DK175604B1 - Hybridt plasminogenaktivatorlignende polypeptid - Google Patents

Hybridt plasminogenaktivatorlignende polypeptid Download PDF

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Publication number
DK175604B1
DK175604B1 DK198700509A DK50987A DK175604B1 DK 175604 B1 DK175604 B1 DK 175604B1 DK 198700509 A DK198700509 A DK 198700509A DK 50987 A DK50987 A DK 50987A DK 175604 B1 DK175604 B1 DK 175604B1
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DK
Denmark
Prior art keywords
polypeptide
plasminogen activator
amino acid
plasmid
terminal
Prior art date
Application number
DK198700509A
Other languages
Danish (da)
English (en)
Other versions
DK50987D0 (da
DK50987A (da
Inventor
Michito Tagawa
Masakatsu Wada
Masayuki Yamada
Midori Yokoyama
Naganori Numao
Original Assignee
Nissan Chemical Ind Ltd
Sagami Chem Res
Nippon Soda Co
Hodogaya Chemical Co Ltd
Tosoh Corp
Central Class Company Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Ind Ltd, Sagami Chem Res, Nippon Soda Co, Hodogaya Chemical Co Ltd, Tosoh Corp, Central Class Company Ltd filed Critical Nissan Chemical Ind Ltd
Publication of DK50987D0 publication Critical patent/DK50987D0/da
Publication of DK50987A publication Critical patent/DK50987A/da
Application granted granted Critical
Publication of DK175604B1 publication Critical patent/DK175604B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK198700509A 1986-01-31 1987-01-30 Hybridt plasminogenaktivatorlignende polypeptid DK175604B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1773486 1986-01-31
JP1773486 1986-01-31

Publications (3)

Publication Number Publication Date
DK50987D0 DK50987D0 (da) 1987-01-30
DK50987A DK50987A (da) 1987-08-01
DK175604B1 true DK175604B1 (da) 2004-12-20

Family

ID=11951975

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198700509A DK175604B1 (da) 1986-01-31 1987-01-30 Hybridt plasminogenaktivatorlignende polypeptid

Country Status (7)

Country Link
EP (1) EP0231883B1 (de)
JP (1) JP2589687B2 (de)
DE (1) DE3781420T2 (de)
DK (1) DK175604B1 (de)
ES (1) ES2043610T3 (de)
SU (1) SU1732814A3 (de)
WO (1) WO1987004720A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4916071A (en) * 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
US5242819A (en) * 1986-12-05 1993-09-07 Ciba-Geigy Corporation DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase
FI100106B (fi) * 1986-12-05 1997-09-30 Novartis Ag Menetelmä plasminogeenin yksisäikeisen yhdistelmäaktivaattorin valmist amiseksi
US5580559A (en) * 1986-12-05 1996-12-03 Ciba-Geigy Corporation Hybrid plasminogen activator
ZA879286B (en) * 1986-12-16 1988-10-26 Smith Kline Rit New plasminogen activators
WO1988005081A2 (en) * 1986-12-30 1988-07-14 Cetus Corporation Novel plasminogen activator
NL8700013A (nl) * 1987-01-06 1988-08-01 Leuven Res & Dev Vzw Hybride plasminogeenactivatoren met verbeterde trombolytische eigenschappen en geneesmiddelen die deze plasminogeenactivatoren bevatten.
NL8701021A (nl) * 1987-04-29 1988-11-16 Stichting Centraal Lab Humane t-pa(u-pa) substitutie-mutant eiwitten, daarvoor coderend recombinant dna, getransfecteerde gastheercellen, bereiding van de mutant eiwitten, en farmaceutische preparaten.
JP2561122B2 (ja) * 1988-04-13 1996-12-04 寳酒造株式会社 機能性ポリペプチド
JPH07143877A (ja) * 1993-10-01 1995-06-06 Sumitomo Pharmaceut Co Ltd 新規なｔ−ＰＡ類似体
AU2021246398A1 (en) * 2020-03-31 2022-11-03 National Cancer Center Fusion protein suitable for dissolving fibrin clot, and pharmaceutical composition containing said fusion protein
TW202405178A (zh) * 2022-04-08 2024-02-01 日商凜研究所股份有限公司 與纖維蛋白結合的抗體及含有該抗體的纖維蛋白溶解性蛋白質以及含有該蛋白質的醫藥製劑

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR241654A1 (es) * 1982-05-05 1992-10-30 Genentech Inc Procedimiento para producir activador de plasminogeno de tejido humano.
GB8314362D0 (en) * 1983-05-24 1983-06-29 Celltech Ltd Polypeptide and protein products
JPS60136520A (ja) * 1983-12-23 1985-07-20 Otsuka Pharmaceut Co Ltd フイブリン吸着性ウロキナ−ゼ複合体
GB8334498D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Compounds

Also Published As

Publication number Publication date
EP0231883B1 (de) 1992-09-02
SU1732814A3 (ru) 1992-05-07
JP2589687B2 (ja) 1997-03-12
EP0231883A1 (de) 1987-08-12
ES2043610T3 (es) 1994-01-01
WO1987004720A1 (en) 1987-08-13
JPS62272975A (ja) 1987-11-27
DK50987D0 (da) 1987-01-30
DK50987A (da) 1987-08-01
DE3781420D1 (de) 1992-10-08
DE3781420T2 (de) 1993-02-25

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