DK169153B1 - Fremgangsmåde til fremstilling af en bispecifik monoklonal antistof-determinant - Google Patents

Fremgangsmåde til fremstilling af en bispecifik monoklonal antistof-determinant Download PDF

Info

Publication number
DK169153B1
DK169153B1 DK601985A DK601985A DK169153B1 DK 169153 B1 DK169153 B1 DK 169153B1 DK 601985 A DK601985 A DK 601985A DK 601985 A DK601985 A DK 601985A DK 169153 B1 DK169153 B1 DK 169153B1
Authority
DK
Denmark
Prior art keywords
molecules
determinants
antibody
disulfide
thiol
Prior art date
Application number
DK601985A
Other languages
Danish (da)
English (en)
Other versions
DK601985D0 (da
DK601985A (da
Inventor
Henry P Paulus
Original Assignee
Boston Biomed Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Biomed Res Inst filed Critical Boston Biomed Res Inst
Publication of DK601985D0 publication Critical patent/DK601985D0/da
Publication of DK601985A publication Critical patent/DK601985A/da
Application granted granted Critical
Publication of DK169153B1 publication Critical patent/DK169153B1/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK601985A 1984-04-23 1985-12-23 Fremgangsmåde til fremstilling af en bispecifik monoklonal antistof-determinant DK169153B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US60312584A 1984-04-23 1984-04-23
US60312584 1984-04-23
PCT/US1985/000737 WO1985004811A1 (en) 1984-04-23 1985-04-22 Bispecific antibody determinants
US8500737 1985-04-22

Publications (3)

Publication Number Publication Date
DK601985D0 DK601985D0 (da) 1985-12-23
DK601985A DK601985A (da) 1985-12-23
DK169153B1 true DK169153B1 (da) 1994-08-29

Family

ID=24414191

Family Applications (1)

Application Number Title Priority Date Filing Date
DK601985A DK169153B1 (da) 1984-04-23 1985-12-23 Fremgangsmåde til fremstilling af en bispecifik monoklonal antistof-determinant

Country Status (11)

Country Link
EP (1) EP0179872B1 (de)
JP (1) JPH0617909B2 (de)
AT (1) ATE64622T1 (de)
AU (1) AU595159B2 (de)
CA (1) CA1338828C (de)
DE (1) DE3583278D1 (de)
DK (1) DK169153B1 (de)
FI (1) FI85946C (de)
IT (1) IT1183798B (de)
NO (1) NO166383C (de)
WO (1) WO1985004811A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0252951A4 (de) * 1986-01-06 1988-09-07 Univ Melbourne Technetium-antikörper konjugate.
FR2604092B1 (fr) * 1986-09-19 1990-04-13 Immunotech Sa Immunoreactifs destines a cibler les cellules animales pour leur visualisation ou leur destruction in vivo
FR2608445B1 (fr) * 1986-12-19 1989-04-21 Muraour Renaud Embout pour manche de raquette de tennis et autres similaires, et raquette equipee de cet embout
EP0301333A3 (de) * 1987-07-29 1992-07-01 Abbott Laboratories Auf liposomen basierter, homogener Immunoassay für diagnostische Teste
US4971916A (en) * 1987-07-29 1990-11-20 Abbott Laboratories Liposome based homogeneous immunoassay for diagnostic tests
US5086002A (en) * 1987-09-07 1992-02-04 Agen Biomedical, Ltd. Erythrocyte agglutination assay
NZ226202A (en) * 1987-09-17 1992-01-29 Agen Ltd Erythrocyte agglutination assay
FI105320B (fi) * 1988-04-04 2000-07-31 Oncogen Menetelmä vasta-aineheterokonjugaattien valmistamiseksi, joita käytetään imusoluaktiivisuuden säätelyssä ja diagnoosissa
US6010902A (en) * 1988-04-04 2000-01-04 Bristol-Meyers Squibb Company Antibody heteroconjugates and bispecific antibodies for use in regulation of lymphocyte activity
SE8804074D0 (sv) * 1988-11-10 1988-11-10 Pharmacia Ab Sensorenhet och dess anvaendning i biosensorsystem
IT1235349B (it) * 1988-12-23 1992-06-30 Biodata Spa Saggio immunologico per determinazioni in fase omogenea
US5583003A (en) * 1989-09-25 1996-12-10 Agen Limited Agglutination assay
TW212184B (de) * 1990-04-02 1993-09-01 Takeda Pharm Industry Co Ltd
WO2008036802A2 (en) * 2006-09-21 2008-03-27 Prometheus Laboratories Inc. Antibody-based arrays for detecting multiple signal transducers in rare circulating cells

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU531777B2 (en) * 1978-04-05 1983-09-08 Syva Co. Label/solid conjugate immunoassay system
US4233402A (en) * 1978-04-05 1980-11-11 Syva Company Reagents and method employing channeling
US4474893A (en) * 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies
US4433859A (en) * 1981-07-16 1984-02-28 Nl Industries, Inc. Wellhead connector with release mechanism
US4433059A (en) * 1981-09-08 1984-02-21 Ortho Diagnostic Systems Inc. Double antibody conjugate
EP0076695B1 (de) * 1981-10-06 1985-02-20 The Board Of Trustees Of The Leland Stanford Junior University Fluoreszierende Konjugate zum Analysieren von Molekülen und Zellen
US4520110A (en) * 1981-10-06 1985-05-28 The Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing a phycobiliprotein labeled ligand or receptor
ES521370A0 (es) * 1982-04-12 1985-04-16 Hybritech Inc Un procedimiento para obtener un polidoma.
US4446233A (en) * 1982-05-05 1984-05-01 E. I. Du Pont De Nemours And Company Homogeneous immunoassay using covalent hybrid antibodies
US4470925A (en) * 1982-05-05 1984-09-11 E. I. Du Pont De Nemours And Company Immunoglobulin half-molecules and process for producing hybrid antibodies
CA1194415A (en) * 1982-05-05 1985-10-01 E. I. Du Pont De Nemours And Company Immunoglobulin half-molecules and process for producing hybrid antibodies

Also Published As

Publication number Publication date
CA1338828C (en) 1997-01-07
FI855086A0 (fi) 1985-12-19
JPS61501418A (ja) 1986-07-10
EP0179872B1 (de) 1991-06-19
WO1985004811A1 (en) 1985-11-07
DE3583278D1 (de) 1991-07-25
NO166383B (no) 1991-04-02
FI855086L (fi) 1985-12-19
FI85946C (fi) 1992-06-25
IT8567383A1 (it) 1986-10-23
NO855200L (no) 1985-12-20
FI85946B (fi) 1992-03-13
DK601985D0 (da) 1985-12-23
AU4290185A (en) 1985-11-15
DK601985A (da) 1985-12-23
EP0179872A1 (de) 1986-05-07
ATE64622T1 (de) 1991-07-15
EP0179872A4 (de) 1988-12-22
AU595159B2 (en) 1990-03-29
IT8567383A0 (it) 1985-04-23
IT1183798B (it) 1987-10-22
NO166383C (no) 1991-07-10
JPH0617909B2 (ja) 1994-03-09

Similar Documents

Publication Publication Date Title
US4444878A (en) Bispecific antibody determinants
US5523210A (en) Bispecific antibody determinants
US4470925A (en) Immunoglobulin half-molecules and process for producing hybrid antibodies
NO166383B (no) Fremgangsmaate ved fremstilling av bispesifikke antistoff-determinanter.
JPS58203919A (ja) 免疫グロブリン半分子および交雑種抗体を製造する方法
Muronetz et al. Isolation of antigens and antibodies by affinity chromatography
Lin et al. Cold pepsin digestion: a novel method to produce the Fv fragment from human immunoglobulin M.
KR0174528B1 (ko) 암과 관련된 헵토글로빈
EP0314338A1 (de) Verfahren zur Messung von humanen Insulin
JPWO1992011384A1 (ja) 抗ヒトプラスミン−α↓２−プラスミンインヒビター複合体抗体、ハイブリドーマ及び免疫学的測定方法
JPH07304800A (ja) ヒトペプシノゲンに対するモノクローナル抗体
SU1158029A3 (ru) Способ количественного определени трийодтиронина
JP4146264B2 (ja) メチルグリオキサール−アルギニン付加体の測定方法
JPS63117253A (ja) 免疫センサ−
JPH01269485A (ja) モノクローナル抗体産生細胞ラインおよびモノクローナル抗体
JPH01269487A (ja) モノクローナル抗体産生細胞ラインおよびモノクローナル抗体
JPS59226864A (ja) トランスホ−ミンググロスファクタ−の酵素免疫測定法
Kuhlmann Immunization, immune sera and the production of antibodies
JPH0225750A (ja) ヒトＭｎ−スーパーオキシドジスムターゼの測定キットおよび測定法
JPH021555A (ja) ヒトプロティンｓの免疫学的測定方法、それに用いる測定試薬及びキット
JPH0826075B2 (ja) 精製されたリボ核蛋白質複合体を構成するポリペプチド鎖、その製造法および抗スミス抗体の測定法
JP2002000268A (ja) モノクローナル抗体
JPH03199967A (ja) 免疫学的測定方法およびその試薬
JPH02189462A (ja) 固定抗体の製造方法
JPH1052270A (ja) 固定化モノクローナル抗体による蛋白質のリフォールディング方法

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed