DK16682A - Fremgangsmaade til fremstilling af humaninsulin eller dets derivater - Google Patents

Fremgangsmaade til fremstilling af humaninsulin eller dets derivater Download PDF

Info

Publication number: DK16682A
Authority: DK; Denmark
Prior art keywords: human insulin; derivatives; procedure; manufacture; insulin
Prior art date: 1981-01-17

Application number

DK16682A

Other languages

English (en)

Other versions

DK149615B (da

Inventor

R Obermeier

J Ludwig

G Seipke

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-01-17

Filing date

1982-01-15

Publication date

1982-07-18

1982-01-15 Application filed by Hoechst Ag filed Critical Hoechst Ag

1982-07-18 Publication of DK16682A publication Critical patent/DK16682A/da

1986-08-11 Publication of DK149615B publication Critical patent/DK149615B/da

Links

PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 title abstract 3
101000976075 Homo sapiens Insulin Proteins 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 3
101000993800 Sus scrofa Insulin Proteins 0.000 abstract 2
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
239000004473 Threonine Substances 0.000 abstract 1
102000004142 Trypsin Human genes 0.000 abstract 1
108090000631 Trypsin Proteins 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1
-1 threonine ester Chemical class 0.000 abstract 1
239000012588 trypsin Substances 0.000 abstract 1
230000001810 trypsinlike Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Diabetes (AREA)
Toxicology (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK16682A 1981-01-17 1982-01-15 Fremgangsmaade til fremstilling af humaninsulin, hvori pheb1 eventuelt er fraspaltet, og som eventuelt baerer beskyttelsesgrupper DK149615B (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3101382		1981-01-17
DE19813101382 DE3101382A1 (de)	1981-01-17	1981-01-17	"verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten"

Publications (2)

Publication Number	Publication Date
DK16682A true DK16682A (da)	1982-07-18
DK149615B DK149615B (da)	1986-08-11

Family

ID=6122819

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK16682A DK149615B (da)	1981-01-17	1982-01-15	Fremgangsmaade til fremstilling af humaninsulin, hvori pheb1 eventuelt er fraspaltet, og som eventuelt baerer beskyttelsesgrupper

Country Status (14)

Country	Link
US (1)	US4601852A (da)
EP (1)	EP0056951B1 (da)
JP (1)	JPS57138396A (da)
KR (1)	KR880001107B1 (da)
AT (1)	ATE13893T1 (da)
AU (1)	AU559235B2 (da)
CA (1)	CA1190496A (da)
DE (2)	DE3101382A1 (da)
DK (1)	DK149615B (da)
ES (1)	ES508657A0 (da)
FI (1)	FI79860C (da)
GR (1)	GR74758B (da)
IL (1)	IL64789A (da)
ZA (1)	ZA82261B (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK147437A (en) *	1980-02-11	1900-01-01		Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
EP0088117B1 (en) *	1981-09-15	1986-09-24	Nordisk Insulinlaboratorium	Process for preparing human insulin or b-30 esters thereof
WO1983002772A1 (en) *	1982-02-08	1983-08-18	Robin Ewart Offord	An improved method for preparing human insulin from non-human insulin
DE3209184A1 (de) *	1982-03-13	1983-09-15	Hoechst Ag, 6230 Frankfurt	Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen
EP0092829B1 (en) *	1982-04-23	1990-11-07	Wako Pure Chemical Industries, Ltd.	Process for semi-synthesis of human insulin and alkaline protease for use therein
DE3333640A1 (de) *	1983-09-17	1985-04-25	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DE3334407A1 (de) *	1983-09-23	1985-04-04	Hoechst Ag, 6230 Frankfurt	In position b 30 modifizierte insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
PT93057B (pt) *	1989-02-09	1995-12-29	Lilly Co Eli	Processo para a preparacao de analogos da insulina
DE4028120C2 (de) *	1990-09-05	1996-09-19	Hoechst Ag	Verfahren zur Reinigung von Insulin und/oder Insulinderivaten
US5106510A (en) *	1991-03-08	1992-04-21	Enviroguard, Inc.	Combined filtration and fixation of heavy metals
EP0547544B1 (de) *	1991-12-18	1997-03-12	Hoechst Aktiengesellschaft	Verfahren zur Gewinnung von insulinhaltigen Lösungen
US5534488A (en) *	1993-08-13	1996-07-09	Eli Lilly And Company	Insulin formulation
DE4404168A1 (de) *	1994-02-10	1995-08-17	Hoechst Ag	Hirudinderivate und Verfahren zu deren Herstellung
RU2120299C1 (ru) *	1995-06-08	1998-10-20	Акционерное курганское общество "Синтез"	Способ получения высокоочищенного монокомпонентного инсулина
RU2126690C1 (ru) *	1996-11-06	1999-02-27	Анистратенко Николай Юрьевич	Способ очистки инсулина-сырца, получаемого из поджелудочной железы свиней
JP2001521004A (ja)	1997-10-24	2001-11-06	イーライ・リリー・アンド・カンパニー	脂肪酸−アシル化インスリン類似体
CO4970787A1 (es) *	1997-12-23	2000-11-07	Lilly Co Eli	Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea
UA46668C2 (en) *	2001-12-29	2006-01-16	Omakooe Ltd Liability Company	Method for preparing combined dosage form of human insulin
UA46667C2 (en) *	2001-12-29	2006-01-16	Omakooe Ltd Liability Company	Method for preparing semisynthetic human insulin
UA46666C2 (en) *	2001-12-29	2006-01-16	Omakooe Ltd Liability Company	Method for preparing dosage form of short-term acting insulin
UA46669C2 (uk) *	2001-12-29	2005-12-15	Товариство З Обмеженою Відповідальністю "Мако"	Спосіб приготування готової лікарської форми інсуліну пролонгованої дії
US6964561B2 (en) *	2002-04-23	2005-11-15	V System Composites, Inc.	High-performance infusion system for VARTM fabrication
US20070108646A1 (en) *	2005-11-15	2007-05-17	Louderback Michael J	Method of fabricating a composite structure with details

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3276961A (en) *	1963-04-08	1966-10-04	Squibb & Sons Inc	Process for preparing human insulin
US3903068A (en) *	1972-12-26	1975-09-02	Us Health Education & Welfare	Facile synthesis of human insulin by modification of porcine insulin
DE2460753A1 (de) *	1974-12-21	1976-06-24	Hoechst Ag	Verfahren zur herstellung von humaninsulin
NO153061C (no) *	1979-04-13	1986-01-08	Shionogi & Co	Fremgangsmaate for fremstilling av et b30-threonininsulin
DK147437A (en) *	1980-02-11	1900-01-01		Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
DK319780A (da) *	1980-07-24	1982-01-25	Forenede Bryggerier As	Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner

1981
- 1981-01-17 DE DE19813101382 patent/DE3101382A1/de not_active Withdrawn
1982
- 1982-01-12 ES ES508657A patent/ES508657A0/es active Granted
- 1982-01-14 FI FI820117A patent/FI79860C/fi not_active IP Right Cessation
- 1982-01-14 EP EP82100217A patent/EP0056951B1/de not_active Expired
- 1982-01-14 AT AT82100217T patent/ATE13893T1/de active
- 1982-01-14 JP JP57003544A patent/JPS57138396A/ja active Granted
- 1982-01-14 DE DE8282100217T patent/DE3264149D1/de not_active Expired
- 1982-01-15 AU AU79554/82A patent/AU559235B2/en not_active Expired
- 1982-01-15 CA CA000394297A patent/CA1190496A/en not_active Expired
- 1982-01-15 DK DK16682A patent/DK149615B/da not_active Application Discontinuation
- 1982-01-15 IL IL64789A patent/IL64789A/xx active IP Right Grant
- 1982-01-15 ZA ZA82261A patent/ZA82261B/xx unknown
- 1982-01-15 GR GR67018A patent/GR74758B/el unknown
- 1982-01-18 KR KR8200188A patent/KR880001107B1/ko not_active Expired
1984
- 1984-08-15 US US06/641,357 patent/US4601852A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU559235B2 (en)	1987-03-05
ZA82261B (en)	1982-12-29
DE3101382A1 (de)	1982-09-02
FI820117L (fi)	1982-07-18
US4601852A (en)	1986-07-22
JPS57138396A (en)	1982-08-26
ES8301206A1 (es)	1982-11-16
GR74758B (da)	1984-07-11
EP0056951A1 (de)	1982-08-04
CA1190496A (en)	1985-07-16
FI79860C (fi)	1990-03-12
IL64789A0 (en)	1982-03-31
ATE13893T1 (de)	1985-07-15
AU7955482A (en)	1982-07-29
ES508657A0 (es)	1982-11-16
IL64789A (en)	1985-09-29
DE3264149D1 (en)	1985-07-25
JPH0141317B2 (da)	1989-09-05
FI79860B (fi)	1989-11-30
KR830008995A (ko)	1983-12-16
DK149615B (da)	1986-08-11
KR880001107B1 (ko)	1988-06-29
EP0056951B1 (de)	1985-06-19

Legal Events

Date	Code	Title	Description
1991-06-03	PRF	Application refused

Publication	Publication Date	Title
FI820117L (fi)	1982-07-18	Foerfarande foer framstaellning av humaninsulin eller dess derivat ur svininsulin eller dess derivat
DK496379A (da)	1980-05-26	Fremgangsmaade til fremstilling af threo-3-amino-2-hydroxy-butanoyl-aminoeddikesyrer samt nye mellemprodukter hertil og fremgangsmaade til fremstilling af disse
ATE10609T1 (de)	1984-12-15	Verfahren zur herstellung von zementklinker.
ATE14597T1 (de)	1985-08-15	Verfahren zur enzymatischen herstellung von l-2- amino-4-methylphosphinobuttersaeure.
AT367748B (de)	1982-07-26	Verfahren zur kontinuierlichen herstellung von percarbonsaeuren
IS1276B6 (is)	1987-05-27	Aðferð til samfelldrar framleiðslu á löngum kolefnishlutum
FI830813A0 (fi)	1983-03-10	Foerfarande foer omvandling av pre-proinsulinanaloger till insulin
NO157881C (no)	1988-06-08	Fremgangsmaate for enzymatisk hydrolyse av et proteinmateriale.
ATA424978A (de)	1980-02-15	Verfahren zur herstellung von stabilisierten traegergebundenen proteinen
ATE10610T1 (de)	1984-12-15	Verfahren zur herstellung von zementklinker.
DK127282A (da)	1982-09-24	Fremgangsmaade til fremstilling af chlormethylestere af penicillansyrer
DK428184A (da)	1985-03-10	2-oxocarbonsyrereduktase, fremgangsmaade til fremstilling heraf samt anvendelse heraf til reduktion af 2-oxocarbonsyrer og disses estere
SE9001707D0 (sv)	1990-05-11	Polymert material och foerfarande foer dess framstaellning
DK247279A (da)	1979-12-27	Fremgangsmaade til fremstilling af carbazolderivater
ATE12391T1 (de)	1985-04-15	Verfahren zur herstellung von tetronsaeure.
ATE17348T1 (de)	1986-01-15	Verfahren zur herstellung von 2,4dihydroxypyrimidin (uracil).
ATE27454T1 (de)	1987-06-15	Verfahren zur herstellung von uracil.
DE3673245D1 (de)	1990-09-13	Verfahren zur herstellung von fluor enthaltenden aliphatischen carbonsaeuren.
SU668674A1 (ru)	1979-06-25	Способ пластики ахиллова сухожили при застарелых разрывах
NO161274C (no)	1989-07-26	Fremgangsm te for fremstilling av immuninterferon.
SU811519A1 (ru)	1996-04-10	Способ получения белкового раствора
IS2620A7 (is)	1981-08-07	Aðferð til framleiðslu á sementi
DD138647A1 (de)	1979-11-14	Verfahren zur herstellung von zementklinker
IS2399A7 (is)	1977-10-05	Aðferð til framleiðslu á þennslusementi