DK1809602T3 - Indolderivater, der kan anvendes som progesteronreceptormodulatorer - Google Patents

Indolderivater, der kan anvendes som progesteronreceptormodulatorer

Info

Publication number: DK1809602T3
Authority: DK; Denmark
Prior art keywords: progesterone receptor; indole derivatives; prevention; treatment; receptor modulators
Prior art date: 2004-10-27

Application number

DK05816083T

Other languages

Danish (da)

English (en)

Inventor

Weiqin Jiang

James Fiordeliso

Zhihua J Sui

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-10-27

Filing date

2005-10-21

Publication date

2009-02-16

2005-10-21 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2009-02-16 Application granted granted Critical

2009-02-16 Publication of DK1809602T3 publication Critical patent/DK1809602T3/da

Links

229940054051 antipsychotic indole derivative Drugs 0.000 title abstract 2
150000002475 indoles Chemical class 0.000 title abstract 2
239000002379 progesterone receptor modulator Substances 0.000 title 1
229940095745 sex hormone and modulator of the genital system progesterone receptor modulator Drugs 0.000 title 1
230000000740 bleeding effect Effects 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
230000002265 prevention Effects 0.000 abstract 2
201000000736 Amenorrhea Diseases 0.000 abstract 1
206010001928 Amenorrhoea Diseases 0.000 abstract 1
201000009030 Carcinoma Diseases 0.000 abstract 1
201000009273 Endometriosis Diseases 0.000 abstract 1
208000009956 adenocarcinoma Diseases 0.000 abstract 1
239000000556 agonist Substances 0.000 abstract 1
231100000540 amenorrhea Toxicity 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
210000000481 breast Anatomy 0.000 abstract 1
210000001072 colon Anatomy 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
210000004696 endometrium Anatomy 0.000 abstract 1
230000037406 food intake Effects 0.000 abstract 1
235000012631 food intake Nutrition 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
230000002175 menstrual effect Effects 0.000 abstract 1
210000001672 ovary Anatomy 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
201000010065 polycystic ovary syndrome Diseases 0.000 abstract 1
102000003998 progesterone receptors Human genes 0.000 abstract 1
108090000468 progesterone receptors Proteins 0.000 abstract 1
210000002307 prostate Anatomy 0.000 abstract 1
230000000638 stimulation Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Nutrition Science (AREA)
Gynecology & Obstetrics (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)

DK05816083T 2004-10-27 2005-10-21 Indolderivater, der kan anvendes som progesteronreceptormodulatorer DK1809602T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US62258204P	2004-10-27	2004-10-27
PCT/US2005/037817 WO2006049889A1 (fr)	2004-10-27	2005-10-21	Derives d'indole utiles en tant que modulateurs recepteurs de progesterone

Publications (1)

Publication Number	Publication Date
DK1809602T3 true DK1809602T3 (da)	2009-02-16

Family

ID=35735187

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK05816083T DK1809602T3 (da)	2004-10-27	2005-10-21	Indolderivater, der kan anvendes som progesteronreceptormodulatorer

Country Status (15)

Country	Link
US (2)	US7183309B2 (fr)
EP (1)	EP1809602B1 (fr)
JP (1)	JP5190268B2 (fr)
CN (1)	CN101087758B (fr)
AT (1)	ATE412631T1 (fr)
AU (1)	AU2005302706B2 (fr)
CA (1)	CA2585334C (fr)
CY (1)	CY1109919T1 (fr)
DE (1)	DE602005010734D1 (fr)
DK (1)	DK1809602T3 (fr)
ES (1)	ES2314739T3 (fr)
PL (1)	PL1809602T3 (fr)
PT (1)	PT1809602E (fr)
SI (1)	SI1809602T1 (fr)
WO (1)	WO2006049889A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ568910A (en) *	2006-01-24	2011-04-29	Lilly Co Eli	Indole sulfonamide modulators of progesterone receptors
SI2148681T1 (sl) *	2007-04-20	2016-07-29	Preglem S.A.	Selektivni modulatorji progesterona v zdravljenju maternične krvavitve
CN111153849B (zh) *	2019-12-19	2021-03-26	南京林业大学	一种2-吲哚甲醇在水相反应体系中合成c3位硫醚化吲哚衍生物的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5081138A (en) *	1986-12-17	1992-01-14	Merck Frosst Canada, Inc.	3-hetero-substituted-n-benzyl-indoles and prevention of leucotriene synthesis therewith
UA68365C2 (en)	1997-11-06	2004-08-16	Wyeth Corp	Peroral contraception by combination of anti-estrogen and progestin
EE200000522A (et)	1998-02-25	2002-02-15	Genetics Institute, Inc.	Fosfolipaas A2 ensüümi inhibiitor, seda sisaldav farmatseutiline kompositsioon ning meetod fosfolipaasensüümi toime pärssimiseks
US6355648B1 (en) *	1999-05-04	2002-03-12	American Home Products Corporation	Thio-oxindole derivatives
BR0208790A (pt) *	2001-04-11	2004-03-30	Idenix Cayman Ltd	Fenilindoìs para o tratamento de hiv
SE0201635D0 (sv) *	2002-05-30	2002-05-30	Astrazeneca Ab	Novel compounds
SE0202241D0 (sv) *	2002-07-17	2002-07-17	Astrazeneca Ab	Novel Compounds

2005
- 2005-10-21 PT PT05816083T patent/PT1809602E/pt unknown
- 2005-10-21 EP EP05816083A patent/EP1809602B1/fr not_active Expired - Lifetime
- 2005-10-21 CN CN2005800446115A patent/CN101087758B/zh not_active Expired - Fee Related
- 2005-10-21 US US11/255,444 patent/US7183309B2/en not_active Expired - Fee Related
- 2005-10-21 DK DK05816083T patent/DK1809602T3/da active
- 2005-10-21 CA CA2585334A patent/CA2585334C/fr not_active Expired - Fee Related
- 2005-10-21 AT AT05816083T patent/ATE412631T1/de active
- 2005-10-21 WO PCT/US2005/037817 patent/WO2006049889A1/fr not_active Ceased
- 2005-10-21 AU AU2005302706A patent/AU2005302706B2/en not_active Ceased
- 2005-10-21 SI SI200530551T patent/SI1809602T1/sl unknown
- 2005-10-21 ES ES05816083T patent/ES2314739T3/es not_active Expired - Lifetime
- 2005-10-21 DE DE602005010734T patent/DE602005010734D1/de not_active Expired - Lifetime
- 2005-10-21 PL PL05816083T patent/PL1809602T3/pl unknown
- 2005-10-21 JP JP2007538996A patent/JP5190268B2/ja not_active Expired - Fee Related
2007
- 2007-01-16 US US11/623,376 patent/US7345084B2/en not_active Expired - Fee Related
2009
- 2009-01-27 CY CY20091100097T patent/CY1109919T1/el unknown

Also Published As

Publication number	Publication date
CN101087758A (zh)	2007-12-12
WO2006049889A1 (fr)	2006-05-11
US7183309B2 (en)	2007-02-27
PT1809602E (pt)	2008-12-15
US20070135511A1 (en)	2007-06-14
AU2005302706B2 (en)	2011-12-15
JP5190268B2 (ja)	2013-04-24
ES2314739T3 (es)	2009-03-16
US20060111427A1 (en)	2006-05-25
EP1809602B1 (fr)	2008-10-29
SI1809602T1 (sl)	2009-04-30
AU2005302706A1 (en)	2006-05-11
EP1809602A1 (fr)	2007-07-25
PL1809602T3 (pl)	2009-04-30
DE602005010734D1 (de)	2008-12-11
CA2585334A1 (fr)	2006-05-11
JP2008518009A (ja)	2008-05-29
CA2585334C (fr)	2014-05-13
ATE412631T1 (de)	2008-11-15
CN101087758B (zh)	2012-06-06
US7345084B2 (en)	2008-03-18
CY1109919T1 (el)	2014-09-10

Publication	Publication Date	Title
EA201200860A1 (ru)	2013-01-30	Нейтрализующие пролактиновый рецептор антитела и их терапевтическое применение
ECSP18047708A (es)	2018-06-30	Derivados de 17-hidroxi-17-pentafluoroetil-estra-4,9(10)-dien-11-arilo como antagonistas de progesterona y procedimientos para su preparación
ATE514700T1 (de)	2011-07-15	Neues tetrazyklisches heteroatom mit als sexualsteroidhormon-rezeptormodulatoren geeigneten derivaten
DE60035496D1 (de)	2007-08-23	Indolinderivate als progesteron antagonisten
AR026916A1 (es)	2003-03-05	Combinaciones farmaceuticas y su uso en el tratamiento de desordenes gastrointestinales
DE602005019905D1 (de)	2010-04-22	-modulatoren
CY1110017T1 (el)	2015-01-14	Μικρονισμενη ταναπρογετη και συνθεσεις που περιεχουν αυτην
BR0316843A (pt)	2005-11-01	Derivados tetracìclicos contendo heteroátomo como moduladores seletivos do receptor de estrogênio
WO2011098437A3 (fr)	2011-10-27	Antagonistes du récepteur de la progestérone
TR200103285T2 (tr)	2002-02-21	Projesteron reseptörü modülatörleri olarak siklokarbamat türevleri.
CY1109919T1 (el)	2014-09-10	Παραγωγα της ινδολης που ειναι χρησιμα σα ρυθμιστες του υποδοχεα της προγεστερονης
CY1121190T1 (el)	2020-05-29	Δοσολογικη μορφη ανταγωνιστη υποδοχεα προγεστερονης
PT1173210E (pt)	2005-01-31	Composicoes contraceptivas antiprogestativos e progestativos
ATE434434T1 (de)	2009-07-15	Zusammensetzungen mit mikronisiertem tanaproget
CL2003001544A1 (es)	2005-01-07	Compuestos derivados de 5-cicloalquenil-5h-cromeno[3,4-f]quinolina de formula i, moduladores selectivos del receptor de progesterona; composicion farmaceutica; y su uso en el tratamiento de sangrado uterino disfuncional, dismenorrea, endometriosis, l
MA32477B1 (fr)	2011-07-03	Derives estratrienes comprenant des bioisosteres heterocycliques pour le cycle a phenolique
EA200702604A1 (ru)	2008-06-30	Производные бензофуранона как нестероидные модуляторы рецептора прогестерона
EA200702524A1 (ru)	2008-06-30	Нестероидные модуляторы рецептора прогестерона
AR023854A1 (es)	2002-09-04	Uso de derivados de indolina y equipo farmaceutico para regimenes ciclicos
CY1113127T1 (el)	2016-04-13	Οξα στεροειδη παραγωγα ως εκλεκτικοι τροποποιητες υποδοχεων προγεστερονης
AR024549A1 (es)	2002-10-16	Uso de moduladores de progesterona del receptor de progesterona y kit farmaceutica para regimenes ciclicos