DK173003B1 - Ether-substituerede isonitriler, radiomærkede komplekser deraf og deres anvendelse - Google Patents

Ether-substituerede isonitriler, radiomærkede komplekser deraf og deres anvendelse Download PDF

Info

Publication number: DK173003B1
Authority: DK; Denmark
Prior art keywords: ether; formula; substituted; isonitrile; complexes
Prior art date: 1985-12-23

Application number

DK198606238A

Other languages

Danish (da)

English (en)

Other versions

DK623886D0 (da

DK623886A (da

Inventor

Vinayakam Subramanyam

Paul Louis Bergstein

Original Assignee

Du Pont Pharm Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-12-23

Filing date

1986-12-22

Publication date

1999-11-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27123612&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK173003(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1986-12-22 Application filed by Du Pont Pharm Co filed Critical Du Pont Pharm Co

1986-12-22 Publication of DK623886D0 publication Critical patent/DK623886D0/da

1987-06-24 Publication of DK623886A publication Critical patent/DK623886A/da

1999-11-01 Application granted granted Critical

1999-11-01 Publication of DK173003B1 publication Critical patent/DK173003B1/da

Links

150000002527 isonitriles Chemical class 0.000 title description 13
125000004432 carbon atom Chemical group C* 0.000 description 10
150000001412 amines Chemical class 0.000 description 8
-1 chloro, bromo, iodo Chemical group 0.000 description 8
125000000217 alkyl group Chemical group 0.000 description 6
238000003384 imaging method Methods 0.000 description 6
150000001408 amides Chemical class 0.000 description 4
125000003118 aryl group Chemical group 0.000 description 4
230000015572 biosynthetic process Effects 0.000 description 4
229910052799 carbon Inorganic materials 0.000 description 4
210000004165 myocardium Anatomy 0.000 description 4
125000001424 substituent group Chemical group 0.000 description 4
125000001931 aliphatic group Chemical group 0.000 description 3
125000003545 alkoxy group Chemical group 0.000 description 3
239000003446 ligand Substances 0.000 description 3
210000004072 lung Anatomy 0.000 description 3
239000000203 mixture Substances 0.000 description 3
125000000962 organic group Chemical group 0.000 description 3
238000003786 synthesis reaction Methods 0.000 description 3
229910052713 technetium Inorganic materials 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
229910001868 water Inorganic materials 0.000 description 3
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
239000003638 chemical reducing agent Substances 0.000 description 2
238000006297 dehydration reaction Methods 0.000 description 2
QVAWPEGWRUXBQH-UHFFFAOYSA-N formamide;formic acid Chemical compound NC=O.OC=O QVAWPEGWRUXBQH-UHFFFAOYSA-N 0.000 description 2
XFXPMWWXUTWYJX-UHFFFAOYSA-N isonitrile group Chemical group N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 description 2
210000004185 liver Anatomy 0.000 description 2
238000000034 method Methods 0.000 description 2
230000007935 neutral effect Effects 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
229910000104 sodium hydride Inorganic materials 0.000 description 2
GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 2
FGRJGEWVJCCOJJ-UHFFFAOYSA-N 2,2-dimethylaziridine Chemical compound CC1(C)CN1 FGRJGEWVJCCOJJ-UHFFFAOYSA-N 0.000 description 1
229940058020 2-amino-2-methyl-1-propanol Drugs 0.000 description 1
125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 description 1
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 description 1
SARBHXGUPQRFTC-UHFFFAOYSA-N C(=O)O.N#[C-] Chemical compound C(=O)O.N#[C-] SARBHXGUPQRFTC-UHFFFAOYSA-N 0.000 description 1
239000004215 Carbon black (E152) Substances 0.000 description 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
238000007167 Hofmann rearrangement reaction Methods 0.000 description 1
229910010082 LiAlH Inorganic materials 0.000 description 1
XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
ORWKVZNEPHTCQE-UHFFFAOYSA-N acetic formic anhydride Chemical compound CC(=O)OC=O ORWKVZNEPHTCQE-UHFFFAOYSA-N 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
125000005262 alkoxyamine group Chemical group 0.000 description 1
230000029936 alkylation Effects 0.000 description 1
238000005804 alkylation reaction Methods 0.000 description 1
150000001414 amino alcohols Chemical class 0.000 description 1
CBTVGIZVANVGBH-UHFFFAOYSA-N aminomethyl propanol Chemical compound CC(C)(N)CO CBTVGIZVANVGBH-UHFFFAOYSA-N 0.000 description 1
229910021529 ammonia Inorganic materials 0.000 description 1
239000000908 ammonium hydroxide Substances 0.000 description 1
125000004429 atom Chemical group 0.000 description 1
235000010290 biphenyl Nutrition 0.000 description 1
239000004305 biphenyl Substances 0.000 description 1
125000006267 biphenyl group Chemical group 0.000 description 1
125000001246 bromo group Chemical group Br* 0.000 description 1
239000003054 catalyst Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
229910052801 chlorine Inorganic materials 0.000 description 1
239000000460 chlorine Substances 0.000 description 1
229910052804 chromium Inorganic materials 0.000 description 1
230000007547 defect Effects 0.000 description 1
230000018044 dehydration Effects 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
238000001514 detection method Methods 0.000 description 1
238000004821 distillation Methods 0.000 description 1
125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
230000000694 effects Effects 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
125000001153 fluoro group Chemical group F* 0.000 description 1
150000003948 formamides Chemical class 0.000 description 1
WBJINCZRORDGAQ-UHFFFAOYSA-N formic acid ethyl ester Natural products CCOC=O WBJINCZRORDGAQ-UHFFFAOYSA-N 0.000 description 1
238000009472 formulation Methods 0.000 description 1
229910052736 halogen Inorganic materials 0.000 description 1
150000002367 halogens Chemical class 0.000 description 1
229930195733 hydrocarbon Natural products 0.000 description 1
125000001183 hydrocarbyl group Chemical group 0.000 description 1
XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
239000012216 imaging agent Substances 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
229910052741 iridium Inorganic materials 0.000 description 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
239000012280 lithium aluminium hydride Substances 0.000 description 1
229910052748 manganese Inorganic materials 0.000 description 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
229910052750 molybdenum Inorganic materials 0.000 description 1
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
125000001624 naphthyl group Chemical group 0.000 description 1
229910052759 nickel Inorganic materials 0.000 description 1
229910052758 niobium Inorganic materials 0.000 description 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
229910052763 palladium Inorganic materials 0.000 description 1
230000010412 perfusion Effects 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 1
229910052697 platinum Inorganic materials 0.000 description 1
230000001698 pyrogenic effect Effects 0.000 description 1
230000002285 radioactive effect Effects 0.000 description 1
229910052702 rhenium Inorganic materials 0.000 description 1
229910052703 rhodium Inorganic materials 0.000 description 1
229910052707 ruthenium Inorganic materials 0.000 description 1
239000012312 sodium hydride Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
229910052715 tantalum Inorganic materials 0.000 description 1
FAGLEPBREOXSAC-UHFFFAOYSA-N tert-butyl isocyanide Chemical compound CC(C)(C)[N+]#[C-] FAGLEPBREOXSAC-UHFFFAOYSA-N 0.000 description 1
125000003944 tolyl group Chemical group 0.000 description 1
229910052721 tungsten Inorganic materials 0.000 description 1
125000005023 xylyl group Chemical group 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
- C07C291/10—Isocyanides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Optics & Photonics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Physics & Mathematics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Toxicology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Position Fixing By Use Of Radio Waves (AREA)

DK198606238A 1985-12-23 1986-12-22 Ether-substituerede isonitriler, radiomærkede komplekser deraf og deres anvendelse DK173003B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US81247085A	1985-12-23	1985-12-23
US81247085		1985-12-23
US92509186A	1986-11-06	1986-11-06
US92509186		1986-11-06

Publications (3)

Publication Number	Publication Date
DK623886D0 DK623886D0 (da)	1986-12-22
DK623886A DK623886A (da)	1987-06-24
DK173003B1 true DK173003B1 (da)	1999-11-01

Family

ID=27123612

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198606238A DK173003B1 (da)	1985-12-23	1986-12-22	Ether-substituerede isonitriler, radiomærkede komplekser deraf og deres anvendelse

Country Status (20)

Country	Link
US (1)	US4988827A (id)
EP (1)	EP0233368B1 (id)
JP (2)	JPH0755914B2 (id)
KR (1)	KR940011456B1 (id)
CN (1)	CN1057470C (id)
AU (1)	AU594407B2 (id)
CA (1)	CA1305160C (id)
DE (1)	DE3673000D1 (id)
DK (1)	DK173003B1 (id)
ES (1)	ES2036171T3 (id)
FI (1)	FI91747C (id)
GR (1)	GR3000681T3 (id)
HU (1)	HU201301B (id)
ID (1)	ID1037B (id)
IE (1)	IE59758B1 (id)
IL (1)	IL81055A (id)
MX (1)	MX168821B (id)
NO (1)	NO166640C (id)
PT (1)	PT83996B (id)
SU (1)	SU1635903A3 (id)

Families Citing this family (34)

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US5028699A (en) *	1987-09-11	1991-07-02	E. I. Du Pont De Nemours And Company	Process for preparing Tc-99m tris(isonitrile) copper complexes
US5008418A (en) *	1987-09-11	1991-04-16	E. I. Du Pont De Nemours And Company	Tris(isonitrile)copper(I) adducts for preparing radionuclide complexes
US4885100A (en) *	1987-09-11	1989-12-05	E. I. Du Pont De Nemours And Company	Tris(isonitrile)copper(I) adducts for preparing radionuclide complexes
US4864051A (en) *	1988-09-02	1989-09-05	E. R. Squibb & Sons, Inc.	Process for preparing 2-methoxyisobutylisonitrile
WO1991019516A1 (en) *	1990-06-18	1991-12-26	Mallinckrodt Medical, Inc.	Metal-radionuclide complex comprising isonitrile ligands
US5210270A (en) *	1991-11-25	1993-05-11	Institute Of Nuclear Energy Research	Method for synthesis and 99m C labelling of 2-alkoxyisobutylisonitrile
US5420321A (en) *	1993-08-03	1995-05-30	The Du Pont Merck Pharmaceutical Company	Tris(isonitrile)copper(i) sulfates for preparing radionuclide complexes
DE4445004A1 (de) *	1994-12-16	1996-06-20	Consortium Elektrochem Ind	Zusammensetzung zur delokalisierten Kennzeichnung von Gegenständen, ihre Herstellung und Verwendung
US5961952A (en) *	1996-01-24	1999-10-05	Dupont Pharmaceuticals Company	99m Tc-tertiary-butyl isonitrile as breast tumor imaging agents
US6416733B1 (en)	1996-10-07	2002-07-09	Bristol-Myers Squibb Pharma Company	Radiopharmaceuticals for imaging infection and inflammation
US20030124053A1 (en) *	1996-10-07	2003-07-03	Barrett John Andrew	Radiopharmaceuticals for imaging infection and inflammation
US6524553B2 (en)	1998-03-31	2003-02-25	Bristol-Myers Squibb Pharma Company	Quinolone vitronectin receptor antagonist pharmaceuticals
US6548663B1 (en)	1998-03-31	2003-04-15	Bristol-Myers Squibb Pharma Company	Benzodiazepine vitronectin receptor antagonist pharmaceuticals
US6537520B1 (en)	1998-03-31	2003-03-25	Bristol-Myers Squibb Pharma Company	Pharmaceuticals for the imaging of angiogenic disorders
WO1999051628A1 (en)	1998-04-03	1999-10-14	Du Pont Pharmaceuticals Company	Radiopharmaceuticals for imaging infection and inflammation and for imaging and treatment of cancer
CA2727746A1 (en)	1998-12-18	2000-06-22	Bristol-Myers Squibb Pharma Company	Quinolone vitronectin receptor antagonist pharmaceuticals
US6794518B1 (en)	1998-12-18	2004-09-21	Bristol-Myers Squibb Pharma Company	Vitronectin receptor antagonist pharmaceuticals
EP1140864A2 (en)	1998-12-18	2001-10-10	Du Pont Pharmaceuticals Company	Vitronectin receptor antagonist pharmaceuticals
US6511649B1 (en) *	1998-12-18	2003-01-28	Thomas D. Harris	Vitronectin receptor antagonist pharmaceuticals
US6569402B1 (en)	1998-12-18	2003-05-27	Bristol-Myers Squibb Pharma Company	Vitronectin receptor antagonist pharmaceuticals
US6656448B1 (en)	2000-02-15	2003-12-02	Bristol-Myers Squibb Pharma Company	Matrix metalloproteinase inhibitors
US6878363B2 (en) *	2000-05-17	2005-04-12	Bristol-Myers Squibb Pharma Company	Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
EP1268450A1 (en) *	2000-06-01	2003-01-02	Bristol-Myers Squibb Pharma Company	Lactams substituted by cyclic succinates as inhibitors of a-beta protein production
AU2002230576A1 (en) *	2000-11-03	2002-05-15	Bristol-Myers Squibb Pharma Company	Simultaneous dual isotope imaging of cardiac perfusion and cardiac inflammation
CN1136921C (zh) *	2001-04-27	2004-02-04	北京师范大学	一种心肌显像剂及其制备方法
US20090062256A1 (en) *	2001-06-01	2009-03-05	Bristol-Myers Squibb Pharma Company	LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Abeta PROTEIN PRODUCTION
RU2186834C1 (ru) *	2001-06-22	2002-08-10	Быстров Владимир Николаевич	Металлоплакирующая присадка к смазочным композициям
MXPA04001113A (es) *	2001-08-08	2004-07-08	Bristol Myers Squibb Pharma Co	Formacion de imagenes simultaneas de perfusion cardiaca y agente formador de imagenes dirigido al receptor de vitronectina.
US6838074B2 (en)	2001-08-08	2005-01-04	Bristol-Myers Squibb Company	Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
US20050106100A1 (en) *	2003-09-03	2005-05-19	Harris Thomas D.	Compounds containing matrix metalloproteinase substrates and methods of their use
WO2007005491A1 (en) *	2005-06-30	2007-01-11	Bristol-Myers Squibb Pharma Company	Hydrazide conjugates as imaging agents
US20110236308A1 (en) *	2006-04-19	2011-09-29	The General Hospital Corporation	Aryl Bidentate Isonitriles and Their Uses
WO2008053285A1 (en) *	2006-10-30	2008-05-08	Draximage Limited	Methods for preparing 2-methoxyisobutylisonitrile and tetrakis(2-methoxyisobutylisonitrile)copper(i) tetrafluoroborate
EP2821394A1 (en) *	2013-07-01	2015-01-07	Fundacion MEDINA. Centro de Excelencia en Investigacion de Medicamentos Innovadores en Andalucia	Compounds with antibacterial activity

Family Cites Families (9)

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Publication number	Priority date	Publication date	Assignee	Title
DE1215142B (de) *	1964-07-09	1966-04-28	Bayer Ag	Verfahren zur Herstellung von araliphatischen Isonitrilen
GB1187755A (en) *	1968-02-24	1970-04-15	Bayer Ag	A Process for the Production of Isonitriles
DE1962898A1 (de) *	1969-12-16	1971-06-24	Bayer Ag	Verfahren zur Herstellung von Isonitrilen
JPS57165370A (en) *	1981-03-18	1982-10-12	Ici Ltd	Triazole or imidazole compounds, manufacture and fungicidal or plant growth regulant agent
US4347251A (en) *	1981-07-13	1982-08-31	American Cyanamid Company	Novel 3-substituted amino-1-substituted heteroaryl-2-pyrazolines
US4452774A (en) *	1982-04-30	1984-06-05	President And Fellows Of Harvard College	Isonitrile radionuclide complexes for labelling and imaging agents
DE3343673A1 (de) *	1983-12-02	1985-09-05	Basf Ag, 6700 Ludwigshafen	Verfahren zur gleichzeitigen herstellung von nitrilen und acrylamid bzw. methacrylamid
US4707544A (en) *	1984-11-28	1987-11-17	President And Fellows Of Harvard College	Metal-isonitrile adducts for preparing radionuclide complexes for labelling and imaging agents
US4735793A (en) *	1985-08-30	1988-04-05	Massachusetts Institute Of Technology	Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide complexes

1986
- 1986-12-16 CA CA000525461A patent/CA1305160C/en not_active Expired - Lifetime
- 1986-12-20 ES ES86117847T patent/ES2036171T3/es not_active Expired - Lifetime
- 1986-12-20 EP EP86117847A patent/EP0233368B1/en not_active Expired - Lifetime
- 1986-12-20 DE DE8686117847T patent/DE3673000D1/de not_active Expired - Lifetime
- 1986-12-22 AU AU66842/86A patent/AU594407B2/en not_active Expired
- 1986-12-22 JP JP61304069A patent/JPH0755914B2/ja not_active Expired - Lifetime
- 1986-12-22 HU HU865398A patent/HU201301B/hu unknown
- 1986-12-22 NO NO865247A patent/NO166640C/no unknown
- 1986-12-22 IL IL81055A patent/IL81055A/xx not_active IP Right Cessation
- 1986-12-22 CN CN91105401A patent/CN1057470C/zh not_active Expired - Lifetime
- 1986-12-22 ID IDP355186A patent/ID1037B/id unknown
- 1986-12-22 MX MX004749A patent/MX168821B/es unknown
- 1986-12-22 KR KR1019860011046A patent/KR940011456B1/ko not_active Expired - Lifetime
- 1986-12-22 DK DK198606238A patent/DK173003B1/da not_active IP Right Cessation
- 1986-12-22 IE IE335386A patent/IE59758B1/en not_active IP Right Cessation
- 1986-12-22 FI FI865260A patent/FI91747C/fi not_active IP Right Cessation
- 1986-12-22 PT PT83996A patent/PT83996B/pt active IP Right Revival
1987
- 1987-06-01 US US07/056,003 patent/US4988827A/en not_active Expired - Lifetime
1989
- 1989-01-09 SU SU894613202A patent/SU1635903A3/ru active
1990
- 1990-07-27 GR GR90400540T patent/GR3000681T3/el unknown
1994
- 1994-09-22 JP JP6227693A patent/JP2774940B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FI865260L (fi)	1987-06-24
NO166640C (no)	1991-08-21
GR3000681T3 (en)	1991-09-27
JP2774940B2 (ja)	1998-07-09
ES2036171T3 (es)	1996-07-16
CN1057470C (zh)	2000-10-18
IE59758B1 (en)	1994-03-23
FI91747B (fi)	1994-04-29
CA1305160C (en)	1992-07-14
NO865247L (no)	1987-06-24
ID1037B (id)	1996-10-24
NO166640B (no)	1991-05-13
EP0233368A1 (en)	1987-08-26
AU594407B2 (en)	1990-03-08
FI865260A0 (fi)	1986-12-22
AU6684286A (en)	1987-06-25
CN1057585A (zh)	1992-01-08
SU1635903A3 (ru)	1991-03-15
HU201301B (en)	1990-10-28
KR870005976A (ko)	1987-07-08
EP0233368B1 (en)	1990-07-25
DE3673000D1 (de)	1990-08-30
IE863353L (en)	1987-06-23
PT83996A (en)	1987-01-01
MX168821B (es)	1993-06-10
KR940011456B1 (ko)	1994-12-15
IL81055A (en)	1991-07-18
HUT43557A (en)	1987-11-30
JPH0755914B2 (ja)	1995-06-14
FI91747C (fi)	1994-08-10
JPH07242615A (ja)	1995-09-19
DK623886D0 (da)	1986-12-22
DK623886A (da)	1987-06-24
US4988827A (en)	1991-01-29
PT83996B (pt)	1989-07-31
IL81055A0 (en)	1987-03-31
JPS62201363A (ja)	1987-09-05
NO865247D0 (no)	1986-12-22

Legal Events

Date	Code	Title	Description
1999-11-01	B1	Patent granted (law 1993)
2007-01-08	PUP	Patent expired

Publication	Publication Date	Title
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JP2547514B2 (ja)	1996-10-23	プロピレンアミンオキシム
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EP0515670B1 (en)	1996-04-03	Hexadentate ligands useful in radiographic imaging agents
JPS5998040A (ja)	1984-06-06	イメ−ジング剤
CA1090804A (en)	1980-12-02	5,6-dihydro-8,9-dimethoxy-1-methyl-3-(phenylamino) imidazo[5,1-a]isoquinoline compounds
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KR20020093404A (ko)	2002-12-16	심근 및 암 영상용 방사성 동위원소 착화합물과 리간드
IL28389A (en)	1971-10-20	4-phenyl-piperidine derivatives and pharmaceutical compositions containing them