DK1765498T3 - Bioreaktor til undersøgelse af virkningerne af påførte stimuli på celleaktiviteten - Google Patents

Bioreaktor til undersøgelse af virkningerne af påførte stimuli på celleaktiviteten

Info

Publication number
DK1765498T3
DK1765498T3 DK05753716.9T DK05753716T DK1765498T3 DK 1765498 T3 DK1765498 T3 DK 1765498T3 DK 05753716 T DK05753716 T DK 05753716T DK 1765498 T3 DK1765498 T3 DK 1765498T3
Authority
DK
Denmark
Prior art keywords
duct
chamber
culture
control unit
culture medium
Prior art date
Application number
DK05753716.9T
Other languages
English (en)
Inventor
Arti Ahluwalia
Federico Vozzi
Giovanni Vozzi
Nicola Forgione
Antonino Previti
Valerio Rossi
Cristiano Scarpa
Original Assignee
Univ Pisa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pisa filed Critical Univ Pisa
Application granted granted Critical
Publication of DK1765498T3 publication Critical patent/DK1765498T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/22—Transparent or translucent parts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/26—Conditioning fluids entering or exiting the reaction vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/08—Chemical, biochemical or biological means, e.g. plasma jet, co-culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Mechanical Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK05753716.9T 2004-06-18 2005-06-16 Bioreaktor til undersøgelse af virkningerne af påførte stimuli på celleaktiviteten DK1765498T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000046A ITPI20040046A1 (it) 2004-06-18 2004-06-18 Bioreattore per lo studio degli effetti sulle attivita' cellulari di stimoli imposti
PCT/IB2005/001691 WO2005123258A1 (en) 2004-06-18 2005-06-16 Bioreactor for studying the effects of imposed stimuli on cellular activity

Publications (1)

Publication Number Publication Date
DK1765498T3 true DK1765498T3 (da) 2010-06-07

Family

ID=34972556

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05753716.9T DK1765498T3 (da) 2004-06-18 2005-06-16 Bioreaktor til undersøgelse af virkningerne af påførte stimuli på celleaktiviteten

Country Status (8)

Country Link
US (1) US7790444B2 (da)
EP (1) EP1765498B1 (da)
AT (1) ATE460226T1 (da)
DE (1) DE602005019883D1 (da)
DK (1) DK1765498T3 (da)
ES (1) ES2341975T3 (da)
IT (1) ITPI20040046A1 (da)
WO (1) WO2005123258A1 (da)

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* Cited by examiner, † Cited by third party
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DE102006022307A1 (de) * 2006-05-11 2007-11-15 Respironics Novametrix, LLC, Wallingford Einwegbioreaktor mit Sensoranordnung
US20080032396A1 (en) * 2006-08-02 2008-02-07 Becton, Dickinson And Company Bioreactor and Method
WO2010013068A2 (en) * 2008-08-01 2010-02-04 Kirkstall Limited Bioreactor chamber
IT1400293B1 (it) * 2009-03-30 2013-05-24 Univ Pisa Bioreattore high-throughput sensorizzato per l'imposizione di pressione idrodinamica e shear stress su colture cellulari.
FR2945818A1 (fr) * 2009-05-20 2010-11-26 Pasteur Institut Dispositif pour cultiver in vitro des biofilms et ensemble d'observation non-invasive du developpement de biofilms sur surface inerte ou sur surface vivante par microscopie confocale
WO2011000572A1 (de) * 2009-07-02 2011-01-06 Patenthandel Portfoliofonds I Gmbh & Co. Kg Verfahren und vorrichtung zum nachweis von biologischen langzeiteffekten in zellen
US20130230907A1 (en) * 2010-03-29 2013-09-05 Arti Ahluwalia High-throughput sensorized bioreactor for applying hydrodynamic pressure and shear stress stimuli on cell cultures
AT511174A1 (de) * 2011-03-01 2012-09-15 Univ Graz Tech Steriles invitro messverfahren für adhärente säugetierzellen
DE102011075762A1 (de) * 2011-05-12 2012-11-15 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Analysegerät zur automatisierten Bestimmung einer Messgröße einer Messflüssigkeit
WO2012156682A1 (en) 2011-05-16 2012-11-22 Parker Hannifin Manufacturing Limited Bioreactor chamber
GB201108165D0 (en) 2011-05-16 2011-06-29 Kirkstall Ltd Bioreactor chamber and method
WO2013053779A1 (en) * 2011-10-10 2013-04-18 DASGIP Information and Process Technology GmbH Biotechnological apparatus comprising a bioreactor, exhaust gas temperature control device for a bioreactor and a method for treating an exhaust gas stream in a biotechnological apparatus
ES2435092B1 (es) 2012-06-14 2014-09-09 Aglaris Cell S.L. Método y sistema de cultivo celular
ES2489315B1 (es) * 2013-01-16 2015-09-09 Fundación Para La Investigación Biomédica Del Hospital Universitario La Paz Cámara de cultivo celular sobre biomateriales
PT106827B (pt) * 2013-03-11 2015-03-11 Univ Aveiro Bioreator de estímulo para caracterização biomecânica de engenharia de tecidos
CN106554902B (zh) * 2016-09-02 2019-03-05 四川大学 一种力-化学耦合生物学实验装置
US20210214713A9 (en) * 2017-02-17 2021-07-15 Massachusetts Institute Of Technology Methods for experimental evolution of natural and synthetic microbes
JP7060513B2 (ja) * 2017-04-10 2022-04-26 古河電気工業株式会社 送液デバイス及び送液方法
EP3546564A1 (en) * 2018-03-27 2019-10-02 The Automation Partnership (Cambridge) Limited Auto-aligning cable sensor
CN108641943A (zh) * 2018-04-10 2018-10-12 中国科学院上海技术物理研究所 一种用于空间胚胎发育及状态保存装置
CN108918451B (zh) * 2018-09-13 2024-02-13 上海健康医学院 一种细胞代谢实时检测及动态干预装置及测试干预方法
CN111363679B (zh) * 2018-12-26 2023-02-28 浙江大学 一种用于刺激细胞大量分泌外泌体的方法
WO2020150107A1 (en) 2019-01-16 2020-07-23 University Of Florida Research Foundation Bioreactor chamber and systems thereof
CN110804547B (zh) * 2019-05-02 2024-10-01 金华职业技术学院 一种细胞样品压力刺激装置
CN113913295B (zh) * 2021-10-22 2023-12-29 上海芙普瑞生物科技有限公司 一种细胞成活率高的免疫细胞car-t培养设备及培养方法
CN115386460A (zh) * 2022-07-22 2022-11-25 中国科学院生态环境研究中心 活细胞培养观测装置、制造方法和使用方法
EP4372074A1 (en) 2022-11-21 2024-05-22 Medizinische Universität Graz Method for in vitro culture under flow and flow chamber therefor

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US20060258000A1 (en) * 2003-02-26 2006-11-16 Allen Jared W Use of steady-state oxygen gradients to modulate animal cell functions

Also Published As

Publication number Publication date
EP1765498B1 (en) 2010-03-10
US20080274539A1 (en) 2008-11-06
ES2341975T3 (es) 2010-06-30
ITPI20040046A1 (it) 2004-09-18
ATE460226T1 (de) 2010-03-15
EP1765498A1 (en) 2007-03-28
DE602005019883D1 (de) 2010-04-22
WO2005123258A1 (en) 2005-12-29
US7790444B2 (en) 2010-09-07

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