DK167618B1 - Dispersionspolymere, fremgangsmaade til deres fremstilling og deres anvendelse - Google Patents

Dispersionspolymere, fremgangsmaade til deres fremstilling og deres anvendelse Download PDF

Info

Publication number: DK167618B1
Authority: DK; Denmark
Prior art keywords: formula; dispersion; dispersion polymers; monomer mixture; latex
Prior art date: 1985-12-21

Application number

DK618786A

Other languages

Danish (da)

English (en)

Other versions

DK618786D0 (da

DK618786A (da

Inventor

Wolfgang Kapmeyer

Helmut Rinno

Original Assignee

Behringwerke Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-12-21

Filing date

1986-12-19

Publication date

1993-11-29

1986-12-19 Application filed by Behringwerke Ag filed Critical Behringwerke Ag

1986-12-19 Publication of DK618786D0 publication Critical patent/DK618786D0/da

1987-06-22 Publication of DK618786A publication Critical patent/DK618786A/da

1993-11-29 Application granted granted Critical

1993-11-29 Publication of DK167618B1 publication Critical patent/DK167618B1/da

Links

239000006185 dispersion Substances 0.000 title claims abstract description 45
229920000642 polymer Polymers 0.000 title claims abstract description 30
238000000034 method Methods 0.000 title claims description 20
238000002360 preparation method Methods 0.000 title description 5
239000004816 latex Substances 0.000 claims abstract description 40
229920000126 latex Polymers 0.000 claims abstract description 40
239000002245 particle Substances 0.000 claims abstract description 24
150000001875 compounds Chemical class 0.000 claims abstract description 11
239000000427 antigen Substances 0.000 claims abstract description 8
102000036639 antigens Human genes 0.000 claims abstract description 8
108091007433 antigens Proteins 0.000 claims abstract description 8
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 7
229910052760 oxygen Inorganic materials 0.000 claims abstract description 5
229920001577 copolymer Polymers 0.000 claims abstract description 4
239000000178 monomer Substances 0.000 claims description 42
239000000203 mixture Substances 0.000 claims description 40
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 15
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 14
-1 methyl acrylamidoacet-aldehyde-di-n-pentylacetal Chemical compound 0.000 claims description 10
NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 9
239000003995 emulsifying agent Substances 0.000 claims description 9
QEFKKDIOPLIVGU-UHFFFAOYSA-N n-(2,3-dihydroxypropyl)-2-methylprop-2-enamide Chemical compound CC(=C)C(=O)NCC(O)CO QEFKKDIOPLIVGU-UHFFFAOYSA-N 0.000 claims description 9
VHSHLMUCYSAUQU-UHFFFAOYSA-N 2-hydroxypropyl methacrylate Chemical compound CC(O)COC(=O)C(C)=C VHSHLMUCYSAUQU-UHFFFAOYSA-N 0.000 claims description 7
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 6
239000012736 aqueous medium Substances 0.000 claims description 6
238000001514 detection method Methods 0.000 claims description 6
239000004815 dispersion polymer Substances 0.000 claims description 6
OKPYIWASQZGASP-UHFFFAOYSA-N n-(2-hydroxypropyl)-2-methylprop-2-enamide Chemical compound CC(O)CNC(=O)C(C)=C OKPYIWASQZGASP-UHFFFAOYSA-N 0.000 claims description 5
IGGDKDTUCAWDAN-UHFFFAOYSA-N 1-vinylnaphthalene Chemical compound C1=CC=C2C(C=C)=CC=CC2=C1 IGGDKDTUCAWDAN-UHFFFAOYSA-N 0.000 claims description 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
125000004036 acetal group Chemical group 0.000 claims description 4
239000001257 hydrogen Substances 0.000 claims description 4
229910052739 hydrogen Inorganic materials 0.000 claims description 4
HJWLCRVIBGQPNF-UHFFFAOYSA-N prop-2-enylbenzene Chemical compound C=CCC1=CC=CC=C1 HJWLCRVIBGQPNF-UHFFFAOYSA-N 0.000 claims description 4
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 4
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 3
LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical compound C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 claims description 3
239000007858 starting material Substances 0.000 claims description 3
LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 claims description 3
238000004519 manufacturing process Methods 0.000 claims description 2
229940063559 methacrylic acid Drugs 0.000 claims 2
YDMRAGMXJYQYLS-UHFFFAOYSA-N ethyl 4-hydroxy-2-methylidenepentanoate Chemical compound CCOC(=O)C(=C)CC(C)O YDMRAGMXJYQYLS-UHFFFAOYSA-N 0.000 claims 1
IPGRTXQKFZCLJS-UHFFFAOYSA-N n-(2-hydroxypropyl)prop-2-enamide Chemical compound CC(O)CNC(=O)C=C IPGRTXQKFZCLJS-UHFFFAOYSA-N 0.000 claims 1
239000003153 chemical reaction reagent Substances 0.000 description 25
238000005259 measurement Methods 0.000 description 19
238000006116 polymerization reaction Methods 0.000 description 14
238000003756 stirring Methods 0.000 description 12
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
210000002966 serum Anatomy 0.000 description 11
239000004793 Polystyrene Substances 0.000 description 10
229920002223 polystyrene Polymers 0.000 description 10
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 8
239000000872 buffer Substances 0.000 description 8
239000000243 solution Substances 0.000 description 8
239000012153 distilled water Substances 0.000 description 7
239000007787 solid Substances 0.000 description 7
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 6
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 6
239000007789 gas Substances 0.000 description 6
235000019333 sodium laurylsulphate Nutrition 0.000 description 6
239000000725 suspension Substances 0.000 description 6
239000003999 initiator Substances 0.000 description 5
239000011541 reaction mixture Substances 0.000 description 5
230000035945 sensitivity Effects 0.000 description 5
102000004190 Enzymes Human genes 0.000 description 4
108090000790 Enzymes Proteins 0.000 description 4
150000001241 acetals Chemical group 0.000 description 4
229910052783 alkali metal Inorganic materials 0.000 description 4
150000001340 alkali metals Chemical class 0.000 description 4
125000000217 alkyl group Chemical group 0.000 description 4
125000004432 carbon atom Chemical group C* 0.000 description 4
238000001816 cooling Methods 0.000 description 4
VFNGKCDDZUSWLR-UHFFFAOYSA-L disulfate(2-) Chemical compound [O-]S(=O)(=O)OS([O-])(=O)=O VFNGKCDDZUSWLR-UHFFFAOYSA-L 0.000 description 4
239000000706 filtrate Substances 0.000 description 4
125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
238000003018 immunoassay Methods 0.000 description 4
125000005395 methacrylic acid group Chemical group 0.000 description 4
WOBOFYREQGFNFY-UHFFFAOYSA-N n-(2,2-dipentoxyethyl)-2-methylprop-2-enamide Chemical compound CCCCCOC(CNC(=O)C(C)=C)OCCCCC WOBOFYREQGFNFY-UHFFFAOYSA-N 0.000 description 4
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 4
XXQBEVHPUKOQEO-UHFFFAOYSA-N potassium superoxide Chemical compound [K+].[K+].[O-][O-] XXQBEVHPUKOQEO-UHFFFAOYSA-N 0.000 description 4
102000004169 proteins and genes Human genes 0.000 description 4
108090000623 proteins and genes Proteins 0.000 description 4
229910000030 sodium bicarbonate Inorganic materials 0.000 description 4
235000017557 sodium bicarbonate Nutrition 0.000 description 4
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 3
239000004471 Glycine Substances 0.000 description 3
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical group NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 3
229920001213 Polysorbate 20 Polymers 0.000 description 3
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 3
239000002253 acid Substances 0.000 description 3
239000011149 active material Substances 0.000 description 3
150000003863 ammonium salts Chemical class 0.000 description 3
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
239000003795 chemical substances by application Substances 0.000 description 3
230000000694 effects Effects 0.000 description 3
229910052757 nitrogen Inorganic materials 0.000 description 3
239000003921 oil Substances 0.000 description 3
239000001301 oxygen Substances 0.000 description 3
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 3
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 3
150000003254 radicals Chemical class 0.000 description 3
239000011734 sodium Substances 0.000 description 3
239000011780 sodium chloride Substances 0.000 description 3
239000012475 sodium chloride buffer Substances 0.000 description 3
ZFEKVFJKFDZSHE-UHFFFAOYSA-M sodium;2-aminoacetic acid;chloride Chemical compound [Na+].[Cl-].NCC(O)=O ZFEKVFJKFDZSHE-UHFFFAOYSA-M 0.000 description 3
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 3
229920002554 vinyl polymer Polymers 0.000 description 3
NARVIWMVBMUEOG-UHFFFAOYSA-N 2-Hydroxy-propylene Natural products CC(O)=C NARVIWMVBMUEOG-UHFFFAOYSA-N 0.000 description 2
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
108010074051 C-Reactive Protein Proteins 0.000 description 2
102100032752 C-reactive protein Human genes 0.000 description 2
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 2
230000004520 agglutination Effects 0.000 description 2
150000001299 aldehydes Chemical group 0.000 description 2
150000008055 alkyl aryl sulfonates Chemical class 0.000 description 2
125000003277 amino group Chemical group 0.000 description 2
ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 description 2
125000000129 anionic group Chemical group 0.000 description 2
230000008033 biological extinction Effects 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
239000007795 chemical reaction product Substances 0.000 description 2
239000003638 chemical reducing agent Substances 0.000 description 2
239000000084 colloidal system Substances 0.000 description 2
239000003599 detergent Substances 0.000 description 2
238000010790 dilution Methods 0.000 description 2
239000012895 dilution Substances 0.000 description 2
150000002148 esters Chemical class 0.000 description 2
238000001914 filtration Methods 0.000 description 2
239000011521 glass Substances 0.000 description 2
238000010324 immunological assay Methods 0.000 description 2
239000011159 matrix material Substances 0.000 description 2
VHRYZQNGTZXDNX-UHFFFAOYSA-N methacryloyl chloride Chemical compound CC(=C)C(Cl)=O VHRYZQNGTZXDNX-UHFFFAOYSA-N 0.000 description 2
GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
JRKICGRDRMAZLK-UHFFFAOYSA-N peroxydisulfuric acid Chemical compound OS(=O)(=O)OOS(O)(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-N 0.000 description 2
229910000027 potassium carbonate Inorganic materials 0.000 description 2
USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 description 2
235000019394 potassium persulphate Nutrition 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
238000011084 recovery Methods 0.000 description 2
230000000405 serological effect Effects 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
239000002904 solvent Substances 0.000 description 2
238000003860 storage Methods 0.000 description 2
239000000126 substance Substances 0.000 description 2
238000003786 synthesis reaction Methods 0.000 description 2
ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
HXKKHQJGJAFBHI-UHFFFAOYSA-N 1-aminopropan-2-ol Chemical compound CC(O)CN HXKKHQJGJAFBHI-UHFFFAOYSA-N 0.000 description 1
UDFGOCHRCDDTFD-UHFFFAOYSA-N 1-ethenoxyicosane Chemical group CCCCCCCCCCCCCCCCCCCCOC=C UDFGOCHRCDDTFD-UHFFFAOYSA-N 0.000 description 1
MFFHOTWDYMNSLG-UHFFFAOYSA-N 2,3,4-tri(propan-2-yl)phenol Chemical compound CC(C)C1=CC=C(O)C(C(C)C)=C1C(C)C MFFHOTWDYMNSLG-UHFFFAOYSA-N 0.000 description 1
SKDGWNHUETZZCS-UHFFFAOYSA-N 2,3-ditert-butylphenol Chemical compound CC(C)(C)C1=CC=CC(O)=C1C(C)(C)C SKDGWNHUETZZCS-UHFFFAOYSA-N 0.000 description 1
TURPNXCLLLFJAP-UHFFFAOYSA-N 2-[2-(2-hydroxyethoxy)ethoxy]ethyl hydrogen sulfate Chemical compound OCCOCCOCCOS(O)(=O)=O TURPNXCLLLFJAP-UHFFFAOYSA-N 0.000 description 1
QWYXNPUTSOVWEA-UHFFFAOYSA-N 2-octylphenol;sodium Chemical compound [Na].CCCCCCCCC1=CC=CC=C1O QWYXNPUTSOVWEA-UHFFFAOYSA-N 0.000 description 1
KQIGMPWTAHJUMN-UHFFFAOYSA-N 3-aminopropane-1,2-diol Chemical compound NCC(O)CO KQIGMPWTAHJUMN-UHFFFAOYSA-N 0.000 description 1
QOXOZONBQWIKDA-UHFFFAOYSA-N 3-hydroxypropyl Chemical group [CH2]CCO QOXOZONBQWIKDA-UHFFFAOYSA-N 0.000 description 1
HGINCPLSRVDWNT-UHFFFAOYSA-N Acrolein Chemical compound C=CC=O HGINCPLSRVDWNT-UHFFFAOYSA-N 0.000 description 1
NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
108010017384 Blood Proteins Proteins 0.000 description 1
102000004506 Blood Proteins Human genes 0.000 description 1
244000060011 Cocos nucifera Species 0.000 description 1
235000013162 Cocos nucifera Nutrition 0.000 description 1
229920002307 Dextran Polymers 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
239000008118 PEG 6000 Substances 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical class OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 1
239000013543 active substance Substances 0.000 description 1
238000001042 affinity chromatography Methods 0.000 description 1
229910052784 alkaline earth metal Inorganic materials 0.000 description 1
229940045714 alkyl sulfonate alkylating agent Drugs 0.000 description 1
150000008052 alkyl sulfonates Chemical class 0.000 description 1
229910001870 ammonium persulfate Inorganic materials 0.000 description 1
235000019395 ammonium persulphate Nutrition 0.000 description 1
150000008064 anhydrides Chemical class 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
229960005070 ascorbic acid Drugs 0.000 description 1
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238000000502 dialysis Methods 0.000 description 1
MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 1
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
229910000397 disodium phosphate Inorganic materials 0.000 description 1
235000019800 disodium phosphate Nutrition 0.000 description 1
LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
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125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
210000003743 erythrocyte Anatomy 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
238000011049 filling Methods 0.000 description 1
QJQZEJFUIOWFMS-UHFFFAOYSA-N formaldehyde;sulfanediol Chemical class O=C.OSO QJQZEJFUIOWFMS-UHFFFAOYSA-N 0.000 description 1
239000008103 glucose Substances 0.000 description 1
238000010559 graft polymerization reaction Methods 0.000 description 1
150000002430 hydrocarbons Chemical group 0.000 description 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
230000001900 immune effect Effects 0.000 description 1
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239000012535 impurity Substances 0.000 description 1
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238000011068 loading method Methods 0.000 description 1
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GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 1
229940055577 oleyl alcohol Drugs 0.000 description 1
XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
150000002978 peroxides Chemical class 0.000 description 1
NUGJFLYPGQISPX-UHFFFAOYSA-N peroxydiphosphoric acid Chemical compound OP(O)(=O)OOP(O)(O)=O NUGJFLYPGQISPX-UHFFFAOYSA-N 0.000 description 1
150000002989 phenols Chemical class 0.000 description 1
235000021317 phosphate Nutrition 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
229920001748 polybutylene Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920000151 polyglycol Polymers 0.000 description 1
239000010695 polyglycol Substances 0.000 description 1
229920001451 polypropylene glycol Polymers 0.000 description 1
239000011591 potassium Substances 0.000 description 1
OLBCVFGFOZPWHH-UHFFFAOYSA-N propofol Chemical compound CC(C)C1=CC=CC(C(C)C)=C1O OLBCVFGFOZPWHH-UHFFFAOYSA-N 0.000 description 1
239000011535 reaction buffer Substances 0.000 description 1
238000010079 rubber tapping Methods 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
PFUVRDFDKPNGAV-UHFFFAOYSA-N sodium peroxide Chemical compound [Na+].[Na+].[O-][O-] PFUVRDFDKPNGAV-UHFFFAOYSA-N 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical class [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
239000011593 sulfur Substances 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
229910021653 sulphate ion Inorganic materials 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
238000009210 therapy by ultrasound Methods 0.000 description 1
150000004764 thiosulfuric acid derivatives Chemical class 0.000 description 1
230000000007 visual effect Effects 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F257/00—Macromolecular compounds obtained by polymerising monomers on to polymers of aromatic monomers as defined in group C08F12/00
- C08F257/02—Macromolecular compounds obtained by polymerising monomers on to polymers of aromatic monomers as defined in group C08F12/00 on to polymers of styrene or alkyl-substituted styrenes
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F291/00—Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds according to more than one of the groups C08F251/00 - C08F289/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Polymers & Plastics (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Food Science & Technology (AREA)
Biotechnology (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Physics & Mathematics (AREA)
Cell Biology (AREA)
Microbiology (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Processes Of Treating Macromolecular Substances (AREA)
Polymerisation Methods In General (AREA)
Graft Or Block Polymers (AREA)
Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

DK618786A 1985-12-21 1986-12-19 Dispersionspolymere, fremgangsmaade til deres fremstilling og deres anvendelse DK167618B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3545595		1985-12-21
DE19853545595 DE3545595A1 (de)	1985-12-21	1985-12-21	Dispersionspolymere, verfahren zu ihrer herstellung und ihre verwendung

Publications (3)

Publication Number	Publication Date
DK618786D0 DK618786D0 (da)	1986-12-19
DK618786A DK618786A (da)	1987-06-22
DK167618B1 true DK167618B1 (da)	1993-11-29

Family

ID=6289261

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK618786A DK167618B1 (da)	1985-12-21	1986-12-19	Dispersionspolymere, fremgangsmaade til deres fremstilling og deres anvendelse

Country Status (13)

Country	Link
US (1)	US4945146A (fr)
EP (1)	EP0227054B1 (fr)
JP (1)	JPH0713126B2 (fr)
AT (1)	ATE67511T1 (fr)
AU (1)	AU601960B2 (fr)
CA (1)	CA1307983C (fr)
DE (2)	DE3545595A1 (fr)
DK (1)	DK167618B1 (fr)
ES (1)	ES2026130T3 (fr)
FI (1)	FI86196C (fr)
NO (1)	NO168048C (fr)
PT (1)	PT83963B (fr)
YU (1)	YU45808B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3613111A1 (de) *	1986-04-18	1987-10-22	Behringwerke Ag	Dispersionspolymere, verfahren zu ihrer herstellung und ihre verwendung
US5252459A (en) *	1988-09-23	1993-10-12	Abbott Laboratories	Indicator reagents, diagnostic assays and test kits employing organic polymer latex particles
ES2073412T3 (es) *	1988-10-19	1995-08-16	Guest Elchrom Scient Ag	Monomeros hidrofilos, sus polimeros y sus utilizaciones.
DE3844211A1 (de) *	1988-12-29	1990-07-05	Hoechst Ag	Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
US5512429A (en) *	1989-09-19	1996-04-30	British Technology Group Limited	Assay for enzyme activity
DE4026992A1 (de) *	1990-08-25	1992-02-27	Roehm Gmbh	Verfahren zur herstellung von traegersystemen fuer biologisch aktive materialien
DE69119688T2 (de) *	1990-10-10	1997-01-16	Minnesota Mining & Mfg	Pfropfcopolymere und Pfropfcopolymer-/Protein- Zusammensetzungen
GB9105707D0 (en) *	1991-03-18	1991-05-01	Wilton David C	Assay
GB2287707B (en) *	1994-03-25	1998-02-25	Erba Carlo Spa	Intermediates for biologically active products
FR2726279B1 (fr) *	1994-10-28	1997-01-17	Prolabo Sa	Particule de latex ou d'oxyde mineral glucosylee, procede de preparation d'une telle particule et utilisation de celle-ci en tant qu'agent de detection biologique ou de chromatographie d'affinite
ATE395364T1 (de)	1999-12-22	2008-05-15	Dade Behring Marburg Gmbh	Gegen procalcitonin gerichtete antikörper, ihre herstellung und verwendung
DE50014159D1 (de)	1999-12-22	2007-04-26	Dade Behring Marburg Gmbh	Lösungen von humanem Procalcitonin
CA2412994A1 (fr) *	2000-06-30	2002-12-27	Kyowa Medex Co., Ltd.	Reactif de dosage immunologique nephelometrique a particules-supports insolubles
DE10064827A1 (de)	2000-12-22	2002-06-27	Dade Behring Marburg Gmbh	Nachweisverfahren
DE20213920U1 (de)	2002-07-03	2003-01-16	Böhm, Martina, 60439 Frankfurt	Diagnostikum zum Nachweis der den von Willebrand-Faktorspaltenden Aktivität von ADAMTS13
US20050118727A1 (en) *	2003-12-01	2005-06-02	Carsten Schelp	Conjugates and their use in detection methods
WO2005062048A1 (fr)	2003-12-01	2005-07-07	Dade Behring Marburg Gmbh	Procede de detection homogene
DE102005026163A1 (de)	2004-08-24	2006-03-02	Dade Behring Marburg Gmbh	Gegen den Marburg I Polymorphismus der Faktor VII aktivierenden Protease (FSAP) gerichtete Antikörper, ihre Herstellung und Verwendung
DE102005022047A1 (de)	2005-05-09	2006-11-30	Dade Behring Marburg Gmbh	Bindungspartner des Plazentalen Wachstumsfaktors insbesondere gegen den Plazentalen Wachstumsfaktor gerichtete Antikörper, ihre Herstellung und Verwendung
DE102008049601A1 (de)	2008-09-30	2010-04-01	Siemens Healthcare Diagnostics Products Gmbh	Antikörper zur Bestimmung des Prothrombin-Fragments F2/F1+2 in einem homogenen Immunoassay
US20110306148A1 (en) *	2010-06-14	2011-12-15	Siemens Healthcare Diagnostics Inc.	Composition for use as an assay reagent
EP2829878A1 (fr)	2013-07-23	2015-01-28	Siemens Healthcare Diagnostics Products GmbH	Procédé de détermination de la fonction plaquettaire en fonction du récepteur GPIb
JP6649271B2 (ja)	2014-04-18	2020-02-19	ベンズリサーチアンドディベロップメントコーポレーション	コンタクトレンズおよび眼内レンズのための（メタ）アクリルアミドポリマー

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3796773A (en) *	1971-03-19	1974-03-12	Lubrizol Corp	Graft polymers
US4210723A (en) *	1976-07-23	1980-07-01	The Dow Chemical Company	Method of coupling a protein to an epoxylated latex
DE3145082A1 (de) *	1981-11-13	1983-05-19	Behringwerke Ag, 3550 Marburg	"ein latex, biologisch aktive latexkonjugate und verfahren zu ihrer herstellung"
FR2534486B1 (fr) *	1982-10-15	1987-11-20	Commissariat Energie Atomique	Support particulaire greffe en surface, son procede de preparation et adsorbants pour chromatographie d'affinite incorporant ce support, ainsi que leur utilisation, notamment en biologie
DE3613111A1 (de) *	1986-04-18	1987-10-22	Behringwerke Ag	Dispersionspolymere, verfahren zu ihrer herstellung und ihre verwendung
DE3622993A1 (de) *	1986-07-09	1988-01-21	Behringwerke Ag	Dispersionspolymere, biologisch aktive dispersionspolymere, verfahren zu ihrer herstellung und verwendung als diagnostisches mittel

1985
- 1985-12-21 DE DE19853545595 patent/DE3545595A1/de not_active Withdrawn
1986
- 1986-12-08 YU YU209386A patent/YU45808B/sh unknown
- 1986-12-18 EP EP86117694A patent/EP0227054B1/fr not_active Expired - Lifetime
- 1986-12-18 FI FI865184A patent/FI86196C/fi not_active IP Right Cessation
- 1986-12-18 DE DE8686117694T patent/DE3681569D1/de not_active Expired - Lifetime
- 1986-12-18 AT AT86117694T patent/ATE67511T1/de not_active IP Right Cessation
- 1986-12-18 ES ES198686117694T patent/ES2026130T3/es not_active Expired - Lifetime
- 1986-12-18 PT PT83963A patent/PT83963B/pt not_active IP Right Cessation
- 1986-12-19 NO NO865190A patent/NO168048C/no not_active IP Right Cessation
- 1986-12-19 AU AU66761/86A patent/AU601960B2/en not_active Ceased
- 1986-12-19 DK DK618786A patent/DK167618B1/da not_active IP Right Cessation
- 1986-12-19 JP JP61301908A patent/JPH0713126B2/ja not_active Expired - Lifetime
- 1986-12-19 CA CA000525857A patent/CA1307983C/fr not_active Expired - Lifetime
1987
- 1987-11-18 US US07/124,338 patent/US4945146A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE3681569D1 (de)	1991-10-24
FI86196C (fi)	1992-07-27
AU601960B2 (en)	1990-09-27
JPS62169813A (ja)	1987-07-27
EP0227054A3 (en)	1988-04-20
ATE67511T1 (de)	1991-10-15
YU209386A (en)	1988-02-29
CA1307983C (fr)	1992-09-29
DK618786D0 (da)	1986-12-19
FI86196B (fi)	1992-04-15
ES2026130T3 (es)	1992-04-16
US4945146A (en)	1990-07-31
AU6676186A (en)	1987-06-25
DE3545595A1 (de)	1987-06-25
FI865184A0 (fi)	1986-12-18
FI865184A7 (fi)	1987-06-22
NO865190L (no)	1987-06-22
PT83963A (de)	1987-01-01
JPH0713126B2 (ja)	1995-02-15
PT83963B (pt)	1989-07-31
NO865190D0 (no)	1986-12-19
NO168048B (no)	1991-09-30
EP0227054A2 (fr)	1987-07-01
DK618786A (da)	1987-06-22
EP0227054B1 (fr)	1991-09-18
YU45808B (sh)	1992-07-20
NO168048C (no)	1992-01-08

Legal Events

Date	Code	Title	Description
1993-11-29	B1	Patent granted (law 1993)
2007-01-08	PUP	Patent expired

Publication	Publication Date	Title
DK167618B1 (da)	1993-11-29	Dispersionspolymere, fremgangsmaade til deres fremstilling og deres anvendelse
US4480042A (en)	1984-10-30	Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays
FI72127B (fi)	1986-12-31	Ett latex biologiskt aktiv latexkonjugat och ett foerfarande foer deras framstaellning
US4401765A (en)	1983-08-30	Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays
EP0038960B1 (fr)	1985-06-19	Agent de diagnostic pour tests immunologiques et procédé pour sa préparation
JP4733335B2 (ja)	2011-07-27	再現性良好な凝集イムノアッセイ法及び試薬
JPWO2002018953A1 (ja)	2003-10-21	再現性良好な凝集イムノアッセイ法及び試薬
US4921915A (en)	1990-05-01	Dispersion polymers, biologically active dispersion polymers, a process for their preparation, and their use as diagnostic aids
AU608753B2 (en)	1991-04-18	Dispersion polymers, processes for their preparation and their use
EP2833146B1 (fr)	2016-12-14	Particules de latex pour dosage d'agglutination
US5086143A (en)	1992-02-04	Copolymers containing polyoxyalkylene side chains
JPH0318875B2 (fr)	1991-03-13
US9383356B2 (en)	2016-07-05	Latex particles for particle agglutination assay
JPH03502247A (ja)	1991-05-23	高分子粒子への直接結合による単純ヘルペスウイルス抗原の測定方法及びキット
JPS5850646B2 (ja)	1983-11-11	血清学的診断試薬用ラテツクスの製造方法
AU621552B2 (en)	1992-03-19	Dispersion polymers comprised of vinyl monomers having an acetal group, their manufacture and their use as carriers of immunologically active materials
US5183766A (en)	1993-02-02	Dispersion polymers, processes for their preparation and their use
JPH0372261A (ja)	1991-03-27	免疫学的測定法
US5232981A (en)	1993-08-03	Dispersion polymers, a process for the preparation thereof, and the use thereof
JPH0157688B2 (fr)	1989-12-07
HRP940757A2 (en)	1997-06-30	Dispersion polymers, process for their preparation and their use
JPS6116944B2 (fr)	1986-05-02