DK174190A - Klonede gener, som koder for ig-cd4-fusionsproteiner, og deres anvendelse - Google Patents

Klonede gener, som koder for ig-cd4-fusionsproteiner, og deres anvendelse Download PDF

Info

Publication number
DK174190A
DK174190A DK174190A DK174190A DK174190A DK 174190 A DK174190 A DK 174190A DK 174190 A DK174190 A DK 174190A DK 174190 A DK174190 A DK 174190A DK 174190 A DK174190 A DK 174190A
Authority
DK
Denmark
Prior art keywords
fusion proteins
immunoglobulin
siv
hiv
genes coding
Prior art date
Application number
DK174190A
Other languages
English (en)
Other versions
DK174190D0 (da
Inventor
Brian Seed
Original Assignee
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp
Publication of DK174190D0 publication Critical patent/DK174190D0/da
Publication of DK174190A publication Critical patent/DK174190A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK174190A 1988-01-22 1990-07-20 Klonede gener, som koder for ig-cd4-fusionsproteiner, og deres anvendelse DK174190A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14735188A 1988-01-22 1988-01-22
PCT/US1989/000238 WO1989006690A1 (en) 1988-01-22 1989-01-23 Cloned genes encoding ig-cd4 fusion proteins and the use thereof

Publications (2)

Publication Number Publication Date
DK174190D0 DK174190D0 (da) 1990-07-20
DK174190A true DK174190A (da) 1990-09-14

Family

ID=22521217

Family Applications (1)

Application Number Title Priority Date Filing Date
DK174190A DK174190A (da) 1988-01-22 1990-07-20 Klonede gener, som koder for ig-cd4-fusionsproteiner, og deres anvendelse

Country Status (12)

Country Link
EP (1) EP0325262B1 (da)
JP (1) JP2980928B2 (da)
KR (1) KR900700606A (da)
AT (1) ATE102996T1 (da)
DE (1) DE68913771T2 (da)
DK (1) DK174190A (da)
ES (1) ES2051897T3 (da)
FI (1) FI903665A7 (da)
IE (1) IE63186B1 (da)
PT (1) PT89484B (da)
WO (1) WO1989006690A1 (da)
ZA (1) ZA89430B (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8037646B2 (en) 2004-04-02 2011-10-18 Aloys Wobben Method for erecting a tower

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6710169B2 (en) 1987-10-02 2004-03-23 Genentech, Inc. Adheson variants
US5336603A (en) * 1987-10-02 1994-08-09 Genentech, Inc. CD4 adheson variants
ZA887365B (en) * 1987-10-02 1990-05-30 Genentech Inc Adheson variants
US6406697B1 (en) 1989-02-23 2002-06-18 Genentech, Inc. Hybrid immunoglobulins
US5225538A (en) * 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
US5116964A (en) * 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
EP0394827A1 (en) * 1989-04-26 1990-10-31 F. Hoffmann-La Roche Ag Chimaeric CD4-immunoglobulin polypeptides
FR2650598B1 (fr) * 1989-08-03 1994-06-03 Rhone Poulenc Sante Derives de l'albumine a fonction therapeutique
JPH05500611A (ja) * 1989-08-23 1993-02-12 ザ・ジェネラル・ホスピタル・コーポレーション 非ヒト霊長類ｃｄ４ポリペプチド、グリコシル化可能なヒトｃｄ４分子、その断片、その融合タンパク質、その遺伝子配列および使用
DE59010908D1 (de) 1989-09-12 2000-08-10 Hoffmann La Roche TNF-bindende Proteine
JP2009165489A (ja) * 1989-11-22 2009-07-30 Genentech Inc リガンド結合タンパク質および安定血漿タンパク質からなる融合タンパク質
US6458360B1 (en) 1990-04-25 2002-10-01 The Johns Hopkins University Soluble complement regulatory molecules
DK106490D0 (da) * 1990-04-30 1990-04-30 Novo Nordisk As Celle
IL97996A0 (en) * 1990-04-30 1992-06-21 Novo Nordisk As Hybrid cellular receptor
US7253264B1 (en) 1990-06-28 2007-08-07 Sanofi-Arentideutschland GmbH Immunoglobulin fusion proteins, their production and use
ATE169030T1 (de) * 1990-06-28 1998-08-15 Hoechst Ag Fusionsproteine mit immunglobulinanteilen, ihre herstellung und verwendung
JPH06502301A (ja) * 1990-08-29 1994-03-17 サントル　オスピタリエ　レジオナル　デ　ナント 安定タンパク質コアに結合されたタンパク質ポリリガンド
GB9022543D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Antibody production
DE4037837A1 (de) * 1990-11-28 1992-06-04 Behringwerke Ag Zellfreie rezeptorbindungsteste, ihre herstellung und verwendung
US7070991B2 (en) 1991-02-08 2006-07-04 Progenics Pharmaceuticals, Inc. Cells expressing a CD4-IgG2 chimeric heterotetramer
CA2080226C (en) 1991-02-08 2004-05-04 Gary A. Beaudry Cd4-gamma2 and cd4-igg2 chimeras
US6004811A (en) 1991-03-07 1999-12-21 The Massachussetts General Hospital Redirection of cellular immunity by protein tyrosine kinase chimeras
US6753162B1 (en) 1991-03-07 2004-06-22 The General Hospital Corporation Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
US7049136B2 (en) 1991-03-07 2006-05-23 The General Hospital Corporation Redirection of cellular immunity by receptor chimeras
US5851828A (en) 1991-03-07 1998-12-22 The General Hospital Corporation Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
MX9203138A (es) * 1991-03-12 1992-09-01 Biogen Inc Dominio de enlace cd2-de antigeno 3 (lfa-3) asociado con funcion linfositos.
WO1992016622A1 (en) * 1991-03-12 1992-10-01 Biogen, Inc. Cd2-binding domain of lymphocyte function associated antigen 3
JPH06508133A (ja) * 1991-05-31 1994-09-14 ジェネンテク，インコーポレイテッド Ｈｉｖに関連した免疫性の血小板減少性紫斑病の治療
EP0533006A1 (en) * 1991-09-18 1993-03-24 F.Hoffmann-La Roche & Co. Aktiengesellschaft Chimaeric interleukin 5-receptor/immunoglobulin polypeptides
US6764681B2 (en) 1991-10-07 2004-07-20 Biogen, Inc. Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
EP0664710A4 (en) 1992-08-07 1998-09-30 Progenics Pharm Inc IMMUNOCONJUGATES COMPOSED OF A NON-PEPTIDYLENE PART AND A CD4-GAMMA2 OR CD4-IgG2 PART AND USES THEREOF.
DE4228839A1 (de) 1992-08-29 1994-03-03 Behringwerke Ag Verfahren zum Nachweis und zur Bestimmung von Mediatoren
EP0676965B1 (en) 1992-11-16 2007-07-25 Centocor Inc. Method of reducing immunogenicity of variable region of antibodies
CA2195653C (en) * 1994-08-02 2010-04-27 Brian Seed Cells bearing cd4 decoy receptors and related molecules and methods
US5723125A (en) * 1995-12-28 1998-03-03 Tanox Biosystems, Inc. Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
DE19826307A1 (de) * 1998-03-08 1999-12-16 Wolfgang Bergter CD4-Radioimmunpharmaka zur Behandlung der HIV-Infektion
PT1137786E (pt) * 1999-10-08 2007-07-13 Univ Maryland Biotech Inst Quimeras de proteína do invólucro/receptor de vírus e métodos de utilização.
US6908612B2 (en) 1999-10-08 2005-06-21 University Of Maryland Biotechnology Institute Virus coat protein/receptor chimeras and methods of use
US7311920B1 (en) 1999-10-08 2007-12-25 University Of Maryland Biotechnology Institute Virus coat protein/receptor chimeras and methods of use
US6946134B1 (en) 2000-04-12 2005-09-20 Human Genome Sciences, Inc. Albumin fusion proteins
EP1274720A4 (en) 2000-04-12 2004-08-18 Human Genome Sciences Inc FUSION PROTEINS CONTAINING ALBUMIN
US7507413B2 (en) 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
WO2003009740A2 (en) 2001-07-24 2003-02-06 Biogen Idec Ma Inc. Methods for treating or preventing sclerotic disorders using cd2-binding agents
PT1463751E (pt) 2001-12-21 2013-08-26 Human Genome Sciences Inc Proteínas de fusão de albumina
CA2513213C (en) 2003-01-22 2013-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
ES2333598T5 (es) 2003-05-06 2013-09-04 Biogen Idec Hemophilia Inc Proteinas quimericas del factor de coagulacion fc para tratar la hemofilia.
AU2012200470B2 (en) * 2003-05-06 2014-12-18 Bioverativ Therapeutics Inc. Immunoglobulin Chimeric Monomer-Dimer Hybrids
US7348004B2 (en) 2003-05-06 2008-03-25 Syntonix Pharmaceuticals, Inc. Immunoglobulin chimeric monomer-dimer hybrids
AU2016244273B2 (en) * 2003-05-06 2018-10-18 Bioverativ Therapeutics Inc. Immunoglobulin Chimeric Monomer-Dimer Hybrids
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
CA2565259A1 (en) 2004-05-07 2005-12-08 Astellas Us Llc Soluble lfa-3 polypeptide for treating viral disorders
WO2010122148A1 (en) * 2009-04-24 2010-10-28 Boehringer Ingelheim International Gmbh An improved antibody domain and antibody fragments and antibodies based thereon
DE102013202353B4 (de) * 2013-02-13 2020-02-20 Adidas Ag Sohle für einen Schuh
CN112933952B (zh) * 2021-02-02 2021-10-22 东莞市科伟环保电力有限公司 一种基于大数据的pncr脱硝优化系统

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US104329A (en) * 1870-06-14 Improvement in warpiitg machines
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
WO1989001940A1 (en) * 1987-09-04 1989-03-09 Biogen, Inc. Dna sequences, recombinant dna molecules and processes for producing soluble t4 proteins
PT88641B (pt) * 1987-10-02 1993-04-30 Genentech Inc Metodo para a preparacao de uma variante de adesao

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8037646B2 (en) 2004-04-02 2011-10-18 Aloys Wobben Method for erecting a tower

Also Published As

Publication number Publication date
FI903665A0 (fi) 1990-07-20
PT89484B (pt) 1994-03-31
WO1989006690A1 (en) 1989-07-27
EP0325262A2 (en) 1989-07-26
ZA89430B (en) 1989-10-25
JPH03502283A (ja) 1991-05-30
DE68913771D1 (de) 1994-04-21
FI903665A7 (fi) 1990-07-20
PT89484A (pt) 1989-10-04
IE890182L (en) 1989-07-22
AU3281889A (en) 1989-08-11
JP2980928B2 (ja) 1999-11-22
EP0325262A3 (en) 1990-05-16
ATE102996T1 (de) 1994-04-15
IE63186B1 (en) 1995-03-22
DE68913771T2 (de) 1994-08-18
KR900700606A (ko) 1990-08-16
EP0325262B1 (en) 1994-03-16
DK174190D0 (da) 1990-07-20
ES2051897T3 (es) 1994-07-01
AU611551B2 (en) 1991-06-13

Similar Documents

Publication Publication Date Title
DK174190D0 (da) Klonede gener, som koder for ig-cd4-fusionsproteiner, og deres anvendelse
EP0613944A3 (en) Methods for regulating the immune response using CTLA4-binding molecules and IL4-binding molecules.
ATE170562T1 (de) Ctl4a rezeptor, ihn enthaltenden fusionsproteine und deren verwendungen
ATE128732T1 (de) Antigenkonstrukte von ''major histocompatibility complex'' klasse i antigenen mit spezifischen trägermolekülen, ihre herstellung und verwendung.
MC2146A1 (fr) Immunoglogulines chimeriques specifiques de la proteine p55 tac du recepteur de l'il-2
DK113389A (da) Monoklonale antistoffer
DE69029294D1 (de) Nichtmenschliche primaten CD4-Polypeptide und menschliche glykosilierbare CD4-Moleküle
ATE122394T1 (de) Pankreatische isletzellen-antigene, erhalten durch molekulare klonierung.
RU94045907A (ru) Вич-антитела человека или их фрагменты, экспрессионные кассеты, клетки-хозяева, фармацевтические композиции, способ защиты
DE68921360D1 (de) Monoklonale Antikörper von Mäusen gegen das gp41 Protein von menschlichem Immunmangelsyndrom-Virus.
DE69025211D1 (de) Protein-Antikrebsmittel
TR199801769T2 (xx) D���k reg�lasyona diren�li C3 d�n��t�r�c�ler.
Bonagura et al. Monomeric (7S) IgM found in the serum of rheumatoid arthritis patients share idiotypes with pentameric (19S) monoclonal rheumatoid factors.
Chuba Susceptibility of Monoclonal IGG Paraproteins to Plasmic Cleavage Using Glycerin Stabilized Human Plasmin
Mohammad et al. Disulfide linking of albumin to the hinge region of immunoglobulin G in normal human serum
GR900100550A (el) Μία μέ?οδος για την αναστολή της αντιγραφής ιού σε κύτταρα ?ηλαστικών χρησιμοποιώντας συζυγείς πρωτεϊνης αντιιού φυτολάκκας - μονοκλωνικού αντισώματος.
McLaughlin et al. Immunochemical classification of nonisolated light chains of immunoglobulins
Agnello et al. Precipitin Reactions of Clq with Various γ Globulins and Anionic Macromolecules
ATE260339T1 (de) Antikörper gegen menschliches restrictin
Tan-Wilson Hindrance in the simultaneous binding of two distinctly separate antibody populations to the hemoglobin antigen
EMONDS et al. An EIA method on single donor solubilized HLA antigens for the identification of anti‐HLA antibodies

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
AHB Application shelved due to non-payment