DK187284A - 7-(3-indolyl)glycylamido-cephalosporin-antibiotika og fremgangsmaade til fremstilling deraf - Google Patents
7-(3-indolyl)glycylamido-cephalosporin-antibiotika og fremgangsmaade til fremstilling deraf Download PDFInfo
- Publication number
- DK187284A DK187284A DK187284A DK187284A DK187284A DK 187284 A DK187284 A DK 187284A DK 187284 A DK187284 A DK 187284A DK 187284 A DK187284 A DK 187284A DK 187284 A DK187284 A DK 187284A
- Authority
- DK
- Denmark
- Prior art keywords
- glycylamido
- indolyl
- procedures
- preparing
- antibiotics
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
gen, hydroxy, C1-C4-alkyl, Cj-C^alkoxy, nitro, amino, C -c -alkanoylamino eller C.-C^-alkylsulfonylamino, eller hvor R og R tilsammen danner methylendioxy; og hvori A og B hver især er hydrogen eller tilsammen danner en dobbeltbinding; R2 er hydrogen, en amino-beskyttende gruppe, hydroxy 7 2 3 eller methoxy og er hydrogen, eller R og R udgør tilsammen gruppen
hvori M og L hver for sig er C^-C^-alkyl; R^ er hydrogen, methoxy eller methylthio; R^ er hydrogen, methoxy, methyl, halogen, methoxymethy1 eller vinyl, og R6 er hydrogen eller en carboxy-beskyttende gruppe, er nyttige som antibiotika til oral indgivelse imod gram-positive mikroorganismer.
Forbindelserne (I), der fremstilles ved en række forskellige fremgangsmåder, udmærker sig ved en meget fordelagtig farmakokinetik.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/484,340 US4492694A (en) | 1983-04-12 | 1983-04-12 | Indolylglycyl cephalosporin derivatives |
| US48434083 | 1983-04-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK187284D0 DK187284D0 (da) | 1984-04-11 |
| DK187284A true DK187284A (da) | 1984-10-13 |
Family
ID=23923746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK187284A DK187284A (da) | 1983-04-12 | 1984-04-11 | 7-(3-indolyl)glycylamido-cephalosporin-antibiotika og fremgangsmaade til fremstilling deraf |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4492694A (da) |
| EP (1) | EP0122157A3 (da) |
| JP (1) | JPS59199693A (da) |
| KR (1) | KR840008655A (da) |
| AU (1) | AU561960B2 (da) |
| CA (1) | CA1212103A (da) |
| DK (1) | DK187284A (da) |
| ES (1) | ES8601215A1 (da) |
| FI (1) | FI841434L (da) |
| GB (1) | GB2137997B (da) |
| HU (1) | HU192003B (da) |
| IL (1) | IL71498A0 (da) |
| NZ (1) | NZ207804A (da) |
| PT (1) | PT78404A (da) |
| ZA (1) | ZA842692B (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4609730A (en) * | 1982-11-22 | 1986-09-02 | Fujisawa Pharmaceutical Co., Ltd. | 7-[substituted imino-2-(2-aminothiazol-4-yl)-acetamido]-3(2,2-dihalovinyl or ethynyl)-3-cephem-4-carboxylic acid (syn isomers), having antimicrobial activities |
| DE3509618A1 (de) * | 1985-03-16 | 1986-09-18 | Bayer Ag, 5090 Leverkusen | Ss-lactam-antibiotika, verfahren zur herstellung und ihre verwendung als arzneimittel |
| US5245046A (en) * | 1988-11-14 | 1993-09-14 | The Upjohn Company | α-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents |
| US6740682B2 (en) | 1997-08-29 | 2004-05-25 | Tularik Limited | Meta-benzamidine derivatives as serine protease inhibitors |
| FR2912133B1 (fr) | 2007-02-01 | 2009-04-24 | Univ Grenoble 1 | Nouveaux derives indoliques,leurs procedes de preparation et leurs utilisations notamment en tant qu'antibacteriens |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1445685A1 (de) * | 1961-09-11 | 1968-12-05 | Lilly Co Eli | Antibiotisch wirksame Cephalospransaeurederivate und Verfahren zu ihrer Herstellung |
| US3364212A (en) * | 1962-01-16 | 1968-01-16 | Merck & Co Inc | Derivatives of 7-aminocephalosporanic acid |
| US3518260A (en) * | 1965-03-08 | 1970-06-30 | Lilly Co Eli | Method for preparing aminoacyl cephalosporins |
| US3560489A (en) * | 1966-08-12 | 1971-02-02 | Lilly Co Eli | 7-alpha-aminoacyl cephalosporins |
| GB1399086A (en) * | 1971-05-14 | 1975-06-25 | Glaxo Lab Ltd | Cephalosporin compounds |
| US4024137A (en) * | 1971-05-14 | 1977-05-17 | Glaxo Laboratories Limited | 7β-[2-Etherified oximino-2-(phenyl- or naphthylacetamido)] cephalosporins |
-
1983
- 1983-04-12 US US06/484,340 patent/US4492694A/en not_active Expired - Fee Related
-
1984
- 1984-04-10 IL IL71498A patent/IL71498A0/xx unknown
- 1984-04-11 KR KR1019840001917A patent/KR840008655A/ko not_active Ceased
- 1984-04-11 CA CA000451709A patent/CA1212103A/en not_active Expired
- 1984-04-11 ZA ZA842692A patent/ZA842692B/xx unknown
- 1984-04-11 FI FI841434A patent/FI841434L/fi not_active Application Discontinuation
- 1984-04-11 EP EP84302459A patent/EP0122157A3/en not_active Withdrawn
- 1984-04-11 ES ES531532A patent/ES8601215A1/es not_active Expired
- 1984-04-11 JP JP59074848A patent/JPS59199693A/ja active Pending
- 1984-04-11 NZ NZ207804A patent/NZ207804A/en unknown
- 1984-04-11 DK DK187284A patent/DK187284A/da not_active Application Discontinuation
- 1984-04-11 GB GB08409383A patent/GB2137997B/en not_active Expired
- 1984-04-11 AU AU26734/84A patent/AU561960B2/en not_active Expired - Fee Related
- 1984-04-11 HU HU841414A patent/HU192003B/hu unknown
- 1984-04-11 PT PT78404A patent/PT78404A/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI841434A7 (fi) | 1984-10-13 |
| FI841434A0 (fi) | 1984-04-11 |
| KR840008655A (ko) | 1984-12-17 |
| GB2137997B (en) | 1986-11-26 |
| ZA842692B (en) | 1985-11-27 |
| JPS59199693A (ja) | 1984-11-12 |
| DK187284D0 (da) | 1984-04-11 |
| CA1212103A (en) | 1986-09-30 |
| PT78404A (en) | 1984-05-01 |
| EP0122157A3 (en) | 1985-08-14 |
| ES531532A0 (es) | 1985-10-16 |
| AU2673484A (en) | 1984-10-18 |
| NZ207804A (en) | 1986-10-08 |
| US4492694A (en) | 1985-01-08 |
| GB2137997A (en) | 1984-10-17 |
| FI841434L (fi) | 1984-10-13 |
| HU192003B (en) | 1987-04-28 |
| AU561960B2 (en) | 1987-05-21 |
| EP0122157A2 (en) | 1984-10-17 |
| GB8409383D0 (en) | 1984-05-23 |
| HUT34496A (en) | 1985-03-28 |
| ES8601215A1 (es) | 1985-10-16 |
| IL71498A0 (en) | 1984-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |