DK1728507T4 - Anvendelse af vitamin K for at omvende forkalkning af blodkar - Google Patents

Anvendelse af vitamin K for at omvende forkalkning af blodkar Download PDF

Info

Publication number
DK1728507T4
DK1728507T4 DK06076172.3T DK06076172T DK1728507T4 DK 1728507 T4 DK1728507 T4 DK 1728507T4 DK 06076172 T DK06076172 T DK 06076172T DK 1728507 T4 DK1728507 T4 DK 1728507T4
Authority
DK
Denmark
Prior art keywords
vitamin
calcification
blood vessel
use according
arterial
Prior art date
Application number
DK06076172.3T
Other languages
English (en)
Other versions
DK1728507T3 (da
Inventor
Cees Vermeer
Original Assignee
Nattopharma Asa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36940251&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1728507(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US11/144,853 external-priority patent/US9364447B2/en
Application filed by Nattopharma Asa filed Critical Nattopharma Asa
Application granted granted Critical
Publication of DK1728507T3 publication Critical patent/DK1728507T3/da
Publication of DK1728507T4 publication Critical patent/DK1728507T4/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nutrition Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (10)

1. Anvendelse af vitamin K til fremstillingen af et farmaceutisk eller næringspræparat for at omvende forkalkning af et blodkar hos et pattedyr der lider af forkalkning af et blodkar, når der til pattedyret administreres en effektiv mængde vitamin K for at omvende forkalkning af blodkarret.
2. Anvendelse ifølge krav 1, hvor omvendelsen af forkalkning af et blodkar omfatter fjernelsen af præ-eksisterende calciumdepoter i og/eller på blodkarret.
3. Anvendelse ifølge krav 1, hvor forkalkning af et blodkar er forbundet med en sygdom valgt fra gruppen bestående af arteriosklerose, inklusiv Monckeberg's sklerose, osteoarthritis, inflammations-induceret forkalkning, inklusiv Bechterev's sygdom, tumorinduceret forkalkning, hudforkalkning inklusiv pseudo-xanthoma elasticum (PXE) og calcifylaxis i slut-stadie nyresygdom.
4. Anvendelse ifølge krav 1, hvor vitamin K er indeholdt et fødevare- eller drikkeprodukt eller i et diætsupplement.
5. Anvendelse ifølge krav 1, hvor formuleringen yderligere omfatter vitamin D.
6. Anvendelse ifølge krav 1, hvor forkalkningen er af tunica media af aorta eller halspulsåren.
7. Anvendelse ifølge krav 1, hvor vitamin K omfatter vitamin Ki (phylloquinon), vitamin K2 (menaquinon) eller en kombination deraf.
8. Anvendelse ifølge krav 1, hvor den daglige dosis af vitamin K er 50 pg - 2000 pg.
9. Anvendelse ifølge krav 5, hvor vitamin D er vitamin D3 (cholecalciferol).
10. Anvendelse ifølge krav 1, hvor pattedyret er et menneske.
DK06076172.3T 2005-06-03 2006-06-06 Anvendelse af vitamin K for at omvende forkalkning af blodkar DK1728507T4 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/144,853 US9364447B2 (en) 2002-08-30 2005-06-03 Compositions for treating or preventing cardiovascular disease

Publications (2)

Publication Number Publication Date
DK1728507T3 DK1728507T3 (da) 2011-05-23
DK1728507T4 true DK1728507T4 (da) 2015-01-12

Family

ID=36940251

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06076172.3T DK1728507T4 (da) 2005-06-03 2006-06-06 Anvendelse af vitamin K for at omvende forkalkning af blodkar

Country Status (8)

Country Link
EP (1) EP1728507B2 (da)
AT (1) ATE501715T1 (da)
DE (1) DE602006020658D1 (da)
DK (1) DK1728507T4 (da)
ES (1) ES2363368T5 (da)
PL (1) PL1728507T3 (da)
PT (1) PT1728507E (da)
SI (1) SI1728507T1 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0220182D0 (en) 2002-08-30 2002-10-09 Cardiovascular Res Inst Maastr Organic compounds
EP2060256A1 (en) 2007-11-16 2009-05-20 Gnosis S.p.A. Pharmaceutical and nutraceutical compositions based on menaquinols
DE102010015242A1 (de) * 2010-04-15 2011-10-20 Fresenius Medical Care Deutschland Gmbh Kombination aus Vitamin K und Nikotinamid
IT1402330B1 (it) * 2010-09-03 2013-08-30 Poli Integratore alimentare
US11344575B2 (en) * 2016-08-15 2022-05-31 Summit Innovation Labs, LLC Vascular calcification prevention and treatment
US11357250B2 (en) 2016-08-15 2022-06-14 Summit Innovation Labs LLC Treatment and prevention of diabetes and obesity
KR20260041925A (ko) * 2017-12-14 2026-03-27 모닝벨 웰니스 엘엘씨 황산화 다당류에 의한 죽상경화성 병변의 안정화 및 역전 방법
BR112020019832A2 (pt) 2018-03-30 2021-01-05 Kaydence Pharma As Métodos para melhorar função cardiovascular, elasticidade, velocidade de onda de pulso ou disfunção endotelial, reduzir rigidez arterial e/ou para reverter calcificação de um vaso sanguíneo em um mamífero e para aumentar produção de óxido nítrico endotelial em um sujeito, e, kit
IL279245B2 (en) 2018-06-08 2024-03-01 Epizon Pharma Inc Compositions comprising menaquinone-7 (mk-7) and/or menquinol for prophylaxis of tissue calcification
WO2019237054A1 (en) 2018-06-08 2019-12-12 Epizon Pharma, Inc. Methods and compositions for preventing or treating calciphylaxis
KR20210137511A (ko) * 2019-03-11 2021-11-17 카이던스 파마 에이에스 비타민 k 투여에 의한 신속한 내피 기능 개선, 동맥 경직 감소 및 혈관 석회화 반전
CN110122866A (zh) * 2019-05-31 2019-08-16 广东双骏生物科技有限公司 一种慢性肾脏病血管钙化的特殊医学用途食品及制备方法
CN114748486A (zh) * 2022-03-25 2022-07-15 南京盛德生物科技研究院有限公司 一种含有维生素k2改善心血管钙化的药物组合物及其制备方法与应用
JP2025518284A (ja) 2022-05-31 2025-06-12 リージョン スイダンマーク 冠動脈石灰化（ｃａｃ）の治療に使用するためのビタミンｋ２
CN118416279B (zh) * 2024-04-23 2025-09-02 大连医科大学附属第二医院 一种预防血管钙化的动静脉内瘘外用敷料及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0679394B1 (en) † 1994-04-28 1998-01-14 Eisai Co., Ltd. Menatetronome derivative as antiarteriosclerotic agent
DK1153548T3 (da) 2000-05-12 2007-09-10 Nattopharma Asa Levnedsmiddelprodukt, der indeholder vitamin k2
WO2003013420A2 (en) † 2001-08-03 2003-02-20 Vitak Bv Isoprenyl derivatives and their use in the treatment and prevention of osteoporosis and cardiovascular calcification
GB0220182D0 (en) † 2002-08-30 2002-10-09 Cardiovascular Res Inst Maastr Organic compounds

Also Published As

Publication number Publication date
ES2363368T3 (es) 2011-08-02
EP1728507A1 (en) 2006-12-06
ES2363368T5 (es) 2015-03-02
DK1728507T3 (da) 2011-05-23
DE602006020658D1 (de) 2011-04-28
SI1728507T1 (sl) 2011-07-29
EP1728507B2 (en) 2014-11-12
EP1728507B1 (en) 2011-03-16
PL1728507T3 (pl) 2011-09-30
PT1728507E (pt) 2011-05-27
ATE501715T1 (de) 2011-04-15

Similar Documents

Publication Publication Date Title
US12144785B2 (en) Composition of vitamin K and vitamin D for treating or preventing cardiovascular disease
DK1728507T4 (da) Anvendelse af vitamin K for at omvende forkalkning af blodkar
US11911349B2 (en) Rapidly improving vascular conditions by administering vitamin K
JP5999209B2 (ja) 血行動態改善剤
JPWO2009057775A1 (ja) アミノ酸組成物を含有する疲労防止剤
AU2024264719A1 (en) Rapidly improving endothelial function, reducing arterial stiffness and reversing calcification of blood vessels by administering vitamin K
JP2004521127A (ja) 異常脂血症及び食事誘発性食後高血糖症のクロム／ビオチン療法
RU2428193C2 (ru) Средство, ускоряющее абсорбцию кальция
CA2568902A1 (en) Use of alpha-ketoglutarate and related compounds for lowering plasma lipids
KR101039818B1 (ko) 남성 갱년기에 의해 유발되는 질환의 예방 및/또는 치료를위한 카르니틴의 용도
TW201717980A (zh) 動脈硬化改善用組成物
JPWO2008136173A1 (ja) スチルベン誘導体を有効成分とする脂肪細胞分化抑制剤
NZ579767A (en) Acetyl L-carnitine, optionally combined with an antihypertensive drug or a statin, for the prevention of type 2 diabetes and its complications in pre-diabetic patients with insulin resistance
CN113260417A (zh) 磷酸盐结合剂与维生素k的联合疗法
JP2002145767A (ja) 循環器疾患治療剤および健康食品
Braam et al. 6Beneficial effects of vitamin K on the elastic properties of