DK1856090T3 - Substituerede thiophen-derivater som glucagon-receptorantagonister, fremstilling og terapeutiske anvendelser - Google Patents

Substituerede thiophen-derivater som glucagon-receptorantagonister, fremstilling og terapeutiske anvendelser

Info

Publication number: DK1856090T3
Authority: DK; Denmark
Prior art keywords: glucagon receptor; preparation; receptor antagonists; compounds; therapeutic applications
Prior art date: 2005-02-11

Application number

DK06720513T

Other languages

Danish (da)

English (en)

Inventor

Mark Donald Chappell

Scott Eugene Conner

Allie Edward Tripp

Guoxin Zhu

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-02-11

Filing date

2006-02-09

Publication date

2009-11-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36694345&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1856090(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-02-09 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2009-11-30 Application granted granted Critical

2009-11-30 Publication of DK1856090T3 publication Critical patent/DK1856090T3/da

Links

229940122904 Glucagon receptor antagonist Drugs 0.000 title abstract 2
230000001225 therapeutic effect Effects 0.000 title 1
150000003577 thiophenes Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
102000051325 Glucagon Human genes 0.000 abstract 1
108060003199 Glucagon Proteins 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 abstract 1
229960004666 glucagon Drugs 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
229940125425 inverse agonist Drugs 0.000 abstract 1
208000030159 metabolic disease Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000002469 receptor inverse agonist Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK06720513T 2005-02-11 2006-02-09 Substituerede thiophen-derivater som glucagon-receptorantagonister, fremstilling og terapeutiske anvendelser DK1856090T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US65249205P	2005-02-11	2005-02-11
PCT/US2006/004461 WO2006086488A2 (fr)	2005-02-11	2006-02-09	Antagonistes du recepteur du glucagon, leur preparation et leurs utilisations therapeutiques

Publications (1)

Publication Number	Publication Date
DK1856090T3 true DK1856090T3 (da)	2009-11-30

Family

ID=36694345

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK06720513T DK1856090T3 (da)	2005-02-11	2006-02-09	Substituerede thiophen-derivater som glucagon-receptorantagonister, fremstilling og terapeutiske anvendelser

Country Status (25)

Country	Link
US (1)	US8084489B2 (fr)
EP (1)	EP1856090B1 (fr)
JP (1)	JP4988604B2 (fr)
KR (1)	KR20070104409A (fr)
CN (1)	CN101115735B (fr)
AT (1)	ATE445609T1 (fr)
AU (1)	AU2006213894B2 (fr)
BR (1)	BRPI0607015A2 (fr)
CA (1)	CA2597073C (fr)
CR (1)	CR9304A (fr)
CY (1)	CY1109624T1 (fr)
DE (1)	DE602006009773D1 (fr)
DK (1)	DK1856090T3 (fr)
EA (1)	EA200701705A1 (fr)
ES (1)	ES2332470T3 (fr)
IL (1)	IL184932A0 (fr)
MA (1)	MA29432B1 (fr)
MX (1)	MX2007009661A (fr)
NO (1)	NO20074567L (fr)
PL (1)	PL1856090T3 (fr)
PT (1)	PT1856090E (fr)
SI (1)	SI1856090T1 (fr)
TN (1)	TNSN07313A1 (fr)
WO (1)	WO2006086488A2 (fr)
ZA (1)	ZA200706354B (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1968921B (zh) *	2004-06-14	2011-11-23	伊莱利利公司	胰高血糖素受体拮抗剂、制备和治疗用途
KR20190126460A (ko)	2007-02-09	2019-11-11	메타베이시스 테라퓨틱스, 인크.	글루카곤 수용체의 길항제
EP2025674A1 (fr)	2007-08-15	2009-02-18	sanofi-aventis	Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament
CA2770298C (fr)	2008-08-13	2017-06-20	Metabasis Therapeutics, Inc.	Antagonistes de glucagon
WO2011107494A1 (fr)	2010-03-03	2011-09-09	Sanofi	Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation
WO2011157827A1 (fr)	2010-06-18	2011-12-22	Sanofi	Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases
US8530413B2 (en)	2010-06-21	2013-09-10	Sanofi	Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en)	2010-07-05	2012-06-01	Sanofi Sa	Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en)	2010-07-05	2012-04-16	Sanofi Aventis	Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en)	2010-07-05	2012-04-16	Sanofi Sa	(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
MX2013006768A (es)	2010-12-23	2013-07-22	Pfizer	Moduladores de receptor de glucagon.
HRP20161177T1 (hr)	2011-02-08	2016-11-04	Pfizer Inc.	Modulator glukagonskog receptora
US8828995B2 (en)	2011-03-08	2014-09-09	Sanofi	Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683705B1 (fr)	2011-03-08	2015-04-22	Sanofi	Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
WO2012120052A1 (fr)	2011-03-08	2012-09-13	Sanofi	Dérivés d'oxathiazine substitués par des carbocycles ou des hétérocycles, leur procédé de préparation, médicaments contenant ces composés et leur utilisation
US8871758B2 (en)	2011-03-08	2014-10-28	Sanofi	Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
EP2683699B1 (fr)	2011-03-08	2015-06-24	Sanofi	Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
AU2012288493B2 (en)	2011-07-22	2015-08-06	Pfizer Inc.	Quinolinyl glucagon receptor modulators
EP2567959B1 (fr)	2011-09-12	2014-04-16	Sanofi	Dérivés d'amide d'acide 6-(4-hydroxy-phényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase
WO2013037390A1 (fr)	2011-09-12	2013-03-21	Sanofi	Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase
EP2760862B1 (fr)	2011-09-27	2015-10-21	Sanofi	Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique utilisés comme inhibiteurs de kinase
TW201427658A (zh)	2012-12-10	2014-07-16	Merck Sharp & Dohme	藉由投予升糖素受體拮抗劑及膽固醇吸收抑制劑治療糖尿病之方法
EP3065736B1 (fr)	2013-11-04	2018-11-14	Merck Sharp & Dohme Corp.	Composés antagonistes du récepteur du glucagon, compositions correspodantes et méthodes d'utilisation
WO2015191900A1 (fr)	2014-06-12	2015-12-17	Ligand Pharmaceuticals, Inc.	Antagonistes du glucagon
WO2017049140A2 (fr)	2015-09-18	2017-03-23	Wake Forest University Health Sciences	Analogues d'angiotensine (1-7) et procédés associés
US20180289859A1 (en)	2015-10-05	2018-10-11	Hettwer Holding Aps	Compositions and methods for treatment of bone defects
CA2914601A1 (fr) *	2015-12-11	2017-06-11	Wake Forest University Health Sciences	Analogues d'angiotensine-(1-7) et methodes associees
MA46089A (fr)	2016-08-30	2019-07-10	Regeneron Pharma	Procédés de traitement de la résistance à l'insuline grave par interférence avec la signalisation du récepteur du glucagon
US20190248888A1 (en)	2016-10-20	2019-08-15	Regeneron Pharmaceuticals, Inc.	Methods of lowering blood glucose levels
CA3071387A1 (fr)	2017-08-22	2019-02-28	Regeneron Pharmaceuticals, Inc.	Methodes de traitement des troubles lies au cycle de l'uree par interference avec la signalisation du recepteur du glucagon
WO2019160940A1 (fr)	2018-02-13	2019-08-22	Ligand Pharmaceuticals Incorporated	Antagonistes de récepteur de glucagon
US20230046892A1 (en)	2019-12-20	2023-02-16	Bayer Aktiengesellschaft	Substituted thiophene carboxamides, thiophene carboxylic acids and derivatives thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1463715A1 (fr) *	2001-12-03	2004-10-06	Novo Nordisk A/S	Nouveaux antagonistes de glucagon
AU2003233780A1 (en) *	2002-06-27	2004-01-19	Novo Nordisk A/S	Novel glucagon antagonists/inverse agonists
EP1758859B1 (fr) *	2004-05-28	2013-07-17	Eli Lilly And Company	Antagonistes vis-a-vis des recepteurs du glucagon, elaboration et utilisations therapeutiques
CN1968921B (zh)	2004-06-14	2011-11-23	伊莱利利公司	胰高血糖素受体拮抗剂、制备和治疗用途

2006
- 2006-02-09 SI SI200630534T patent/SI1856090T1/sl unknown
- 2006-02-09 MX MX2007009661A patent/MX2007009661A/es active IP Right Grant
- 2006-02-09 PT PT06720513T patent/PT1856090E/pt unknown
- 2006-02-09 DE DE602006009773T patent/DE602006009773D1/de not_active Expired - Lifetime
- 2006-02-09 PL PL06720513T patent/PL1856090T3/pl unknown
- 2006-02-09 CN CN2006800046189A patent/CN101115735B/zh not_active Expired - Fee Related
- 2006-02-09 US US11/815,987 patent/US8084489B2/en not_active Expired - Fee Related
- 2006-02-09 DK DK06720513T patent/DK1856090T3/da active
- 2006-02-09 JP JP2007555195A patent/JP4988604B2/ja not_active Expired - Fee Related
- 2006-02-09 AT AT06720513T patent/ATE445609T1/de active
- 2006-02-09 AU AU2006213894A patent/AU2006213894B2/en not_active Ceased
- 2006-02-09 WO PCT/US2006/004461 patent/WO2006086488A2/fr not_active Ceased
- 2006-02-09 CA CA2597073A patent/CA2597073C/fr not_active Expired - Fee Related
- 2006-02-09 EA EA200701705A patent/EA200701705A1/ru unknown
- 2006-02-09 EP EP06720513A patent/EP1856090B1/fr not_active Expired - Lifetime
- 2006-02-09 ES ES06720513T patent/ES2332470T3/es not_active Expired - Lifetime
- 2006-02-09 BR BRPI0607015-9A patent/BRPI0607015A2/pt not_active IP Right Cessation
- 2006-02-09 KR KR1020077018437A patent/KR20070104409A/ko not_active Ceased
2007
- 2007-07-30 IL IL184932A patent/IL184932A0/en unknown
- 2007-07-31 ZA ZA200706354A patent/ZA200706354B/xx unknown
- 2007-08-10 TN TNP2007000313A patent/TNSN07313A1/en unknown
- 2007-08-10 CR CR9304A patent/CR9304A/es not_active Application Discontinuation
- 2007-09-10 NO NO20074567A patent/NO20074567L/no not_active Application Discontinuation
- 2007-09-11 MA MA30221A patent/MA29432B1/fr unknown
2009
- 2009-11-12 CY CY20091101192T patent/CY1109624T1/el unknown

Also Published As

Publication number	Publication date
AU2006213894A1 (en)	2006-08-17
WO2006086488A2 (fr)	2006-08-17
NO20074567L (no)	2007-11-08
AU2006213894B2 (en)	2011-12-08
MA29432B1 (fr)	2008-05-02
JP2008530102A (ja)	2008-08-07
MX2007009661A (es)	2007-09-25
SI1856090T1 (sl)	2010-02-26
PT1856090E (pt)	2009-11-18
EA200701705A1 (ru)	2008-02-28
CR9304A (es)	2008-03-31
DE602006009773D1 (de)	2009-11-26
WO2006086488A3 (fr)	2006-12-14
CA2597073C (fr)	2014-11-25
ZA200706354B (en)	2008-11-26
EP1856090B1 (fr)	2009-10-14
EP1856090A2 (fr)	2007-11-21
JP4988604B2 (ja)	2012-08-01
US8084489B2 (en)	2011-12-27
CN101115735A (zh)	2008-01-30
CY1109624T1 (el)	2014-08-13
ES2332470T3 (es)	2010-02-05
ATE445609T1 (de)	2009-10-15
CN101115735B (zh)	2013-01-09
TNSN07313A1 (en)	2008-12-31
BRPI0607015A2 (pt)	2009-12-01
US20100137417A1 (en)	2010-06-03
IL184932A0 (en)	2007-12-03
KR20070104409A (ko)	2007-10-25
PL1856090T3 (pl)	2010-02-26
CA2597073A1 (fr)	2006-08-17

Publication	Publication Date	Title
DK1856090T3 (da)	2009-11-30	Substituerede thiophen-derivater som glucagon-receptorantagonister, fremstilling og terapeutiske anvendelser
NO20070213L (no)	2007-03-12	Glucagon reseptorantagonister, fremstilling og terapeutiske anvendelser
CY1110922T1 (el)	2015-06-10	Ανταγωνιστες υποδοχεα γλυκαγονης, παρασκευη και θεραπευτικες χρησεις
WO2007106181A3 (fr)	2007-12-06	Antagonistes des récepteurs du glucagon, leur préparation et leurs utilisations thérapeutiques
DK1735278T3 (da)	2010-04-12	Histamin H3-receptormidler, fremstilling og terapeutiske anvendelser
WO2007120270A3 (fr)	2008-02-28	Antagonistes de récepteur du glucagon, procédés de préparation et utilisations thérapeutiques
CY1109694T1 (el)	2014-08-13	Παραγωγα πυρρολιδινης ως ανταγωνιστες υποδοχεα η3 ισταμινης
DK1951659T3 (da)	2010-10-11	Glucagonreceptorantagonister, fremstilling og terapeutisk anvendelse heraf