DK176890A - Analogifremgangsmaade til fremstilling af dialkylaminoethenyl-2(1h)pyridinoner - Google Patents

Analogifremgangsmaade til fremstilling af dialkylaminoethenyl-2(1h)pyridinoner Download PDF

Info

Publication number: DK176890A
Authority: DK; Denmark
Prior art keywords: hydrogen; cyano; pyridinones; preparing; dialkylaminoethenyl
Prior art date: 1982-08-02

Application number

DK176890A

Other languages

English (en)

Other versions

DK176890D0 (da

Inventor

George Yohe Lesher

Baldev Singh

Original Assignee

Sterling Drug Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-08-02

Filing date

1990-07-25

Publication date

1990-07-25

1990-07-25 Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc

1990-07-25 Publication of DK176890A publication Critical patent/DK176890A/da

1990-07-25 Publication of DK176890D0 publication Critical patent/DK176890D0/da

Links

229910052739 hydrogen Inorganic materials 0.000 abstract 8
239000001257 hydrogen Substances 0.000 abstract 8
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 5
125000004093 cyano group Chemical group *C#N 0.000 abstract 4
-1 hydroxy, amino, cyano, carbamyl Chemical group 0.000 abstract 4
150000002431 hydrogen Chemical group 0.000 abstract 3
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
239000000496 cardiotonic agent Substances 0.000 abstract 2
239000000543 intermediate Substances 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
230000003177 cardiotonic effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
150000005054 naphthyridines Chemical class 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000005299 pyridinones Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK176890A 1982-08-02 1990-07-25 Analogifremgangsmaade til fremstilling af dialkylaminoethenyl-2(1h)pyridinoner DK176890D0 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/404,454 US4415580A (en)	1982-08-02	1982-08-02	Certain 2-(1H)-pyridinones cardiotonic compositions containing same and method of using same

Publications (2)

Publication Number	Publication Date
DK176890A true DK176890A (da)	1990-07-25
DK176890D0 DK176890D0 (da)	1990-07-25

Family

ID=23599673

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK350983A DK350983A (da)	1982-08-02	1983-08-01	Fremgangsmaade til fremstilling af 5-(alkyl)-1,6-naphthyridin-2(1h)oner og mellemprodukter til brug herved
DK176890A DK176890D0 (da)	1982-08-02	1990-07-25	Analogifremgangsmaade til fremstilling af dialkylaminoethenyl-2(1h)pyridinoner

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK350983A DK350983A (da)	1982-08-02	1983-08-01	Fremgangsmaade til fremstilling af 5-(alkyl)-1,6-naphthyridin-2(1h)oner og mellemprodukter til brug herved

Country Status (20)

Country	Link
US (1)	US4415580A (da)
EP (2)	EP0101952B1 (da)
JP (1)	JPS5944387A (da)
KR (1)	KR870000959B1 (da)
AT (1)	ATE29883T1 (da)
AU (1)	AU561679B2 (da)
DE (1)	DE3373813D1 (da)
DK (2)	DK350983A (da)
EG (1)	EG16284A (da)
ES (2)	ES8605515A1 (da)
FI (1)	FI74001C (da)
GR (1)	GR79370B (da)
GT (1)	GT198303012A (da)
IL (1)	IL69325A (da)
MY (1)	MY102475A (da)
NO (1)	NO160077C (da)
NZ (1)	NZ204969A (da)
PH (1)	PH19871A (da)
PT (1)	PT77118B (da)
ZA (1)	ZA835446B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4595762A (en) *	1982-08-25	1986-06-17	Sterling Drug Inc.	5-α-bromoalkanoyl-2-oxo-3-pyridinecarbonitriles
US4532247A (en) *	1983-08-08	1985-07-30	Sterling Drug Inc.	5-(Hydroxyalkyl or alkanoyloxymethyl)-1,6-naphthyridin-2(1H)-one and cardiotonic use thereof
US4560691A (en) *	1984-07-13	1985-12-24	Sterling Drug Inc.	5-(Phenyl)-1,6-naphthyridin-2(1H)-ones, their cardiotonic use and preparation
US4657919A (en) *	1984-08-03	1987-04-14	E. I. Du Pont De Nemours & Co.	Pyridone esters as inotropic agents
DE3431303A1 (de) *	1984-08-25	1986-02-27	Goedecke Ag	1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung
US4567186A (en) *	1985-01-14	1986-01-28	Sterling Drug Inc.	5-Heteryl-1,6-naphthyridin-2(1H)-ones, cardiotonic use thereof and intermediates therefor
US4650806A (en) *	1985-01-14	1987-03-17	Sterling Drug Inc.	Cardiotonic 5-(heterylcarbonyl)-pyridones
US4697021A (en) *	1985-01-28	1987-09-29	Sterling Drug Inc.	1,6-dihydro-6-oxo-3-pyridinecarbonitriles, intermediates for cardiotonic agents
US4634772A (en) *	1985-01-28	1987-01-06	Sterling Drug Inc.	2-[2-(di-lower-alkylamino)-1-propenyl]-6-methoxy-3-pyridinecarbonitriles, intermediates for cardiotonic agents
US4657915A (en) *	1985-01-28	1987-04-14	Sterling Drug Inc.	1,6-naphthyridine-2(1H)-ones and their use as cardiotonic agents
NZ214837A (en) *	1985-01-28	1988-10-28	Sterling Drug Inc	5-substituted 1,6 naphthyridin-2(1h)-ones
US4716170A (en) *	1985-01-28	1987-12-29	Sterling Drug Inc.	5-[1H-(5-membered-N-aromatic heteryl)-1-yl]-1,6-naphthyridin-2(1H)-ones and their cardiotonic use
TW486479B (en) *	1997-07-15	2002-05-11	Dainippon Pharmaceutical Co	5-substituted-3-oxadiazolyl-1,6-naphthyridin-2(1H)-one derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4072746A (en) *	1975-10-14	1978-02-07	Sterling Drug Inc.	3-Amino-5-(pyridinyl)-2(1H)-pyridinones
US4363911A (en) *	1981-09-03	1982-12-14	Sterling Drug Inc.	1,2-Dihydro-6-[2-(dimethylamino)ethenyl]-2-oxo-5-(pyridinyl) nicotinonitriles

1982
- 1982-08-02 US US06/404,454 patent/US4415580A/en not_active Expired - Fee Related
1983
- 1983-07-20 NZ NZ204969A patent/NZ204969A/xx unknown
- 1983-07-25 IL IL69325A patent/IL69325A/xx unknown
- 1983-07-26 AU AU17291/83A patent/AU561679B2/en not_active Ceased
- 1983-07-26 ZA ZA835446A patent/ZA835446B/xx unknown
- 1983-07-27 PT PT77118A patent/PT77118B/pt not_active IP Right Cessation
- 1983-07-28 EP EP83107465A patent/EP0101952B1/en not_active Expired
- 1983-07-28 DE DE8383107465T patent/DE3373813D1/de not_active Expired
- 1983-07-28 GR GR72074A patent/GR79370B/el unknown
- 1983-07-28 AT AT83107465T patent/ATE29883T1/de active
- 1983-07-28 FI FI832739A patent/FI74001C/fi not_active IP Right Cessation
- 1983-07-28 EP EP86107627A patent/EP0204335A3/en not_active Ceased
- 1983-07-29 GT GT198303012A patent/GT198303012A/es unknown
- 1983-08-01 ES ES524642A patent/ES8605515A1/es not_active Expired
- 1983-08-01 NO NO832784A patent/NO160077C/no unknown
- 1983-08-01 DK DK350983A patent/DK350983A/da not_active Application Discontinuation
- 1983-08-01 KR KR1019830003601A patent/KR870000959B1/ko not_active Expired
- 1983-08-02 PH PH29344A patent/PH19871A/en unknown
- 1983-08-02 EG EG480/83A patent/EG16284A/xx active
- 1983-08-02 JP JP58141813A patent/JPS5944387A/ja active Pending
1984
- 1984-03-15 ES ES530632A patent/ES530632A0/es active Granted
1987
- 1987-09-29 MY MYPI87002238A patent/MY102475A/en unknown
1990
- 1990-07-25 DK DK176890A patent/DK176890D0/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
US4415580A (en)	1983-11-15
NO160077C (no)	1989-03-08
ES524642A0 (es)	1986-03-16
ZA835446B (en)	1984-03-28
IL69325A0 (en)	1983-11-30
FI74001B (fi)	1987-08-31
EP0101952B1 (en)	1987-09-23
PT77118A (en)	1983-08-01
NO160077B (no)	1988-11-28
NO832784L (no)	1984-02-03
EP0101952A1 (en)	1984-03-07
ES8507497A1 (es)	1985-09-01
JPS5944387A (ja)	1984-03-12
FI832739A0 (fi)	1983-07-28
ATE29883T1 (de)	1987-10-15
IL69325A (en)	1986-12-31
NZ204969A (en)	1989-01-27
ES530632A0 (es)	1985-09-01
PH19871A (en)	1986-08-13
FI832739L (fi)	1984-02-03
DK350983A (da)	1984-02-03
DE3373813D1 (en)	1987-10-29
EG16284A (en)	1987-09-30
GR79370B (da)	1984-10-22
ES8605515A1 (es)	1986-03-16
KR840005809A (ko)	1984-11-19
FI74001C (fi)	1987-12-10
EP0204335A2 (en)	1986-12-10
DK350983D0 (da)	1983-08-01
PT77118B (en)	1986-02-18
KR870000959B1 (ko)	1987-05-14
MY102475A (en)	1992-06-30
AU1729183A (en)	1984-02-09
DK176890D0 (da)	1990-07-25
AU561679B2 (en)	1987-05-14
EP0204335A3 (en)	1987-11-25
GT198303012A (es)	1985-01-19

Legal Events

Date	Code	Title	Description
1991-05-27	AHB	Application shelved due to non-payment
2014-03-31	PBP	Patent lapsed	Effective date: 20130831

Publication	Publication Date	Title
DK176890D0 (da)	1990-07-25	Analogifremgangsmaade til fremstilling af dialkylaminoethenyl-2(1h)pyridinoner
ATE49763T1 (de)	1990-02-15	1h-imidazo(4,5c)chinoline und 1h-imidazo(4,5c)chinolin-4-amine.
DK502781A (da)	1982-05-15	Fremgangsmaade til fremstilling af 3-aryloxy-3-phenylpropylaminer
DK1369409T3 (da)	2006-08-14	Fremgangsmåde til fremstilling af forbindelser, der er anvendelige som mellemprodukter
DK159148C (da)	1991-02-11	Analogifremgangsmaade til fremstilling af tranexamsyrederivater
NZ228065A (en)	1990-09-26	1,2,4-triazinediones and parasiticidal compositions; processes for preparation
DK182783D0 (da)	1983-04-25	Fremgangsmade til fremstilling af 1-carboxy-(alkanoyl eller aralkanoyl)-indolin-2-carboxylsyreestere eller salte deraf
DK160309C (da)	1991-07-29	Analogifremgangsmaade til fremstilling af 8-substituerede pyrrolizidinderivater
DK149270C (da)	1986-08-25	Analogifremgangsmaade til fremstilling af beta-carbolin-3-carboxylsyrederivater
DK148804C (da)	1986-04-01	Fremgangsmaade til fremstilling af 1,2,3,4-tetrahydroquinolin-4-oner
DK0786459T3 (da)	2003-01-06	Fremgangsmåde til fremstilling af en heterobicyklisk alkoholenantiomer
DK164908C (da)	1993-01-25	Phenoxyphthalidderivater, fremgangsmaade til deres fremstilling, samt herbicidt praeparat indeholdende disse
PE20020260A1 (es)	2002-04-19	Proceso para preparar 2-(4-piridil) amino-6-dialquiloxifenil-pirido [2,3-d]pirimidin-7-onas
DK488282A (da)	1983-05-05	Fremgangsmaade til fremstilling af imidazolcarboxylsyrederivater
DK277783A (da)	1983-12-18	Fremgangsmaade til fremstilling af 4-hydroxyquinoliner
IL65666A (en)	1985-12-31	Derivatives of 4-aminomethyl-5-acyl-1,3-dihydro-2h-imidazol-2-ones and process for their preparation
SE8101592L (sv)	1981-09-18	Pyrazolopyridinoner och pyridinylnikotinater och forfarande for framstellning derav
DK452984A (da)	1985-03-23	Fremgangsmaade til fremstilling af quinolin-4-oner
IE812607L (en)	1982-05-10	Heterobicyclic compounds
DK504788A (da)	1989-03-12	Fremgangsmaade til fremstilling af makrolidforbindelser