DK1656391T3 - Modificerede humane IGF-1R antistoffer - Google Patents

Modificerede humane IGF-1R antistoffer

Info

Publication number: DK1656391T3
Authority: DK; Denmark
Prior art keywords: antibodies; modified human; human igf; igf; modified
Prior art date: 2003-08-13

Application number

DK04744197.7T

Other languages

English (en)

Inventor

Bruce David Cohen

Vahe Bedian

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-08-13

Filing date

2004-08-03

Publication date

2011-01-03

2004-08-03 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2011-01-03 Application granted granted Critical

2011-01-03 Publication of DK1656391T3 publication Critical patent/DK1656391T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Oncology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Transplantation (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK04744197.7T 2003-08-13 2004-08-03 Modificerede humane IGF-1R antistoffer DK1656391T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US49520003P	2003-08-13	2003-08-13
PCT/IB2004/002555 WO2005016967A2 (en)	2003-08-13	2004-08-03	Modified human igf-1r antibodies

Publications (1)

Publication Number	Publication Date
DK1656391T3 true DK1656391T3 (da)	2011-01-03

Family

ID=34193291

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04744197.7T DK1656391T3 (da)	2003-08-13	2004-08-03	Modificerede humane IGF-1R antistoffer

Country Status (37)

Country	Link
US (2)	US7371378B2 (da)
EP (1)	EP1656391B1 (da)
JP (1)	JP4638870B2 (da)
KR (1)	KR100825156B1 (da)
CN (1)	CN1835975B (da)
AP (1)	AP2006003510A0 (da)
AR (1)	AR045247A1 (da)
AT (1)	ATE484525T1 (da)
AU (1)	AU2004265152A1 (da)
BR (1)	BRPI0413466A (da)
CA (1)	CA2535071A1 (da)
CL (1)	CL2004002035A1 (da)
CR (1)	CR8233A (da)
DE (1)	DE602004029581D1 (da)
DK (1)	DK1656391T3 (da)
EA (1)	EA200600234A1 (da)
EC (1)	ECSP066359A (da)
ES (1)	ES2351395T3 (da)
GT (1)	GT200400158A (da)
IL (1)	IL173273A (da)
IS (1)	IS8266A (da)
MA (1)	MA27988A1 (da)
MX (1)	MXPA06001634A (da)
NL (1)	NL1026829C2 (da)
NO (1)	NO20060542L (da)
OA (1)	OA13234A (da)
PA (1)	PA8608801A1 (da)
PE (1)	PE20050339A1 (da)
PL (1)	PL1656391T3 (da)
PT (1)	PT1656391E (da)
RS (1)	RS20060099A (da)
TN (1)	TNSN06050A1 (da)
TW (1)	TWI294915B (da)
UA (1)	UA85058C2 (da)
UY (1)	UY28464A1 (da)
WO (1)	WO2005016967A2 (da)
ZA (1)	ZA200601231B (da)

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PA8535501A1 (es)	2001-01-05	2003-07-28	Pfizer	Anticuerpos contra el receptor del factor de crecimiento similar a insulina
NZ536475A (en)	2002-05-24	2008-06-30	Schering Corp	Neutralizing human anti-igfr antibody
CA2524305C (en) *	2003-05-01	2015-12-08	Imclone Systems Incorporated	Fully human antibodies directed against the human insulin-like growth factor-1 receptor
DK1656391T3 (da) *	2003-08-13	2011-01-03	Pfizer Prod Inc	Modificerede humane IGF-1R antistoffer
ATE514783T1 (de)	2003-11-12	2011-07-15	Schering Corp	Plasmidsystem zur expression mehrerer gene
PE20050928A1 (es)	2003-11-21	2005-11-08	Schering Corp	Combinaciones terapeuticas de anticuerpo anti-igfr1
RU2342159C2 (ru)	2004-07-16	2008-12-27	Пфайзер Продактс Инк.	Комбинированная терапия негематологических злокачественных опухолей с использованием анти-igf-1r-антитела
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MY146381A (en)	2004-12-22	2012-08-15	Amgen Inc	Compositions and methods relating relating to anti-igf-1 receptor antibodies
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WO2010146059A2 (en)	2009-06-16	2010-12-23	F. Hoffmann-La Roche Ag	Biomarkers for igf-1r inhibitor therapy
TWI513465B (zh)	2009-06-25	2015-12-21	Regeneron Pharma	以ｄｌｌ４拮抗劑與化學治療劑治療癌症之方法
CN104928336B (zh)	2009-10-26	2020-05-08	弗·哈夫曼-拉罗切有限公司	用于生产糖基化免疫球蛋白的方法
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WO2011101328A2 (en)	2010-02-18	2011-08-25	Roche Glycart Ag	Treatment with a humanized igg class anti egfr antibody and an antibody against insulin like growth factor 1 receptor
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JP5913307B2 (ja)	2010-07-12	2016-04-27	コヴェックス・テクノロジーズ・アイルランド・リミテッド	多機能性抗体複合体
AU2012212075A1 (en)	2011-02-02	2013-07-18	Amgen Inc.	Methods and compositons relating to inhibition of IGF-1R
EP2699598B1 (en)	2011-04-19	2019-03-06	Pfizer Inc	Combinations of anti-4-1bb antibodies and adcc-inducing antibodies for the treatment of cancer
WO2013056069A1 (en)	2011-10-13	2013-04-18	Bristol-Myers Squibb Company	Methods for selecting and treating cancer in patients with igf-1r/ir inhibitors
JP6413127B2 (ja) *	2012-01-09	2018-10-31	コヴェックス・テクノロジーズ・アイルランド・リミテッド	変異抗体およびそのコンジュゲーション
EP2631653A1 (en)	2012-02-24	2013-08-28	Charité - Universitätsmedizin Berlin	Identification of modulators of binding properties of antibodies reactive with a member of the insulin receptor family
WO2013152252A1 (en)	2012-04-06	2013-10-10	OSI Pharmaceuticals, LLC	Combination anti-cancer therapy
JP2015535005A (ja) *	2012-11-06	2015-12-07	メディミューン，エルエルシー	抗シュードモナス属（Ｐｓｅｕｄｏｍｏｎａｓ）ＰｓｌおよびＰｃｒＶ結合分子を用いた併用治療
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2004
- 2004-08-03 DK DK04744197.7T patent/DK1656391T3/da active
- 2004-08-03 BR BRPI0413466-4A patent/BRPI0413466A/pt not_active IP Right Cessation
- 2004-08-03 CN CN2004800230991A patent/CN1835975B/zh not_active Expired - Fee Related
- 2004-08-03 ES ES04744197T patent/ES2351395T3/es not_active Expired - Lifetime
- 2004-08-03 OA OA1200600046A patent/OA13234A/en unknown
- 2004-08-03 KR KR1020067002957A patent/KR100825156B1/ko not_active Expired - Fee Related
- 2004-08-03 MX MXPA06001634A patent/MXPA06001634A/es unknown
- 2004-08-03 UA UAA200601349A patent/UA85058C2/ru unknown
- 2004-08-03 EA EA200600234A patent/EA200600234A1/ru unknown
- 2004-08-03 PL PL04744197T patent/PL1656391T3/pl unknown
- 2004-08-03 CA CA002535071A patent/CA2535071A1/en not_active Abandoned
- 2004-08-03 WO PCT/IB2004/002555 patent/WO2005016967A2/en not_active Ceased
- 2004-08-03 PT PT04744197T patent/PT1656391E/pt unknown
- 2004-08-03 AP AP2006003510A patent/AP2006003510A0/xx unknown
- 2004-08-03 RS YUP-2006/0099A patent/RS20060099A/sr unknown
- 2004-08-03 EP EP04744197A patent/EP1656391B1/en not_active Expired - Lifetime
- 2004-08-03 AT AT04744197T patent/ATE484525T1/de active
- 2004-08-03 JP JP2006523070A patent/JP4638870B2/ja not_active Expired - Fee Related
- 2004-08-03 AU AU2004265152A patent/AU2004265152A1/en not_active Abandoned
- 2004-08-03 DE DE602004029581T patent/DE602004029581D1/de not_active Expired - Lifetime
- 2004-08-09 PE PE2004000773A patent/PE20050339A1/es not_active Application Discontinuation
- 2004-08-10 CL CL200402035A patent/CL2004002035A1/es unknown
- 2004-08-11 UY UY28464A patent/UY28464A1/es not_active Application Discontinuation
- 2004-08-11 AR ARP040102870A patent/AR045247A1/es active IP Right Grant
- 2004-08-12 GT GT200400158A patent/GT200400158A/es unknown
- 2004-08-12 NL NL1026829A patent/NL1026829C2/nl not_active IP Right Cessation
- 2004-08-12 US US10/917,073 patent/US7371378B2/en not_active Expired - Fee Related
- 2004-08-12 TW TW093124269A patent/TWI294915B/zh not_active IP Right Cessation
- 2004-08-12 PA PA20048608801A patent/PA8608801A1/es unknown
2006
- 2006-01-19 IL IL173273A patent/IL173273A/en not_active IP Right Cessation
- 2006-01-26 IS IS8266A patent/IS8266A/is unknown
- 2006-02-02 NO NO20060542A patent/NO20060542L/no not_active Application Discontinuation
- 2006-02-10 ZA ZA200601231A patent/ZA200601231B/en unknown
- 2006-02-10 EC EC2006006359A patent/ECSP066359A/es unknown
- 2006-02-13 CR CR8233A patent/CR8233A/es not_active Application Discontinuation
- 2006-02-13 TN TNP2006000050A patent/TNSN06050A1/fr unknown
- 2006-02-13 MA MA28790A patent/MA27988A1/fr unknown
2008
- 2008-03-03 US US12/041,341 patent/US7575746B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR100825156B1 (ko)	2008-04-24
NO20060542L (no)	2006-05-03
CA2535071A1 (en)	2005-02-24
EP1656391B1 (en)	2010-10-13
US20050069539A1 (en)	2005-03-31
US7371378B2 (en)	2008-05-13
TW200516145A (en)	2005-05-16
TWI294915B (en)	2008-03-21
WO2005016967A2 (en)	2005-02-24
US20080181891A1 (en)	2008-07-31
EP1656391A2 (en)	2006-05-17
PA8608801A1 (es)	2005-03-03
IS8266A (is)	2006-01-26
AP2006003510A0 (en)	2006-02-28
EA200600234A1 (ru)	2006-08-25
AR045247A1 (es)	2005-10-19
CN1835975A (zh)	2006-09-20
ES2351395T3 (es)	2011-02-04
JP2007527705A (ja)	2007-10-04
RS20060099A (sr)	2008-08-07
MXPA06001634A (es)	2006-04-28
OA13234A (en)	2006-12-13
UY28464A1 (es)	2005-03-31
NL1026829C2 (nl)	2005-07-05
GT200400158A (es)	2005-07-22
IL173273A (en)	2011-10-31
MA27988A1 (fr)	2006-07-03
KR20060035796A (ko)	2006-04-26
NL1026829A1 (nl)	2005-02-15
TNSN06050A1 (fr)	2007-10-03
PL1656391T3 (pl)	2011-03-31
ATE484525T1 (de)	2010-10-15
JP4638870B2 (ja)	2011-02-23
UA85058C2 (ru)	2008-12-25
ECSP066359A (es)	2006-10-31
US7575746B2 (en)	2009-08-18
PE20050339A1 (es)	2005-05-17
AU2004265152A1 (en)	2005-02-24
CL2004002035A1 (es)	2005-06-03
BRPI0413466A (pt)	2006-10-17
CN1835975B (zh)	2012-11-21
DE602004029581D1 (de)	2010-11-25
WO2005016967A3 (en)	2005-04-14
ZA200601231B (en)	2007-05-30
PT1656391E (pt)	2010-12-06
IL173273A0 (en)	2006-06-11
CR8233A (es)	2007-01-18

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