DK1856063T3 - 5-phenyl-pentansyrederivater som matrix- metalloproteinaseinhibitorer til behandlingen af astma og andre sygdomme - Google Patents

5-phenyl-pentansyrederivater som matrix- metalloproteinaseinhibitorer til behandlingen af astma og andre sygdomme

Info

Publication number: DK1856063T3
Authority: DK; Denmark
Prior art keywords: astma; diseases; phenyl; matrix; treatment
Prior art date: 2005-02-22

Application number

DK06727254.2T

Other languages

English (en)

Inventor

Viswajanani Jitendra Sattigeri

Manoj Kumar Khera

Abhijit Ray

Sunanda G Dastidar

Venkata P Palle

Sreedhara Rao Voleti

Original Assignee

Ranbaxy Lab Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-02-22

Filing date

2006-02-21

Publication date

2012-03-26

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36591260&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1856063(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-02-21 Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd

2012-03-26 Application granted granted Critical

2012-03-26 Publication of DK1856063T3 publication Critical patent/DK1856063T3/da

Links

BYHDDXPKOZIZRV-UHFFFAOYSA-N 5-phenylpentanoic acid Chemical class OC(=O)CCCCC1=CC=CC=C1 BYHDDXPKOZIZRV-UHFFFAOYSA-N 0.000 title 1
201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1

Classifications

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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/04—1,2,3-Triazines
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- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
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- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
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DK06727254.2T 2005-02-22 2006-02-21 5-phenyl-pentansyrederivater som matrix- metalloproteinaseinhibitorer til behandlingen af astma og andre sygdomme DK1856063T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IN380DE2005		2005-02-22
PCT/IB2006/000349 WO2006090235A1 (en)	2005-02-22	2006-02-21	5-phenyl-pentanoic acid derivatives as matrix metalloproteinase inhibitors for the treatment of asthma and other diseases

Publications (1)

Publication Number	Publication Date
DK1856063T3 true DK1856063T3 (da)	2012-03-26

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ID=36591260

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK06727254.2T DK1856063T3 (da)	2005-02-22	2006-02-21	5-phenyl-pentansyrederivater som matrix- metalloproteinaseinhibitorer til behandlingen af astma og andre sygdomme

Country Status (32)

Country	Link
US (1)	US8710261B2 (da)
EP (1)	EP1856063B1 (da)
JP (1)	JP4994247B2 (da)
KR (1)	KR101274309B1 (da)
CN (1)	CN101151255B (da)
AP (1)	AP2413A (da)
AT (1)	ATE542804T1 (da)
AU (1)	AU2006217615B2 (da)
BR (1)	BRPI0607469A2 (da)
CA (1)	CA2598518C (da)
CR (1)	CR9384A (da)
CY (1)	CY1112795T1 (da)
DK (1)	DK1856063T3 (da)
EA (1)	EA013539B1 (da)
ES (1)	ES2381681T3 (da)
GE (1)	GEP20094786B (da)
HR (1)	HRP20120250T1 (da)
IL (1)	IL185457A0 (da)
MA (1)	MA29312B1 (da)
MX (1)	MX2007010185A (da)
NI (1)	NI200700220A (da)
NO (1)	NO20074648L (da)
NZ (1)	NZ560803A (da)
PL (1)	PL1856063T3 (da)
PT (1)	PT1856063E (da)
RS (2)	RS52232B (da)
SI (1)	SI1856063T1 (da)
SM (1)	SMP200700038B (da)
TN (1)	TNSN07320A1 (da)
UA (1)	UA98292C2 (da)
WO (1)	WO2006090235A1 (da)
ZA (1)	ZA200707560B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0321538D0 (en) *	2003-09-13	2003-10-15	Glaxo Group Ltd	Therapeutically useful compounds
EA013539B1 (ru)	2005-02-22	2010-06-30	Рэнбакси Лабораториз Лимитед	Производные 5-фенилпентановой кислоты в качестве ингибиторов матричной металлопротеиназы для лечения астмы и других заболеваний
AU2013200728B2 (en) *	2006-08-22	2014-12-18	Sun Pharmaceutical Industries Limited	Matrix metalloproteinase inhibitors
JO2868B1 (en) *	2006-08-22	2015-03-15	رانبكسي لابوراتوريز ليمتد	Inhibitors of metabolic protein protein enzyme
FR2949463B1 (fr) *	2009-08-26	2011-09-16	Commissariat Energie Atomique	Inhibiteurs de mmp
CN103119030A (zh)	2010-07-30	2013-05-22	兰贝克赛实验室有限公司	基质金属蛋白酶抑制剂
US20140148459A1 (en)	2010-09-24	2014-05-29	Ranbaxy Laboratories Limited	Matrix metalloproteinase inhibitors
EP2643693A2 (en) *	2010-11-23	2013-10-02	KCI Licensing, Inc.	Devices and methods for the diagnosis and treatment of wounds using biomarkers
EP2556832B1 (en) *	2011-08-12	2017-07-19	Universitätsklinikum Freiburg	Uridine and uridine analogues for use in the treatment of chronic obstructive pulmonary disease
GB201322512D0 (en) *	2013-12-19	2014-02-05	Glaxosmithkline Ip Dev Ltd	Novel compounds
MX385777B (es) *	2014-12-24	2025-03-04	Lg Chemical Ltd	Derivado de biarilo como agonista de gpr120.

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5109002A (en)	1989-09-08	1992-04-28	Du Pont Merck Pharmaceutical Company	Antipsychotic 1-cycloalkylpiperidines
CA2150550A1 (en)	1992-12-01	1994-06-09	Melissa S. Egbertson	Fibrinogen receptor antagonists
US5789434A (en) *	1994-11-15	1998-08-04	Bayer Corporation	Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors
US5516789A (en)	1995-04-12	1996-05-14	Abbott Laboratories	Lipoxygenase and cyclooxygenase inhibiting compounds
WO1998009940A1 (en)	1996-09-04	1998-03-12	Warner-Lambert Company	Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
MY117687A (en) *	1996-10-31	2004-07-31	Bayer Corp	Substituted 4-biphenyl-4-hydroxybutric acid derivatives as matrix metalloprotease inhibitors
AU8020398A (en)	1997-06-10	1998-12-30	Unilever Plc	Method for enhancing the activity of an enzyme, bleach composition, detergent composition and process for inhibiting dye transfer
US6037361A (en) *	1998-03-09	2000-03-14	Warner-Lambert Company	Fluorinated butyric acids and their derivatives as inhibitors of matrix metalloproteinases
US6350885B1 (en)	1998-07-30	2002-02-26	Warner-Lambert Company	Tricyclic heteroaromatics and their derivatives as inhibitors of matrix metalloproteinases
WO2000040539A1 (en) *	1998-12-30	2000-07-13	Bayer Aktiengesellschaft	Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors for the treatment of respiratory diseases
ITRM20010464A1 (it)	2001-07-31	2003-01-31	Sigma Tau Ind Farmaceuti	Derivati retinoidi ad attivita' antiangiogenica, antitumorale e pro-apoptotica.
US7550474B2 (en)	2003-04-10	2009-06-23	Johnson & Johnson Pharmaceuticals Research & Development, L.L.C.	Substituted phenyl acetamides and their use as protease inhibitors
GB0312654D0 (en) *	2003-06-03	2003-07-09	Glaxo Group Ltd	Therapeutically useful compounds
GB0314488D0 (en)	2003-06-20	2003-07-23	Glaxo Group Ltd	Therapeutically useful compounds
GB0321538D0 (en) *	2003-09-13	2003-10-15	Glaxo Group Ltd	Therapeutically useful compounds
EA013539B1 (ru)	2005-02-22	2010-06-30	Рэнбакси Лабораториз Лимитед	Производные 5-фенилпентановой кислоты в качестве ингибиторов матричной металлопротеиназы для лечения астмы и других заболеваний

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Also Published As

Publication number	Publication date
CN101151255B (zh)	2013-09-11
RS20070374A (sr)	2008-09-29
SMAP200700038A (it)	2007-09-26
CY1112795T1 (el)	2016-02-10
NI200700220A (es)	2010-10-05
MX2007010185A (es)	2007-12-06
PT1856063E (pt)	2012-04-12
US8710261B2 (en)	2014-04-29
ZA200707560B (en)	2008-11-26
CA2598518A1 (en)	2006-08-31
GEP20094786B (en)	2009-09-25
JP4994247B2 (ja)	2012-08-08
CR9384A (es)	2008-01-11
UA98292C2 (ru)	2012-05-10
EA013539B1 (ru)	2010-06-30
CN101151255A (zh)	2008-03-26
HRP20120250T1 (hr)	2012-04-30
KR101274309B1 (ko)	2013-06-13
AU2006217615B2 (en)	2012-07-12
TNSN07320A1 (en)	2008-12-31
BRPI0607469A2 (pt)	2009-09-08
US20080194565A1 (en)	2008-08-14
EP1856063B1 (en)	2012-01-25
RS52232B (sr)	2012-10-31
AP2413A (en)	2012-06-01
NZ560803A (en)	2010-10-29
JP2008531494A (ja)	2008-08-14
ATE542804T1 (de)	2012-02-15
KR20070110384A (ko)	2007-11-16
WO2006090235A1 (en)	2006-08-31
PL1856063T3 (pl)	2012-07-31
SMP200700038B (it)	2007-09-26
SI1856063T1 (sl)	2012-04-30
HK1115379A1 (en)	2008-11-28
MA29312B1 (fr)	2008-03-03
CA2598518C (en)	2015-04-21
NO20074648L (no)	2007-11-22
IL185457A0 (en)	2008-01-06
AP2007004146A0 (en)	2007-10-31
ES2381681T3 (es)	2012-05-30
EP1856063A1 (en)	2007-11-21
AU2006217615A1 (en)	2006-08-31
EA200701768A1 (ru)	2008-02-28

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