DK180182A - Fremgangsmaade til fremstilling af bezylaminoderivater - Google Patents

Fremgangsmaade til fremstilling af bezylaminoderivater Download PDF

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Publication number
DK180182A
DK180182A DK180182A DK180182A DK180182A DK 180182 A DK180182 A DK 180182A DK 180182 A DK180182 A DK 180182A DK 180182 A DK180182 A DK 180182A DK 180182 A DK180182 A DK 180182A
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DK
Denmark
Prior art keywords
bezylamino
derivatives
preparing
procedure
alkyl
Prior art date
Application number
DK180182A
Other languages
English (en)
Inventor
G H Baker
L J Beeley
P M Newsome
D H Richards
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of DK180182A publication Critical patent/DK180182A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Description

hvor R* betegner halogen, alkyl eller alkoxy, R1 betegner hydrogen, halogen, aikyl eller alkoxy, RJ betegner en eventuelt substitueret, mættet, umættet eller aromatisk, carbocyclisk, heterocyclisk, monoeller bicyclisk gruppe, R" betegner hydrogen eller alkyl, -N(R4)-(CH2)n‘RJ sidder i meta- eller para-stilling i forhold til imidazolinylaminogruppen. det ene af symbolerne Rs og Rc betegner hydrogen, og det andet betegner hydrogen, alkyl eller acyl, og n betegner 0, 1, 2 eller 3, eller et syreadditionssalt deraf fremstilles ved en række forskellige fremgangsmåder. Forbindelser med formlen I har virkning mod diarré.
DK180182A 1981-04-24 1982-04-22 Fremgangsmaade til fremstilling af bezylaminoderivater DK180182A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8112692 1981-04-24
GB8112692 1981-04-24

Publications (1)

Publication Number Publication Date
DK180182A true DK180182A (da) 1982-10-25

Family

ID=10521338

Family Applications (1)

Application Number Title Priority Date Filing Date
DK180182A DK180182A (da) 1981-04-24 1982-04-22 Fremgangsmaade til fremstilling af bezylaminoderivater

Country Status (6)

Country Link
EP (1) EP0070084A3 (da)
JP (1) JPS57181060A (da)
AU (1) AU8293682A (da)
DK (1) DK180182A (da)
ES (1) ES8306727A1 (da)
ZA (1) ZA822780B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4461904A (en) * 1981-11-20 1984-07-24 Alcon Laboratories, Inc. 2-(Trisubstituted phenylimino)-imidazolines
EP0107306B1 (en) * 1982-09-16 1986-04-30 Beecham Group Plc Imidazoline derivatives
GB8304593D0 (en) * 1983-02-18 1983-03-23 Beecham Group Plc Amidines
GB8333835D0 (en) * 1983-12-20 1984-02-01 Beecham Group Plc Compounds
US4588737A (en) * 1984-12-20 1986-05-13 Usv Pharmaceutical Corp. Antiallergic bis-imidazolinoamino derivatives
GB8903592D0 (en) * 1989-02-16 1989-04-05 Boots Co Plc Therapeutic agents
AU704972B2 (en) 1994-08-04 1999-05-13 H. Lundbeck A/S Novel benzimidazole derivatives
DE19514579A1 (de) * 1995-04-20 1996-10-24 Boehringer Ingelheim Kg Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz
US6495583B1 (en) 1997-03-25 2002-12-17 Synaptic Pharmaceutical Corporation Benzimidazole derivatives
DE10163239A1 (de) * 2001-12-21 2003-07-10 Aventis Pharma Gmbh Substituierte Imidazolidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie enthaltendes Medikament
JP2012227306A (ja) 2011-04-19 2012-11-15 Ngk Insulators Ltd セラミック基板の製造方法
WO2016043260A1 (ja) * 2014-09-19 2016-03-24 塩野義製薬株式会社 環状グアニジンまたはアミジン化合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2806775A1 (de) * 1978-02-17 1979-08-30 Boehringer Sohn Ingelheim Neue substituierte 2-phenylimino- imidazolidine deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben
US4287201A (en) * 1980-03-03 1981-09-01 Merck & Co., Inc. Anovulatory method and chicken feed compositions
EP0043659B1 (en) * 1980-07-09 1985-02-06 Beecham Group Plc Clonidine derivatives useful in the treatment of diarrhoea

Also Published As

Publication number Publication date
JPS57181060A (en) 1982-11-08
AU8293682A (en) 1983-10-27
ES511665A0 (es) 1983-06-01
ZA822780B (en) 1983-02-23
ES8306727A1 (es) 1983-06-01
EP0070084A2 (en) 1983-01-19
EP0070084A3 (en) 1983-02-16

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