DK1694660T3 - Fremgangsmåde til fremstilling af vandfri og hydrerede aktive farmaceutiske bestanddele (API's); stabile farmaceutiske sammensætninger fremstillet af disse og anvendelser af disse sammensætninger - Google Patents

Fremgangsmåde til fremstilling af vandfri og hydrerede aktive farmaceutiske bestanddele (API's); stabile farmaceutiske sammensætninger fremstillet af disse og anvendelser af disse sammensætninger

Info

Publication number: DK1694660T3
Authority: DK; Denmark
Prior art keywords: beta; apis; preparation; compositions; anhydrous
Prior art date: 2003-12-12

Application number

DK04801143T

Other languages

English (en)

Inventor

Marco Antonio Santini

Aurelio Maranduba

Eneida Guimaraes

Junior Marcio Santiago

Richard Grazul

Antonio Salustiano Machado

Silva Maria Mirtes Da

Original Assignee

Biorganica Ltda

Quiral Quimica Do Brasil

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-12

Filing date

2004-12-10

Publication date

2009-08-10

2004-12-08 Priority claimed from BRPI0405797 external-priority patent/BRPI0405797B1/pt

2004-12-10 Application filed by Biorganica Ltda, Quiral Quimica Do Brasil filed Critical Biorganica Ltda

2009-08-10 Application granted granted Critical

2009-08-10 Publication of DK1694660T3 publication Critical patent/DK1694660T3/da

Links

239000008186 active pharmaceutical agent Substances 0.000 title abstract 6
238000000034 method Methods 0.000 title abstract 4
239000000203 mixture Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
HYJVYOWKYPNSTK-UONOGXRCSA-N (2r,3s)-3-benzamido-2-hydroxy-3-phenylpropanoic acid Chemical compound N([C@H]([C@@H](O)C(O)=O)C=1C=CC=CC=1)C(=O)C1=CC=CC=C1 HYJVYOWKYPNSTK-UONOGXRCSA-N 0.000 abstract 1
ZVAFCKLQJCZGAP-UHFFFAOYSA-N 2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoic acid Chemical compound CC(C)(C)OC(=O)NC(C(O)C(O)=O)C1=CC=CC=C1 ZVAFCKLQJCZGAP-UHFFFAOYSA-N 0.000 abstract 1
PSSVSAXRAMDXPH-DELBANIYSA-N O.O.O.C(C)(C)(C)OC(=O)N[C@H]([C@H](C(=O)O)O)C1=CC=CC=C1 Chemical compound O.O.O.C(C)(C)(C)OC(=O)N[C@H]([C@H](C(=O)O)O)C1=CC=CC=C1 PSSVSAXRAMDXPH-DELBANIYSA-N 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Dermatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK04801143T 2003-12-12 2004-12-10 Fremgangsmåde til fremstilling af vandfri og hydrerede aktive farmaceutiske bestanddele (API's); stabile farmaceutiske sammensætninger fremstillet af disse og anvendelser af disse sammensætninger DK1694660T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
BR0305824		2003-12-12
BRPI0405797 BRPI0405797B1 (pt)	2004-12-08	2004-12-08	processo para a preparação de princìpios farmacêuticos ativos (pfa's), anidros e hidratados; composições farmacêuticas estáveis a partir dos mesmos e usos das composições
PCT/BR2004/000242 WO2005061474A1 (en)	2003-12-12	2004-12-10	Process for the preparation of anhydrous and hydrated active pharmaceutical ingredients (apis); stable pharmaceutical compositions prepared from the same and uses of said compositions

Publications (1)

Publication Number	Publication Date
DK1694660T3 true DK1694660T3 (da)	2009-08-10

Family

ID=37719821

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04801143T DK1694660T3 (da)	2003-12-12	2004-12-10	Fremgangsmåde til fremstilling af vandfri og hydrerede aktive farmaceutiske bestanddele (API's); stabile farmaceutiske sammensætninger fremstillet af disse og anvendelser af disse sammensætninger

Country Status (8)

Country	Link
US (2)	US7838551B2 (da)
EP (2)	EP1947094A3 (da)
AT (1)	ATE427943T1 (da)
DE (1)	DE602004020506D1 (da)
DK (1)	DK1694660T3 (da)
ES (1)	ES2325506T3 (da)
PT (1)	PT1694660E (da)
WO (1)	WO2005061474A1 (da)

Families Citing this family (19)

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EP1947094A3 (en)	2003-12-12	2009-02-18	Quiral Quimica Do Brasil	Process for the preparation of taxane derivatives
CN101291658B (zh) *	2005-08-31	2014-04-16	阿布拉科斯生物科学有限公司	用于制备稳定性增加的水难溶性药物的组合物和方法
US7771751B2 (en)	2005-08-31	2010-08-10	Abraxis Bioscience, Llc	Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents
KR100995390B1 (ko)	2006-01-02	2010-11-19	주식회사 삼양제넥스	무정형, 무수결정형 또는 수화 결정형 도세탁셀의 제조방법
BRPI0600194A (pt) *	2006-01-30	2007-10-23	Quiral Quimica Do Brasil S A	composições farmacêuticas contendo docetaxel e um inibidor de degradação e processo de obtenção das mesmas
AU2007246077A1 (en)	2006-05-03	2007-11-08	I.Q.A., A.S.	Pharmaceutical composition containing taxane derivative destined for the preparation of an infusion solution, method of preparation thereof and use thereof
EP2330101A1 (en) *	2006-10-20	2011-06-08	Scinopharm Singapore Pte, Ltd.	Process for making crystalline docetaxel
WO2008102374A1 (en) *	2007-02-20	2008-08-28	Dabur Pharma Limited	Amorphous form of docetaxel
KR100878455B1 (ko) *	2007-04-10	2009-01-13	한미약품 주식회사	안정한 무수결정형 도세탁셀 및 이의 제조방법
EP2080764B1 (en)	2008-01-18	2012-08-22	INDENA S.p.A.	Solid forms of ortataxel
EP2080763A1 (en) *	2008-01-18	2009-07-22	INDENA S.p.A.	Crystalline form I of ortataxel
KR100965867B1 (ko) *	2009-06-23	2010-06-24	주식회사 삼양제넥스	수화결정형 도세탁셀의 제조방법
KR101149600B1 (ko) *	2009-12-31	2012-05-29	주식회사 삼양제넥스바이오	고순도 무수결정형 도세탁셀 제조방법
JP5824511B2 (ja)	2010-05-03	2015-11-25	テイコクファーマユーエスエーインコーポレーテッド	非水タキサンプロエマルジョン配合物ならびにそれを調製および使用する方法
CN102250047B (zh) *	2011-08-26	2013-06-05	贺金凤	一种紫杉醇化合物的制备方法
WO2013096596A1 (en) *	2011-12-20	2013-06-27	Latham Keith R	Sustained drug release and improved product stability using non-covalent particle coating methods
JO3685B1 (ar)	2012-10-01	2020-08-27	Teikoku Pharma Usa Inc	صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
US10004824B2 (en) *	2015-05-11	2018-06-26	Laboratoires Vivacy	Compositions comprising at least one polyol and at least one anesthetic
CN111718316A (zh) *	2020-07-02	2020-09-29	无锡紫杉药业有限公司	一种三水多西他赛生产工艺

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US5475120A (en) *	1990-11-02	1995-12-12	University Of Florida	Method for the isolation and purification of taxol and its natural analogues
MX9102128A (es)	1990-11-23	1992-07-08	Rhone Poulenc Rorer Sa	Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5698582A (en)	1991-07-08	1997-12-16	Rhone-Poulenc Rorer S.A.	Compositions containing taxane derivatives
CA2149150C (en) *	1992-11-27	2000-08-01	David R. Carver	Injectable taxol composition with improved stability
TW406020B (en) *	1993-09-29	2000-09-21	Bristol Myers Squibb Co	Stabilized pharmaceutical composition and its method for preparation and stabilizing solvent
FR2722191B1 (fr)	1994-07-08	1996-08-23	Rhone Poulenc Rorer Sa	Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle
FR2729666A1 (fr)	1995-01-25	1996-07-26	Rhone Poulenc Rorer Sa	Procede de preparation du trihydrate du (2r, 3s)- benzoylamino-2-hydroxy-3-phenylpropionate de 4,10-diacetoxy- 2alpha-benzoyloxy-5beta,20-epoxy-1,7beta-dihydroxy-9-oxo- tax-11-en-13alpha-yle
US5679807A (en)	1995-01-30	1997-10-21	Hauser, Inc.	Preparation of taxol and docetaxel through primary amines
US6040330A (en) *	1999-01-08	2000-03-21	Bionumerik Pharmaceuticals, Inc.	Pharmaceutical formulations of taxanes
US6002025A (en) *	1999-02-24	1999-12-14	Bcm Developement Inc.	Method for the purification of taxanes
GB9920548D0 (en) *	1999-08-31	1999-11-03	Rhone Poulenc Rorer Sa	Treatment of hepatocellular carcinoma
NZ522767A (en) *	2000-05-15	2004-07-30	Celgene Corp	Thalidomide and a topoisomerase inhibitor for the treatment of cancer
PL203300B1 (pl)	2000-10-31	2009-09-30	Akad Medyczna	Stabilna postać farmaceutyczna leku przeciwnowotworowego oraz sposób wytwarzania stabilnej postaci farmaceutycznej leku przeciwnowotworowego
JP2004536026A (ja) *	2000-11-28	2004-12-02	トランスフォームファーマシューティカルズ，インコーポレーティッド．	パクリタキセル、その誘導体、および薬剤として許容される塩を含む医薬品製剤
ITMI20020680A1 (it)	2002-03-29	2003-09-29	Acs Dobfar Spa	Composizione antitumorale migliorata a base di paclitaxel e metodo per il suo ottenimento
US6838569B2 (en) *	2002-12-16	2005-01-04	Dabur India Limited	Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
EP1947094A3 (en)	2003-12-12	2009-02-18	Quiral Quimica Do Brasil	Process for the preparation of taxane derivatives

2004
- 2004-12-10 EP EP08152493A patent/EP1947094A3/en not_active Withdrawn
- 2004-12-10 WO PCT/BR2004/000242 patent/WO2005061474A1/en not_active Ceased
- 2004-12-10 EP EP04801143A patent/EP1694660B1/en not_active Expired - Lifetime
- 2004-12-10 DK DK04801143T patent/DK1694660T3/da active
- 2004-12-10 ES ES04801143T patent/ES2325506T3/es not_active Expired - Lifetime
- 2004-12-10 PT PT04801143T patent/PT1694660E/pt unknown
- 2004-12-10 US US10/582,385 patent/US7838551B2/en not_active Expired - Fee Related
- 2004-12-10 AT AT04801143T patent/ATE427943T1/de active
- 2004-12-10 DE DE602004020506T patent/DE602004020506D1/de not_active Expired - Lifetime
2008
- 2008-08-07 US US12/188,157 patent/US8304450B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US7838551B2 (en)	2010-11-23
ES2325506T3 (es)	2009-09-07
US20090069409A1 (en)	2009-03-12
EP1947094A2 (en)	2008-07-23
US20080051450A1 (en)	2008-02-28
ATE427943T1 (de)	2009-04-15
WO2005061474A1 (en)	2005-07-07
EP1947094A3 (en)	2009-02-18
DE602004020506D1 (de)	2009-05-20
EP1694660B1 (en)	2009-04-08
US8304450B2 (en)	2012-11-06
PT1694660E (pt)	2009-07-16
EP1694660A1 (en)	2006-08-30

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ATE433447T1 (de)	2009-06-15	Pyrimiidinverbindungen
EA200601555A1 (ru)	2007-02-27	Замещенные индазол-о-глюкозиды
SE0102315D0 (sv)	2001-06-28	Compounds
EA200601554A1 (ru)	2006-12-29	Замещенные индол-о-глюкозиды
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SE0200920D0 (sv)	2002-03-25	Novel compounds
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NO20043016L (no)	2004-07-15	6-aminomorfinan-derivater, fremgangsmate for fremstilling og anvendelse derav
PL376176A1 (en)	2005-12-27	Solid preparation
SE0203825D0 (sv)	2002-12-20	Novel fused heterocycles and uses thereof
PA8568101A1 (es)	2003-11-12	Indolil-urea derivados de tienopiridinas utiles como agentes antiangiogenicos, y procedimientos para su uso
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SE0101038D0 (sv)	2001-03-23	Novel compounds
BRPI0408299A (pt)	2006-03-07	inibidores de catepsina s
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