DK164392C - Anvendelse af 3'-azido-3'-desoxythymidin til fremstilling af et laegemiddel til behandling af eller profylakse for en human retrovirusinfektion - Google Patents

Anvendelse af 3'-azido-3'-desoxythymidin til fremstilling af et laegemiddel til behandling af eller profylakse for en human retrovirusinfektion

Info

Publication number
DK164392C
DK164392C DK118086A DK118086A DK164392C DK 164392 C DK164392 C DK 164392C DK 118086 A DK118086 A DK 118086A DK 118086 A DK118086 A DK 118086A DK 164392 C DK164392 C DK 164392C
Authority
DK
Denmark
Prior art keywords
desoxythymidine
prophylaxy
azido
medicine
prepare
Prior art date
Application number
DK118086A
Other languages
English (en)
Other versions
DK118086D0 (da
DK164392B (da
DK118086A (da
Inventor
Janet Litster Rideout
David Walter Barry
Sandra Nusinoff Lehrman
Clair Martha Heider St
Phillip Allen Furman
George Andrew Freeman
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27516579&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK164392(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB858506869A external-priority patent/GB8506869D0/en
Priority claimed from GB858511774A external-priority patent/GB8511774D0/en
Priority claimed from US06/776,899 external-priority patent/US4724232A/en
Priority claimed from GB858523881A external-priority patent/GB8523881D0/en
Priority claimed from GB868603450A external-priority patent/GB8603450D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of DK118086D0 publication Critical patent/DK118086D0/da
Publication of DK118086A publication Critical patent/DK118086A/da
Priority to DK199102027A priority Critical patent/DK175192B1/da
Priority to DK199102026A priority patent/DK175122B1/da
Publication of DK164392B publication Critical patent/DK164392B/da
Publication of DK164392C publication Critical patent/DK164392C/da
Application granted granted Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DK118086A 1985-03-16 1986-03-14 Anvendelse af 3'-azido-3'-desoxythymidin til fremstilling af et laegemiddel til behandling af eller profylakse for en human retrovirusinfektion DK164392C (da)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DK199102026A DK175122B1 (da) 1985-03-16 1991-12-18 Farmaceutisk præparat omfattende et farmaceutisk acceptabelt derivat af 3'azido-3'-desoxythymidin samt fremgangsmåde til fremstilling deraf
DK199102027A DK175192B1 (da) 1985-03-16 1991-12-18 Farmaceutisk præparat med indhold af 3'-azido-3'-desoxythymidin som aktiv ingrediens samt 3'-azido-3'-desoxythymidin til anvendelse mod en human retrovirusinfektion

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
GB858506869A GB8506869D0 (en) 1985-03-16 1985-03-16 Antiviral compound
GB8506869 1985-03-16
GB8511774 1985-05-09
GB858511774A GB8511774D0 (en) 1985-05-09 1985-05-09 Antiviral compounds
US77689985 1985-09-17
US06/776,899 US4724232A (en) 1985-03-16 1985-09-17 Treatment of human viral infections
GB858523881A GB8523881D0 (en) 1985-09-27 1985-09-27 Antiviral compounds
GB8523881 1985-09-27
GB868603450A GB8603450D0 (en) 1986-02-12 1986-02-12 Antiviral compounds
GB8603450 1986-02-12

Publications (4)

Publication Number Publication Date
DK118086D0 DK118086D0 (da) 1986-03-14
DK118086A DK118086A (da) 1986-09-17
DK164392B DK164392B (da) 1992-06-22
DK164392C true DK164392C (da) 1992-11-09

Family

ID=27516579

Family Applications (1)

Application Number Title Priority Date Filing Date
DK118086A DK164392C (da) 1985-03-16 1986-03-14 Anvendelse af 3'-azido-3'-desoxythymidin til fremstilling af et laegemiddel til behandling af eller profylakse for en human retrovirusinfektion

Country Status (21)

Country Link
EP (2) EP0291633B1 (da)
JP (1) JPH0780898B2 (da)
AP (1) AP11A (da)
AT (4) ATE113603T1 (da)
AU (1) AU572019B2 (da)
CA (1) CA1238277A (da)
CS (1) CS385191A3 (da)
CY (2) CY1508A (da)
DE (4) DE3608606A1 (da)
DK (1) DK164392C (da)
FI (1) FI85978C (da)
GR (1) GR860712B (da)
HK (2) HK85789A (da)
IE (1) IE56503B1 (da)
IL (1) IL78158A (da)
MC (1) MC1742A1 (da)
MY (1) MY102693A (da)
NZ (1) NZ215486A (da)
PH (1) PH24388A (da)
PT (1) PT82199B (da)
SG (1) SG62889G (da)

Families Citing this family (48)

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DE3650741T2 (de) * 1985-09-17 2000-10-12 The Wellcome Foundation Ltd., Greenford Kombination therapeutische Nukleoside mit weiteren therapeutisch wirksamen Komponenten.
US5084445A (en) * 1986-05-01 1992-01-28 University Of Georgia Research Foundation, Inc. 3'-azido-2',3'-dideoxy-5-methylcytidine
US4916122A (en) * 1987-01-28 1990-04-10 University Of Georgia Research Foundation, Inc. 3'-Azido-2',3'-dideoxyuridine anti-retroviral composition
US4841039A (en) * 1986-05-01 1989-06-20 Emory University 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents
US5077279A (en) * 1986-05-01 1991-12-31 University Of Georgia Research Foundation, Inc. 3'-azido-2',3'-dideoxy-5-methylcytidine anti-viral composition
EP0332626A1 (en) * 1986-11-21 1989-09-20 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Compositions for treating viral infections in humans
US4880782A (en) * 1986-11-21 1989-11-14 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften E.V. Method of treating viral infections in humans and compositions therefor
SE8605503D0 (sv) * 1986-12-19 1986-12-19 Astra Laekemedel Ab Novel medicinal use
US5190926A (en) * 1987-01-28 1993-03-02 University Of Georgia Research Foundation, Inc. 3'-azido-2',3'-dideoxypyrimidines and related compounds as antiviral agents
PL271196A1 (en) * 1987-03-16 1988-12-08 Wellcome Found Method for manufacturing a new i-(3-azide-2,3-didesoxy-d-erythro-pentafuranosil)-5-methyl-ih-pyrimidinon-2
EP0282618A1 (en) * 1987-03-18 1988-09-21 Vereniging Het Nederlands Kanker Instituut 1-Deoxynojirimycin as an anti-HIV therapeutic
EP0286825A3 (en) * 1987-03-18 1989-04-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Use of 3'-fluro-3' deoxythymidine for the manufacture of a medicament for the treatment of virus infections
US4950652A (en) * 1987-03-23 1990-08-21 Hem Research, Inc. dsRNAs for combination therapy in the treatment of viral diseases
IL85852A0 (en) * 1987-03-25 1988-09-30 Wellcome Found Process and intermediates for the manufacture of zidovudine
GB8707421D0 (en) * 1987-03-27 1987-04-29 Wellcome Found Pharmaceutical formulations
US5185437A (en) * 1987-04-09 1993-02-09 Burroughs Wellcome Co. Therapeutic nucleosides
IL86007A0 (en) * 1987-04-09 1988-09-30 Wellcome Found 6-substituted purine nucleosides,their preparation and pharmaceutical compositions containing them
IL86009A (en) * 1987-04-10 1991-09-16 Us Health Liposome-encapsulated phosphorylated nucleosides for treatment of retroviral diseases
SE8701605D0 (sv) * 1987-04-16 1987-04-16 Astra Ab Novel medicinal compounds
US5215970A (en) * 1987-04-16 1993-06-01 Medivir Ab Nucleosides and nucleotide analogues, pharmaceutical composition and processes for the preparation of the compounds
EP0289229B1 (en) * 1987-04-24 1992-01-29 The Wellcome Foundation Limited Antiviral combinations
US4863927A (en) * 1987-05-11 1989-09-05 Merck & Co., Inc. 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils
YU110888A (en) * 1987-06-10 1989-08-31 Wellcome Found Process for obtaining timine derivatives
USRE33887E (en) * 1987-06-22 1992-04-14 Hoffmann-La Roche Inc. Anti-retroviral compounds
SU1548182A1 (ru) * 1987-12-29 1990-03-07 Институт молекулярной биологии АН СССР 5 @ -Фосфонаты 3 @ -азидо-2 @ ,3 @ -дидезоксинуклеозидов, вл ющиес специфическими ингибиторами вируса СПИД в культуре лимфоцитов человека Н9/ШВ
US5384396A (en) * 1988-02-23 1995-01-24 The University Of Georgia Research Foundation, Inc. Process for the deoxygenation of nucleosides
DE3824669C2 (de) * 1988-07-20 1999-05-06 Wondrak Ewald M Verwendung von Trinatrium-Phosphonoformat
US4987224A (en) * 1988-08-02 1991-01-22 University Of Georgia Research Foundation, Inc. Method of preparation of 2',3'-dideoxynucleosides
EP0355245A1 (fr) * 1988-08-26 1990-02-28 Michel Vandevelde Utilisation d'agents d'inhibition de la réverse-transcriptase des rétrovirus
HU205089B (en) * 1989-05-31 1992-03-30 Biogal Gyogyszergyar Process for producing new thymine derivatives and pharmaceutical compositions comprising same
AT500684B8 (de) * 1989-11-09 2006-11-15 Meda Pharma Gmbh & Co Kg Verwendung von schwefelhältigen carbonsäuren zur herstellung eines arzneimittels zur bekämpfung von erkrankungen durch retroviren
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US5585367A (en) * 1990-04-19 1996-12-17 Previsan S.A. Method of treating humans and animals infected with viruses of the retrovirus group
GB9104740D0 (en) * 1991-03-06 1991-04-17 Wellcome Found Antiviral nucleoside combination
US6812233B1 (en) 1991-03-06 2004-11-02 Emory University Therapeutic nucleosides
US5593993A (en) * 1991-08-02 1997-01-14 Medivir Ab Method for inhibition of HIV related viruses
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Also Published As

Publication number Publication date
JPH0780898B2 (ja) 1995-08-30
MC1742A1 (fr) 1987-02-26
DE3650130D1 (de) 1994-12-08
NZ215486A (en) 1988-09-29
HK85789A (en) 1989-11-03
PH24388A (en) 1990-06-13
FI861069L (fi) 1986-09-17
DK118086D0 (da) 1986-03-14
AP8600027A0 (en) 1986-02-01
IE56503B1 (en) 1991-08-14
AU572019B2 (en) 1988-04-28
DK164392B (da) 1992-06-22
CY1889A (en) 1996-11-22
IL78158A0 (en) 1986-07-31
EP0291633A1 (en) 1988-11-23
EP0196185B1 (en) 1989-07-12
DK118086A (da) 1986-09-17
CY1508A (en) 1990-08-03
HK164395A (en) 1995-10-27
EP0196185A3 (en) 1988-01-13
ATE113603T1 (de) 1994-11-15
AP11A (en) 1987-12-22
DE196185T1 (de) 1987-04-30
AT390000B (de) 1990-02-26
CA1238277A (en) 1988-06-21
FI85978B (fi) 1992-03-13
ATA68386A (de) 1989-08-15
PT82199B (pt) 1990-11-07
CS385191A3 (en) 1992-05-13
DE3650130T2 (de) 1995-03-16
FI861069A0 (fi) 1986-03-14
IL78158A (en) 1988-04-29
DE3687069D1 (de) 1992-12-10
IE860677L (en) 1986-09-16
SG62889G (en) 1990-01-26
GR860712B (en) 1986-07-16
EP0291633B1 (en) 1992-11-04
MY102693A (en) 1992-09-30
PT82199A (en) 1986-04-01
DE3687069T2 (de) 1993-03-25
ATE81978T1 (de) 1992-11-15
JPS63290895A (ja) 1988-11-28
DE3608606A1 (de) 1986-09-18
ATE44464T1 (de) 1989-07-15
AU5475886A (en) 1986-09-18
FI85978C (fi) 1992-06-25
DE3650130T3 (de) 2003-07-24
EP0196185A2 (en) 1986-10-01

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