DK1781787T3 - Behandling af øjenforstyrrelser kendetegnet ved et forhøjet intraokkulært tryk med sirnas - Google Patents

Behandling af øjenforstyrrelser kendetegnet ved et forhøjet intraokkulært tryk med sirnas Download PDF

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DK1781787T3
DK1781787T3 DK05781264.6T DK05781264T DK1781787T3 DK 1781787 T3 DK1781787 T3 DK 1781787T3 DK 05781264 T DK05781264 T DK 05781264T DK 1781787 T3 DK1781787 T3 DK 1781787T3
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seq
sirna
sequence selected
targeted
target gene
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Ángela Sesto
José P Román
Irene Gascón
De Buitrago Gonzalo González
Ana I Jimenez
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Sylentis Sau
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Priority claimed from GBGB0418762.1A external-priority patent/GB0418762D0/en
Priority claimed from GB0503412A external-priority patent/GB0503412D0/en
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Claims (37)

  1. BEHANDLING AF ØJENFORSTYRRELSER KENDETEGNET VED ET FORHØJET INTRAOKKULÆRT TRYK MED SIRNAS
    1. Anvendelse af siRNA i fremstillingen af et medikament til behandling af en øjentilstand, der er kendetegnet ved et øget intraokkulært tryk (IOP), hvor medikamentet er formuleret til topisk administration på hornhindeoverfladen og nedregulerer ekspressionen af et rnålgen i øjet, der er udvalgt fra gruppen bestående af carbonanhydraser II, IV og XII; adrenerge receptorer: beta 1 og 2 og alfa 1A, IB og ID; acetylcholinesterase; cyclooxygenaser 1 og 2; ATPaser: alfa 1, alfa 2, alfa 3, beta 1, beta 2; endotelleukocytadhæsionsmolekyle I (ELAM-1); angiotensin II, angiotensin Il-konverterende enzymer (ACE I og ACE II), angiotensin Il-receptors (ATR1 og ATR2) og renin; cochlin.
  2. 2. Anvendelse ifølge krav 1, hvor øjentilstanden er udvalgt fra gruppen bestående af glaukom, infektion, inflammation, uveitis, og ekspression af systemiske sygdomme.
  3. 3. Anvendelse ifølge et hvilket som helst af de foregående krav, hvor øjentilstanden er glaukom.
  4. 4. Anvendelse ifølge et hvilket som helst af de foregående krav, hvor øjentilstanden er diabetisk retinopati.
  5. 5. Anvendelse ifølge et hvilket som helst af de foregående, krav hvor siRNA’et er shRNA.
  6. 6. Anvendelse ifølge et hvilket som helst af de foregående krav, hvor siRNA’et omfatter et modificeret oligonukleotid.
  7. 7. Anvendelse ifølge et hvilket som helst af de foregående krav, hvor der anvendes en flerhed af arter af siRNA.
  8. 8. Anvendelse ifølge krav 7 hvor flerheden af arter er modrettet mod de samme mRNA-arter.
  9. 9. Anvendelse ifølge krav 7 hvor flerheden af arter er modrettet mod forskellige mRNA-arter.
  10. 10. Anvendelse ifølge et hvilket som helst af de foregående krav hvor siRNA’et er målrettet mod en sekvens, der er udvalgt fra SEQ ID 1 til SEQ ID 1829.
  11. 11. Anvendelse ifølge krav 10, hvor målgenet er carbonanhydrase IV, og siRNA’et er målrettet mod en sekvens, der er udvalgt fra SEQ ID 1 til SEQ ID 46.
  12. 12. Anvendelse ifølge krav 10, hvor målgenet er carbonanhydrase II, og siRNA’et er målrettet mod en sekvens, der er udvalgt fra SEQ ID 47 til SEQ ID 98.
  13. 13. Anvendelse ifølge krav 10, hvor målgenet er beta-adrenerg receptor 1, og siRNA’et er målrettet mod en sekvens, der er udvalgt fra SEQ ID 99 til SEQ ID 109.
  14. 14. Anvendelse ifølge krav 10, hvor målgenet er beta-adrenerg receptor 2, og siRNA’et er målrettet mod en sekvens, der er udvalgt fra SEQ ID 110 til SEQ ID 160.
  15. 15. Anvendelse ifølge krav 10, hvor målgenet er acetylcholinesterase, og siRNA’et er målrettet mod en sekvens, der er udvalgt fra SEQ ID 161 til SEQ ID 190.
  16. 16. Anvendelse ifølge krav 10, hvor målgenet er ELAM-1 (selectin E), og siRNA’et er målrettet mod en sekvens, der er udvalgt fra SEQ ID 191 til SEQ ID 318.
  17. 17. Anvendelse ifølge krav 10, hvor målgenet er prostaglandin-endoperoxidsyntase 1, og siRNA’et er målrettet mod en sekvens, der er udvalgt fra SEQ ID 319 til SEQ ID 374.
  18. 18. Anvendelse ifølge krav 10, hvor målgenet er prostaglandin-endoperoxidsyntase 2, og siRNA’et er målrettet mod en sekvens, der er udvalgt fra SEQ ID 375 til SEQ ID 491.
  19. 19. Anvendelse ifølge krav 10, hvor målgenet er carbonanhydrasc XII, og siRNA’et er målrettet mod en sekvens, der er udvalgt fra SEQ ID 492 til SEQ ID 538.
  20. 20. Anvendelse ifølge krav 10, hvor målgenet er alfa-adrenerg receptor 1A, og siRNA’et er målrettet mod en sekvens, der er udvalgt fra SEQ ID 539 til SEQ ID 598.
  21. 21. Anvendelse ifølge krav 10, hvor målgenet er alfa-adrenerg receptor IB, og siRNA’et er målrettet mod en sekvens, der er udvalgt fra SEQ ID 599 til SEQ ID 634.
  22. 22. Anvendelse ifølge krav 10, hvor målgenet er alfa-adrenerg receptor ID, og siRNA’et er målrettet mod en sekvens, der er udvalgt fra SEQ ID 635 til SEQ ID 646.
  23. 23. Anvendelse ifølge krav 10, hvor målgenet er angiotensinogen, og siRNA’et er målrettet mod en sekvens, der er udvalgt fra SEQ ID 647 til SEQ ID 694.
  24. 24. Anvendelse ifølge krav 10, hvor målgenet er angiotensin II receptortype 1, og siRNA’et er målrettet mod en sekvens, der er udvalgt fra SEQ ID 695 til SEQ ID 749.
  25. 25. Anvendelse ifølge krav 10, hvor målgenet er angiotensin II receptortype 2, og siRNA’et er målrettet mod en sekvens, der er udvalgt fra SEQ ID 750 til SEQ ID 807.
  26. 26. Anvendelse ifølge krav 10, hvor målgenet er angiotensin I konverterende enzym 1, og siRNA’et er målrettet mod en sekvens, der er udvalgt fra SEQ ID 808 til SEQ ID 939.
  27. 27. Anvendelse ifølge krav 10, hvor målgenet er angiotensin I konverterende enzym 2, og siRNA’et er målrettet mod en sekvens, der er udvalgt fra SEQ ID 940 til SEQ ID 1139.
  28. 28. Anvendelse ifølge krav 10, hvor målgenet er renin, og siRNA’et er målrettet mod en sekvens, der er udvalgt fra SEQ ID 1140 til SEQ ID 1196.
  29. 29. Anvendelse ifølge krav 10, hvor målgenet er cochlin, og siRNA’et er målrettet mod en sekvens, der er udvalgt fra SEQ ID 1197 til SEQ ID 1307.
  30. 30. Anvendelse ifølge krav 10, hvor målgenet er ATPase alpha 1, og siRNA’et er målrettet mod en sekvens, der er udvalgt fra SEQ ID 1308 til SEQ ID 1500.
  31. 31. Anvendelse ifølge krav 10, hvor målgenet er ATPase alpha 2, og siRNA’et er målrettet mod en sekvens, der er udvalgt fra SEQ ID 1501 til SEQ ID 1606.
  32. 32. Anvendelse ifølge krav 10, hvor målgenet er ATPase alpha 3, og siRNA’et er målrettet mod en sekvens, der er udvalgt fra SEQ ID 1607 til SEQ ID 1705.
  33. 33. Anvendelse ifølge krav 10, hvor målgenet er ATPase beta 1, og siRNA’et er målrettet mod en sekvens, der er udvalgt fra SEQ ID 1706 til SEQ ID 1780.
  34. 34. Anvendelse ifølge krav 10, hvor målgenet er ATPase beta 2, og siRNA’et er målrettet mod en sekvens, der er udvalgt fra SEQ ID 1780 til SEQ ID 1829.
  35. 35. Isoleret siRNA-molekyle til anvendelse i behandling af en øjentilstand, der er kendetegnet ved et intraokkulært tryk (TOP) hos patienten, hvor siRNA’et er komplementært til et nukleotidsekvensen, der er udvalgt fra SEQ ID 1 til SEQ ID 1829, hvor siRNA’et er til topisk administration på homhindeoverfladen.
  36. 36. Anvendelse af et isoleret siRNA-molekyle med en sekvens, der er komplementær til en nukleotidsekvens, der er udvalgt fra SEQ ID 1 til SEQ ID 1829 i fremstillingen af et medikament til behandling af en øjentilstand, hvor medikamentet er formuleret til topisk administration på homhindeoverfladen.
  37. 37. Farmaceutisk sammensætning, der omfatter siRNA med en sekvens, der er komplementær til en nukleotidsekvens udvalgt fra SEQ ID 1 til SEQ ID 1829, hvor den farmaceutiske sammensætning er formuleret til topisk administration på homhindeoverfladen.
DK05781264.6T 2004-08-23 2005-08-23 Behandling af øjenforstyrrelser kendetegnet ved et forhøjet intraokkulært tryk med sirnas DK1781787T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0418762.1A GB0418762D0 (en) 2004-08-23 2004-08-23 Methods and compositions to treat glaucoma
GB0503412A GB0503412D0 (en) 2005-02-18 2005-02-18 Methods and compositions to treat glaucoma
PCT/GB2005/050134 WO2006021817A2 (en) 2004-08-23 2005-08-23 Treatment of eye disorders characterized by an elevated introacular pressure by sirnas

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DK1781787T3 true DK1781787T3 (da) 2017-07-31

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US (11) US8030284B2 (da)
EP (3) EP2292757A3 (da)
JP (2) JP5766900B2 (da)
CN (2) CN105251024A (da)
AU (1) AU2005276245C1 (da)
CA (1) CA2578064C (da)
CY (1) CY1119061T1 (da)
DK (1) DK1781787T3 (da)
ES (1) ES2632913T3 (da)
HR (1) HRP20171010T8 (da)
HU (1) HUE033977T2 (da)
LT (1) LT1781787T (da)
PL (1) PL1781787T3 (da)
PT (1) PT1781787T (da)
RU (1) RU2407531C2 (da)
SI (1) SI1781787T1 (da)
WO (1) WO2006021817A2 (da)

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