DK1660491T3 - Benzimidazol-, benzthiazol- og benzoxazolderivater og deres anvendelse som LTA4Hmodulatorer - Google Patents

Benzimidazol-, benzthiazol- og benzoxazolderivater og deres anvendelse som LTA4Hmodulatorer

Info

Publication number: DK1660491T3
Authority: DK; Denmark
Prior art keywords: benzthiazole; benzimidazole; benzoxazole derivatives; lta4h modulators; lta4h
Prior art date: 2003-07-28

Application number

DK04779219T

Other languages

Danish (da)

English (en)

Inventor

Frank U Axe

Scott D Bembenek

Christopher R Butler

James P Edwards

Anne M Fourie

Cheryl A Grice

Brad M Savall

Kevin L Tays

Jianmei Wei

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-28

Filing date

2004-07-27

Publication date

2008-11-10

2004-07-27 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2008-11-10 Application granted granted Critical

2008-11-10 Publication of DK1660491T3 publication Critical patent/DK1660491T3/da

Links

IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 title 2
BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical class C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 title 1
HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title 1
101000619898 Homo sapiens Leukotriene A-4 hydrolase Proteins 0.000 title 1
102100022118 Leukotriene A-4 hydrolase Human genes 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pulmonology (AREA)
Manufacturing & Machinery (AREA)
Ceramic Engineering (AREA)
Biomedical Technology (AREA)
Materials Engineering (AREA)
Cardiology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Structural Engineering (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Inorganic Chemistry (AREA)
Hospice & Palliative Care (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DK04779219T 2003-07-28 2004-07-27 Benzimidazol-, benzthiazol- og benzoxazolderivater og deres anvendelse som LTA4Hmodulatorer DK1660491T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US49071003P	2003-07-28	2003-07-28
PCT/US2004/024050 WO2005012296A1 (en)	2003-07-28	2004-07-27	Benzimidazole, benzthiazole and benzoxazole derivatives and their use as lta4h modulators

Publications (1)

Publication Number	Publication Date
DK1660491T3 true DK1660491T3 (da)	2008-11-10

Family

ID=34115427

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK04779219T DK1660491T3 (da)	2003-07-28	2004-07-27	Benzimidazol-, benzthiazol- og benzoxazolderivater og deres anvendelse som LTA4Hmodulatorer
DK04779375T DK1660492T3 (da)	2003-07-28	2004-07-27	Benzimidazol-, benzthiazol- og benzoxazolderivater og deres anvendelse som LTA4H-modulatorer

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK04779375T DK1660492T3 (da)	2003-07-28	2004-07-27	Benzimidazol-, benzthiazol- og benzoxazolderivater og deres anvendelse som LTA4H-modulatorer

Country Status (28)

Country	Link
US (2)	US20050043379A1 (pt)
EP (2)	EP1660491B1 (pt)
JP (2)	JP4726238B2 (pt)
KR (2)	KR101149379B1 (pt)
CN (2)	CN1856490A (pt)
AR (2)	AR045729A1 (pt)
AT (2)	ATE403654T1 (pt)
AU (2)	AU2004261610B2 (pt)
BR (2)	BRPI0413072A (pt)
CA (2)	CA2534212A1 (pt)
CY (1)	CY1108560T1 (pt)
DE (2)	DE602004015620D1 (pt)
DK (2)	DK1660491T3 (pt)
ES (2)	ES2311858T3 (pt)
HR (2)	HRP20060039A2 (pt)
IL (1)	IL173372A (pt)
MY (1)	MY145080A (pt)
NO (2)	NO20060771L (pt)
NZ (2)	NZ544938A (pt)
PL (2)	PL1660491T3 (pt)
PT (2)	PT1660492E (pt)
RU (2)	RU2359970C2 (pt)
SG (2)	SG129449A1 (pt)
SI (2)	SI1660492T1 (pt)
TW (2)	TWI362383B (pt)
UA (2)	UA87986C2 (pt)
WO (2)	WO2005012296A1 (pt)
ZA (2)	ZA200601720B (pt)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE403654T1 (de) *	2003-07-28	2008-08-15	Janssen Pharmaceutica Nv	Benzimidazol-, benzothiazol- und benzoxazolderivate und deren verwendung als lta4h-modulatoren
CA2603122A1 (en) *	2005-03-31	2006-10-05	Janssen Pharmaceutica N.V.	Phenyl and pyridyl lta4h modulators
JP5154406B2 (ja)	2005-04-13	2013-02-27	アステックス、セラピューティックス、リミテッド	医薬化合物
EP1717235A3 (en) *	2005-04-29	2007-02-28	Bioprojet	Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands
CA2620127A1 (en) *	2005-09-02	2007-03-08	F. Hoffmann-La Roche Ag	Benzooxazole, oxazolopyridine, benzothiazole and thiazolopyridine derivatives
JP5133889B2 (ja) *	2005-09-21	2013-01-30	デコードジェネティクスイーエイチエフ	炎症治療のためのビアリール基置換複素環ｌｔａ４ｈ阻害剤
EP1963261A1 (en)	2005-12-21	2008-09-03	Decode Genetics EHF	Biaryl substituted nitrogen containing heterocycle inhibitors of lta4h for treating inflammation
CA2634699A1 (en)	2005-12-21	2007-06-28	Decode Genetics Ehf	N-linked aryl heteroaryl inhibitors of lta4h for treating inflammation
CA2636929A1 (en) *	2005-12-21	2007-07-12	Decode Genetics, Ehf	Biaryl nitrogen heterocycle inhibitors of lta4h for treating inflammation
LT1976828T (lt) *	2005-12-29	2017-04-25	Celtaxsys, Inc.	Diamino dariniai, kaip leukotrieno a4 hidrolazės inhibitoriai
JP2009525269A (ja) *	2006-01-30	2009-07-09	ユーロ−セルティークエス．エイ．	カルシウムチャネルブロッカーとしての環状尿素化合物
US7754725B2 (en)	2006-03-01	2010-07-13	Astex Therapeutics Ltd.	Dihydroxyphenyl isoindolymethanones
US7951829B2 (en) *	2006-05-03	2011-05-31	Janssen Pharmaceutica Nv	Benzimidazole modulators of VR1
CA2656057C (en) *	2006-06-16	2012-10-02	H. Lundbeck A/S	Crystalline forms of 4-[2-(4-methylphenylsulfanyl)-phenyl]piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of neuropathic pain
EP2066800A2 (en) *	2006-08-04	2009-06-10	Decode Genetics EHF	Aryl amino acid derivatives as inhibitors of lta4h (leukotriene a4 hydrolase) for treating inflammation
US8115005B2 (en)	2006-08-04	2012-02-14	Decode Genetics Ehf.	Pyrazolylphenyl and pyrrolylphenyl inhibitors of LTA4H for treating inflammation
US7728032B2 (en) *	2006-08-04	2010-06-01	Decode Genetics Ehf	Phenoxymethylalkyne inhibitors of LTA4H for treating inflammation
JP5518478B2 (ja)	2006-10-12	2014-06-11	アステックス、セラピューティックス、リミテッド	医薬化合物
GB0620259D0 (en)	2006-10-12	2006-11-22	Astex Therapeutics Ltd	Pharmaceutical compounds
EP2073802A1 (en)	2006-10-12	2009-07-01	Astex Therapeutics Limited	Pharmaceutical combinations
WO2008044041A1 (en)	2006-10-12	2008-04-17	Astex Therapeutics Limited	Pharmaceutical combinations
EP2073807A1 (en)	2006-10-12	2009-07-01	Astex Therapeutics Limited	Pharmaceutical combinations
TW200906396A (en) *	2007-02-14	2009-02-16	Janssen Pharmaceutica Nv	LTA4H modulators and uses thereof
JP2010520878A (ja) *	2007-03-08	2010-06-17	アイアールエム・リミテッド・ライアビリティ・カンパニー	Ｇｐｒ１１９活性の調節剤としての化合物および組成物
US20100100012A1 (en) *	2007-03-30	2010-04-22	Yoshihiro Matsumura	Activity intensity measurement device
AR069126A1 (es) *	2007-10-31	2009-12-30	Janssen Pharmaceutica Nv	Diaminas en puente o fusionadas sustituidas con arilo como moduladores de leucotrieno a4 hidrolasa
CA2705294C (en) *	2007-11-16	2016-05-17	Abbott Laboratories	Methods of treating arthritis by the administration of substituted benzenesulfonamides
GB0806527D0 (en)	2008-04-11	2008-05-14	Astex Therapeutics Ltd	Pharmaceutical compounds
MY157597A (en)	2008-04-11	2016-06-30	Janssen Pharmaceutica Nv	Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene a4 hydrolase
PT2294066E (pt)	2008-04-28	2014-11-21	Janssen Pharmaceutica Nv	Benzoimidazoles como inibidores da prolil-hidroxilase
US8399465B2 (en) *	2009-05-14	2013-03-19	Janssen Pharmaceutica Nv	Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene A4 hydrolase
CN102442961A (zh) *	2010-11-10	2012-05-09	江苏德峰药业有限公司	1-甲基四氮唑的生产方法
CN102442962A (zh) *	2010-11-10	2012-05-09	江苏德峰药业有限公司	1-烷基四氮唑的生产方法
WO2013063221A1 (en)	2011-10-25	2013-05-02	Janssen Pharmaceutica Nv	Meglumine salt formulations of 1-(5,6-dichloro-1h-benzo[d]imidazol-2-yl)-1h-pyrazole-4-carboxylic acid
AU2014249168B2 (en)	2013-03-12	2018-07-12	Celltaxis, Llc	Methods of inhibiting leukotriene A4 hydrolase
BR112015022864A8 (pt)	2013-03-14	2019-11-26	Celtaxsys Inc	composto, composição farmacêutica e uso dos mesmos
CA2906035A1 (en)	2013-03-14	2014-09-25	Celtaxsys, Inc.	Inhibitors of leukotriene a4 hydrolase
WO2014152536A2 (en)	2013-03-14	2014-09-25	Celtaxsys, Inc.	Inhibitors of leukotriene a4 hydrolase
ME02896B (me) *	2013-12-17	2018-04-20	Lilly Co Eli	Fenoksietilni derivati prstenastog amina i njihova aktivnost kao modulatora receptora ep4
US10752588B2 (en)	2014-12-19	2020-08-25	The Broad Institute, Inc.	Dopamine D2 receptor ligands
WO2016100940A1 (en)	2014-12-19	2016-06-23	The Broad Institute, Inc.	Dopamine d2 receptor ligands
JP6549735B2 (ja)	2015-06-09	2019-07-24	アッヴィ・インコーポレイテッド	核内受容体調節剤
JP6931058B2 (ja)	2016-12-21	2021-09-01	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	抗体のインビトロ糖鎖工学における酵素の再使用
CN117887794A (zh)	2016-12-21	2024-04-16	豪夫迈·罗氏有限公司	用于体外糖工程化抗体的方法
CN107663192B (zh) *	2017-11-03	2019-05-10	梯尔希（南京）药物研发有限公司	一种雷贝拉唑杂质的制备方法
ES3014615T3 (en)	2018-05-31	2025-04-23	Celltaxis Llc	Method of reducing pulmonary exacerbations in respiratory disease patients
US20210393621A1 (en)	2018-10-26	2021-12-23	The Research Foundation For The State University Of New York	Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
CN113784713A (zh) *	2019-01-11	2021-12-10	纳吉斯制药股份有限公司	白三烯合成抑制剂
CN110026557B (zh) *	2019-05-28	2021-08-27	南方科技大学	一种混合固体颗粒重熔的直写装置及成型方法
BR112023009665A2 (pt) *	2020-11-19	2023-12-12	Telo Therapeutics Inc	Compostos e composições de molécula pequena
US11932630B2 (en) *	2021-04-16	2024-03-19	Novartis Ag	Heteroaryl aminopropanol derivatives
CN113683491A (zh) *	2021-09-01	2021-11-23	王传良	一种4-(2-溴乙基)苯酚的制备方法
CN113735798B (zh) *	2021-09-27	2022-07-12	安徽美致诚药业有限公司	一种盐酸罗沙替丁醋酸酯的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4873346A (en) *	1985-09-20	1989-10-10	The Upjohn Company	Substituted benzothiazoles, benzimidazoles, and benzoxazoles
CA1319144C (en) *	1986-11-14	1993-06-15	Quirico Branca	Tetrahydronaphthalene derivatives
IL90337A0 (en) *	1988-05-24	1989-12-15	Pfizer	Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents
IT1240598B (it) *	1990-03-13	1993-12-17	Mini Ricerca Scient Tecnolog	Derivati amminici ad azione antifungina
US5585492A (en) *	1994-10-11	1996-12-17	G. D. Searle & Co.	LTA4 Hydrolase inhibitors
US5889006A (en) *	1995-02-23	1999-03-30	Schering Corporation	Muscarinic antagonists
IL117149A0 (en) *	1995-02-23	1996-06-18	Schering Corp	Muscarinic antagonists
US5925654A (en) *	1997-03-12	1999-07-20	G.D. Searle & Co.	LTA4 , hydrolase inhibitors
HUP0100156A3 (en) *	1998-02-25	2002-12-28	Genetics Inst Inc Cambridge	Indole derivatives as inhibitors of phospholipase a2 and use of them for producing pharmaceutical compositions
US6514964B1 (en) *	1999-09-27	2003-02-04	Amgen Inc.	Fused cycloheptane and fused azacycloheptane compounds and their methods of use
US20040110757A1 (en) *	2002-03-21	2004-06-10	Thomas Arrhenius	Flt-1 ligands and their uses in the treatment of diseases regulatable by angiogenesis
ATE403654T1 (de) *	2003-07-28	2008-08-15	Janssen Pharmaceutica Nv	Benzimidazol-, benzothiazol- und benzoxazolderivate und deren verwendung als lta4h-modulatoren
US7541466B2 (en) *	2003-12-23	2009-06-02	Genzyme Corporation	Tetrahydroisoquinoline derivatives for treating protein trafficking diseases
EP1863476B1 (en) *	2005-03-16	2016-02-03	MEDA Pharma GmbH & Co. KG	The combination of anticholinergics and leukotriene receptor antagonists for the treatment of respiratory diseases
TW200906396A (en) *	2007-02-14	2009-02-16	Janssen Pharmaceutica Nv	LTA4H modulators and uses thereof

2004
- 2004-07-27 AT AT04779219T patent/ATE403654T1/de not_active IP Right Cessation
- 2004-07-27 RU RU2006102508/04A patent/RU2359970C2/ru not_active IP Right Cessation
- 2004-07-27 CN CNA2004800279067A patent/CN1856490A/zh active Pending
- 2004-07-27 EP EP04779219A patent/EP1660491B1/en not_active Expired - Lifetime
- 2004-07-27 WO PCT/US2004/024050 patent/WO2005012296A1/en not_active Ceased
- 2004-07-27 UA UAA200601433A patent/UA87986C2/uk unknown
- 2004-07-27 JP JP2006522022A patent/JP4726238B2/ja not_active Expired - Fee Related
- 2004-07-27 AU AU2004261610A patent/AU2004261610B2/en not_active Ceased
- 2004-07-27 UA UAA200601432A patent/UA82888C2/uk unknown
- 2004-07-27 PT PT04779375T patent/PT1660492E/pt unknown
- 2004-07-27 DK DK04779219T patent/DK1660491T3/da active
- 2004-07-27 BR BRPI0413072-3A patent/BRPI0413072A/pt not_active IP Right Cessation
- 2004-07-27 JP JP2006521973A patent/JP2007500703A/ja active Pending
- 2004-07-27 AT AT04779375T patent/ATE405562T1/de active
- 2004-07-27 SI SI200430927T patent/SI1660492T1/sl unknown
- 2004-07-27 SG SG200700691A patent/SG129449A1/en unknown
- 2004-07-27 BR BRPI0412345-0A patent/BRPI0412345A/pt not_active IP Right Cessation
- 2004-07-27 RU RU2006102510/04A patent/RU2373204C2/ru not_active IP Right Cessation
- 2004-07-27 DK DK04779375T patent/DK1660492T3/da active
- 2004-07-27 HR HR20060039A patent/HRP20060039A2/xx not_active Application Discontinuation
- 2004-07-27 US US10/900,152 patent/US20050043379A1/en not_active Abandoned
- 2004-07-27 PT PT04779219T patent/PT1660491E/pt unknown
- 2004-07-27 ES ES04779219T patent/ES2311858T3/es not_active Expired - Lifetime
- 2004-07-27 SG SG200700817-0A patent/SG130192A1/en unknown
- 2004-07-27 SI SI200430904T patent/SI1660491T1/sl unknown
- 2004-07-27 PL PL04779219T patent/PL1660491T3/pl unknown
- 2004-07-27 PL PL04779375T patent/PL1660492T3/pl unknown
- 2004-07-27 ES ES04779375T patent/ES2313079T3/es not_active Expired - Lifetime
- 2004-07-27 EP EP04779375A patent/EP1660492B1/en not_active Expired - Lifetime
- 2004-07-27 KR KR1020067002194A patent/KR101149379B1/ko not_active Expired - Fee Related
- 2004-07-27 DE DE602004015620T patent/DE602004015620D1/de not_active Expired - Lifetime
- 2004-07-27 CA CA002534212A patent/CA2534212A1/en not_active Abandoned
- 2004-07-27 WO PCT/US2004/024309 patent/WO2005012297A1/en not_active Ceased
- 2004-07-27 NZ NZ544938A patent/NZ544938A/en unknown
- 2004-07-27 NZ NZ544970A patent/NZ544970A/en unknown
- 2004-07-27 DE DE602004016002T patent/DE602004016002D1/de not_active Expired - Lifetime
- 2004-07-27 AU AU2004261628A patent/AU2004261628B2/en not_active Ceased
- 2004-07-27 US US10/900,103 patent/US20050043378A1/en not_active Abandoned
- 2004-07-27 HR HRP20060041AA patent/HRP20060041B1/hr not_active IP Right Cessation
- 2004-07-27 CA CA002534228A patent/CA2534228A1/en not_active Abandoned
- 2004-07-27 KR KR1020067002211A patent/KR20060054408A/ko not_active Ceased
- 2004-07-27 CN CN200480028138A patent/CN100591679C/zh not_active Expired - Fee Related
- 2004-07-28 TW TW093122570A patent/TWI362383B/zh not_active IP Right Cessation
- 2004-07-28 AR ARP040102682A patent/AR045729A1/es unknown
- 2004-07-28 AR ARP040102683A patent/AR045730A1/es not_active Application Discontinuation
- 2004-07-28 TW TW093122566A patent/TW200520756A/zh unknown
- 2004-07-28 MY MYPI20043045A patent/MY145080A/en unknown
2006
- 2006-01-26 IL IL173372A patent/IL173372A/en not_active IP Right Cessation
- 2006-02-17 NO NO20060771A patent/NO20060771L/no not_active Application Discontinuation
- 2006-02-20 NO NO20060823A patent/NO20060823L/no not_active Application Discontinuation
- 2006-02-27 ZA ZA200601720A patent/ZA200601720B/en unknown
- 2006-02-27 ZA ZA200601716A patent/ZA200601716B/en unknown
2008
- 2008-10-27 CY CY20081101220T patent/CY1108560T1/el unknown

Also Published As

Publication number	Publication date
SG129449A1 (en)	2007-02-26
CN100591679C (zh)	2010-02-24
ZA200601716B (en)	2007-05-30
ES2313079T3 (es)	2009-03-01
NO20060771L (no)	2006-04-21
CN1856490A (zh)	2006-11-01
ATE403654T1 (de)	2008-08-15
UA87986C2 (uk)	2009-09-10
US20050043379A1 (en)	2005-02-24
RU2373204C2 (ru)	2009-11-20
CY1108560T1 (el)	2014-04-09
JP4726238B2 (ja)	2011-07-20
DK1660492T3 (da)	2008-11-03
ATE405562T1 (de)	2008-09-15
KR20060054408A (ko)	2006-05-22
JP2007500703A (ja)	2007-01-18
PL1660491T3 (pl)	2009-01-30
DE602004015620D1 (de)	2008-09-18
RU2359970C2 (ru)	2009-06-27
SI1660491T1 (sl)	2009-02-28
DE602004016002D1 (de)	2008-10-02
WO2005012297A9 (en)	2007-01-04
CN1860117A (zh)	2006-11-08
PT1660491E (pt)	2008-10-10
NZ544938A (en)	2009-05-31
RU2006102508A (ru)	2006-07-27
AR045729A1 (es)	2005-11-09
CA2534212A1 (en)	2005-02-10
WO2005012297A1 (en)	2005-02-10
EP1660492B1 (en)	2008-08-20
CA2534228A1 (en)	2005-02-10
KR20060057593A (ko)	2006-05-26
MY145080A (en)	2011-12-15
HRP20060041A2 (en)	2006-11-30
JP2007500706A (ja)	2007-01-18
EP1660491A1 (en)	2006-05-31
NZ544970A (en)	2009-02-28
SG130192A1 (en)	2007-03-20
EP1660491B1 (en)	2008-08-06
HK1092790A1 (en)	2007-02-16
AR045730A1 (es)	2005-11-09
IL173372A0 (en)	2006-06-11
RU2006102510A (ru)	2006-07-27
KR101149379B1 (ko)	2012-06-28
PL1660492T3 (pl)	2009-01-30
NO20060823L (no)	2006-03-15
UA82888C2 (en)	2008-05-26
AU2004261628A1 (en)	2005-02-10
ZA200601720B (en)	2007-11-28
TW200523255A (en)	2005-07-16
HK1090359A1 (en)	2006-12-22
HRP20060039A2 (en)	2006-08-31
ES2311858T3 (es)	2009-02-16
US20050043378A1 (en)	2005-02-24
EP1660492A1 (en)	2006-05-31
BRPI0413072A (pt)	2006-10-03
IL173372A (en)	2010-11-30
TW200520756A (en)	2005-07-01
AU2004261610B2 (en)	2010-05-20
AU2004261628B2 (en)	2011-05-12
BRPI0412345A (pt)	2006-10-03
PT1660492E (pt)	2008-11-13
WO2005012296A1 (en)	2005-02-10
HRP20060041B1 (hr)	2014-06-06
AU2004261610A1 (en)	2005-02-10
TWI362383B (en)	2012-04-21
SI1660492T1 (sl)	2009-02-28

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DE602006010546D1 (de)	2009-12-31	N-(pyridin-2-yl)sulfonamidderivate
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DK1500654T3 (da)	2006-06-06	Benzoxazinonderivater, fremstilling deraf og anvendelse deraf som lægemidler
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