DK1789036T3 - 5-[3-(4-benzyloxyphenylthio)-fur-2-yl]-imidazolidin-2,4-dion og analoger som inhibitorer af makrofagelastase - Google Patents

5-[3-(4-benzyloxyphenylthio)-fur-2-yl]-imidazolidin-2,4-dion og analoger som inhibitorer af makrofagelastase

Info

Publication number: DK1789036T3
Authority: DK; Denmark
Prior art keywords: benzyloxyphenylthio; fur; dione; inhibitors; analogues
Prior art date: 2004-08-19

Application number

DK05786673.3T

Other languages

English (en)

Inventor

Fude Yang

Original Assignee

Quest Pharmaceutical Services

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-08-19

Filing date

2005-08-17

Publication date

2011-06-27

2005-08-17 Application filed by Quest Pharmaceutical Services filed Critical Quest Pharmaceutical Services

2011-06-27 Application granted granted Critical

2011-06-27 Publication of DK1789036T3 publication Critical patent/DK1789036T3/da

Links

ZUOUZWHAINARGI-UHFFFAOYSA-N 5-[3-(4-phenylmethoxyphenyl)sulfanylfuran-2-yl]imidazolidine-2,4-dione Chemical compound O=C1NC(=O)NC1C1=C(SC=2C=CC(OCC=3C=CC=CC=3)=CC=2)C=CO1 ZUOUZWHAINARGI-UHFFFAOYSA-N 0.000 title abstract 2
108030001712 Macrophage elastases Proteins 0.000 title abstract 2
102100027998 Macrophage metalloelastase Human genes 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title abstract 2

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK05786673.3T 2004-08-19 2005-08-17 5-[3-(4-benzyloxyphenylthio)-fur-2-yl]-imidazolidin-2,4-dion og analoger som inhibitorer af makrofagelastase DK1789036T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US60273604P	2004-08-19	2004-08-19
PCT/US2005/029259 WO2006023562A2 (en)	2004-08-19	2005-08-17	5-[3-(4-benzyloxyphenylthio)-fur-2-yl]-imidazolidin-2, 4-dione and analogues as inhibitors of macrophage elastase

Publications (1)

Publication Number	Publication Date
DK1789036T3 true DK1789036T3 (da)	2011-06-27

Family

ID=35968136

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK05786673.3T DK1789036T3 (da)	2004-08-19	2005-08-17	5-[3-(4-benzyloxyphenylthio)-fur-2-yl]-imidazolidin-2,4-dion og analoger som inhibitorer af makrofagelastase

Country Status (16)

Country	Link
US (1)	US7179831B2 (da)
EP (1)	EP1789036B1 (da)
JP (1)	JP5042833B2 (da)
KR (1)	KR101197325B1 (da)
CN (1)	CN101014338B (da)
AT (1)	ATE508744T1 (da)
AU (1)	AU2005277432B2 (da)
BR (1)	BRPI0514470B8 (da)
CA (1)	CA2577430C (da)
DK (1)	DK1789036T3 (da)
ES (1)	ES2364068T3 (da)
MX (1)	MX2007001940A (da)
NZ (1)	NZ553258A (da)
RU (1)	RU2391339C2 (da)
SI (1)	SI1789036T1 (da)
WO (1)	WO2006023562A2 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2636990A1 (en) *	2006-01-13	2007-07-26	Battelle Memorial Institute	Animal model for assessing copd-related diseases
EP2907512A1 (en)	2014-02-14	2015-08-19	Commissariat A L'energie Atomique Et Aux Energies Alternatives	Inhibitors of MMP-12 as antiviral Agents
ES2910833T3 (es) *	2016-08-19	2022-05-13	Foresee Pharmaceuticals Co Ltd	Composición farmacéutica y procedimientos de usos
US10532102B2 (en)	2016-08-19	2020-01-14	Foresee Pharmaceuticals Co., Ltd.	Pharmaceutical composition and methods of uses
CN109803961B (zh) *	2016-09-23	2021-03-23	科研制药株式会社	(r)-5-(3,4-二氟苯基)-5-[(3-甲基-2-氧代吡啶-1(2h)-基)甲基]咪唑烷-2,4-二酮的制造方法及用于该制造的中间体
SG11202011318QA (en) *	2018-05-15	2020-12-30	Foresee Pharmaceuticals Usa Inc	Matrix metalloproteinase (mmp) inhibitors and methods of use thereof
DK4058437T3 (da) *	2019-11-14	2025-01-20	Foresee Pharmaceuticals Usa Inc	Matrix-metalloproteinase-(MMP)-inhibitorer og fremgangsmåder til anvendelse heraf
KR20240019265A (ko) *	2021-06-08	2024-02-14	포시 파마슈티컬스 컴퍼니 리미티드	Mmp-12 억제제의 안전한 투여
RU2766551C1 (ru) *	2021-07-19	2022-03-15	Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ)	5-(4-хлорфенил)-3-((4-хлорфенил)амино)-5-(фенилтио)фуран-2(5н)-он, обладающий противомикробной активностью

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU1817700A (en)	1998-12-31	2000-07-24	Aventis Pharmaceuticals Inc.	1-carboxymethyl-2-oxo-azepan derivatives useful as selective inhibitors of mmp-12
US6352976B1 (en)	1998-12-31	2002-03-05	Aventis Pharmaceuticals Inc.	Selective inhibitors of MMP-12
RU2150469C1 (ru) *	1999-06-01	2000-06-10	Уфимский государственный нефтяной технический университет	Способ получения 2-(фурил-2)-1,3-имидазолидинов
AU4882101A (en)	2000-04-28	2001-11-12	Shionogi & Co., Ltd.	Mmp-12 inhibitors
SE0100903D0 (sv)	2001-03-15	2001-03-15	Astrazeneca Ab	Compounds
ATE445400T1 (de)	2001-05-25	2009-10-15	Bristol Myers Squibb Co	Hydantion-derivate als hemmer von matrix- metalloproteinasen
EP1394159A1 (fr)	2002-08-13	2004-03-03	Warner-Lambert Company LLC	Nouveaux dérivés de thiophène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
SE0202539D0 (sv) *	2002-08-27	2002-08-27	Astrazeneca Ab	Compounds
GB0219896D0 (en)	2002-08-27	2002-10-02	Bayer Ag	Dihydropyridine derivatives
WO2004033632A2 (en) *	2002-10-04	2004-04-22	Bristol-Myers Squibb Company	Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme (tace)
US7132432B2 (en) *	2003-06-05	2006-11-07	Bristol-Myers Squibb Company	Hydantoin derivatives as inhibitors of tumor necrosis factor-alpha converting enzyme (TACE)

2005
- 2005-08-17 ES ES05786673T patent/ES2364068T3/es not_active Expired - Lifetime
- 2005-08-17 BR BRPI0514470A patent/BRPI0514470B8/pt not_active IP Right Cessation
- 2005-08-17 EP EP05786673A patent/EP1789036B1/en not_active Expired - Lifetime
- 2005-08-17 NZ NZ553258A patent/NZ553258A/en not_active IP Right Cessation
- 2005-08-17 MX MX2007001940A patent/MX2007001940A/es active IP Right Grant
- 2005-08-17 WO PCT/US2005/029259 patent/WO2006023562A2/en not_active Ceased
- 2005-08-17 CA CA2577430A patent/CA2577430C/en not_active Expired - Fee Related
- 2005-08-17 RU RU2007105822/04A patent/RU2391339C2/ru not_active IP Right Cessation
- 2005-08-17 AU AU2005277432A patent/AU2005277432B2/en not_active Ceased
- 2005-08-17 SI SI200531283T patent/SI1789036T1/sl unknown
- 2005-08-17 US US11/205,954 patent/US7179831B2/en not_active Expired - Lifetime
- 2005-08-17 JP JP2007527975A patent/JP5042833B2/ja not_active Expired - Fee Related
- 2005-08-17 AT AT05786673T patent/ATE508744T1/de not_active IP Right Cessation
- 2005-08-17 CN CN2005800285556A patent/CN101014338B/zh not_active Expired - Fee Related
- 2005-08-17 KR KR1020077006294A patent/KR101197325B1/ko not_active Expired - Fee Related
- 2005-08-17 DK DK05786673.3T patent/DK1789036T3/da active

Also Published As

Publication number	Publication date
JP2008510701A (ja)	2008-04-10
NZ553258A (en)	2011-02-25
RU2007105822A (ru)	2008-09-27
CA2577430C (en)	2010-12-07
EP1789036A4 (en)	2008-08-27
MX2007001940A (es)	2007-07-24
US20060041000A1 (en)	2006-02-23
BRPI0514470B1 (pt)	2021-01-05
BRPI0514470A (pt)	2008-06-10
KR101197325B1 (ko)	2012-11-05
KR20070045330A (ko)	2007-05-02
WO2006023562A3 (en)	2006-04-20
WO2006023562A2 (en)	2006-03-02
RU2391339C2 (ru)	2010-06-10
AU2005277432A1 (en)	2006-03-02
AU2005277432B2 (en)	2011-11-24
SI1789036T1 (sl)	2011-09-30
CN101014338A (zh)	2007-08-08
US7179831B2 (en)	2007-02-20
HK1107774A1 (en)	2008-04-18
BRPI0514470B8 (pt)	2021-07-20
ATE508744T1 (de)	2011-05-15
CN101014338B (zh)	2010-06-16
EP1789036A2 (en)	2007-05-30
EP1789036B1 (en)	2011-05-11
CA2577430A1 (en)	2006-03-02
ES2364068T3 (es)	2011-08-24
JP5042833B2 (ja)	2012-10-03
WO2006023562B1 (en)	2006-06-22

Publication	Publication Date	Title
NO20053340D0 (no)	2005-07-08	Substituerte dihydropyrano-indol-3,4-dion-derivater som inhibitorer for plasmigogenaktivator-1 (CPAI-1).
DE602005018509D1 (de)	2010-02-04	N-2-adamantanyl-2-phenoxy-acetamid-derivate als 11-betahydroxysteroid-dehydrogenase-hemmer
EA201001359A1 (ru)	2011-04-29	Гетероциклические соединения в качестве ингибиторов cxcr2
DK1480644T3 (da)	2011-01-24	Heterocykliske forbindelser, der er aktive som inhibitorer af beta-lactamaser
DE60325032D1 (de)	2009-01-15	2-hydroxy-3-heteroarylindole derivate als gsk3 inhibitoren
ATE449605T1 (de)	2009-12-15	N3-alkylierte benzimidazol-derivate als mek- hemmer
NO20071309L (no)	2007-05-10	Fremgangsmate for ekspansjon
DK1931350T3 (da)	2014-02-10	Administration af inhibitorer af dipeptidylpeptidase
DK2057153T3 (da)	2012-10-15	(3-aryl-piperazin-1-yl)-derivater af 6,7 dialkoxyquinazolin, 6,7- dialkoxyphtalazin og 6,7-dialkoxyisoquinolin
DK1962830T3 (da)	2013-06-24	Azaindolhæmmere af aurorakinaser.
DK1848694T3 (da)	2010-01-25	Heterocykliske substituerede phenylmethanoner som inhibitorer af glycintransporter
ATE400271T1 (de)	2008-07-15	Aryl-pyridinderivate als 11-beta-hsd1-hemmer
DE602004012154D1 (de)	2008-04-10	Pyridoä2,3-düpyrimidin-2,4-diamine als pde-2-inhibitoren
ATE420076T1 (de)	2009-01-15	Indozolonderivate als 11b-hsd1-inhibitoren
EP1765856A4 (en)	2010-08-11	RNA-dependent DNA polymerase from GEOBACILLUS STEAROTHERMOPHILUS
CY1109911T1 (el)	2014-09-10	Πυρρολοβενζοδιαζεπινες
DK1740569T3 (da)	2008-06-02	Imidazol-derivater som TAFla-inhibitorer
ATE509011T1 (de)	2011-05-15	Pyrimidinderivate als 11beta-hsd1-inhibitoren
DK1711177T3 (da)	2008-09-29	1H-thieno-2,3-c-pyrazolderivater, der er egnede som kinase-I-inhibitorer
NO20082185L (no)	2008-08-05	Heterocykliske CETP-inhibitorer
DE112005003431A5 (de)	2007-10-31	Neuartige Inhibitoren der Lysyloxidase
MX2007001940A (es)	2007-07-24	5-[3-(4-benciloxifeniltio)-fur-2-il]-imidazolidin-2,4-diona y analogos como inhibidores de macrofago elastasa.
NL1030487A1 (nl)	2006-05-24	Nieuwe, op pyrazool gebaseerde HMG-Co-A-reductaseremmers.
ATE417849T1 (de)	2009-01-15	Pyrazoloä4,3-düpyrimidine
DK1828166T3 (da)	2009-10-05	Hydantoinderivater, der kan anvendes som metalloproteinase-inhibitorer