DK1781782T3 - Modificerede vitamin K-afhængige polypeptider - Google Patents
Modificerede vitamin K-afhængige polypeptiderInfo
- Publication number
- DK1781782T3 DK1781782T3 DK05786243.5T DK05786243T DK1781782T3 DK 1781782 T3 DK1781782 T3 DK 1781782T3 DK 05786243 T DK05786243 T DK 05786243T DK 1781782 T3 DK1781782 T3 DK 1781782T3
- Authority
- DK
- Denmark
- Prior art keywords
- derivatives
- human factor
- human
- recombinant
- polypeptides
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 229930003448 Vitamin K Natural products 0.000 title abstract 2
- 230000001419 dependent effect Effects 0.000 title abstract 2
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 title abstract 2
- 235000019168 vitamin K Nutrition 0.000 title abstract 2
- 239000011712 vitamin K Substances 0.000 title abstract 2
- 150000003721 vitamin K derivatives Chemical class 0.000 title abstract 2
- 229940046010 vitamin k Drugs 0.000 title abstract 2
- 239000002299 complementary DNA Substances 0.000 abstract 2
- 239000013604 expression vector Substances 0.000 abstract 2
- 238000003259 recombinant expression Methods 0.000 abstract 2
- 108010054265 Factor VIIa Proteins 0.000 abstract 1
- 101500025568 Homo sapiens Saposin-D Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 229940012414 factor viia Drugs 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 229960000027 human factor ix Drugs 0.000 abstract 1
- 229940099816 human factor vii Drugs 0.000 abstract 1
- 229940100689 human protein c Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04019485 | 2004-08-17 | ||
| PCT/EP2005/008678 WO2006018204A1 (en) | 2004-08-17 | 2005-08-10 | Modified vitamin k dependent polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1781782T3 true DK1781782T3 (da) | 2010-08-23 |
Family
ID=34926200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05786243.5T DK1781782T3 (da) | 2004-08-17 | 2005-08-10 | Modificerede vitamin K-afhængige polypeptider |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8828939B2 (da) |
| EP (1) | EP1781782B1 (da) |
| JP (1) | JP2008509688A (da) |
| KR (1) | KR20070043051A (da) |
| CN (1) | CN101006175A (da) |
| AT (1) | ATE469216T1 (da) |
| AU (1) | AU2005274406B2 (da) |
| BR (1) | BRPI0514396A2 (da) |
| CA (1) | CA2592521A1 (da) |
| DE (1) | DE602005021509D1 (da) |
| DK (1) | DK1781782T3 (da) |
| ES (1) | ES2346072T3 (da) |
| MX (1) | MX2007001294A (da) |
| PL (1) | PL1781782T3 (da) |
| RU (1) | RU2396347C2 (da) |
| WO (1) | WO2006018204A1 (da) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| NZ542586A (en) | 2003-04-09 | 2009-11-27 | Biogenerix Ag | Method of forming a covalent conjugate between a G-CSF peptide and PEG |
| US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
| EP2392655A3 (en) | 2003-09-09 | 2012-02-29 | Novo Nordisk Health Care AG | Coagulation factor VII polypeptides |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| WO2006010143A2 (en) | 2004-07-13 | 2006-01-26 | Neose Technologies, Inc. | Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1] |
| EP3061461A1 (en) | 2004-10-29 | 2016-08-31 | ratiopharm GmbH | Remodeling and glycopegylation of fibroblast growth factor (fgf) |
| US9029331B2 (en) | 2005-01-10 | 2015-05-12 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
| EP1871795A4 (en) | 2005-04-08 | 2010-03-31 | Biogenerix Ag | COMPOSITIONS AND METHOD FOR PRODUCING GLYCOSYLATION MUTANTS OF A PROTEASE-RESISTANT HUMAN GROWTH HORMONE |
| WO2006134173A2 (en) | 2005-06-17 | 2006-12-21 | Novo Nordisk Health Care Ag | Selective reduction and derivatization of engineered proteins comprising at least one non-native cysteine |
| US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
| WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
| US20150038413A1 (en) | 2006-02-03 | 2015-02-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8759292B2 (en) | 2006-02-03 | 2014-06-24 | Prolor Biotech, Llc | Long-acting coagulation factors and methods of producing same |
| WO2007092252A2 (en) * | 2006-02-03 | 2007-08-16 | Modigene Inc | Long-acting polypeptides and methods of producing same |
| US20140113860A1 (en) | 2006-02-03 | 2014-04-24 | Prolor Biotech Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US10221228B2 (en) | 2006-02-03 | 2019-03-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8048848B2 (en) | 2006-02-03 | 2011-11-01 | Prolor Biotech Ltd. | Long-acting interferons and derivatives thereof and methods thereof |
| US9458444B2 (en) | 2006-02-03 | 2016-10-04 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US9249407B2 (en) | 2006-02-03 | 2016-02-02 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US8476234B2 (en) * | 2006-02-03 | 2013-07-02 | Prolor Biotech Inc. | Long-acting coagulation factors and methods of producing same |
| US8946155B2 (en) | 2006-02-03 | 2015-02-03 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US10351615B2 (en) | 2006-02-03 | 2019-07-16 | Opko Biologics Ltd. | Methods of treatment with long-acting growth hormone |
| US8450269B2 (en) | 2006-02-03 | 2013-05-28 | Prolor Biotech Ltd. | Long-acting growth hormone and methods of producing same |
| US8304386B2 (en) * | 2006-02-03 | 2012-11-06 | Prolor Biotech, Inc. | Long-acting growth hormone and methods of producing same |
| US8048849B2 (en) | 2006-02-03 | 2011-11-01 | Modigene, Inc. | Long-acting polypeptides and methods of producing same |
| EP1816201A1 (en) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
| EP1996186A4 (en) * | 2006-03-06 | 2009-07-22 | Humagene Inc | PROCESS FOR THE PREPARATION OF RECOMBINANT HUMAN THROMBIN AND FIBRINOGEN |
| US20090252720A1 (en) | 2006-05-24 | 2009-10-08 | Novo Nordisk Health Care Ag | Prolonged FIX Analogues and Derivatives |
| US7939632B2 (en) | 2006-06-14 | 2011-05-10 | Csl Behring Gmbh | Proteolytically cleavable fusion proteins with high molar specific activity |
| WO2007149406A2 (en) | 2006-06-19 | 2007-12-27 | Nautilus Technology Llc | Modified coagulation factor ix polypeptides and use thereof for treatment |
| US20080242607A1 (en) | 2006-07-21 | 2008-10-02 | Neose Technologies, Inc. | Glycosylation of peptides via o-linked glycosylation sequences |
| US8969532B2 (en) | 2006-10-03 | 2015-03-03 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography |
| CA2673459C (en) | 2006-12-22 | 2016-09-13 | Stefan Schulte | Modified coagulation factors with prolonged in vivo half-life |
| CN101796063B (zh) | 2007-04-03 | 2017-03-22 | 拉蒂奥法姆有限责任公司 | 使用糖聚乙二醇化g‑csf的治疗方法 |
| US9493499B2 (en) | 2007-06-12 | 2016-11-15 | Novo Nordisk A/S | Process for the production of purified cytidinemonophosphate-sialic acid-polyalkylene oxide (CMP-SA-PEG) as modified nucleotide sugars via anion exchange chromatography |
| US20100184672A1 (en) * | 2007-06-18 | 2010-07-22 | Mccarty Owen J T | Protein c for use in maintaining hemostasis |
| EP2209487A4 (en) * | 2007-10-15 | 2012-06-20 | Univ North Carolina | Human factor ix variants with an extended half life |
| AU2008342260B2 (en) * | 2007-12-27 | 2013-10-17 | Baxter Healthcare S.A. | Chemically modified Factor IX |
| DK2257311T3 (da) | 2008-02-27 | 2014-06-30 | Novo Nordisk As | Konjugerede Faktor VIII-Molekyler |
| TWI465247B (zh) | 2008-04-11 | 2014-12-21 | Catalyst Biosciences Inc | 經修飾的因子ｖｉｉ多肽和其用途 |
| JP5665733B2 (ja) | 2008-04-21 | 2015-02-04 | ノボ ノルディスク ヘルス ケア アーゲー | 高度にグリコシル化されたヒト凝固第ｉｘ因子 |
| EP2149603A1 (en) * | 2008-07-28 | 2010-02-03 | DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH | Factor IX variants with clotting activity in absence of their cofactor and their use for treating bleeding disorders |
| FI3581650T3 (fi) | 2008-09-15 | 2023-03-23 | Uniqure Biopharma B V | IX-tekijän polypeptidimutantti, sen käyttöjä ja menetelmä sen valmistamiseksi |
| EP2199387A1 (en) * | 2008-12-19 | 2010-06-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Serine protease derivatives and uses for the prevention and/or the treatment of blood coagulation disorders |
| ES2629099T3 (es) * | 2008-12-19 | 2017-08-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Derivados de serin proteasa y usos en la prevención o el tratamiento de y trastornos de la coagulación sanguinea |
| US9663778B2 (en) | 2009-07-09 | 2017-05-30 | OPKO Biologies Ltd. | Long-acting coagulation factors and methods of producing same |
| US12203113B2 (en) | 2009-07-09 | 2025-01-21 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| WO2011092242A1 (en) | 2010-01-28 | 2011-08-04 | Novo Nordisk Health Care Ag | Factor vii fusion polypeptides |
| PT3552619T (pt) | 2010-07-09 | 2025-10-23 | Bioverativ Therapeutics Inc | Polipéptidos de fator ix e métodos de uso dos mesmos |
| WO2012045769A1 (en) | 2010-10-05 | 2012-04-12 | Novo Nordisk Health Care Ag | Process for protein production |
| JP6012923B2 (ja) | 2010-12-22 | 2016-10-25 | 株式会社Ｍｃｂｉ | 認知機能障害疾患のバイオマーカーおよび該バイオマーカーを用いる認知機能障害疾患の検出方法 |
| US9522945B2 (en) | 2012-04-19 | 2016-12-20 | Opko Biologics Ltd. | Long-acting oxyntomodulin variants and methods of producing same |
| SG10202010383YA (en) | 2012-11-20 | 2020-11-27 | Opko Biologics Ltd | Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides |
| FR3001729B1 (fr) * | 2013-02-04 | 2015-03-06 | Lab Francais Du Fractionnement | Mutants du facteur x |
| JP6471385B2 (ja) * | 2013-03-15 | 2019-02-20 | グラディエーター・バイオサイエンシーズ・インコーポレイテッド | 標的化剤としてのＧｌａドメイン |
| SG11201601221XA (en) | 2013-09-24 | 2016-04-28 | Pfizer | Compositions comprising heterogeneous populations of recombinant human clotting factor xa proteins |
| US20150158926A1 (en) | 2013-10-21 | 2015-06-11 | Opko Biologics, Ltd. | Long-acting polypeptides and methods of producing and administering same |
| GB201420139D0 (en) | 2014-11-12 | 2014-12-24 | Ucl Business Plc | Factor IX gene therapy |
| EA201791275A1 (ru) | 2014-12-10 | 2017-12-29 | Опко Байолоджикс Лтд. | Способы получения ctp-модифицированных полипептидов длительного действия |
| IL301728A (en) | 2015-06-19 | 2023-05-01 | Opko Biologics Ltd | Long-term coagulation factors and methods for their preparation |
| HUE064463T2 (hu) | 2016-07-11 | 2024-03-28 | Opko Biologics Ltd | Hosszantartó hatású VII. koagulációs faktor és az elõállítására vonatkozó eljárások |
| PE20201462A1 (es) | 2017-09-05 | 2020-12-17 | Gladiator Biosciences Inc | Metodo de direccionamiento de exosomas |
| GB201813528D0 (en) | 2018-08-20 | 2018-10-03 | Ucl Business Plc | Factor IX encoding nucleotides |
| US10842885B2 (en) | 2018-08-20 | 2020-11-24 | Ucl Business Ltd | Factor IX encoding nucleotides |
| WO2021030787A1 (en) | 2019-08-15 | 2021-02-18 | Catalyst Biosciences, Inc. | Modified factor vii polypeptides for subcutaneous administration and on-demand treatment |
| CN120272568B (zh) * | 2025-06-11 | 2025-08-19 | 苏州良辰生物仪器试剂有限公司 | 抗凝血酶iii测定试剂盒及其应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR860984B (en) | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
| DK323587D0 (da) | 1987-06-25 | 1987-06-25 | Novo Industri As | Protein |
| ZA889497B (en) * | 1987-12-28 | 1990-08-29 | Lilly Co Eli | Vectors and compounds for expression of zymogen forms of human protein c |
| US5580560A (en) | 1989-11-13 | 1996-12-03 | Novo Nordisk A/S | Modified factor VII/VIIa |
| US5358932A (en) * | 1989-12-29 | 1994-10-25 | Zymogenetics, Inc. | Hybrid protein C |
| JP3270462B2 (ja) * | 1989-12-29 | 2002-04-02 | ザイモジェネティクス，インコーポレイティド | ハイブリッドプロテインｃ |
| DE19538715A1 (de) | 1995-10-18 | 1997-04-30 | Behringwerke Ag | Verfahren zur Reinigung von Faktor VII und aktiviertem Faktor VII |
| AU710069B2 (en) | 1996-06-11 | 1999-09-16 | Roche Diagnostics Gmbh | Recombinant blood-coagulation proteases |
| AT405516B (de) * | 1997-02-27 | 1999-09-27 | Immuno Ag | Faktor x-analoge mit modifizierter proteasespaltstelle |
| WO1999003496A1 (en) * | 1997-07-21 | 1999-01-28 | The University Of North Carolina At Chapel Hill | Factor ix antihemophilic factor with increased clotting activity |
| US6693075B1 (en) | 1997-10-23 | 2004-02-17 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US6747003B1 (en) | 1997-10-23 | 2004-06-08 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US7247708B2 (en) * | 1997-10-23 | 2007-07-24 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| NL1007767C2 (nl) | 1997-12-11 | 1999-06-14 | Dsm Nv | Werkwijze voor de bereiding van een polyamide nanocomposiet samenstelling. |
| AT410216B (de) * | 1999-08-10 | 2003-03-25 | Baxter Ag | Faktor x-analogon mit verbesserter aktivierbarkeit |
| JP4451514B2 (ja) | 1999-08-24 | 2010-04-14 | 財団法人化学及血清療法研究所 | 血液凝固第ｖｉｉ因子改変体 |
| EP1982732A3 (en) | 2000-02-11 | 2011-06-08 | Bayer HealthCare LLC | Factor VII or VIIA-like conjugates |
| US6905683B2 (en) | 2000-05-03 | 2005-06-14 | Novo Nordisk Healthcare A/G | Human coagulation factor VII variants |
| RU2326126C2 (ru) | 2000-09-13 | 2008-06-10 | Ново Нордиск Хелт Кэр Аг | Полипептид фактора vii свертывания крови, его получение и применение |
| EP1325127B1 (en) | 2000-10-02 | 2009-03-11 | Novo Nordisk Health Care AG | Method for the production of vitamin k-dependent proteins |
| AU2002218029A1 (en) | 2000-11-09 | 2002-05-21 | The Scripps Research Institute | Modified factor viia |
| IL157842A0 (en) | 2001-03-22 | 2004-03-28 | Novo Nordisk Healthcare Ag | Coagulation factor vii derivatives |
| US7052868B2 (en) * | 2001-09-27 | 2006-05-30 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
| FR2831170B1 (fr) * | 2001-10-19 | 2004-03-19 | Inst Nat Sante Rech Med | Proteines c modifiees activables directement par la thrombine |
| US6960657B2 (en) | 2001-11-02 | 2005-11-01 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
| US7700733B2 (en) | 2002-04-30 | 2010-04-20 | Bayer Healthcare Llc | Factor VII or VIIa polypeptide variants |
| ES2226533B1 (es) | 2002-07-25 | 2005-12-16 | Fundacio Privada I Institut De Recerca De L'hospital De La Santa Creu I Sant Pau | Nuevas variantes alelicas en el gen del factor vii. |
| WO2004029090A1 (en) | 2002-09-25 | 2004-04-08 | Novo Nordisk Health Care Ag | Human coagulation factor vii polypeptides |
| EP1549677B1 (en) | 2002-09-30 | 2011-04-13 | Bayer HealthCare LLC | FVII OR FVIIa VARIANTS HAVING INCREASED CLOTTING ACTIVITY |
| DK2085470T3 (da) | 2003-03-20 | 2012-08-06 | Bayer Healthcare Llc | FVII- eller FVIIa-varianter |
| CA2528239A1 (en) | 2003-06-05 | 2004-12-16 | Canadian Blood Services | Mutants of the factor vii epidermal growth factor domain |
| DK1644504T3 (da) | 2003-06-19 | 2010-05-25 | Bayer Healthcare Llc | Faktor VII- eller -VIIA-Gla-domænevarianter |
| WO2005032581A2 (en) | 2003-10-07 | 2005-04-14 | Novo Nordisk Health Care Ag | Hybrid molecules having factor vii/viia activity |
-
2005
- 2005-08-10 BR BRPI0514396-9A patent/BRPI0514396A2/pt not_active IP Right Cessation
- 2005-08-10 RU RU2007105677/13A patent/RU2396347C2/ru not_active IP Right Cessation
- 2005-08-10 KR KR1020077006161A patent/KR20070043051A/ko not_active Ceased
- 2005-08-10 ES ES05786243T patent/ES2346072T3/es not_active Expired - Lifetime
- 2005-08-10 DE DE602005021509T patent/DE602005021509D1/de not_active Expired - Lifetime
- 2005-08-10 MX MX2007001294A patent/MX2007001294A/es not_active Application Discontinuation
- 2005-08-10 CN CNA2005800281907A patent/CN101006175A/zh active Pending
- 2005-08-10 DK DK05786243.5T patent/DK1781782T3/da active
- 2005-08-10 WO PCT/EP2005/008678 patent/WO2006018204A1/en not_active Ceased
- 2005-08-10 CA CA002592521A patent/CA2592521A1/en not_active Abandoned
- 2005-08-10 AU AU2005274406A patent/AU2005274406B2/en not_active Ceased
- 2005-08-10 EP EP05786243A patent/EP1781782B1/en not_active Expired - Lifetime
- 2005-08-10 PL PL05786243T patent/PL1781782T3/pl unknown
- 2005-08-10 AT AT05786243T patent/ATE469216T1/de active
- 2005-08-10 JP JP2007526355A patent/JP2008509688A/ja active Pending
- 2005-08-10 US US11/632,552 patent/US8828939B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN101006175A (zh) | 2007-07-25 |
| US8828939B2 (en) | 2014-09-09 |
| DE602005021509D1 (de) | 2010-07-08 |
| ATE469216T1 (de) | 2010-06-15 |
| ES2346072T3 (es) | 2010-10-08 |
| WO2006018204A1 (en) | 2006-02-23 |
| RU2396347C2 (ru) | 2010-08-10 |
| AU2005274406A1 (en) | 2006-02-23 |
| EP1781782B1 (en) | 2010-05-26 |
| RU2007105677A (ru) | 2008-08-20 |
| US20090130060A1 (en) | 2009-05-21 |
| JP2008509688A (ja) | 2008-04-03 |
| AU2005274406B2 (en) | 2010-07-01 |
| MX2007001294A (es) | 2008-03-04 |
| KR20070043051A (ko) | 2007-04-24 |
| CA2592521A1 (en) | 2006-02-23 |
| BRPI0514396A2 (pt) | 2009-05-12 |
| EP1781782A1 (en) | 2007-05-09 |
| PL1781782T3 (pl) | 2010-10-29 |
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