DK1743027T3 - Mutantpneumolysinproteiner - Google Patents
MutantpneumolysinproteinerInfo
- Publication number
- DK1743027T3 DK1743027T3 DK05742528.2T DK05742528T DK1743027T3 DK 1743027 T3 DK1743027 T3 DK 1743027T3 DK 05742528 T DK05742528 T DK 05742528T DK 1743027 T3 DK1743027 T3 DK 1743027T3
- Authority
- DK
- Denmark
- Prior art keywords
- mutant pneumolysin
- pneumolysin proteins
- proteins
- mutant
- pneumolysin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Gram-positive bacteria
- C07K16/1275—Streptococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56941504P | 2004-05-07 | 2004-05-07 | |
| GBGB0410220.8A GB0410220D0 (en) | 2004-05-07 | 2004-05-07 | Mutant pneumolysin proteins |
| PCT/GB2005/001792 WO2005108580A1 (en) | 2004-05-07 | 2005-05-09 | Mutant pneumolysin proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1743027T3 true DK1743027T3 (da) | 2013-09-30 |
Family
ID=32482854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05742528.2T DK1743027T3 (da) | 2004-05-07 | 2005-05-09 | Mutantpneumolysinproteiner |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7820789B2 (da) |
| EP (1) | EP1743027B1 (da) |
| JP (1) | JP4848552B2 (da) |
| KR (1) | KR101191591B1 (da) |
| CN (1) | CN101018863B (da) |
| AU (1) | AU2005240835B2 (da) |
| CA (1) | CA2566344C (da) |
| DK (1) | DK1743027T3 (da) |
| ES (1) | ES2427978T3 (da) |
| GB (1) | GB0410220D0 (da) |
| IL (2) | IL178885A (da) |
| PL (1) | PL1743027T3 (da) |
| PT (1) | PT1743027E (da) |
| SI (1) | SI1743027T1 (da) |
| WO (1) | WO2005108580A1 (da) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| US7785608B2 (en) | 2002-08-30 | 2010-08-31 | Wyeth Holdings Corporation | Immunogenic compositions for the prevention and treatment of meningococcal disease |
| US9370557B2 (en) * | 2006-06-15 | 2016-06-21 | The University Court Of The University Of Glasgow | Adjuvant compounds |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| CA2683748C (en) * | 2007-04-13 | 2016-02-16 | The Board Of Regents Of The University Of Oklahoma | Mutants of cholesterol-dependent cytolysins and uses thereof |
| GB0714963D0 (en) | 2007-08-01 | 2007-09-12 | Novartis Ag | Compositions comprising antigens |
| BRPI0821240B8 (pt) * | 2007-12-21 | 2022-10-04 | Novartis Ag | formas mutantes de estreptolisina o |
| US9125863B2 (en) * | 2008-05-22 | 2015-09-08 | Children's Medical Center Corporation | Synergistic immunogenic fusion protein-polysaccharide conjugate |
| CN102712680B (zh) * | 2008-12-24 | 2016-06-22 | 荷兰王国卫生福利和运动部国家公共卫生和环境研究所 | 修饰的肺炎链球菌溶血素(ply)多肽 |
| US20120064103A1 (en) | 2009-03-24 | 2012-03-15 | Novartis Ag | Combinations of meningococcal factor h binding protein and pneumococcal saccharide conjugates |
| WO2010125480A1 (en) * | 2009-04-30 | 2010-11-04 | Coley Pharmaceutical Group, Inc. | Pneumococcal vaccine and uses thereof |
| WO2011030218A1 (en) | 2009-09-10 | 2011-03-17 | Novartis Ag | Combination vaccines against respiratory tract diseases |
| CN102939105B (zh) * | 2009-12-22 | 2016-11-16 | 赛诺菲巴斯德有限公司 | 免疫原性组合物和相关的方法 |
| WO2011075823A1 (en) * | 2009-12-22 | 2011-06-30 | Sanofi Pasteur Limited | Immunogenic compositions |
| RU2580620C2 (ru) | 2010-08-23 | 2016-04-10 | ВАЙЕТ ЭлЭлСи | СТАБИЛЬНЫЕ КОМПОЗИЦИИ АНТИГЕНОВ Neisseria meningitidis rLP2086 |
| WO2012032489A1 (en) | 2010-09-10 | 2012-03-15 | Wyeth Llc | Non-lipidated variants of neisseria meningitidis orf2086 antigens |
| WO2012072769A1 (en) | 2010-12-01 | 2012-06-07 | Novartis Ag | Pneumococcal rrgb epitopes and clade combinations |
| US9181308B2 (en) | 2011-03-28 | 2015-11-10 | St. Jude Children's Research Hospital | Methods and compositions employing immunogenic fusion proteins |
| US20130164774A9 (en) | 2011-04-08 | 2013-06-27 | University Of Massachusetts | Methods, compositions and kits for assaying mitochondrial function |
| US9034322B2 (en) * | 2011-04-21 | 2015-05-19 | The Rockefeller University | Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria |
| CN108840912B (zh) | 2011-05-11 | 2023-07-04 | 儿童医疗中心有限公司 | 修饰的生物素结合蛋白及其融合蛋白和应用 |
| SG194733A1 (en) | 2011-05-17 | 2013-12-30 | Glaxosmithkline Biolog Sa | Vaccine against streptococcus pneumoniae |
| ITMI20111182A1 (it) | 2011-06-28 | 2012-12-29 | Canio Buonavoglia | Vaccino per coronavirus canino |
| CN104519910B (zh) | 2012-03-07 | 2017-05-03 | 诺华股份有限公司 | 肺炎链球菌抗原的含佐剂制剂 |
| CA2865745C (en) | 2012-03-09 | 2018-01-09 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| CA2900008C (en) | 2013-02-07 | 2025-10-07 | Children's Medical Center Corporation | PROTEIN ANTIGENS THAT CONFER PROTECTION AGAINST COLONIZATION AND/OR PNEUMOCOCCAL DISEASE |
| US9802987B2 (en) | 2013-03-08 | 2017-10-31 | Pfizer Inc. | Immunogenic fusion polypeptides |
| US11207396B2 (en) | 2013-05-17 | 2021-12-28 | The Board Of Regents Of The University Of Texas System | Immunization to protect against adverse cardiac events relating to pneumococcal infection |
| RU2662968C2 (ru) | 2013-09-08 | 2018-07-31 | Пфайзер Инк. | Иммуногенная композиция против neisseria meningitidis (варианты) |
| CN103936842B (zh) * | 2014-04-30 | 2016-03-23 | 重庆医科大学 | 肺炎链球菌溶血素突变体及其作为粘膜免疫佐剂的应用 |
| US9815886B2 (en) | 2014-10-28 | 2017-11-14 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| ES2993430T3 (en) * | 2014-11-21 | 2024-12-30 | Univ Oklahoma | Pneumolysin mutants and methods of use thereof |
| AU2016221318B2 (en) | 2015-02-19 | 2020-06-25 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| GB201610599D0 (en) | 2016-06-17 | 2016-08-03 | Glaxosmithkline Biologicals Sa | Immunogenic Composition |
| US10183070B2 (en) | 2017-01-31 | 2019-01-22 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| WO2018183475A1 (en) | 2017-03-28 | 2018-10-04 | Children's Medical Center Corporation | A multiple antigen presenting system (maps)-based staphylococcus aureus vaccine, immunogenic composition, and uses thereof |
| MX2019015524A (es) | 2017-06-23 | 2020-09-10 | Univ Maryland | Composiciones inmunogenicas. |
| IL281204B2 (en) | 2018-09-12 | 2025-07-01 | Affinivax Inc | Multivalent pneumococcal vaccines |
| TWI852943B (zh) | 2018-09-12 | 2024-08-21 | 美商兒童醫療中心公司 | 肺炎鏈球菌融合蛋白疫苗 |
| EP4034157A1 (en) | 2019-09-27 | 2022-08-03 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| KR20230162797A (ko) * | 2021-03-22 | 2023-11-28 | 스타맵 바이오로직스 (쑤저우) 씨오., 엘티디 | 뉴몰리신을 표적으로 하는 항원 결합 단백질 및 이의 용도 |
| CN113264999B (zh) * | 2021-04-29 | 2023-02-28 | 星济生物(苏州)有限公司 | 中和肺炎链球菌溶血素蛋白的抗原结合蛋白及其用途 |
| AU2022342080A1 (en) | 2021-09-09 | 2024-03-28 | Affinivax, Inc. | Multivalent pneumococcal vaccines |
| AU2022391752A1 (en) | 2021-11-18 | 2024-06-13 | Matrivax, Inc. | Immunogenic fusion protein compositions and methods of use thereof |
| WO2025193903A1 (en) | 2024-03-15 | 2025-09-18 | Affinivax, Inc. | Pneumococcal polysaccharide compositions and uses thereof |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5078996A (en) | 1985-08-16 | 1992-01-07 | Immunex Corporation | Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| US6716432B1 (en) * | 1988-12-16 | 2004-04-06 | James Cleland Paton | Pneumolysin mutants and pneumococcal vaccines made therefrom |
| MC2178A1 (fr) * | 1988-12-16 | 1992-05-22 | Nederlanden Staat | Mutants de la pneumolysine et vaccins a base de pneumocoque prepares a partir de ces mutants |
| IL101715A (en) | 1991-05-02 | 2005-06-19 | Amgen Inc | Recombinant dna-derived cholera toxin subunit analogs |
| WO1993013302A1 (de) | 1991-12-23 | 1993-07-08 | Michael Zoche | Motor mit einer vorrichtung zur entölung |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US5565204A (en) * | 1994-08-24 | 1996-10-15 | American Cyanamid Company | Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections |
| CN1257976C (zh) | 1996-10-23 | 2006-05-31 | 宾夕法尼亚州立大学托管会 | 改良疫苗 |
| US6113918A (en) | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| AU740956B2 (en) * | 1997-07-21 | 2001-11-15 | Baxter Healthcare Sa | Modified immunogenic pneumolysin compositions as vaccines |
| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| CA2792479A1 (en) | 1998-02-27 | 1999-09-02 | The Trustees Of The University Of Pennsylvania | Vaccines, immunotherapeutics and methods for using the same |
| JP4673974B2 (ja) | 1998-09-30 | 2011-04-20 | ワイス・ホールディングズ・コーポレイション | アジュバントとしての変異コレラホロトキシン |
| CN1977971A (zh) | 2001-06-07 | 2007-06-13 | 惠氏控股有限公司 | 作为佐剂的霍乱全毒素的突变体形式 |
| IL159209A0 (en) | 2001-06-07 | 2004-06-01 | Wyeth Corp | Mutant forms of cholera holotoxin as an adjuvant |
| UA93854C2 (ru) | 2003-12-17 | 2011-03-25 | Вайет Ллк | Иммуногенный конъюгат и способ его получения |
-
2004
- 2004-05-07 GB GBGB0410220.8A patent/GB0410220D0/en not_active Ceased
-
2005
- 2005-05-09 AU AU2005240835A patent/AU2005240835B2/en not_active Ceased
- 2005-05-09 JP JP2007512334A patent/JP4848552B2/ja not_active Expired - Fee Related
- 2005-05-09 PL PL05742528T patent/PL1743027T3/pl unknown
- 2005-05-09 CA CA2566344A patent/CA2566344C/en not_active Expired - Fee Related
- 2005-05-09 WO PCT/GB2005/001792 patent/WO2005108580A1/en not_active Ceased
- 2005-05-09 SI SI200531774T patent/SI1743027T1/sl unknown
- 2005-05-09 KR KR1020067025760A patent/KR101191591B1/ko not_active Expired - Fee Related
- 2005-05-09 CN CN2005800220763A patent/CN101018863B/zh not_active Expired - Fee Related
- 2005-05-09 US US11/568,802 patent/US7820789B2/en not_active Expired - Fee Related
- 2005-05-09 PT PT57425282T patent/PT1743027E/pt unknown
- 2005-05-09 EP EP05742528.2A patent/EP1743027B1/en not_active Expired - Lifetime
- 2005-05-09 ES ES05742528T patent/ES2427978T3/es not_active Expired - Lifetime
- 2005-05-09 DK DK05742528.2T patent/DK1743027T3/da active
-
2006
- 2006-10-26 IL IL178885A patent/IL178885A/en not_active IP Right Cessation
-
2010
- 2010-01-24 IL IL203479A patent/IL203479A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SI1743027T1 (sl) | 2013-10-30 |
| CN101018863A (zh) | 2007-08-15 |
| PL1743027T3 (pl) | 2013-11-29 |
| JP4848552B2 (ja) | 2011-12-28 |
| CA2566344A1 (en) | 2005-11-17 |
| CN101018863B (zh) | 2012-01-04 |
| EP1743027B1 (en) | 2013-07-10 |
| IL203479A (en) | 2013-04-30 |
| GB0410220D0 (en) | 2004-06-09 |
| KR101191591B1 (ko) | 2012-10-15 |
| AU2005240835B2 (en) | 2011-12-01 |
| WO2005108580A1 (en) | 2005-11-17 |
| ES2427978T3 (es) | 2013-11-05 |
| KR20070073602A (ko) | 2007-07-10 |
| JP2008505617A (ja) | 2008-02-28 |
| AU2005240835A1 (en) | 2005-11-17 |
| CA2566344C (en) | 2015-07-07 |
| US7820789B2 (en) | 2010-10-26 |
| IL178885A (en) | 2011-11-30 |
| EP1743027A1 (en) | 2007-01-17 |
| US20080112964A1 (en) | 2008-05-15 |
| IL178885A0 (en) | 2007-03-08 |
| PT1743027E (pt) | 2013-10-08 |
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