DK170187B1 - Fremgangsmåde til bestemmelse af indholdet af ligevægts-iod i en vandig opløsning af en iodofor samt et kimdræbende middel indeholdende en vandig opløsning af povidon-iod og en iodatforbindelse i opløsning - Google Patents
Fremgangsmåde til bestemmelse af indholdet af ligevægts-iod i en vandig opløsning af en iodofor samt et kimdræbende middel indeholdende en vandig opløsning af povidon-iod og en iodatforbindelse i opløsning Download PDFInfo
- Publication number
- DK170187B1 DK170187B1 DK242185A DK242185A DK170187B1 DK 170187 B1 DK170187 B1 DK 170187B1 DK 242185 A DK242185 A DK 242185A DK 242185 A DK242185 A DK 242185A DK 170187 B1 DK170187 B1 DK 170187B1
- Authority
- DK
- Denmark
- Prior art keywords
- iodine
- solution
- equilibrium
- amount
- iodophore
- Prior art date
Links
- 229910052740 iodine Inorganic materials 0.000 title claims abstract description 412
- 239000011630 iodine Substances 0.000 title claims abstract description 411
- 239000000243 solution Substances 0.000 title claims abstract description 244
- 230000002070 germicidal effect Effects 0.000 title claims abstract description 63
- 239000007864 aqueous solution Substances 0.000 title claims abstract description 20
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 title claims abstract 26
- 238000000034 method Methods 0.000 title claims description 34
- -1 iodate compound Chemical class 0.000 title claims description 28
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 title claims description 24
- 229920000153 Povidone-iodine Polymers 0.000 title claims description 24
- 229960001621 povidone-iodine Drugs 0.000 title claims description 24
- 230000008569 process Effects 0.000 title claims description 19
- 239000003795 chemical substances by application Substances 0.000 title claims description 17
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims abstract description 423
- 239000002904 solvent Substances 0.000 claims abstract description 83
- 238000000605 extraction Methods 0.000 claims abstract description 49
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 33
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 24
- ICIWUVCWSCSTAQ-UHFFFAOYSA-M iodate Chemical compound [O-]I(=O)=O ICIWUVCWSCSTAQ-UHFFFAOYSA-M 0.000 claims abstract description 12
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical group CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims description 41
- 230000003247 decreasing effect Effects 0.000 claims description 4
- 230000003641 microbiacidal effect Effects 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 abstract description 31
- 239000000203 mixture Substances 0.000 abstract description 12
- 229920000642 polymer Polymers 0.000 description 60
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 43
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 43
- 238000009826 distribution Methods 0.000 description 33
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 24
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 24
- 230000000813 microbial effect Effects 0.000 description 23
- 238000006243 chemical reaction Methods 0.000 description 21
- 241000894007 species Species 0.000 description 18
- WRTMQOHKMFDUKX-UHFFFAOYSA-N triiodide Chemical compound I[I-]I WRTMQOHKMFDUKX-UHFFFAOYSA-N 0.000 description 18
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- JLKDVMWYMMLWTI-UHFFFAOYSA-M potassium iodate Chemical compound [K+].[O-]I(=O)=O JLKDVMWYMMLWTI-UHFFFAOYSA-M 0.000 description 10
- 239000001230 potassium iodate Substances 0.000 description 10
- 235000006666 potassium iodate Nutrition 0.000 description 10
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- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 238000010668 complexation reaction Methods 0.000 description 4
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- 229940005633 iodate ion Drugs 0.000 description 4
- XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 description 4
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- 239000007787 solid Substances 0.000 description 4
- 231100000331 toxic Toxicity 0.000 description 4
- 230000002588 toxic effect Effects 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
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- 238000004448 titration Methods 0.000 description 3
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- 230000002776 aggregation Effects 0.000 description 2
- 238000004220 aggregation Methods 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 description 2
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- 239000001488 sodium phosphate Substances 0.000 description 2
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- 229910000679 solder Inorganic materials 0.000 description 2
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- DHCDFWKWKRSZHF-UHFFFAOYSA-L thiosulfate(2-) Chemical compound [O-]S([S-])(=O)=O DHCDFWKWKRSZHF-UHFFFAOYSA-L 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical class [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- 230000003313 weakening effect Effects 0.000 description 2
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- QBWKPGNFQQJGFY-QLFBSQMISA-N 3-[(1r)-1-[(2r,6s)-2,6-dimethylmorpholin-4-yl]ethyl]-n-[6-methyl-3-(1h-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine Chemical compound N1([C@H](C)C2=NSC(NC=3C4=NC=C(N4C=C(C)N=3)C3=CNN=C3)=C2)C[C@H](C)O[C@H](C)C1 QBWKPGNFQQJGFY-QLFBSQMISA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
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- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
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- 229910019142 PO4 Inorganic materials 0.000 description 1
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- 229920003082 Povidone K 90 Polymers 0.000 description 1
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- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 1
- OBOXTJCIIVUZEN-UHFFFAOYSA-N [C].[O] Chemical group [C].[O] OBOXTJCIIVUZEN-UHFFFAOYSA-N 0.000 description 1
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- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- IIEWJVIFRVWJOD-UHFFFAOYSA-N ethyl cyclohexane Natural products CCC1CCCCC1 IIEWJVIFRVWJOD-UHFFFAOYSA-N 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
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- 150000004694 iodide salts Chemical class 0.000 description 1
- 150000002497 iodine compounds Chemical class 0.000 description 1
- 125000002346 iodo group Chemical group I* 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910001511 metal iodide Inorganic materials 0.000 description 1
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- 239000002736 nonionic surfactant Substances 0.000 description 1
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- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000006461 physiological response Effects 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- QGKLPGKXAVVPOJ-UHFFFAOYSA-N pyrrolidin-3-one Chemical group O=C1CCNC1 QGKLPGKXAVVPOJ-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
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- 239000011593 sulfur Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/12—Iodine, e.g. iodophors; Compounds thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/19—Halogen containing
- Y10T436/193333—In aqueous solution
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
- Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Inorganic Chemistry (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Catching Or Destruction (AREA)
- Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/615,835 US4575491A (en) | 1984-05-31 | 1984-05-31 | Method of controlling and determining germicidal activity |
| US61583584 | 1984-05-31 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK242185D0 DK242185D0 (da) | 1985-05-30 |
| DK242185A DK242185A (da) | 1985-12-01 |
| DK170187B1 true DK170187B1 (da) | 1995-06-06 |
Family
ID=24467013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK242185A DK170187B1 (da) | 1984-05-31 | 1985-05-30 | Fremgangsmåde til bestemmelse af indholdet af ligevægts-iod i en vandig opløsning af en iodofor samt et kimdræbende middel indeholdende en vandig opløsning af povidon-iod og en iodatforbindelse i opløsning |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4575491A (de) |
| EP (1) | EP0169320B1 (de) |
| AT (1) | ATE66339T1 (de) |
| CA (1) | CA1255226A (de) |
| DE (1) | DE3583833D1 (de) |
| DK (1) | DK170187B1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4996048A (en) * | 1988-11-30 | 1991-02-26 | Euroceltique, S.A. | Stabilizing packaged iodophor and minimizing leaching of iodine through packaging |
| US5252320A (en) * | 1989-06-05 | 1993-10-12 | Isp Investments Inc. | PVP-HI-I2 complexes having a partition coefficient above 300, and process for making same |
| WO1990014834A1 (en) * | 1989-06-05 | 1990-12-13 | Gaf Chemicals Corporation | Pvp-hi-i2 complexes having a partition coefficient above 300, and process for making same |
| GB9006346D0 (en) * | 1990-03-21 | 1990-05-16 | Euro Celtique Sa | Pharmaceutical composition |
| US5643608A (en) * | 1996-03-01 | 1997-07-01 | West Agro, Inc. | Low pH germicidal iodine compositions having enhanced stability |
| US6398961B1 (en) | 2000-07-20 | 2002-06-04 | Ecolab Inc. | Device and method for sensing low level iodine in aqueous solution |
| US6663902B1 (en) | 2000-09-19 | 2003-12-16 | Ecolab Inc. | Method and composition for the generation of chlorine dioxide using Iodo-Compounds, and methods of use |
| US20150305343A1 (en) * | 2014-04-28 | 2015-10-29 | American Sterilizer Company | Process and composition for killing spores |
| CN105865883A (zh) * | 2016-03-31 | 2016-08-17 | 常州大学 | 一种聚维酮碘中络合的单质碘含量的测定方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3028300A (en) * | 1960-09-13 | 1962-04-03 | West Laboratories Inc | Germicidal compositions and methods for preparing the same |
| DE2540170C3 (de) * | 1975-09-10 | 1979-01-18 | Basf Ag, 6700 Ludwigshafen | Verwendung von in organischer Lösung hergestelltem Polyvinylpyrrolidon zur Herstellung von stabilen wäßrigen PoIyvinylpyrrolidon-Jod-Lösungen |
| US4113857A (en) * | 1977-05-16 | 1978-09-12 | The Purdue Frederick Company | Process for the preparation of iodophor compounds and methods for stabilizing iodophor pharmaceutical compositions containing the same |
| US4271149A (en) * | 1979-09-21 | 1981-06-02 | West Agro-Chemical, Inc. | Germicidal iodine compositions with enhanced iodine stability |
-
1984
- 1984-05-31 US US06/615,835 patent/US4575491A/en not_active Expired - Lifetime
-
1985
- 1985-05-01 CA CA000480543A patent/CA1255226A/en not_active Expired
- 1985-05-09 EP EP85105664A patent/EP0169320B1/de not_active Expired - Lifetime
- 1985-05-09 AT AT85105664T patent/ATE66339T1/de not_active IP Right Cessation
- 1985-05-09 DE DE8585105664T patent/DE3583833D1/de not_active Expired - Lifetime
- 1985-05-30 DK DK242185A patent/DK170187B1/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0169320A3 (en) | 1986-06-11 |
| DK242185A (da) | 1985-12-01 |
| EP0169320B1 (de) | 1991-08-21 |
| CA1255226A (en) | 1989-06-06 |
| US4575491A (en) | 1986-03-11 |
| DK242185D0 (da) | 1985-05-30 |
| EP0169320A2 (de) | 1986-01-29 |
| ATE66339T1 (de) | 1991-09-15 |
| DE3583833D1 (de) | 1991-09-26 |
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| Date | Code | Title | Description |
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| PUP | Patent expired |