DK165406C - Substituerede n-(2,4,6-trimethoxyphenyl)-fedtsyreamider, fremgangsmaade til fremstilling deraf, farmaceutisk praeparat indeholdende disse forbindelser samt anvendelse af disse forbindelser til fremstilling af et farmaceutisk praeparat til inhibering af intestinal absorption af kolesterol - Google Patents
Substituerede n-(2,4,6-trimethoxyphenyl)-fedtsyreamider, fremgangsmaade til fremstilling deraf, farmaceutisk praeparat indeholdende disse forbindelser samt anvendelse af disse forbindelser til fremstilling af et farmaceutisk praeparat til inhibering af intestinal absorption af kolesterolInfo
- Publication number
- DK165406C DK165406C DK094188A DK94188A DK165406C DK 165406 C DK165406 C DK 165406C DK 094188 A DK094188 A DK 094188A DK 94188 A DK94188 A DK 94188A DK 165406 C DK165406 C DK 165406C
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- trimethoxyphenyl
- procedures
- substituted
- preparing
- Prior art date
Links
- 150000001408 amides Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 2
- -1 2,4,6-TRIMETHOXYPHENYL Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000001494 Sterol O-Acyltransferase Human genes 0.000 abstract 1
- 108010054082 Sterol O-acyltransferase Proteins 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000031891 intestinal absorption Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 235000003441 saturated fatty acids Nutrition 0.000 abstract 1
- 150000004671 saturated fatty acids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/07—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/09—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/017,960 US4716175A (en) | 1987-02-24 | 1987-02-24 | Saturated fatty acid amides as inhibitors of acyl-CoA:cholesterol acyltransferase |
| US1796087 | 1987-02-24 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK94188D0 DK94188D0 (da) | 1988-02-23 |
| DK94188A DK94188A (da) | 1988-08-25 |
| DK165406B DK165406B (da) | 1992-11-23 |
| DK165406C true DK165406C (da) | 1993-04-13 |
Family
ID=21785503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK094188A DK165406C (da) | 1987-02-24 | 1988-02-23 | Substituerede n-(2,4,6-trimethoxyphenyl)-fedtsyreamider, fremgangsmaade til fremstilling deraf, farmaceutisk praeparat indeholdende disse forbindelser samt anvendelse af disse forbindelser til fremstilling af et farmaceutisk praeparat til inhibering af intestinal absorption af kolesterol |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4716175A (de) |
| EP (1) | EP0283742B1 (de) |
| JP (1) | JPH07121895B2 (de) |
| KR (1) | KR880009933A (de) |
| AT (1) | ATE89814T1 (de) |
| CA (1) | CA1336913C (de) |
| DE (1) | DE3881249T2 (de) |
| DK (1) | DK165406C (de) |
| ES (1) | ES2056843T3 (de) |
| FI (1) | FI89593C (de) |
| HK (1) | HK148195A (de) |
| IE (1) | IE59998B1 (de) |
| MX (1) | MX9203139A (de) |
| NO (1) | NO174043C (de) |
| NZ (1) | NZ223410A (de) |
| PT (1) | PT86811B (de) |
| ZA (1) | ZA88604B (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8827152D0 (en) * | 1988-11-21 | 1988-12-29 | Wellcome Found | Anti-atherosclerotic diaryl compounds |
| US5290814A (en) * | 1988-11-21 | 1994-03-01 | Burroughs Wellcome Co. | Anti-atherosclerotic diaryl compounds |
| US5153226A (en) * | 1989-08-31 | 1992-10-06 | Warner-Lambert Company | Acat inhibitors for treating hypocholesterolemia |
| WO1991004027A1 (en) * | 1989-09-15 | 1991-04-04 | Pfizer Inc. | New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat) |
| AU6659090A (en) * | 1989-11-16 | 1991-06-13 | Warner-Lambert Company | Acat inhibitors |
| AU7745991A (en) * | 1990-04-11 | 1991-10-30 | Warner-Lambert Company | Amide ester acat inhibitors |
| US5149709A (en) * | 1990-07-03 | 1992-09-22 | Schering Corporation | Inhibitors of acyl-coenzyme A: cholesterol acyl transferase |
| CA2087423A1 (en) * | 1990-07-25 | 1992-01-26 | Tatsuki Shiota | Benzopyran derivative, process for producing the same and pharmaceutical composition containing the same |
| US5668136A (en) * | 1990-09-25 | 1997-09-16 | Eisai Co., Ltd. | Trisubstituted benzene derivatives, composition and methods of treatment |
| WO1992009572A1 (en) * | 1990-11-26 | 1992-06-11 | Taisho Pharmaceutical Co., Ltd. | Anilide derivative |
| FR2673625B1 (fr) * | 1991-03-08 | 1993-05-07 | Adir | Nouveaux derives d'acylaminophenol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5420164A (en) * | 1991-04-04 | 1995-05-30 | Yoshitomi Pharmaceutical Industries, Ltd. | Cycloalkylurea compounds |
| JP3087307B2 (ja) * | 1991-12-25 | 2000-09-11 | 大正製薬株式会社 | アニリド誘導体 |
| RU94046149A (ru) * | 1992-05-28 | 1996-11-27 | Пфайзер Инк. (US) | Новые n-арил и n-гетероарил производные мочевины как ингибиторы ацил кофермента а:холестерин ацил трансферазы (асат) фармацевтическая композиция, способ ингибирования (асат) |
| WO1994002452A1 (fr) * | 1992-07-20 | 1994-02-03 | Eisai Co., Ltd. | Derive du benzene |
| US5321031A (en) * | 1992-09-23 | 1994-06-14 | Schering Corporation | 1,2-disubstituted ethyl amides as inhibitors of ACAT |
| CA2107196A1 (en) * | 1992-09-29 | 1994-03-30 | Mitsubishi Chemical Corporation | Carboxamide derivatives |
| US5565472A (en) * | 1992-12-21 | 1996-10-15 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents |
| US5534529A (en) * | 1993-06-30 | 1996-07-09 | Sankyo Company, Limited | Substituted aromatic amides and ureas derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses |
| NZ264063A (en) * | 1993-08-13 | 1995-11-27 | Nihon Nohyaku Co Ltd | N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions |
| US5596001A (en) * | 1993-10-25 | 1997-01-21 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)quinoline derivatves |
| IT1265209B1 (it) * | 1993-11-22 | 1996-10-31 | Pierrel Spa | Difenilimidazoli utili nel trattamento di dislipidemia, arteriosclerosi e malattie coronariche procedimento per la loro |
| US6133326A (en) | 1994-08-31 | 2000-10-17 | Pfizer Inc | Compositions and methods for decreasing sebum production |
| KR960031425A (ko) * | 1995-02-08 | 1996-09-17 | 시미주 마사미 | 다중불포화된 지방산 잔기를 갖는 아닐린 유도체 및 그의 용도 |
| HUP0301010A3 (en) * | 2000-02-02 | 2005-03-29 | Warner Lambert Co | Dual inhibitors of cholesteryl ester and wax ester synthesis for sebaceous gland disorders and pharmaceutical compositions containing them |
| AU4368001A (en) * | 2000-03-16 | 2001-09-24 | Neurogen Corporation | 5-substituted arylpyrimidines |
| US20040072903A1 (en) * | 2001-05-08 | 2004-04-15 | Auerbach Bruce Jeffrey | Carboxyalkylether-acat inhibitors combinations |
| EP1281399A3 (de) * | 2001-08-01 | 2004-02-11 | Warner-Lambert Company | Hemmer mit doppelter Wirkung auf Wachsester- und Cholesterylestersynthese zur Hemmung der Sebumproduktion |
| PT1725234E (pt) | 2004-03-05 | 2013-03-04 | Univ Pennsylvania | Métodos com efeitos secundários reduzidos para tratamento de patologias ou doenças associadas a hiperlipidemia e hipercolesterolemia |
| US20100210633A1 (en) * | 2006-10-12 | 2010-08-19 | Epix Delaware, Inc. | Carboxamide compounds and their use |
| AU2008335135A1 (en) | 2007-12-11 | 2009-06-18 | Cytopathfinder, Inc. | Carboxamide compounds and their use as chemokine receptor agonists |
| EP2341924A4 (de) | 2008-10-02 | 2013-01-23 | David Gladstone Inst | Verfahren zur behandlung von hepatitis-c-virusinfektionen |
| BR112023000808A2 (pt) | 2020-07-29 | 2023-02-07 | Amryt Pharmaceuticals Inc | Lomitapida para uso em métodos para tratar hiperlipidemia e hipercolesterolemia em pacientes pediátricos |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL238088A (de) * | 1958-04-14 | |||
| BE620639A (de) * | 1961-07-25 | |||
| SE353319B (de) * | 1964-08-15 | 1973-01-29 | Sumitomo Chemical Co | |
| DE1618959C3 (de) * | 1967-10-04 | 1978-12-14 | Sumitomo Chemical Co., Ltd., Osaka (Japan) | Fettsäureamide und Verfahren zu ihrer Herstellung |
| DE2830351A1 (de) * | 1978-07-11 | 1980-01-24 | Consortium Elektrochem Ind | Acylanilide |
| GR69291B (de) * | 1979-06-25 | 1982-05-13 | May & Baker Ltd | |
| US4410697A (en) * | 1980-01-25 | 1983-10-18 | Reanal Finomvegyszergyar | Process for the preparation of N-aryl-N'-(mono- or di substituted)-urea derivatives |
| US4749812A (en) * | 1985-05-27 | 1988-06-07 | Mitsui Toatsu Chemicals, Inc. | N-(3-chloro-4-isopropylphenyl) carboxamide derivative and selective herbicide |
| MA20552A1 (fr) * | 1985-10-11 | 1986-07-01 | Pan Medica Sa | Alkylacarboxamides de pyridylalkylamines,leurs preparations et leurs utilisations |
-
1987
- 1987-02-24 US US07/017,960 patent/US4716175A/en not_active Expired - Lifetime
-
1988
- 1988-01-26 IE IE20488A patent/IE59998B1/en not_active IP Right Cessation
- 1988-01-27 CA CA000557467A patent/CA1336913C/en not_active Expired - Fee Related
- 1988-01-28 ZA ZA88604A patent/ZA88604B/xx unknown
- 1988-02-04 NZ NZ223410A patent/NZ223410A/xx unknown
- 1988-02-19 FI FI880796A patent/FI89593C/fi not_active IP Right Cessation
- 1988-02-23 DE DE8888102644T patent/DE3881249T2/de not_active Expired - Fee Related
- 1988-02-23 ES ES88102644T patent/ES2056843T3/es not_active Expired - Lifetime
- 1988-02-23 AT AT88102644T patent/ATE89814T1/de not_active IP Right Cessation
- 1988-02-23 JP JP63038777A patent/JPH07121895B2/ja not_active Expired - Lifetime
- 1988-02-23 PT PT86811A patent/PT86811B/pt not_active IP Right Cessation
- 1988-02-23 NO NO880774A patent/NO174043C/no unknown
- 1988-02-23 EP EP88102644A patent/EP0283742B1/de not_active Expired - Lifetime
- 1988-02-23 DK DK094188A patent/DK165406C/da not_active IP Right Cessation
- 1988-02-24 KR KR1019880001910A patent/KR880009933A/ko not_active Abandoned
-
1992
- 1992-06-23 MX MX9203139A patent/MX9203139A/es unknown
-
1995
- 1995-09-14 HK HK148195A patent/HK148195A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US4716175B1 (de) | 1993-06-22 |
| DK165406B (da) | 1992-11-23 |
| KR880009933A (ko) | 1988-10-05 |
| EP0283742A2 (de) | 1988-09-28 |
| DE3881249D1 (en) | 1993-07-01 |
| PT86811B (pt) | 1992-05-29 |
| NO880774D0 (no) | 1988-02-23 |
| FI89593C (fi) | 1993-10-25 |
| IE880204L (en) | 1988-08-24 |
| US4716175A (en) | 1987-12-29 |
| MX9203139A (es) | 1992-07-01 |
| ES2056843T3 (es) | 1994-10-16 |
| ATE89814T1 (de) | 1993-06-15 |
| NO174043C (no) | 1994-03-09 |
| FI880796A0 (fi) | 1988-02-19 |
| ZA88604B (en) | 1989-09-27 |
| IE59998B1 (en) | 1994-05-18 |
| AU610558B2 (en) | 1991-05-23 |
| JPS63253060A (ja) | 1988-10-20 |
| NO880774L (no) | 1988-08-25 |
| AU1135488A (en) | 1988-08-25 |
| EP0283742A3 (en) | 1989-07-26 |
| DE3881249T2 (de) | 1993-09-16 |
| FI880796A7 (fi) | 1988-08-25 |
| FI89593B (fi) | 1993-07-15 |
| CA1336913C (en) | 1995-09-05 |
| PT86811A (pt) | 1988-03-01 |
| HK148195A (en) | 1995-09-22 |
| EP0283742B1 (de) | 1993-05-26 |
| NO174043B (no) | 1993-11-29 |
| NZ223410A (en) | 1989-11-28 |
| DK94188D0 (da) | 1988-02-23 |
| DK94188A (da) | 1988-08-25 |
| JPH07121895B2 (ja) | 1995-12-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |