderivate und verfahren zu deren herstellung.

1984
- 1984-10-01 US US06/656,561 patent/US4548939A/en not_active Expired - Fee Related
1985
- 1985-07-30 CN CN85105804A patent/CN1011311B/zh not_active Expired
- 1985-09-10 CA CA000490317A patent/CA1262348A/en not_active Expired
- 1985-09-16 NZ NZ213498A patent/NZ213498A/en unknown
- 1985-09-18 DE DE8585201484T patent/DE3581577D1/de not_active Expired - Fee Related
- 1985-09-18 AT AT85201484T patent/ATE60604T1/de not_active IP Right Cessation
- 1985-09-18 EP EP85201484A patent/EP0177087B1/de not_active Expired - Lifetime
- 1985-09-27 JP JP60212731A patent/JPH0653742B2/ja not_active Expired - Lifetime
- 1985-09-30 AU AU48124/85A patent/AU576386B2/en not_active Ceased
- 1985-09-30 FI FI853763A patent/FI83220C/fi not_active IP Right Cessation
- 1985-09-30 ES ES547447A patent/ES8609324A1/es not_active Expired
- 1985-09-30 IE IE240385A patent/IE58747B1/en not_active IP Right Cessation
- 1985-09-30 DK DK444085A patent/DK163996C/da not_active IP Right Cessation
- 1985-09-30 GR GR852375A patent/GR852375B/el unknown
- 1985-09-30 ZA ZA857553A patent/ZA857553B/xx unknown
- 1985-09-30 NO NO853856A patent/NO162069C/no unknown
- 1985-10-01 PT PT81229A patent/PT81229B/pt not_active IP Right Cessation

Also Published As

Publication number	Publication date
IE852403L (en)	1986-04-01
DK163996B (da)	1992-04-27
DK444085D0 (da)	1985-09-30
GR852375B (de)	1986-01-31
NO853856L (no)	1986-04-02
ES8609324A1 (es)	1986-07-16
EP0177087A2 (de)	1986-04-09
EP0177087B1 (de)	1991-01-30
US4548939A (en)	1985-10-22
ES547447A0 (es)	1986-07-16
PT81229A (en)	1985-11-01
CN1011311B (zh)	1991-01-23
JPS6187681A (ja)	1986-05-06
IE58747B1 (en)	1993-11-03
AU4812485A (en)	1986-04-10
ZA857553B (en)	1987-05-27
FI853763L (fi)	1986-04-02
ATE60604T1 (de)	1991-02-15
CA1262348A (en)	1989-10-17
AU576386B2 (en)	1988-08-25
DE3581577D1 (de)	1991-03-07
NO162069C (no)	1989-11-01
JPH0653742B2 (ja)	1994-07-20
FI83220C (fi)	1991-06-10
NZ213498A (en)	1988-04-29
EP0177087A3 (en)	1986-06-11
DK444085A (da)	1986-04-02
FI83220B (fi)	1991-02-28
CN85105804A (zh)	1986-10-22
PT81229B (pt)	1987-11-30
NO162069B (no)	1989-07-24
FI853763A0 (fi)	1985-09-30

Legal Events

Date	Code	Title	Description
1995-05-22	PBP	Patent lapsed

Publication	Publication Date	Title
ES8706668A1 (es)	1987-06-16	Un procedimiento para la preparacion de derivados de piperidina.
HUT71130A (en)	1995-11-28	Condensed indole derivatives of protein kinase c inhibitor activity, process for preparing them and pharmaceutical compositions containing them
ES8603870A1 (es)	1986-01-01	Un procedimiento para la preparacion de derivados de 2,2'-iminobisetanol.
FI872864A0 (fi)	1987-06-29	Menetelmä farmaseuttisesti aktiivisten bentsimidatsolijohdannaisten valmistamiseksi
DE69130412D1 (de)	1998-12-03	Pyrazolopyridinverbindung und Verfahren zu ihrer Herstellung
PH21554A (en)	1987-12-11	N-(4-piperidinyl)bicyclic condensed-2-imidazolamine derivatives
MY121908A (en)	2006-03-31	3-amidopyrazole derivatives, process for preparing these and pharmaceutical compositions containing them.
PH25504A (en)	1991-07-24	Novel substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides pharmaceutical composition containing said compound, method of use thereof
DE3581577D1 (de)	1991-03-07	1h-indol-3-yl enthaltende 1,3-dimethyl-1-h-purine-2,6-dione.
EP0184258A3 (en)	1987-05-13	Novel derivatives of hydroxy- or amino-substituted (piperidinylalkyl)quinazolines
GB8401093D0 (en)	1984-02-15	Cephem compounds
HUT53664A (en)	1990-11-28	Process for producing enzyme inhibiting amino acid derivatives and pharmaceutical compositions comprising such compounds as active ingredient
GR852395B (de)	1985-12-03
EP0194579A3 (en)	1987-09-30	3-pyridylmethylnaphthyl derivatives, process for their preparation and their use as medicaments
SE8303719L (sv)	1983-12-31	Eburnan-oximderivat, forfarande for framstellning derav samt farmaceutiska kompositioner innehallande dessa foreningar
YU199985A (en)	1987-12-31	Process for preparation of n-substituted derivatives of azyridine -2-carboxylic acids
HUT43065A (en)	1987-09-28	Process for preparing 1-/acyl-amino-methyl/-imidazo/1,2-a/-quinoline derivatives and pharmaceutical compositions containing such compounds
DK34882A (da)	1982-07-30	Fremgangsmaade til fremstilling af peptidderivater
EP0321967A3 (en)	1990-10-24	Compounds active on the cardiovascular system