DK175695B1 - Midler til bevaring eller retablering af hudens sundhed - Google Patents

Midler til bevaring eller retablering af hudens sundhed Download PDF

Info

Publication number: DK175695B1
Authority: DK; Denmark
Prior art keywords: formula; compound; alkyl; hydrogen; use according
Prior art date: 1988-03-28

Application number

DK198901465A

Other languages

Danish (da)

English (en)

Other versions

DK146589D0 (da

DK146589A (da

Inventor

Gerard Frans Maria Cauwenbergh

Marc Joris De Brabander

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-03-28

Filing date

1989-03-22

Publication date

2005-01-24

1989-03-22 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1989-03-22 Publication of DK146589D0 publication Critical patent/DK146589D0/da

1989-09-29 Publication of DK146589A publication Critical patent/DK146589A/da

2005-01-24 Application granted granted Critical

2005-01-24 Publication of DK175695B1 publication Critical patent/DK175695B1/da

Links

230000036559 skin health Effects 0.000 title claims description 5
150000001875 compounds Chemical class 0.000 claims abstract description 28
FPCCSQOGAWCVBH-UHFFFAOYSA-N ketanserin Chemical compound C1=CC(F)=CC=C1C(=O)C1CCN(CCN2C(C3=CC=CC=C3NC2=O)=O)CC1 FPCCSQOGAWCVBH-UHFFFAOYSA-N 0.000 claims abstract description 19
229960005417 ketanserin Drugs 0.000 claims abstract description 18
150000003839 salts Chemical class 0.000 claims abstract description 9
239000000203 mixture Substances 0.000 claims description 40
239000001257 hydrogen Substances 0.000 claims description 21
229910052739 hydrogen Inorganic materials 0.000 claims description 21
239000002502 liposome Substances 0.000 claims description 18
125000000217 alkyl group Chemical group 0.000 claims description 14
239000002674 ointment Substances 0.000 claims description 13
206010040925 Skin striae Diseases 0.000 claims description 12
229910052736 halogen Inorganic materials 0.000 claims description 11
150000002367 halogens Chemical class 0.000 claims description 11
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 10
208000002260 Keloid Diseases 0.000 claims description 10
210000001117 keloid Anatomy 0.000 claims description 10
208000032544 Cicatrix Diseases 0.000 claims description 8
239000002253 acid Substances 0.000 claims description 8
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 8
231100000241 scar Toxicity 0.000 claims description 8
230000037387 scars Effects 0.000 claims description 8
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims description 8
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
230000003042 antagnostic effect Effects 0.000 claims description 5
239000006071 cream Substances 0.000 claims description 5
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239000002537 cosmetic Substances 0.000 claims description 4
229910052740 iodine Inorganic materials 0.000 claims description 4
229940076279 serotonin Drugs 0.000 claims description 4
125000003545 alkoxy group Chemical group 0.000 claims description 3
239000003814 drug Substances 0.000 claims description 3
206010040954 Skin wrinkling Diseases 0.000 claims description 2
125000003277 amino group Chemical group 0.000 claims description 2
125000005843 halogen group Chemical group 0.000 claims description 2
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238000004519 manufacturing process Methods 0.000 claims description 2
238000004321 preservation Methods 0.000 claims description 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
150000002431 hydrogen Chemical class 0.000 claims 3
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239000004480 active ingredient Substances 0.000 description 21
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DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 15
238000000034 method Methods 0.000 description 14
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238000003756 stirring Methods 0.000 description 13
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LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 9
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
239000000463 material Substances 0.000 description 8
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 8
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HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
150000003904 phospholipids Chemical class 0.000 description 6
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
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VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 4
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WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 4
239000012153 distilled water Substances 0.000 description 4
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 4
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UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 4
235000019388 lanolin Nutrition 0.000 description 4
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239000012669 liquid formulation Substances 0.000 description 4
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
239000002304 perfume Substances 0.000 description 4
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 4
239000004405 propyl p-hydroxybenzoate Substances 0.000 description 4
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239000002904 solvent Substances 0.000 description 4
LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 3
208000002874 Acne Vulgaris Diseases 0.000 description 3
229920002043 Pluronic® L 35 Polymers 0.000 description 3
RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 3
239000002202 Polyethylene glycol Substances 0.000 description 3
208000031439 Striae Distensae Diseases 0.000 description 3
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239000007864 aqueous solution Substances 0.000 description 3
239000000872 buffer Substances 0.000 description 3
235000012000 cholesterol Nutrition 0.000 description 3
229940107161 cholesterol Drugs 0.000 description 3
GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 3
235000014113 dietary fatty acids Nutrition 0.000 description 3
239000000975 dye Substances 0.000 description 3
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239000003925 fat Substances 0.000 description 3
239000000194 fatty acid Substances 0.000 description 3
229930195729 fatty acid Natural products 0.000 description 3
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 3
229910052738 indium Inorganic materials 0.000 description 3
239000007924 injection Substances 0.000 description 3
238000002347 injection Methods 0.000 description 3
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230000002335 preservative effect Effects 0.000 description 3
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PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
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NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
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FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
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FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
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239000000654 additive Substances 0.000 description 2
150000001298 alcohols Chemical class 0.000 description 2
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OWBTYPJTUOEWEK-UHFFFAOYSA-N butane-2,3-diol Chemical compound CC(O)C(C)O OWBTYPJTUOEWEK-UHFFFAOYSA-N 0.000 description 2
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PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
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HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Birds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Cosmetics (AREA)
Thermotherapy And Cooling Therapy Devices (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

DK198901465A 1988-03-28 1989-03-22 Midler til bevaring eller retablering af hudens sundhed DK175695B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US17385888A	1988-03-28	1988-03-28
US17385888		1988-03-28

Publications (3)

Publication Number	Publication Date
DK146589D0 DK146589D0 (da)	1989-03-22
DK146589A DK146589A (da)	1989-09-29
DK175695B1 true DK175695B1 (da)	2005-01-24

Family

ID=22633820

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198901465A DK175695B1 (da)	1988-03-28	1989-03-22	Midler til bevaring eller retablering af hudens sundhed

Country Status (15)

Country	Link
EP (1)	EP0335442B1 (fr)
JP (1)	JP2747317B2 (fr)
KR (1)	KR890014089A (fr)
AT (1)	ATE137964T1 (fr)
CA (1)	CA1331140C (fr)
DE (1)	DE68926473T2 (fr)
DK (1)	DK175695B1 (fr)
ES (1)	ES2087072T3 (fr)
GR (1)	GR3019926T3 (fr)
IE (1)	IE73206B1 (fr)
IL (1)	IL89749A (fr)
NZ (1)	NZ228447A (fr)
PH (1)	PH26635A (fr)
PT (1)	PT90134B (fr)
ZA (1)	ZA892231B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5703088A (en) *	1989-08-21	1997-12-30	Beth Israel Deaconess Medical Center, Inc.	Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
US5693645A (en) *	1992-12-23	1997-12-02	Beth Israel Deaconess Medical Center, Inc.	Use of spiperone or spiperone derivatives as immunosuppressant agents
FR2758263B1 (fr) *	1997-01-16	1999-12-17	Oreal	Utilisation d'un antagoniste ou d'un agoniste de serotonine specifiques respectivement du recepteur 5ht2 et 5ht1d dans une composition cosmetique ou dermatologique pour peaux sensibles et composition obtenue
US6150403A (en) *	1997-10-14	2000-11-21	The Procter & Gamble Company	Topical compositions for regulating the oily/shiny appearance of skin
KR20260042078A (ko) *	2023-07-14	2026-03-30	앨러스틴 스킨케어, 인크.	국소 항산화제 조성물 및 이의 사용 방법
CN118384042B (zh) *	2024-06-28	2024-10-29	花安堂生物科技集团有限公司	一种组合物和应用

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Publication number	Priority date	Publication date	Assignee	Title
US4335127A (en) *	1979-01-08	1982-06-15	Janssen Pharmaceutica, N.V.	Piperidinylalkyl quinazoline compounds, composition and method of use
DK151811C (da) *	1979-11-23	1988-06-06	Pfizer	Analogifremgangsmaade til fremstilling af n-(5-tetrazolyl)-1-oxo-1h-thiazolooe3,2-aaa-pyrimidin-2-carboxamider eller farmaceutisk acceptable kationsalte deraf samt 1-oxo-1h-thiazolooe3,2-aaapyrimidin-2-carboxylsyrer til anvendelse som udgangsmaterialer ved fremgangsmaaden
JPS56150091A (en) *	1980-03-28	1981-11-20	Janssen Pharmaceutica Nv	3-(1-piperidinylalkyl)-4h-pyrido(1,2-a)pyrimidine- 4-one derivative and its manufacture
US4444780A (en) *	1982-08-30	1984-04-24	Ortho Pharmaceutical Corporation	Method for treating atopic dermatitis
US4665075A (en) *	1984-12-05	1987-05-12	Janssen Pharmaceutica N.V.	Derivatives of hydroxy- or amino-substituted (piperidinylalkyl)quinazolines
AU598002B2 (en) *	1986-07-15	1990-06-14	Cilag Ltd.	Method of preparing single bilayered liposomes
JPH07103029B2 (ja) *	1986-09-03	1995-11-08	ライオン株式会社	イソチペンジル類含有組成物
ES2094718T3 (es) *	1986-09-22	1997-02-01	Janssen Pharmaceutica Nv	Antagonistas de la serotonine para el tratamiento de heridas.
JPH0655682A (ja) *	1992-08-06	1994-03-01	Gunze Ltd	熱収縮性多層フィルム

1989
- 1989-03-21 ES ES89200713T patent/ES2087072T3/es not_active Expired - Lifetime
- 1989-03-21 DE DE68926473T patent/DE68926473T2/de not_active Expired - Lifetime
- 1989-03-21 EP EP89200713A patent/EP0335442B1/fr not_active Expired - Lifetime
- 1989-03-21 AT AT89200713T patent/ATE137964T1/de not_active IP Right Cessation
- 1989-03-21 NZ NZ228447A patent/NZ228447A/xx unknown
- 1989-03-22 DK DK198901465A patent/DK175695B1/da not_active IP Right Cessation
- 1989-03-22 PH PH38373A patent/PH26635A/en unknown
- 1989-03-22 CA CA000594415A patent/CA1331140C/fr not_active Expired - Lifetime
- 1989-03-23 ZA ZA892231A patent/ZA892231B/xx unknown
- 1989-03-23 IE IE94389A patent/IE73206B1/en not_active IP Right Cessation
- 1989-03-27 IL IL89749A patent/IL89749A/xx unknown
- 1989-03-27 JP JP1072035A patent/JP2747317B2/ja not_active Expired - Lifetime
- 1989-03-28 KR KR1019890003893A patent/KR890014089A/ko not_active Ceased
- 1989-03-28 PT PT90134A patent/PT90134B/pt not_active IP Right Cessation
1996
- 1996-05-16 GR GR960401222T patent/GR3019926T3/el unknown

Also Published As

Publication number	Publication date
GR3019926T3 (en)	1996-08-31
PT90134A (pt)	1989-11-10
KR890014089A (ko)	1989-10-21
DE68926473T2 (de)	1996-10-02
ATE137964T1 (de)	1996-06-15
EP0335442A3 (fr)	1992-08-12
PH26635A (en)	1992-09-04
JPH029808A (ja)	1990-01-12
ZA892231B (en)	1990-11-28
ES2087072T3 (es)	1996-07-16
EP0335442B1 (fr)	1996-05-15
DK146589D0 (da)	1989-03-22
DK146589A (da)	1989-09-29
PT90134B (pt)	1994-12-30
NZ228447A (en)	1990-08-28
IE890943L (en)	1989-09-28
IL89749A (en)	1993-08-18
IE73206B1 (en)	1997-05-07
DE68926473D1 (de)	1996-06-20
CA1331140C (fr)	1994-08-02
EP0335442A2 (fr)	1989-10-04
JP2747317B2 (ja)	1998-05-06

Legal Events

Date	Code	Title	Description
1994-02-28	PBP	Patent lapsed
2009-04-06	PUP	Patent expired

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