DK166806B1 - Anvendelse af plantepollenekstrakter til fremstilling af farmaceutiske, tumorcellevaeksthaemmende praeparater - Google Patents
Anvendelse af plantepollenekstrakter til fremstilling af farmaceutiske, tumorcellevaeksthaemmende praeparater Download PDFInfo
- Publication number
- DK166806B1 DK166806B1 DK445686A DK445686A DK166806B1 DK 166806 B1 DK166806 B1 DK 166806B1 DK 445686 A DK445686 A DK 445686A DK 445686 A DK445686 A DK 445686A DK 166806 B1 DK166806 B1 DK 166806B1
- Authority
- DK
- Denmark
- Prior art keywords
- pollen
- cells
- amino acids
- peptides
- extracts
- Prior art date
Links
- 239000000284 extract Substances 0.000 title claims abstract description 83
- 238000002360 preparation method Methods 0.000 title claims description 18
- 230000004565 tumor cell growth Effects 0.000 title description 2
- 210000004027 cell Anatomy 0.000 claims abstract description 94
- 150000001413 amino acids Chemical class 0.000 claims abstract description 29
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 27
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 24
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 21
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 20
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 20
- 239000000126 substance Substances 0.000 claims abstract description 20
- 208000032839 leukemia Diseases 0.000 claims abstract description 19
- 201000011510 cancer Diseases 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 241000282414 Homo sapiens Species 0.000 claims abstract description 15
- 210000004881 tumor cell Anatomy 0.000 claims abstract description 13
- 230000004060 metabolic process Effects 0.000 claims abstract description 11
- 230000012010 growth Effects 0.000 claims abstract description 10
- 235000013343 vitamin Nutrition 0.000 claims abstract description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 20
- 239000000047 product Substances 0.000 claims description 18
- 238000004113 cell culture Methods 0.000 claims description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 11
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 9
- 230000004614 tumor growth Effects 0.000 claims description 9
- 239000013543 active substance Substances 0.000 claims description 8
- 239000003960 organic solvent Substances 0.000 claims description 7
- 239000002244 precipitate Substances 0.000 claims description 7
- 239000012736 aqueous medium Substances 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- 206010060862 Prostate cancer Diseases 0.000 claims description 5
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 5
- 244000005700 microbiome Species 0.000 claims description 5
- 239000005711 Benzoic acid Substances 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 235000010233 benzoic acid Nutrition 0.000 claims description 4
- 230000004936 stimulating effect Effects 0.000 claims description 4
- 208000024313 Testicular Neoplasms Diseases 0.000 claims description 3
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- 150000002576 ketones Chemical class 0.000 claims description 3
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- 239000011782 vitamin Substances 0.000 claims description 3
- 229930003231 vitamin Natural products 0.000 claims description 3
- 229940088594 vitamin Drugs 0.000 claims description 3
- 206010005003 Bladder cancer Diseases 0.000 claims description 2
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 206010023825 Laryngeal cancer Diseases 0.000 claims description 2
- 229920005654 Sephadex Polymers 0.000 claims description 2
- 239000012507 Sephadex™ Substances 0.000 claims description 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 2
- 230000005907 cancer growth Effects 0.000 claims description 2
- 206010023841 laryngeal neoplasm Diseases 0.000 claims description 2
- 201000007270 liver cancer Diseases 0.000 claims description 2
- 208000014018 liver neoplasm Diseases 0.000 claims description 2
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 claims description 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 2
- 239000004215 Carbon black (E152) Substances 0.000 claims 1
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- 238000001704 evaporation Methods 0.000 claims 1
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- 229930195733 hydrocarbon Natural products 0.000 claims 1
- 150000002430 hydrocarbons Chemical class 0.000 claims 1
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- 150000001720 carbohydrates Chemical class 0.000 abstract description 4
- 235000014633 carbohydrates Nutrition 0.000 abstract description 4
- 239000000470 constituent Substances 0.000 abstract description 4
- 238000000605 extraction Methods 0.000 abstract description 3
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- 238000004519 manufacturing process Methods 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000009036 growth inhibition Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 235000007238 Secale cereale Nutrition 0.000 description 2
- 230000002009 allergenic effect Effects 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 239000006286 aqueous extract Substances 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000002512 chemotherapy Methods 0.000 description 2
- 239000000824 cytostatic agent Substances 0.000 description 2
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- 238000001914 filtration Methods 0.000 description 2
- 238000001502 gel electrophoresis Methods 0.000 description 2
- 230000009422 growth inhibiting effect Effects 0.000 description 2
- 230000002147 killing effect Effects 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 210000002332 leydig cell Anatomy 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 210000005267 prostate cell Anatomy 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 240000000724 Berberis vulgaris Species 0.000 description 1
- 235000016068 Berberis vulgaris Nutrition 0.000 description 1
- 208000010392 Bone Fractures Diseases 0.000 description 1
- IVOMOUWHDPKRLL-KQYNXXCUSA-N Cyclic adenosine monophosphate Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-KQYNXXCUSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- 241001117491 Mucor brunneogriseus Species 0.000 description 1
- 241001169397 Mucor corticola Species 0.000 description 1
- 241000114093 Mucor flavus Species 0.000 description 1
- 241000907556 Mucor hiemalis Species 0.000 description 1
- 241000025769 Mucor luteus Species 0.000 description 1
- 241001149951 Mucor mucedo Species 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000209056 Secale Species 0.000 description 1
- 244000082988 Secale cereale Species 0.000 description 1
- GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 1
- 229930003537 Vitamin B3 Natural products 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 230000000973 chemotherapeutic effect Effects 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 230000001085 cytostatic effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 125000003563 glycoside group Chemical group 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 201000004962 larynx cancer Diseases 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000011278 mitosis Effects 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 230000017095 negative regulation of cell growth Effects 0.000 description 1
- 230000017066 negative regulation of growth Effects 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 1
- 239000000813 peptide hormone Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 208000017497 prostate disease Diseases 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019160 vitamin B3 Nutrition 0.000 description 1
- 239000011708 vitamin B3 Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH408985 | 1985-09-20 | ||
| CH408985 | 1985-09-20 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK445686D0 DK445686D0 (da) | 1986-09-17 |
| DK445686A DK445686A (da) | 1987-03-21 |
| DK166806B1 true DK166806B1 (da) | 1993-07-19 |
Family
ID=4269616
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK445686A DK166806B1 (da) | 1985-09-20 | 1986-09-17 | Anvendelse af plantepollenekstrakter til fremstilling af farmaceutiske, tumorcellevaeksthaemmende praeparater |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4952399A (fr) |
| EP (1) | EP0220453B1 (fr) |
| AT (1) | ATE74761T1 (fr) |
| DE (1) | DE3684868D1 (fr) |
| DK (1) | DK166806B1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030148933A1 (en) * | 1990-10-01 | 2003-08-07 | Pharma Mar S.A. | Derivatives of dehydrodidemnin B |
| EP0757055B1 (fr) * | 1995-06-30 | 1999-10-27 | Cerbios-Pharma S.A. | Glycosides, produits de dégradation exempt de sucre, et dérivés de tels produits |
| US6440448B1 (en) | 1998-03-16 | 2002-08-27 | Joseph Intelisano | Food supplement/herbal composition for health enhancement |
| CN1423564A (zh) * | 1999-11-15 | 2003-06-11 | 法马马有限公司 | 癌症的aplidine治疗 |
| WO2004080421A2 (fr) * | 2003-03-12 | 2004-09-23 | Pharma Mar, S.A. | Traitement antitumoraux ameliores |
| FR2881649B1 (fr) * | 2005-02-10 | 2007-04-06 | Du Sert Patrice Percie | Procede d'extraction de pollen frais, extrait lipidique obtenu et applications associees |
| WO2006136871A1 (fr) * | 2005-06-21 | 2006-12-28 | Codex V S.R.L. | Utilisation d'extraits de pollen pour traiter des infections, des neoplasmes et pour equilibrer la reponse immunitaire |
| CN101389347B (zh) * | 2006-02-28 | 2013-03-27 | 法马马有限公司 | 提高的抗肿瘤治疗 |
| AU2008313627A1 (en) * | 2007-10-19 | 2009-04-23 | Pharma Mar, S.A. | Improved antitumoral treatments |
| US20110009335A1 (en) * | 2008-03-07 | 2011-01-13 | Pharma Mar, S.A. | Anticancer Treatments |
| HRP20231233T1 (hr) | 2017-04-27 | 2024-01-19 | Pharma Mar, S.A. | Antitumorski spojevi |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1025574B (de) * | 1955-02-10 | 1958-03-06 | Jean D Albret S A R L Soc | Verfahren zur Herstellung von Koerperpflegemitteln, insbesondere Hautpflegemitteln |
| SE307063B (fr) * | 1963-07-30 | 1968-12-16 | Cernelle Ab | |
| FR1575114A (fr) * | 1968-07-24 | 1969-07-18 | ||
| FR2142194A5 (en) * | 1971-06-16 | 1973-01-26 | Socibre | Allergen-free pollen extracts - stabilized by freeze-drying |
| CH663900A5 (de) * | 1985-05-06 | 1988-01-29 | Cernitin Sa | Pharmazeutisches praeparat zur prophylaktischen behandlung von allergien und verfahren zur herstellung dieses praeparates. |
-
1986
- 1986-09-13 AT AT86112691T patent/ATE74761T1/de not_active IP Right Cessation
- 1986-09-13 DE DE8686112691T patent/DE3684868D1/de not_active Expired - Fee Related
- 1986-09-13 EP EP86112691A patent/EP0220453B1/fr not_active Expired - Lifetime
- 1986-09-17 DK DK445686A patent/DK166806B1/da not_active IP Right Cessation
-
1989
- 1989-07-20 US US07/384,054 patent/US4952399A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US4952399A (en) | 1990-08-28 |
| EP0220453A3 (en) | 1988-03-23 |
| DE3684868D1 (de) | 1992-05-21 |
| ATE74761T1 (de) | 1992-05-15 |
| DK445686A (da) | 1987-03-21 |
| EP0220453B1 (fr) | 1992-04-15 |
| EP0220453A2 (fr) | 1987-05-06 |
| DK445686D0 (da) | 1986-09-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHS | Application shelved for other reasons than non-payment | ||
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |